In episode two, we explore the past, present and future of neurodegenerative diseases linked to misfolded proteins, namely, Alzheimer’s disease and prion diseases such as Creutzfeldt-Jakob disease (CJD).

September 2022 (Part Two): The past, present and future of misfolded proteins and neurodegeneration

R-loops are structures that form when the nascent RNA hybridizes with the template DNA strand, displacing the non-template strand. Nascent RNA refers to the newly synthesized RNA molecule that is produced during the process of transcription. Transcription is the first step in gene expression where the information in a DNA sequence is used to create an RNA molecule. In addition to transcription, R-loops are involved in various biological processes, such as splicing, DNA repair and chromatin remodeling. However, when R-loop homeostasis is disrupted, they can also cause transcriptional impairment, genome instability and cellular dysfunction.

"R-loops have been shown and studied in a wide range of organisms and while they have important regulatory roles, persistent R-loops can be detrimental to cell function and survival, having been closely linked to both gene expression dysregulation and increased genome instability."

In a new editorial paper, researcher Hana Hall from the Purdue Institute for Integrative Neuroscience at Purdue University, discusses the role of R-loops in neuronal aging and neurodegeneration. On September 13, 2023, her editorial was published in Aging’s Volume 15, Issue 17, and entitled, “R-loops in neuronal aging.” Hall summarizes her recent study and the current knowledge on how R-loop levels change during aging, how they affect gene expression and neuronal function, and how they are regulated by different factors.

Full blog - https://aging-us.org/2023/09/the-role-of-r-loops-in-neuronal-aging/

Paper DOI - https://doi.org/10.18632/aging.205070

Corresponding author - Hana Hall - hallh@purdue.edu

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Keywords - aging, R-loops, neuron, transcription, genome instability, neurodegeneration

About Aging-US

Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

Please visit our website at https://www.Aging-US.com​​ and connect with us:

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Aging (Aging-US)

Blog: The Role of R-loops in Neuronal Aging

20  minutes ago  -  COPY LINK TO DOWNLOAD : https://terbarupwman.blogspot.com/?now=1632203022 | READ [PDF]  250 Amazing Fishing Tips: The Best Tactics and Techniques to Catch Any and All Game Fish | The very best tactics and techniques that successful anglers use to get their fish.With decades of experience on the water, Lamar Underwood knows the best gear, the best times to head out, the best lures to select for certain fish, and the best casts to use for every angling situation. Now, he wants you to know the tips that he&#8217 s picked up from his long experience. 250 Amazing Fishing Tips is a concise, easy to read collection of the best tested tidbits of fishing wisdom from a lifetime angler.250 Amazing Fishing Tips focuses on the most popular freshwater gamefish?trout, bass, crappie, bluegill, walleye, catfish, salmon, and pike?and saltwater favorites, such as striped bass, bluefish, flounder, redfish, weakfish, and sea trout. The techniques and tips here are applicable to rivers and streams, lakes and ponds, estuaries and inlets, bays, beaches, and offshore.The angler you always see catching fish isn&#8217 t lucky?he just studies his quarry thoroughly, so there is nothing

[PDF READ ONLINE] 250 Amazing Fishing Tips: The Best Tactics and Techniques to C

Today I had Dr Robert Dickson back on the podcast to give us an update on the Calgary fluoride water situation. Dr Bob first appeared on the podcast a few years back, and his return was actually (recently) requested by several of my followers. Lucky for us, Dr Bob kindly obliged. :)
If you are in Calgary, Airdrie, Strathmore or surrounding areas, actually if you have any interest in knowing the issues around fluoride, then you will enjoy this conversation. 
Dr Bob is a family physician, kinesiologist, and founder of Safe water Calgary. He is a long term advocate of medical freedom and safe healthcare for all. Find out more and have your say here;
TAKE ACTION = https://www.safewatercalgary.com/action
https://www.safewatercalgary.com/
https://www.fluoridefreecanada.ca/
https://fluoridealert.org/
Link to our original conversation - https://youtu.be/sn9rlq2BZpg

As always, please like, share and subscribe. And let us know if you have any questions or feedback in the comments. :)

#295 Fluoride in our water - including a Calgary water update with Dr Bob Dickson

We live in a toxic environment that negatively impacts our health and specifically our cellular function.  Methylene Blue is a chemical compound that was discovered during the industrial revolution and was initially used as a blue dye. Today, it is used primarily for mitochondrial function and is only available at compounding pharmacies. People living with neurodegeneration (ALS, Parkinson’s, Alzheimer’s, dementia) can see improvement in symptoms with methylene blue. Methylene blue can also help with lack of focus, mood swings, and memory retention. 
  
