Catéchèse du P. Mathieu - 2023-02-24 Pouvons-nous réellement offenser Dieu?

In this episode, Ambassador Robert Joseph, former Under Secretary of State for Arms Control and International Security, discusses various aspects of Iran's nuclear program and ambitions. He delved into the issue of weapons-grade uranium enrichment in Iran's nuclear facilities, and whether the UN will intervene in Iran's nuclear program. The recent trip of Rafael Grossi, the Director General of the International Atomic Energy Agency (IAEA), to Tehran is also examined. The podcast explores the two decades of escalation over Iran's nuclear program, and the differences between the nuclear programs of Libya, North Korea, and Iran. The discussion also places Iran's nuclear program in the context of Russia's war on Ukraine and examines the Iran-Russia-China relations. Robert Joseph analyzes how Iran's protests affect the nuclear program and discusses ways to prevent Iran from acquiring nuclear weapons.

Robert Joseph Iran S Nuclear Program Iran Policy Podcast #2

Aujourd’hui j’ai pris le temps d’échanger avec Myriam Suchet autour de son livre L’horizon est ici, paru aux éditions du commun. Nous revenons sur cette aventure éditoriale collective, nous dévoilons comment les proliférations et relations évoquées en sous-titre sont présentes autant dans la forme de son ouvrage que dès les premières étapes de sa conception. En s’inspirant du Talmud, un des textes fondamentaux du judaïsme, mais aussi de ses souvenirs d’enfance des repas de famille, nous avons exploré comment Myriam Suchet fait vivre les relations jusque dans la mise en forme des pages. Nous avons aussi questionné l’idée qui voudrait que « tout ai déjà été dit » en regardant ce qui fait que cet ouvrage propose des orchestrations inédites, comme peuvent l'être les rencontres débarrassées d'étiquettes. Nous avons exploré les relations au territoire, ou comment les textes imprimés font prolifération depuis un photocopieur mutualisé ou par des formes de publication plus spontanées et ouvertes comme les fanzines et autres objets agrafés-pliés. Ce qui nous a finalement amené à ses derniers travaux qui, en prenant le s de français comme une marque de pluriel, proposent de faire entendre les relations jusque dans "la langue".

Pour prolonger notre échange :
- consulter la page 62 animée (gif)
- consulter la page 78 animée (gif)
- consulter un cadavre exquis issu d’un atelier avec un dessin de David Elghozi
- utiliser la maquette-gabarit afin d’essayer vous aussi
- consulter le site internet En français au pluriel : https://www.enfrancaisaupluriel.fr/
- et mon site internet où se prolonge ce travail : http://www.cultivateurdeprecedents.org/

Intermèdes musicaux :
- James Blake – Fire the editor (https://www.jamesblakemusic.com/)
- Les Marx sisters - Oy mame bin ikh farlibt (https://www.marxsisters.com/)

Sélection musicale : Benjamin Roux et Myriam Suchet
Montage et prise de son : Benjamin Roux
Mastering : Leks
Matériel : Zoom H4N pro, deux micros Shure SM58
Logiciel : Reaper
Musique de générique : Apa$h

Ce podcast ne pourrait exister sans les précieux conseils, retours et accompagnement :
- de Leks (studio Surmezur) pour le mastering,
- de Sika Gblondoumé et Aurélien Lambert (Doudou records) pour la prise de son et le montage,
- d’Apa$h pour son soutien de longue date et son morceau qui pose l’identité sonore de ce podcast,
- d’Esther pour ses relectures et retours sur l’ensemble.

Podcast Récits, contre-récits

Récits, contre-récits - Ep /2 avec Myriam Suchet

BUFFALO, NY- January 17, 2024 – A new #research paper was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 1, entitled, “Aberrant RBMX expression is relevant for cancer prognosis and immunotherapy response.”

Cancer accounts for the highest rates of morbidity and mortality worldwide. RNA binding motif protein X-linked (RBMX) is a nuclear RNA-binding protein, associated with certain types of cancer by participating in the integration of sister chromatids and a combination of ribonucleoprotein complexes. However, the specific role of RBMX in cancer immunity remains unknown.

