Made this while on probation, passion peace more so, then a validation thing

i'd do anything for your love

do the time

something special

pep talk

Why You're Burning Out (And How Creation Mode Fixes It) talks about how to enter a state of creation instead of survival for maximum performance. Work doesn't have to be stressful, dreading, and insufferable.

Why You're Burning Out (And How Creation Mode Fixes It)

BUFFALO, NY — July 1, 2025 — A new #research paper, featured on the #cover of Aging (Aging-US) Volume 17, Issue 6, was #published on June 4, 2025, titled “DoliClock: a lipid-based aging clock reveals accelerated aging in neurological disorders.”

This study, led by first author Djakim Latumalea from the National University of Singapore and Hanze University of Applied Sciences, with corresponding author Brian K. Kennedy from the National University of Singapore, introduces DoliClock, a biological aging clock based on lipid profiles in the human brain. The researchers found that individuals with autism, schizophrenia, and Down syndrome show signs of accelerated brain aging compared to individuals without these conditions. The discovery offers a new approach to measuring brain aging using lipid markers instead of traditional DNA-based methods.

The team developed DoliClock using lipidomic data from post-mortem prefrontal cortex samples. Lipids are fat-like molecules that play a key role in brain health. Changes in lipid patterns can reflect the biological age of brain tissue. The study focused on a specific class of lipids called dolichols, which increase gradually with age. The DoliClock model was trained to predict biological age by analyzing levels of dolichols and other lipid molecules. It accurately estimated brain age and revealed higher aging rates in individuals with neurological disorders.

One notable finding was a sharp increase in lipid profile variability—also known as entropy—around the age of 40. This suggests a disruption in lipid metabolism during midlife, possibly caused by changes in the mevalonate pathway, a critical biological process involved in producing lipids like cholesterol and dolichol. These disruptions may contribute to aging-related brain decline.

The study also found that dolichol levels could serve as reliable biomarkers of aging. Their consistent increase with age and strong influence on DoliClock’s predictions make them especially useful. In individuals with autism, schizophrenia, and Down syndrome, the clock indicated more advanced biological brain aging than expected, supporting the idea that these conditions are associated with premature aging.

DoliClock offers a new perspective in aging research, complementing existing biological clocks based on DNA or protein markers. Because it relies on lipids, it may detect aspects of aging that other tools cannot. While the current model is based on brain tissue samples, future research may examine whether similar lipid patterns can be identified in more accessible fluids such as blood or cerebrospinal fluid.

“These findings suggest that lipidomics can provide valuable insights into the molecular mechanisms of brain aging and neurological disorders.”

This study highlights the growing potential of lipidomics in the study of aging and neurological disorders. It opens the door to new biomarkers that could help researchers and clinicians better monitor brain aging and develop more targeted interventions for age-related and neurodevelopmental diseases.
DOI - https://doi.org/10.18632/aging.206266

Corresponding author - Brian K. Kennedy - bkennedy@nus.edu.sg

Video short - https://www.youtube.com/watch?v=-FEiyj9PjBE

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Aging (Aging-US)

New Lipid-Based Aging Clock Reveals Faster Brain Aging in Autism, Schizophrenia, and Down Syndrome

The provided text explores the revolutionary concept of biophotons, or ultra-faint photon emissions (UPEs), establishing them as a quantifiable light emitted by living organisms, which increases with stress or injury. A significant breakthrough in April 2025 involved the detection of light directly from the human brain, leading to photophilography as a new, cost-effective neuroimaging technique that correlates UPE output with brain electrical activity during tasks. Future implications include advanced brain mapping and identifying "biophoton fingerprints" for thought patterns, potentially diagnosing neurological issues. Dr. Jack Kruse's "Operational Consciousness" framework offers a theoretical underpinning, proposing that life and consciousness are fundamentally quantum processes fueled by entropy, with the brain acting as an "antenna" that utilizes structured water and iron to harness light and facilitate nonlocal communication via UPEs, emphasizing the importance of light exposure and cold thermogenesis for health.



DECENTRALIZED MEDICINE | Biophotons - The Brain's Luminous Secret (Audio Summary)

A new study published recently as the cover of Aging Volume 17, Issue 6, describes a new method to estimate how fast the brain is aging. By analyzing lipids, or fat molecules, in brain tissue, researchers from the National University of Singapore and Hanze University of Applied Sciences created a biological “clock” called DoliClock. This innovation highlights how conditions such as autism, schizophrenia, and Down syndrome are associated with accelerated brain aging.

Understanding Brain Aging

As people grow older, their brains naturally change. However, in many neurological disorders, these changes seem to appear earlier and progress more rapidly. Disorders like autism, schizophrenia, and Down syndrome reduce quality of life and contribute to premature death. Scientists have long searched for better ways to measure biological age in the brain to understand these processes and develop strategies to slow them down.

