In this essential episode of Parallax, Dr Ankur Kalra is joined by Dr Carolyn Ho, Professor of Medicine at Harvard Medical School and Medical Director of the Cardiovascular Genetics Program at Brigham and Women's Hospital, for a comprehensive discussion on how genetic testing is reshaping hypertrophic cardiomyopathy management.

The conversation explores the VANISH HCM trial results, which showed that valsartan can slow disease progression in young, asymptomatic individuals with early sarcomeric HCM. Dr Ho discusses how this evidence influenced the 2024 HCM guidelines and created new opportunities for disease-modifying therapy before clinical symptoms appear. The episode also examines emerging gene-based therapeutics, from current adeno-associated virus approaches to future CRISPR technologies that could address the underlying genetic causes of HCM.

Dr Ho addresses practical considerations for clinicians, including when to initiate genetic testing, how to manage family screening, and the promise of AI-assisted screening tools. The discussion highlights both current therapeutic options and the evolving landscape of precision medicine in inherited cardiovascular disease.

Questions and comments can be sent to "podcast@radcliffe-group.com" and may be answered by Ankur in the next episode. Host: @AnkurKalraMD and produced by: @RadcliffeCardio
Parallax is Ranked in the Top 100 Health Science Podcasts (#48) by Million Podcasts.

EP 139: The Genetic Revolution in HCM: Mapping Family Risk to Targeted Treatment

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Tekno Journey

THE BEST BOOK CLUB IN THE MULTIVERSE!


Join the Book Club Bois for the grand finale of Geoff Johns’ GREEN LANTERN!


The First Lantern, Volthoom, has awakened… and now the entire universe is under threat. With the ability to rewrite history and alter reality, Volthoom plans to remake the universe in his image. It’s up to the united might of EVERY Lantern Corps to challenge Volthoom - but will they be enough? Meanwhile, Sinestro and Hal Jordan still find themselves trapped in the Dead Zone! Who will live? Who will die? Find out in the explosive finale nearly 10 years in the making!


Covers Green Lantern (2011) #17-20 by Geoff Johns, Doug Mahnke, Pete Tomasi, Aaron Kuder, Szymon Kudranski, Cully Hamner, Jerry Ordway, Dan Jurgens, Ivan Reis & THAT FUCKING GUY


Time Stamps:
00:00:21 Intro & Whatcha Doin’?
00:26:36 Book Club Begins
02:38:45 Break
02:40:30 Sinestro’s Mailbag
03:30:30 Patreon Shout-Outs & Wrap-Up


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Check out BIFF BAM POW!, a podcast hosted by friend of the show Gianni Palumbo filled with SENSATIONAL comics conversations!:
https://open.spotify.com/show/462wfQoHMrBEHWkcK6pSa2 


Music Sampled:
“Alive” by Warbly Jets


GIANT-SIZED Book Club: Geoff Johns' Green Lantern Part 19 (WRATH OF THE FIRST LANTERN)

In this compelling episode of Parallax, Dr Ankur Kalra sits down with Dr Anandita Kulkarni, preventive cardiologist at Baylor Scott and White Heart Hospital, for an eye-opening conversation about addressing cardiovascular disparities in South Asian populations through the innovative Dilwale registry.

Dr Kulkarni tells the story of returning to her Texas community to serve South Asian patients and her determination to create meaningful change through data. What started as a local initiative grew into something much larger: a comprehensive registry of over 31,000 South Asian patients that's revealing critical insights about heart disease in this underserved population.

Beyond the clinical data, this episode delves into the practical challenges of culturally informed preventive care. Dr Kulkarni shares insights on addressing barriers to physical activity within South Asian communities, helping patients navigate dietary changes while respecting cultural food traditions, and the delicate work of motivating lifestyle modifications in a population already facing higher cardiovascular risks. Her patient-centered approach demonstrates how combining population-level research with deep cultural understanding can fundamentally improve both individual outcomes and community health.

Questions and comments can be sent to "podcast@radcliffe-group.com" and may be answered by Ankur in the next episode. Host: @AnkurKalraMD and produced by: @RadcliffeCardio

Parallax is Ranked in the Top 100 Health Science Podcasts (#48) by Million Podcasts

EP 140: Breaking Barriers in South Asian Heart Health: The Dilwale Registry Revolution

Game Over.. literally | Parallox OST

In this essential episode of Parallax, Dr Ankur Kalra welcomes Dr Shelley Zieroth, Professor of Medicine, clinician-scientist, and advanced heart failure and transplant cardiologist in Winnipeg, Canada. As we mark the 10-year anniversary of the landmark EMPA-REG OUTCOME trial, Dr Zieroth provides a comprehensive update on how SGLT2 inhibitors have revolutionized cardiovascular care.

Dr Zieroth takes us through the remarkable journey from the initial 2015 trial that transformed SGLT2 inhibitors from anti-diabetic agents into cardiovascular powerhouses, delivering highly significant reductions in cardiovascular death and heart failure hospitalization. She explores how these medications have become fundamental pillars of cardio-kidney-metabolic medicine, with evidence spanning the entire ejection fraction spectrum.

Dr Zieroth discusses prescribing these agents in heart failure - including the straightforward 10-mg daily dosing, monitoring strategies, and crucial patient selection criteria. She shares insights from the recent EMPULSE trial on safe in-hospital initiation, addresses important considerations for diabetic patients, and highlights key contraindications like indwelling catheters that clinicians must recognize.