Join Bryana Gregory, PharmD, RPh, Pharmacist and Physician Liaison at Physicians Preference Pharmacy as she discusses the benefits of Methylene Blue and answers the most common questions we receive! 
  
Watch now and subscribe to our podcasts at www.HotzePodcast.com. To receive a FREE copy of Dr. Hotze’s best-selling book, “Hormones, Health, and Happiness,” call 281-698-8698 and mention this podcast. Includes free shipping!

Methylene Blue FAQs with Bryana Gregory, PharmD, RPh

Neurons, the building blocks of the nervous system, play a vital role in our body’s function and longevity. Unlike other cells, neurons do not undergo replicative aging. However, they are still susceptible to various sources of damage throughout life, leading to neuronal death. Understanding the mechanisms behind aging and neuronal death is crucial for uncovering the secrets of brain longevity and developing potential interventions to promote healthy aging.

In a new editorial, researchers Fang Fang, Robert Usselman and Renee Reijo Pera from the University of Science and Technology of China, Florida Institute of Technology and McLaughlin Research Institute discussed new interconnected mechanisms of neuronal functionality and available tools to investigate neuronal aging and longevity. On December 13, 2023, their editorial was published in Aging’s Volume 15, Issue 23, entitled, “Aging and neuronal death.”

Full blog - https://aging-us.org/2023/12/understanding-the-mechanisms-of-brain-aging-and-longevity-in-neurons/

Paper DOI - https://doi.org/10.18632/aging.205433

Corresponding author - Renee Reijo Pera - reneer@mclaughlinresearch.org

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Keywords - aging, neurodegeneration, reactive oxygen species, histone h3k79 methyltransferase, dopaminergic neurons

About Aging-US

Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

Please visit our website at https://www.Aging-US.com​​ and connect with us:

SoundCloud - https://soundcloud.com/Aging-Us
Facebook - https://www.facebook.com/AgingUS/
X - https://twitter.com/AgingJrnl
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Understanding the Mechanisms of Brain Aging and Longevity in Neurons

BUFFALO, NY- February 15, 2024 – A new #research paper was #published on the #cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 3, entitled, “GV1001 reduces neurodegeneration and prolongs lifespan in 3xTg-AD mouse model through anti-aging effects.”

GV1001, which mimics the activity of human telomerase reverse transcriptase, protects neural cells from amyloid beta (Aβ) toxicity and other stressors through extra-telomeric function, as noted in our prior in vitro studies. As per a recent phase II clinical trial, it improves cognitive function in patients with moderate to severe dementia. However, the underlying protective mechanisms remain unclear. 

In this new study, researchers Hyun-Hee Park, Hyuk Sung Kwon, Kyu-Yong Lee, Ye Eun Kim, Jeong-Woo Son, Na-Young Choi, Myung-Hoon Han, Dong Woo Park, Sangjae Kim, and Seong-Ho Koh from Hanyang University Guri Hospital, Hanyang University Graduate School of Biomedical Science and Engineering and Teloid Inc. aimed to investigate the effects of GV1001 on neurodegeneration, senescence, and survival in triple transgenic Alzheimer’s disease (AD) (3xTg-AD) mice. 

“ [...] we hypothesised that GV1001 might have anti-aging effects and improve neurodegeneration and senescence in vivo as a possible mechanism for its beneficial effects on AD.”

GV1001 (1 mg/kg) was subcutaneously injected into old 3xTg-AD mice thrice a week until the endpoint for sacrifice, and survival was analysed. Magnetic resonance imaging (MRI) and Prussian blue staining (PBS) were performed to evaluate entry of GV1001 entrance into the brain. Diverse molecular studies were performed to investigate the effect of GV1001 on neurodegeneration and cellular senescence in AD model mice, with a particular focus on BACE, amyloid beta1-42 (Aβ1-42), phosphorylated tau, volume of dentate gyrus, β-galactosidase positive cells, telomere length, telomerase activity, and ageing-associated proteins. 