Most existing methods for estimating biological age rely on genetic markers, such as DNA methylation, which are chemical modifications of DNA. While useful, these approaches may not fully capture the complexity of aging, especially in the brain. Lipids, which are essential components of brain cells and play important roles in energy storage and signaling, offer another perspective.

Full blog - https://aging-us.org/2025/07/doliclock-a-lipid-based-clock-for-measuring-brain-aging/

Paper DOI - https://doi.org/10.18632/aging.206266

Corresponding author - Brian K. Kennedy - bkennedy@nus.edu.sg

Video short - https://www.youtube.com/watch?v=-FEiyj9PjBE

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Keywords - aging, aging clock, down syndrome, autism, schizophrenia, dolichol

To learn more about the journal, please visit our website at https://www.Aging-US.com​​ and connect with us:

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DoliClock: A Lipid-Based Clock for Measuring Brain Aging

BUFFALO, NY — July 8, 2025 — As populations worldwide continue to age, understanding the mechanisms and manifestations of cognitive aging is increasingly urgent for science, medicine, and society. Age-related cognitive decline ranges from mild memory lapses to the onset of dementia, and is shaped by a complex interplay of molecular, cellular, systemic, and social determinants.

In this special collection, Aging (Aging-US) seeks to bring together cutting-edge research that spans the cellular and molecular underpinnings of cognitive aging with insights into the psychosocial, behavioral, and environmental factors that modulate its course. By integrating basic biology with translational and societal dimensions, this collection aims to foster a holistic understanding of how and why cognitive function changes with age—and what can be done to preserve it.

We welcome original research articles, reviews, and perspectives across model systems and human studies, particularly those that promote interdisciplinary insights and translational potential.

POTENTIAL TOPICS

Molecular and Cellular Mechanisms

-Senescence, inflammation, and neurodegeneration in cognitive decline
-Mitochondrial dysfunction and oxidative stress in aging neurons
-Neurovascular aging and blood-brain barrier integrity
-Single-cell and spatial transcriptomics of the aging brain
-mTOR, autophagy, and proteostasis in age-related cognitive impairment
-The role of glial cells (microglia, astrocytes) in brain aging

 Genetics and Biomarkers

-Genetic risk factors and epigenetic modifications associated with cognitive aging
-Biomarkers of cognitive resilience and vulnerability
-Neuroimaging and fluid-based biomarkers in aging populations

Interventions and Lifestyle Factors

-Cognitive benefits of caloric restriction, exercise, or senolytic therapies
-Preclinical and clinical trials targeting aging pathways to prevent cognitive decline
-Impact of sleep, nutrition, and metabolic health on cognition in older adults
-Use of cognitive strategies and compensatory techniques to maintain or enhance function in aging

Environmental and Social Contexts

-Impact of social isolation, education, and socioeconomic status on cognitive trajectories
-Lifelong cognitive reserve and its determinants
-Cross-cultural and demographic studies on aging and cognition
-Digital health tools for monitoring or enhancing cognitive function in the elderly

SUBMISSION DETAILS:

-Submission Deadline: March 31, 2026
-Manuscript Format: Please follow the journal’s submission guidelines
-Peer Review: All submissions will undergo a rigorous peer-review process
-Submission Link: https://aging.msubmit.net/cgi-bin/main.plex

To learn more about the journal, please visit our website at https://www.Aging-US.com​​ and connect with us on social media at:

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Now Accepting Submissions: Special Collection on Cognitive Aging

Tracklist: [148 BPM]
1.	Hypnoise - Unified Field (Ana Valeriano Remix)
2.	Alter Vu & Ana Valeriano - Anagram (UNR)
3.	Ana Valeriano & Neurology - The Hive (UNR)
4.	Neurology & Benedix - NN (UNR)
5.	Avan7 - Biological Connection (Original Mix)
6.	Ana Valeriano - Gosto Meio Roxo (Original Mix)
7.	Limbu & Brainlapse - NN  (UNR)
8.	Ana Valeriano - Cabron (Original Mix)
9.	Volcano On Mars - Connected (Original Mix)
10.	Ana Valeriano - Welcome (Original Mix)
11.	Ana Valeriano & Evocar - Oppenheimer (Original Mix)
12.	Hyperflex - Made of Light (Ana Valeriano & Cosmic Wolf Remix)
13.	Cosmic Wolf, Ana Valeriano, Alien Talk - Melded (Original Mix)
14.	Avan7 & Br1sa - Free Soul (Original Mix)
15.	Cosmic Wolf & Ana Valeriano - Hypnotic (Original Mix)
16.	Cosmic Wolf & Ana Valeriano - Wake Up (Original Mix)

