What if the next advance in vaccination didn’t come from a chemical lab — but from a living cell? This episode explores how scientists in Wrocław turned Escherichia coli into a microscopic factory capable of producing a vaccine candidate against Porphyromonas gingivalis, the stealthy bacterium behind gum disease and systemic inflammation.

We explore:
🔹 Why traditional vaccine strategies failed to stop P. gingivalis after decades of research
🔹 How engineered E. coli cells can fuse proteins and sugars into a single, precisely designed antigen
🔹 The promise of biological synthesis — safer, faster, and more reproducible than chemical methods
🔹 What this innovation could mean for the future of vaccines against other Gram-negative pathogens

Beyond the microscope lies a quiet revolution in immunology — where biology itself becomes the tool of protection.


This content was developed with the assistance of artificial intelligence (AI) tools: DeepDive (Notebook LM, Google).

Fighting Periodontal Diseases. An E. coli-based vaccine against a dangerous pathogen

Leading in medical research and education, Wrocław Medical University drives innovation in health sciences and clinical advancements. Based in Wrocław, Poland.

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