GV1001 crossed the blood-brain barrier, as confirmed by assessing the status of ferrocenecarboxylic acid-conjugated GV1001 using magnetic resonance imaging and PBS. GV1001 increased the survival of 3xTg-AD mice. It decreased BACE and Aβ1-42 levels, neurodegeneration (i.e., reduced CA1, CA3 and dentate gyrus volume, decreased levels of senescence-associated β-galactosidase positive cells, and increased telomere length and telomerase activity), and levels of ageing-associated proteins. 

“We suggest that GV1001 exerts anti-ageing effects in 3xTg-AD mice by reducing neurodegeneration and senescence, which contributes to improved survival.”

DOI - https://doi.org/10.18632/aging.205489

Corresponding authors - Sangjae Kim - chiron@gemvax.com, and Seong-Ho Koh - ksh213@hanyang.ac.kr

Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts

About Aging-US

Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

Please visit our website at https://www.Aging-US.com​​ and connect with us:

Facebook - https://www.facebook.com/AgingUS/
X - https://twitter.com/AgingJrnl
Instagram - https://www.instagram.com/agingjrnl/
YouTube - https://www.youtube.com/@AgingJournal
LinkedIn - https://www.linkedin.com/company/aging/
Pinterest - https://www.pinterest.com/AgingUS/
Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc

MEDIA@IMPACTJOURNALS.COM

GV1001 Reduces Neurodegeneration and Prolongs Lifespan in Mouse Model of Alzheimer’s Disease

Mortality from nervous system diseases has more than doubled in Australia in the last 50 years. Today, many things can undermine the brain’s health. This program explores what the brain needs to function well, factors that threaten brain health, and lifestyle choices that optimise brain health.

Host: Kaysie Vokurka, Nutritionist & Lifestyle Medicine Practitioner
Guest: Dr Ross Grant, Biochemical Pharmacologist

How to Keep the Brain Healthy - YLAM240010

#Demenz
#VaskuläreDemenz
#Schlaganfall
#Gedächtnisverlust
#Hirnkrankheit
#Bluthochdruck
#Symptome
#Krankheitsverlauf
#Gehirn
#Neurologie
#DemenzUrsachen
#DemenzSymptome
#Kognition
#DemenzForschung
#Medizin
#Gesundheit
#Neurodegeneration
#DemenzPflege
#Gedächtnisstörungen
#Wissenschaft
#Prävention
#KrankheitVerstehen
#Altersmedizin
#DemenzVerlauf
#Blutgefäße
#Hirnfunktion
#DemenzAwareness
#Gehirngesundheit
#Krankheitsbewusstsein
#PflegeDemenz

Vaskuläre Demenz

Synopsis: 

Explore the forefront of biotech innovation as host Rahul Chaturvedi interviews Dr. Dave Bearss, Co-Founder & CEO of Halia Therapeutics, in this engaging episode of Biotech 2050. Dr. Bearss shares the story behind Halia’s pioneering genetic discoveries and their mission to tackle Alzheimer’s disease. Learn about the science driving breakthrough therapies that target neuroinflammation, offering hope in the fight against neurodegenerative disorders. Packed with insights and inspiration, this episode is a must-listen for anyone interested in the future of healthcare and biotech innovation.

Biography:

Dr. David J. Bearss, a serial entrepreneur and pharmaceutical innovator, has over two decades of experience spanning academic and industrial roles. His expertise lies at the intersection of structure-based small-molecule drug discovery and the utilization of genetic model systems for drug discovery. Dr. Bearss's career is marked by significant achievements, with a strong foundation in translational research focused on drug advancement to the clinic and using genetic markers for predictive drug sensitivity.
Notably, Dr. Bearss has discovered 16 compounds that have successfully navigated from discovery in the lab to IND into clinical development. His entrepreneurial experience is evident through his roles as the co-founder of eight biotechnology companies. More importantly, his unwavering commitment to advancing novel drug development truly sets him apart.
Before taking on his role as chief scientific officer at Halia in January 2021 and assuming the CEO position in March 2022, Dr. Bearss served as the CEO of Tolero Pharmaceuticals, an organization later acquired by Sumitomo Dainippon Pharma in 2017. His tenure as chief scientific officer at Montigen Pharmaceuticals, followed by its acquisition by SuperGen Inc., demonstrates his dedication to driving early-stage drug discovery and development. At SuperGen, he continued to develop his expertise in these critical areas.
Dr. Bearss's academic career is equally impressive. It led to his founding role as the Center for Investigational Therapeutics Co-Director at the Huntsman Cancer Institute. He also held academic positions as an Associate Professor in the Department of Oncological Sciences at the University of Utah and as an Associate Professor of Physiology and Developmental Biology at Brigham Young University, demonstrating his deep knowledge and expertise in these fields.
Dr. Bearss's academic career began with a Ph.D. in cell biology from the University of Texas Health Science Center in San Antonio, Texas, and a post-doctoral fellowship at the Institute for Drug Development at the Cancer Therapy and Research Center also in Texas. He has won several awards for his entrepreneurial and scientific achievements, including the Utah Governor's Medal of Science and BIO Utah Entrepreneur of the Year.