Beyond the basics, Dr Kalra and Dr Zieroth examine the evolving role of SGLT2 inhibitors in valvular disease and diastolic dysfunction, tackle the ongoing reimbursement challenges across different healthcare systems, and discuss the critical importance of multidisciplinary collaboration in the cardio-kidney-metabolic space. They also look ahead to exciting combination therapies on the horizon that promise to further advance heart failure prevention and treatment.

Questions and comments can be sent to "podcast@radcliffe-group.com" and may be answered by Ankur in the next episode.

Host: @AnkurKalraMD and produced by: @RadcliffeCardio
Parallax is Ranked in the Top 100 Health Science Podcasts (#48) by Million Podcasts.

EP 141: From EMPA-REG to Clinical Practice: Mastering SGLT2 Inhibitors in Modern Cardiology

In this fascinating episode of Parallax, Dr Ankur Kalra sits down with Dr Alexander Fanaroff, an interventional cardiologist, clinical trialist, and behavioral economist at the University of Pennsylvania. Dr Fanaroff brings a unique perspective to cardiovascular medicine, combining his expertise in interventional cardiology with cutting-edge insights from behavioral economics to transform how we approach patient care and clinical decision-making.

Dr Fanaroff demystifies behavioral economics for the medical community, explaining how this field studies real-world decision-making beyond traditional economic models. He introduces key concepts like status quo bias, prospect theory, and the power of defaults in shaping both physician and patient behaviors. Through compelling examples, including Penn's successful intervention that increased 90-day statin prescriptions from 70% to 90% simply by changing EHR defaults, Dr Fanaroff demonstrates how small design changes can yield significant clinical improvements.

Looking beyond individual interventions, Dr Fanaroff discusses how behavioral economics can address healthcare disparities by creating system-wide improvements that lift all patients while specifically targeting underserved communities. He envisions a future where AI identifies at-risk patients from routine imaging, and where interventional cardiologists focus not just on procedural excellence but on ensuring optimal long-term medical management through thoughtfully designed care systems.

Questions and comments can be sent to "podcast@radcliffe-group.com" and may be answered by Ankur in the next episode.

Host: @AnkurKalraMD and produced by: @RadcliffeCardio
Parallax is Ranked in the Top 100 Health Science Podcasts (#48) by Million Podcasts.

EP 142: The Psychology of Patient Care: Nudges, Gamification, and the Future of Cardiology

 “Parallax Factor” – a retro-futuristic electronic pop journey inspired by the 1980s synthwave era.

Parallax Factor

In this episode of Parallax, Dr Ankur Kalra speaks with Dr Benjamin A D’Souza, Associate Professor of Medicine at the University of Pennsylvania and Section Chief of Cardiac Electrophysiology at Presbyterian Medical Center. Together, they explore the challenges of mitigating sudden cardiac death and the evolving role of guideline-directed medical therapy in optimising patient outcomes.

Dr D’Souza reflects on current strategies for risk assessment and prevention, highlighting the importance of medical therapy, careful monitoring and timely use of defibrillators. He stresses that management must be tailored to individual patients, with decisions guided by evidence, imaging and multidisciplinary collaboration.

The conversation also turns to women’s cardiac health and representation in electrophysiology. Dr D’Souza highlights the persistent under-enrolment of women in clinical trials and their lower access to ablation and device therapy. He stresses the need for inclusive trial design, mentorship and acknowledgement of systemic bias to improve equity in cardiovascular care.

This series is supported by ZOLL and is intended for Health Care Professionals.

EP 143: GDMT Optimisation: Mitigating SCD Risk and Addressing Women’s Cardiac Health

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Disclaimer : I do not own any of music in this mix!!

PARALLAX - Wedding Mix Vol 1

TEKNO Music Producer & Dj
Youtube : www.youtube.com/@ParallaxOfficial

Contact for work : parallaxthedj@gmail.com
Viber : +95 943166054

A geek who explains things!

Each week, join host Aeric Azana on his journey to GEEKsplain every corner of pop culture! Featuring discussions on comics, film, TV, and more, this podcast is for the geeks, BY a geek! New episodes drop every Wednesday!

Connect with Us!
Twitter & IG - @GeeksplainedPod
Email - Geeksplained@gmail.com

‘Parallax’ (/ˈparəlaks/)-noun: the effect whereby the position or direction of an object appears to differ when viewed from different positions. Join Ankur Kalra, MD as he shows you a different side to cardiovascular care, management and science. Listen to Ankur’s conversations with legendary cardiologists, critical reviews of key congresses and late-breaking trials, and concise summaries. Published every second Monday of the month, this is your fix of reliable updates on all things cardiology by someone from a non-traditional background, who is always trying to look at it from new angles! Dear cardiologists, we want to make this podcast about you, and for you! Please email us critical thoughts, comments and questions for Ankur at podcast@radcliffe-group.com.

Lyricist, vocalist, keyboard player for Modern Chant 1980s. 
Co-composer, vocalist, lyricist, keyboard player, Impressionist Music improvising collective 1990s-2000s. 
Vocalist with Medusa singing Goddess acapella 2000s. 
Collaborated with Dale Chant, Marc Tracey, Chris Parthenides, Roland Seidel, Riley Jordan

New tracks tagged #ParallaX