(Español) Ana Valeriano, nacida en Belo Horizonte, es una de las DJs femeninas más destacadas del trance psicodélico en Minas Gerais, con una personalidad fuerte que se refleja en su sonido característico.
Apasionada por la música, Ana siempre ha encarado su trabajo con creatividad, destacándose no solo por la autenticidad al expresar sus ideas, sino también por la importancia que le da a las sensaciones que transmite el sonido.
En su trayectoria musical, lanzó sus primeras canciones, alcanzando el prestigioso puesto número 1 en Beatport con su EP “Mystic Chants”, y participó en colaboraciones junto a otros artistas de renombre.
Sus sets transitan por las sutilezas del Full On y presentan repertorios cuidadosamente seleccionados, construyendo una atmósfera única y llevando la pista a momentos de intensa euforia y éxtasis.
Ana es representante del sello Maharetta Records, una influyente discográfica española que reúne a reconocidos artistas internacionales.

(Portugués) Ana Valeriano, nascida em Belo Horizonte, é uma das mais expressivas DJs femininas do trance psicodélico mineiro, com uma forte personalidade que se reflete em sua sonoridade marcante.
Apaixonada por música, Ana sempre encarou seu trabalho com criatividade, destacando-se não apenas pela autenticidade ao expressar suas ideias, mas também pela ênfase na importância das sensações transmitidas pelo som.
Na trajetória musical, lançou suas primeiras faixas, alcançando o prestigioso Top 1 no Beatport com seu EP "Mystic Chants", e participou de colaborações em lançamentos com outros artistas de renome.
Seus sets transitam nas nuances do Full On e apresentam repertórios bem selecionados, construindo uma atmosfera única e levando a pista a momentos de intensa euforia e êxtase.
Ana é representante do selo Maharetta Records, uma influente gravadora espanhola que reúne renomados artistas internacionais.

Ana Valeriano On
SoundCloud: @djanavaleriano
Redes Sociales: https://linktr.ee/djanavaleriano

Pulpa Music on
Instagram: www.instagram.com/pulpamusic
Facebook: www.facebook.com/pulpa.music
YouTube: www.youtube.com/pulpamusic
SoundCloud: @pulpa_music

It's Time to Psychedelic #0165 by ANA VALERIANO (BR)

Cancer and aging are two sides of age-related tumorigenesis.

The mission of the journal is to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population.

The journal aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.)

Read about the Aging (Aging-US) Scientific Integrity Process: https://aging-us.com/scientific-integrity

I genuinely believe in the potential of music to facilitate personal growth, foster meaningful connections, and cultivate shared experiences. My mission centers on producing dynamic musical works, both in the booth and studio, as an effective medium for storytelling, spiritual exploration, and the creation of deep emotional bonds.


+ Life Long Musical Professional & Enthusiast | Creative Entrepreneur | Music Producer | Club DJ | Event Production, Management, and Design Specialist | Electrician | Graphic Designer | Barber & Comedian 
+ Academic Background Master of Arts in Arts and Media, Audio Production, Media Management, Psychology, Mathematics, Sciences, and Business.   

**UNIFI MUSIC LLC**
NYC-Based Record Label, Music Production & Artist Management
At UNIFI MUSIC LLC, we aim to cultivate a creative and collaborative ecosystem for emerging musicians, artists, and producers. We are dedicated to educating up-and-coming artists to help them reach their highest potential while providing them the means to release music on all essential platforms. Our goal is to create an inspiring and lasting impact on the music industry. Music, dance, and storytelling are fundamental parts of the human experience. Art inspires, helps us find purpose, and fosters meaningful, lifelong connections..

Website - https://bio.site/anelo
Label - https://UnifiMusicRecords.com
Email - Promo@UnifiMusic.info

Pulpa Music es una productora de eventos con base en Buenos Aires, Argentina.
Dedicada a la música electrónica, se enfoca en los géneros Psytrance, Progressive Psytrance & Full On.
Fue fundada en el año 2017 por EarthNoise (Arg), y desde su creación ha logrado consagrar el evento que realiza año tras año como la fiesta más esperada de cada verano, siendo en formato outdoor, se caracteriza como festival al celebrarse todos los años en el mes de Diciembre, mes en el que originalmente nació esta fiesta.

Artistas - Team Pulpero 2025
- EarthNoise https://soundcloud.com/earthnoisemusic
- Zaratustra https://soundcloud.com/zaratustrapsytrance
- 1000oK https://soundcloud.com/miloka1
- Gmey https://soundcloud.com/gonza-mey
- Agus Casanova https://soundcloud.com/ac_arg

Booking: pulpamusic.producciones@gmail.com

New tracks tagged #Neurology