Trey Knowles’ Messenger RNA is a sharp-witted comedy where he riffs on the bizarre idea of Nazi extraterrestrial chemists sneaking RNA into American DNA—an operation he jokingly attributes to Operation Paperclip. The audience laughs at the absurdity, until the punchline hits: what if RNA vaccines slipped in through everyday vegetables were really changing behavior? With a playful jab, Trey asks—if you start thinking like Trump, how do you know your DNA hasn’t been swapped with “Trump RNA”? It’s a hilarious, eye-opening set that leaves the audience laughing and thinking. A must-see comedy experience of Trey Knowles Messenger RNA.

Messenger RNA

The emerging therapy improved vision for some participants in an earlier clinical trial.

Sepul Bio’s LCA10 RNA Therapy Moves into Phase 3 Clinical Trial

A poetic ballad of wonder, legacy, and the questions that guide us.
This is the English release of a 19-verse scientific ballad, part of a multilingual project spanning 15 languages. Inspired by the image of a child beneath the stars, it explores the emotional and philosophical journey of discovery—where science meets soul.
Crafted with lyrical precision and visual storytelling, this version invites reflection on the true direction of our shared human story.
Dedication: For every child who wonders beneath the stars.
Caption: “A question arises… one that should help us understand what the true direction is.”

Был задан вопрос rus

एक वैज्ञानिक प्रश्न पूछा गया। - Hindi

問いかけられた質問  jp

The Cosmic Symphony

Eine Frage wurde gestellt ger

ایک سوال اٹھایا گیا - Urdu

Swali la kisayansi liliulizwa sw

BUFFALO, NY - November 10, 2025 – A new #research paper was #published in Oncotarget (Volume 16) on November 6, 2025, titled “Anti-DNA virus agent cidofovir - loaded green synthesized cerium oxide nanoparticles (Nanoceria): Nucleic acids (DNA and RNA) binding affinity and cytotoxicity effects.”

In this study, led by Nahid Shahabadi from Razi University in Kermanshah, researchers developed an environmentally friendly approach to enhance the performance of cidofovir, a drug used to treat infections caused by DNA viruses. The work responds to the growing need for therapies that are safer, more effective, and better targeted.

The research team developed a new compound by loading cidofovir onto green-synthesized cerium oxide nanoparticles (nanoceria), known as CDV-CeO2 NPs. This method combines the drug’s antiviral and anticancer properties with the biological activity of nanoceria, which is known for its antioxidant, anti-inflammatory, and tumor-targeting effects. To avoid toxic chemicals, the nanoparticles were synthesized using quince fruit peel extract, making the process more sustainable and suitable for medical applications.

Laboratory experiments showed that the CDV-CeO2 nanoparticles were significantly more effective at killing breast cancer cells than either cidofovir or cerium oxide nanoparticles alone. At the highest tested concentration, the new compound destroyed more than 97% of cancer cells, compared to 72% with cidofovir alone and 50% with nanoparticles alone. These findings suggest that the combined formulation enhances anticancer activity and may allow for lower drug doses with fewer side effects.

To understand how these nanoparticles interact with genetic material, the team studied their binding to DNA and RNA, two key molecules involved in cancer development and viral replication. CDV-CeO2 nanoparticles showed strong binding affinity through two mechanisms: groove binding, which fits into natural curves of the genetic molecule strands, and intercalation, which inserts between base pairs. The nanoparticles formed stable complexes that responded to temperature, indicating reliable interactions in biological systems.

“The novelty of this work lies in the innovative green synthesis method, the dual-functional therapeutic application, and the enhanced biological activity of the CDV-CeO2 NPs, which collectively position these nanoparticles as promising candidates for future cancer and antiviral therapies.”

This research presents a potential new strategy for improving drug targeting and delivery using green nanotechnology. The approach could lead to more effective treatments for diseases such as breast cancer and infections caused by human papillomavirus (HPV) and other DNA viruses. However, further research, including animal and clinical studies, is needed to confirm the safety and long-term effectiveness of this treatment.

Overall, this study represents a significant step toward combining natural materials with nanomedicine to create more efficient therapies. If supported by future research, CDV-CeO2 nanoparticles could offer a new generation of dual-action treatments.

DOI - https://doi.org/10.18632/oncotarget.28774

Correspondence to - Nahid Shahabadi - nahidshahabadi@yahoo.com

Abstract video - https://www.youtube.com/watch?v=Il9CsfgO2mU

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Oncotarget

Eco-Friendly Nanoparticles Improve Cidofovir’s Anticancer and Antiviral Effects

Trey Knowles is a visionary artist and deep thinker who explores the human experience through creativity, truth, and purpose. As an author, comedian, music artist, visual storyteller, and speaker, his work bridges art and insight—sparking transformation, self-awareness, and spiritual growth. Each project carries a message of redemption and depth, inviting listeners to reflect, grow, and be inspired.

Father, of some great Children, Grandfather of some great Grandchildren (see what I did there) I meant exceptional. I make music for the love of music. A technician by trade, and artist by passion and musician for fun

Oncotarget is a primarily oncology-focused, peer-reviewed, open access journal. Papers are published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Oncotarget is now indexed by MEDLINE, PubMed and PMC/PubMed.

Read about the Oncotarget Scientific Integrity Process: https://www.oncotarget.com/scientific_integrity/

The Foundation Fighting Blindness is the driving force in the global development of treatments and cures for blinding diseases. To learn more, go to FightingBlindness.org.

New tracks tagged #RNA