In this new study, researchers Yilei Sheng, Kunjian Lei, Chengpeng Sun, Jia Liu, Zewei Tu, Xingen Zhu, and Kai Huang from Nanchang University, The Second Affiliated Hospital of Nanchang University, Jiangxi Key Laboratory of Neurological Tumors and Cerebrovascular Diseases, JXHC Key Laboratory of Neurological Medicine, and Yale School of Medicine present the aberrant expression levels, single-cell distributions, effective prognostic roles, immune cell infiltration associations, and immunotherapy responses of RBMX as a biomarker in various types of cancer. Moreover, they validate the aberrant expression of RBMX in clinical cancer samples. 

“[...] a pan-cancer analysis is necessary for the identification of novel biological targets and biomarkers involved in carcinogenesis, cancer progression, and immunotherapy response. Such knowledge would improve the precision of cancer therapy.”

The researchers also evaluated the relationships between RBMX expression and myeloid-derived suppressor cells in clinical samples by immunofluorescent staining. Results showed that knockdown of RBMX can impair the proliferation, migration, and invasion of liver cancer cells. Finally, the team indicated that RBMX may play an immunoregulatory role in cancer progression, affecting the therapeutic effects of immune checkpoint inhibitors in patients with cancer.

“In conclusion, we performed an integrated analysis of RBMX, revealing its effective role in predicting cancer prognosis and response to immunotherapy. Abnormal expression of RBMX is associated with immune regulation, prognosis, the tumor microenvironment, immune cell infiltration, MSI, and TMB. The results of this study indicated that RBMX may play an independent role in clinical diagnosis and prediction.”

DOI - https://doi.org/10.18632/aging.205363

Corresponding authors - Zewei Tu - 401441619022@email.ncu.edu.cn, Xingen Zhu - ndefy89006@ncu.edu.cn, Kai Huang - kaihuang@ncu.edu.cn

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Keywords - aging, RBMX, cancer prognosis, immunotherapy response, proliferation, invasion

About Aging-US

Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

Please visit our website at https://www.Aging-US.com​​ and connect with us:

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Media Contact
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Aging (Aging-US)

Aberrant RBMX Expression Relevant for Cancer Prognosis and Immunotherapy Response

Writer and filmmaker Emma Claire Foley on her Jacobin article, "How Israel Became a Nuclear Power."

Check out Emma's article here: https://jacobin.com/2024/06/israel-nuclear-weapons-nonproliferation-iran-gaza

Help keep This Is Hell! completely listener supported and access weekly bonus episodes by subscribing to our Patreon: https://www.patreon.com/thisishell

How Israel Became a Nuclear Power / Emma Claire Foley

Fiddler - Partial [Batavia records]

01. Fiddler - Partial (Original Mix)[7:45]
02. Fiddler - Proliferation (Original Mix)[7:33]
03. Fiddler - Doxasma (Original Mix) [9:46]

Artist(s): Fiddler
Ep: Partial
Label: Batavia Records
Catalog: #BATREC073
--------------------------------------------------------------------
Pre-Order date: October 11, 2024 (Beatport Only)
Release date: October 25, 2024 (Excl. Spotify, iTunes, Beatport)
All Stores: November 8, 2024
--------------------------------------------------------------------
• Artist(s) on Soundcloud:
○ https://soundcloud.com/fiddler-tibbbi

• Artist(s) on Beatport:
○ https://www.beatport.com/artist/fiddler/258935

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○ https://www.facebook.com/FiddlerOfficial

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○ https://www.instagram.com/fiddler.tibor.hegedus/

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Released by:
Batavia Records

Partial

Proliferation (Original Mix)

Fiddler - Proliferation (Original Mix)

BUFFALO, NY — June 3, 2025 — A new #research paper was #published in  Aging (Aging-US) on May 1, 2025, as the #cover of Volume 17, Issue 5, titled “Defining the hypoxic thresholds that trigger blood-brain barrier disruption: the effect of age.”

In this study, researchers Arjun Sapkota, Sebok K. Halder, and Richard Milner from San Diego Biomedical Research Institute investigated how aging affects the brain’s vulnerability to low oxygen, or hypoxia. Using C57BL/6J mice ranging from 2 to 23 months of age, they identified specific oxygen levels that disrupt the blood-brain barrier (BBB)—a critical structure that protects brain tissue from harmful substances. The findings are important for understanding age-related cognitive decline and the potential risks faced by individuals with chronic oxygen-limiting conditions such as asthma, sleep apnea, emphysema, and heart disease.