Dr. Dave Bearss, Co-Founder & CEO of Halia, on Pioneering Genetic Discoveries to Defeat Alzheimer’s

Harness Therapeutics' CEO talked to In Vivo about the company's scientific strategy, and its plans for expansion and partnering in the neurodegeneration space.

Harness Therapeutics CEO Talks Somatic Expansion for Neurodegeneration

UC Irvine School of Medicine interviewed Dr. Albert La Spada about his recent research on ataxia. La Spada's research is focused on neurodegenerative disease. His lab is seeking the molecular events that underlie neurodegeneration and neuron cell death in spinocerebellar ataxia type 7, spinal and bulbar muscular atrophy, Huntington’s Disease, ALS, Parkinson’s disease, and Alzheimer's disease. 

Ataxia research study: https://www.science.org/doi/10.1126/scitranslmed.adn5449

To watch his lecture on YouTube:
https://www.youtube.com/watch?v=lHaiGqk9OVI

03/01/2025

UC Irvine School of Medicine interview on ataxia with Albert La Spada, MD, PhD

When you eat very few carbs or go for a while without eating, your body can change its main energy source. Instead of running on sugar from food, your body starts burning fat, producing another source of energy in the process: ketones.  For many years now, ketones have been investigated for multiple health benefits, such as weight loss, but also for boosting energy, improving focus, and supporting brain and heart health. Some research even suggests ketones might help protect against diseases like Alzheimer’s.  But how legitimate is the hype surrounding ketogenic diets?  In this grad student interview episode with Paule, we discuss ketogenic diets, the aging brain and the potential to use ketones as a therapeutic strategy for Alzheimer's disease.

Paule defines herself as a curious limitless African neuroscientist. She left her country Côte d’Ivoire to study the complexity of the aging brain. She is currently doing her PhD between the University of Montreal and the University of Sherbrooke. Using behavioural tests as well as cellular and molecular analytic tools, she investigates the therapeutic potential of ketogenic dietary interventions in Alzheimer’s Disease. The goal is to optimize lifestyle-based interventions for the prevention and treatment of aging-related neurodegenerative disorders.

Authors: Eve Racette, Golnar Taheri

Email: thinktwicepodcast@outlook.com 
Instagram: @thinktwice_podcast
LinkedIN: Think Twice Podcast
Patreon: https://www.patreon.com/ThinkTwicePodcast 

Disclaimer: Think Twice is a podcast for general information and entertainment purposes only. The content discussed in the episodes does not reflect the views of the podcast committee members or any institution they are affiliated with. The use of the information presented in this podcast is at the user’s own risk and is not intended to replace professional healthcare services.

43: Ketogenic Cure? Exploring Ketones in Alzheimer’s Disease

How is venture philanthropy revolutionizing Alzheimer's drug discovery? We sit down with Karen Harris, CFO at the Alzheimer's Drug Discovery Foundation, to explore their game-changing approach to funding early-stage research.

With $370M+ awarded to 765+ programs globally, the ADDF operates like a VC firm—using convertible debt and preferred equity to accelerate breakthrough treatments.
 
Topics:
Venture philanthropy vs traditional grants
Shift from amyloid to combination therapies
Blood-based biomarkers & precision medicine
NIH funding cuts impact on research ecosystem

Karen brings 20+ years investment banking experience to discuss how strategic capital is changing Alzheimer's research.

ADDF's Karen Harris: Investing in Alzheimer's Like a VC

Citeline places biopharma and medical device professionals, and those who focus on these industries, at the forefront of knowledge and insight, by providing the perfect combination of news and information together with penetrating insight and analysis. Citeline is a leader in the field of healthcare industry information.

