leroy - her head is so0o0o0o0 rolling (post-mortem mix)
pluko - bite

biteherhead

wylinroller

stayforever

flume - get u
kucka, flume - one more night

getuonemorenight

jackal, karra - ice
skrillex, fred again, flowdan - rumble

icerumble

fall

tracklist:
charli xcx - everything is romantic with caroline polachek
2hollis - all 2s
pluko, sublab - let go
rl grime - metro north
pluko, chopsoe - xtraaa
bdb - chroma 002 lava
pluko - bite
pluko - thinkabme
pluko, jukaa - talk2me
carti - different day
pluko - stutter
charli xcx - club classics
quiet bison - 26fe
nia archives - tell me what its like?
pinkpantheress - noises x internet baby

*oxytocin: companion mix

BUFFALO, NY — October 1, 2025 — A new #research paper #featured as the #cover of  Volume 17, Issue 9 of Aging-US was published on August 21, 2025, titled “Sex-specific longitudinal reversal of aging in old frail mice.” 

The study, led by first author Cameron Kato and corresponding author and Aging-US Editorial Board Member Irina M. Conboy from the University of California, Berkeley, reports that a combination of oxytocin and an Alk5 inhibitor (OT+A5i) significantly extended both lifespan and healthspan in frail, elderly, male mice. These rejuvenating effects were not seen in female mice, highlighting key biological differences between the sexes in their response to aging therapies.

The researchers tested a dual-drug approach targeting two biological pathways that change with age. Oxytocin, a hormone that declines with aging and supports tissue repair, was combined with an Alk5 inhibitor that blocks the TGF-beta pathway. TGF-beta becomes overactive with age and contributes to chronic inflammation and tissue damage. In this study, frail mice at 25 months of age—roughly equivalent to 75 human years—were treated regularly with the OT+A5i combination.

Male mice receiving the therapy lived over 70% longer than untreated controls and showed significant improvements in physical endurance, agility, and memory. According to hazard ratio analysis, the treated males were nearly three times less likely to die at any given time than untreated males. 

“Treatment of old frail male mice with OT+A5i resulted in a remarkable 73% life extension from that time, and a 14% increase in the overall median lifespan.”

The therapy also reduced “biological noise” in circulating blood proteins—an established marker of aging—bringing those levels back to a more youthful state. Short-term benefits, were seen in both sexes, however, after four months of continuous treatment, only the male mice showed sustained improvement in systemic protein balance. Female mice did not experience significant gains in lifespan or healthspan, though middle-aged females did show improved fertility after treatment.

These results underscore the importance of understanding sex-specific biology when developing treatments for aging. While the reasons for these differences remain unclear, the findings provide a new model for studying and designing longevity therapies.

Oxytocin is already FDA-approved, and Alk5 inhibitors are currently in clinical trials, suggesting that this approach could be translated to humans. With strong results in aged and frail male animals, OT+A5i appears to be a promising candidate for improving late-life health and survival.

DOI - https://doi.org/10.18632/aging.206304

Corresponding author - Irina M. Conboy - irina@generationlab.co

Abstract video - https://www.youtube.com/watch?v=bpWxDd7hHhM

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Keywords - aging, lifespan, healthspan, Alk5 inhibitor, oxytocin, sex-specific differences

To learn more about the journal, please visit our website at https://www.Aging-US.com​​ and connect with us:

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Pinterest - https://www.pinterest.com/AgingUS/
Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc

MEDIA@IMPACTJOURNALS.COM

Aging-US

Sex-Specific Effects Found in New Anti-Aging Therapy for Elderly Mice

As life expectancy increases, there is growing interest not only in extending lifespan but also in improving the quality of those additional years. To address the physical and cognitive decline that often accompanies aging, researchers have explored a variety of strategies. Many of these focus on a single biological factor, such as reducing inflammation or stimulating stem cell activity. However, aging is a complex process involving multiple, interconnected changes in the body.

Recognizing this, researchers at the University of California, Berkeley proposed a more comprehensive approach: targeting multiple aging-related pathways simultaneously. Their study, titled “Sex-specific longitudinal reversal of aging in old frail mice,” was recently featured on the cover of Aging-US (Volume 17, Issue 9).

Full blog - https://aging-us.org/2025/10/new-anti-aging-combo-boosts-lifespan-in-old-male-mice/

Paper DOI - https://doi.org/10.18632/aging.206304

Corresponding author - Irina M. Conboy - irina@generationlab.co

Abstract video - https://www.youtube.com/watch?v=bpWxDd7hHhM

Sign up for free Altmetric alerts about this article - 
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Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts

Keywords - aging, lifespan, healthspan, Alk5 inhibitor, oxytocin, sex-specific differences

To learn more about the journal, please visit our website at https://www.Aging-US.com​​ and connect with us:

Facebook - https://www.facebook.com/AgingUS/
X - https://twitter.com/AgingJrnl
Instagram - https://www.instagram.com/agingjrnl/
YouTube - https://www.youtube.com/@AgingJournal
LinkedIn - https://www.linkedin.com/company/aging/
Bluesky - https://bsky.app/profile/aging-us.bsky.social
Pinterest - https://www.pinterest.com/AgingUS/
Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc

MEDIA@IMPACTJOURNALS.COM

New Anti-Aging Combo Boosts Lifespan in Old Male Mice

Neurotransmitters (Inner Universes)

Oxytocin

Towolve - Oxytocin

Menniel x Oxytocin - Pres. Sensory Overload EP - CTP: Halloween Special

(To) Wolve, to act like a wolf. Music as translation for Worlds within Worlds.

Willkommen bei RauchigeKrach!

Wir sind Sebbe und Heiko ein Duo, 
das die Leidenschaft für Krach und Gesäge teilt.


Unser guter Freund und Begleiter, die Räuchertonne, Mister Knister, ist das Herzstück von RauchigeKrach. Mit seinen göttlichen Klängen bringt er so viel Krach und Gesäge, dass er sich im Kühlschrank abkühlen muss, um nicht zu schmelzen! Sein rauchiger Krach und das Gesäge schallern durch die Wälder, wodurch die Bäume im Rhythmus wackeln und die Vögel fröhlich zwitschern!


Unsere Reise begann spontan mit TikTok Lives. Wir lieben es, unsere Musik und die Energie, die wir teilen, mit euch zu erleben. In unseren Lives möchten wir nicht nur eine großartige Zeit haben, sondern auch die Produzenten und Künstler aus der Szene unterstützen. Es ist uns wichtig, eine Community zu schaffen, in der wir alle zusammen feiern und wachsen können. Bleibt dran für mehr Krach und gute Vibes! Wir freuen uns auf euch! 




#rauchigekrach #uptempo #rawtempo #krach #deutscherkrach

Aging-US is dedicated to advancing our understanding of the biological mechanisms that drive aging and the development of age-related diseases. Our mission is to serve as a platform for high-quality research that uncovers the cellular, molecular, and systemic processes underlying aging, and translates these insights into strategies to extend healthspan and delay the onset of chronic disease.

Read about the Aging (Aging-US) Scientific Integrity Process: https://aging-us.com/scientific-integrity

New tracks tagged #OXYTOCIN