The BBB is essential for maintaining brain health. In this study, mild and prolonged hypoxia—called chronic mild hypoxia—was found to compromise the BBB in mice. Older mice showed significantly more BBB disruption than younger ones. Notably, barrier weakening and blood vessel changes occurred at oxygen levels of just 15% in aged mice, compared to 13% in young mice. These data suggest that the aging brain is more sensitive to oxygen deprivation, even at levels that may be considered only mildly hypoxic.

The researchers also determined when this vulnerability emerged. The BBB showed increased sensitivity to low oxygen not only in aged mice but also in mice as young as 2 to 6 months, with a second spike occurring between 12 and 15 months—equivalent to middle age in mice. These findings may reflect age-dependent changes in brain vascular function and remodeling capacity.

“Hypoxia-induced endothelial proliferation was relatively constant across the age range, but advanced age strongly enhanced the degree of BBB disruption (4-6-fold greater in 23 months vs. 2 months old).”

Another key focus was microglial activation, a sign of brain inflammation. Aged mice exhibited higher microglial activation across all oxygen levels, including normal conditions. Chronic microglial activation is closely linked to neuroinflammation and has been implicated in diseases such as Alzheimer’s. While the rate of blood vessel formation was constant across ages, the degree of BBB disruption increased sharply with age, suggesting that repair mechanisms may weaken over time.

These results may help explain why older adults with chronic hypoxia-related diseases are at higher risk for neurodegeneration and cognitive decline. The study also draws attention to the risks of high-altitude exposure for aging populations, where oxygen levels naturally drop.

Altogether, these findings underscore the importance of protecting brain health in older individuals by managing oxygen exposure and reducing hypoxia-related risks. The researchers emphasize the need to develop new therapies that support blood-brain barrier integrity, particularly in aging populations exposed to chronic or intermittent low-oxygen conditions.

DOI - https://doi.org/10.18632/aging.206241

Corresponding author - Richard Milner - rmilner@sdbri.org

Video short - https://www.youtube.com/watch?v=Nr6rTm7aJRo

Keywords - aging, blood-brain barrier integrity, endothelial, proliferation, microglia, chronic mild hypoxia, hypoxic threshold

To learn more about the journal, please visit our website at https://www.Aging-US.com​​ and connect with us:

Facebook - https://www.facebook.com/AgingUS/
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Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc

MEDIA@IMPACTJOURNALS.COM

Aging Increases Brain’s Sensitivity to Hypoxia and Blood-Brain Barrier Damage in Mice

As we age, our brains become more sensitive to stress and disease. A recent study sheds light on a lesser-known risk: reduced oxygen levels. The study, titled “Defining the hypoxic thresholds that trigger blood-brain barrier disruption: the effect of age” and recently published as the cover for Volume 17, Issue 5 of Aging (Aging-US), found that low oxygen—also called hypoxia—can harm the aging brain by disrupting the blood-brain barrier (BBB). This damage may contribute to cognitive decline, memory problems, and an increased risk of dementia.

Understanding Hypoxia in the Brain

The brain relies on a steady supply of oxygen to stay healthy. When oxygen levels fall—a condition known as hypoxia—the brain undergoes changes to adapt. These changes include the remodeling of blood vessels and, importantly, a weakening of the blood-brain barrier. The BBB acts as a filter, protecting brain tissue from harmful substances. When it breaks down, it can lead to inflammation, brain cell damage, and cognitive issues.

Hypoxia is common in older adults, especially those with conditions like sleep apnea, chronic obstructive pulmonary disease (COPD), heart failure, and asthma. That is why understanding the connection between low oxygen and the aging brain is crucial for preventing long-term neurological damage.

Full blog - https://aging-us.org/2025/06/oxygen-deprivation-and-the-aging-brain-a-hidden-trigger-for-cognitive-decline/

Paper DOI - https://doi.org/10.18632/aging.206241

Corresponding author - Richard Milner - rmilner@sdbri.org

Video short - https://www.youtube.com/watch?v=Nr6rTm7aJRo

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Keywords - aging, blood-brain barrier integrity, endothelial, proliferation, microglia, chronic mild hypoxia, hypoxic threshold

To learn more about the journal, please visit our website at https://www.Aging-US.com​​ and connect with us:

Facebook - https://www.facebook.com/AgingUS/
X - https://twitter.com/AgingJrnl
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Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc

MEDIA@IMPACTJOURNALS.COM

Oxygen Deprivation and the Aging Brain: A Hidden Trigger for Cognitive Decline

◙ Batavia Records
Batavia Records is located in ‘Heiloo’ the Netherlands near Amsterdam [Europe] and is powered by Proton LLC Soundsystem.