Get your critical thinking caps on! ‘Think Twice’ discusses controversial topics in the field of neuroscience with the goal of bringing more nuance and rigor to mainstream media. We’ll take you past the headlines by breaking down relevant neuroscience topics, interviewing experts in the field and overcoming misinformation/disinformation with evidence-based content. This podcast is run by a small group of graduate students at the Centre for Neuroscience Studies at Queen’s University. We hope to bring down barriers to the dissemination of scientific information, give early-career neuroscientists a voice, and foster a culture of entertaining and accessible science communication.

The Royal College of Pathologists promotes excellence in the practice of pathology. Members work across 17 specialties in healthcare, universities & industry. Find out more at www.rcpath.org

For a wealth of life changing information visit:  3abnaustralia.org.au/radio/listen 

3ABN (Three Angels Broadcasting Network) Australia Radio is the "Mending Broken People Network," broadcasting Christian content 24/7.

Willkommen auf meinem SoundCloud-Profil! Schön, dass ihr hier seid. Hier findet ihr eine Mischung aus energievollen Beats und einzigartigen Klängen, die mich inspirieren. Viel Spaß beim Entdecken meiner Musik!

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Each year, the UC Irvine School of Medicine educates more than 500 medical students and nearly 150 PhD and MS students. More than 750 residents and fellows are trained at the UCI Medical Center and affiliated institutions. The School of Medicine offers multiple MD, PhD and MS degrees, and students are encouraged to pursue an expansive range of interests and options. For more information, visit medschool.uci.edu.

Proverbs 18:21 "Death and life are in the power of the tongue, and those who love it shall eat of its fruit."
It is my hope that my podcast and these conversations bring you insight and the tools to take responsibility for your health and hormones, so that you may live your best life AND fulfill your life's purpose with determination and happiness. Please like and subscribe if you are enjoying my content. :)

If you are considering reaching out, I work with high-achieving motivated people in a 1:1 position to optimize their health and life through a science backed holistic approach. This includes personalized nutrition and hormone therapy, 360° sleep improvement, strategic supplementation, movement and more.📝📊🧬

Don't be afraid to say Hi sometime!
support@chemainesmodelhealth.com or on Facebook and Instagram - I swear I do respond! ;)

Aging-US is dedicated to advancing our understanding of the biological mechanisms that drive aging and the development of age-related diseases. Our mission is to serve as a platform for high-quality research that uncovers the cellular, molecular, and systemic processes underlying aging, and translates these insights into strategies to extend healthspan and delay the onset of chronic disease.

Read about the Aging (Aging-US) Scientific Integrity Process: https://aging-us.com/scientific-integrity

Rising healthcare costs, increasing insurance premiums, and decreasing care - this is the current state of our healthcare system. The pharmaceutical industry continues to make empty promises by masking patients symptoms and providing a false sense of hope.

"Dr. Hotze's Wellness Revolution" is a paradigm shift in the way we look at modern medicine and gives listeners hope to get to the root cause of their symptoms, naturally.

Steven F. Hotze, M.D., is the founder and CEO of the Hotze Health & Wellness Center, Hotze Vitamins and Hotze Pharmacy. His goal is to change the way women and men are treated in midlife. Dr. Hotze has helped thousands of individuals to get on a path of health and wellness and enjoy a better quality of life, naturally. 

Dr. Hotze is the best-selling author of Hormones, Health, and Happiness" and "Hypothyroidism, Health & Happiness and has appeared on hundreds of television and radio shows across the nation, including ABC, NBC, CBS, and FOX affiliates, CBS' "The Morning Show" and The Biography Channel. He is also a regular guest on the KHOU Channel 11 morning program, "Great Day Houston" as well as radio talk shows across the country.

Dr. Hotze is a member of the American Academy of Otolaryngic Allergy, the Association of American Physicians and Surgeons, and is former president of the Pan American Allergy Society.

Join Dr. Hotze, his colleagues, and insightful experts from around the world as they get you on a path to health and wellness naturally. "Dr. Hotze's Wellness Revolution" airs weekdays at 1 p.m. on KPRC AM 950 and iHeartRadio.

Biotech2050 Podcast is a think tank chronicling the disruptions changing the biotech industry over the next 50 years.

New tracks tagged #Neurodegeneration