• Sven Dekker [owner / label manager]
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Batavia Records is supported by great artists, big labels, respected radioshows and magazines. 

Paypal donations: svendekker73@gmail.com

◙ Music Styles
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Sub styles: Organic House - Downtempo - Lounge - Deep Tech - Dub House - Triphop - Ambient 

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Listen to our hosts ZaVen & Steve Mag every 1st Sunday / Month 10-11 PM CET on Batavia's Treasure show with the finest Deep House on this planet mixed for your ears only... Ahoy Enjoy!
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 ◙ Batavia Signed Artists
(updated September 2025)

■ [ARG] Argentina
• Ruben Rivadeneira
• Matías Delóngaro

■ [BRA] Brasil
• Dj Guilherme Amaral
• Koala
• Peter Mac

■ [BY] Belarus
• Buben

■ [CAN] Canada
• BiG Al

■ [COL] Columbia
• Deep Code

■ [CRO] Croatia
• Below Bangkok 
• Kiano 
• Mo' Funk
• Dennis Spinn

■ [CZ] Tsjechië Republic
• JHNS

■ [DK] Denmark
• Alvaro Hylander

■ [ESP] Spain
• David Devilla
• Deephope 
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• JfAlexsander
• UruMusicArt

■ [FIN] Finland
• Henri Michael

■ [FR] France
• B&S Concept
• Cali Kula

■ [GER] Germany
• Claus Pieper
• Loft 15 A

■ [GRC] Greece
• Andi Vasilos
• Ilias Katelanos
• Vaggelhs Dean
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■ [HUN] Hungary
• BDTom
• Diolenmoby
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• Forteba
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■ [ITA] Italy
• Anthony Mea
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• Emiliano S
• Mirco B
• Ricky kk
• Steve Mag
• Tony Deledda
• Vincenzo de Robertis

■ [JPN] Japan
• Spinnage

■ [KEN] Kenia
• Imran Mwangi

■ [LEB] Lebanon
• ID.Jay

■ [MEX] Mexico
• Eisenheim

■ [MNE] Montenegro
• Crack D
• Lerr

■ [NLD] the Netherlands
• La Rose
• Kalou 
• Marmir
• SB-SIX
• ZaVen

■ [POL] Poland
• Jayson Jenx
• Ramzes (PL)
• Stromer Music
• Tidy Daps

■ [PRT] Portugal
• Deepbreath

■ [RSA] South Africa
• Aaron Demac 
• A.b.o.
• Becanoe Da Voe
• BioHazard People
• Brian Que-Soul 
• Chanwill Maconi
• Deep KayGee
• Deep Owen
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■ [RUS] Russia
• Alexander Saykov
• Igor Gonya 
• Krav
• Malkov
• Soledrifter
• Spring Reason
• Ten Patterns
• Vasily Unamets

■ [SUI] Switzerland
• Micronoise

■ [TR] Turkey
• DaDa Sound Project
• Sinan Kaya

■ [UA] Oekraïne
• Ame Vent

■ [UK] United Kingdom
• Col Lawton
• Damien Exton
• Ian Faze 
• J-Uno
• Johnny Deep
• Lucky Sun
• Mark Mac
• Nigel Hayes
• V77NNY

■ [USA] United States of America
• Brenden Walsh
• Deeplux
• Jerdie
• Michael Oberling 
• L.G.V
• Processing Vessel
• Ray Dickerson
• Rishi K.

aka Benjamin Roux
Chercheur - éditeur - digger

Aging-US is dedicated to advancing our understanding of the biological mechanisms that drive aging and the development of age-related diseases. Our mission is to serve as a platform for high-quality research that uncovers the cellular, molecular, and systemic processes underlying aging, and translates these insights into strategies to extend healthspan and delay the onset of chronic disease.

Read about the Aging (Aging-US) Scientific Integrity Process: https://aging-us.com/scientific-integrity

Radio Maria est née en Italie dans les années 1980. Elle s'est rapidement développée en Europe et dans le monde pour atteindre 83 pays en 2024. En France depuis 1998,  sa mission est de diffuser l'Evangile en harmonie avec la doctrine et les indications pastorales fournies par l'Eglise catholique, dans la fidélité au Saint Père, et en utilisant toutes les possibilités que peut offrir un moyen de diffusion radiophonique. Radio Maria est une radio catholique, mariale, d'évangélisation.

New tracks tagged #Proliferation