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החיסונים לקורונה היו רק יריית הפתיחה. על פי כל הסימנים, נראה ש-RNA עומד לשמש בסיס למגוון עצום של טכנולוגיות רפואיות וביולוגיות כבר בעתיד הקרוב.
לכתבה באתר: https://bit.ly/3CgyYxe

מולקולת העתיד

Synopsis: 

Geoff Nosrati is the Chief Business Officer of Nutcracker Therapeutics, an early-stage company that is pioneering a revolutionary therapeutic development and manufacturing platform designed to enable the advancement of RNA-based treatments for as many diseases as possible. Early in his career, Geoff joined McKinsey & Co. as a consultant, working with biotech and pharma companies. He then worked with several small oncology-focused biotech companies, including Aduro Biotech and ImmunoScape before joining Nutcracker. In this episode he provides his perspective on the RNA space as it stands right now and the diversity of applications that exist, some of the opportunities and challenges of working on an RNA therapeutic, how he thinks about indication selection, Nutcracker’s complete RNA platform and the work they’re doing to develop therapeutics, and where the company is now from a building and R&D perspective.

Biography: 

As Chief Business Officer, Geoff oversees Nutcracker’s business development and corporate strategy functions. Prior to Nutcracker, Geoff served as Chief Business Officer at ImmunoScape and as SVP of Strategy and Corporate Development at Aduro Biotech. Earlier in his career, Geoff was a consultant with McKinsey & Co., where he primarily served clients across the pharmaceutical and biotechnology industries.

Geoff was awarded a B.S. in Chemistry from Duke University and received his Ph.D. in Biochemistry and Molecular Biology from the University of California, Los Angeles.

JPM23 Special: Advancing RNA Therapeutics, Geoff Nosrati, CBO, Nutcracker Therapeutics

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Synopsis: 

This special episode features a panel discussion with three biotech leaders about drug development for rare diseases. James Mackay, Ph.D., is the Founder, President and CEO of Aristea Therapeutics, an immunology-focused clinical stage biotech that is focused on inflammatory diseases. Arthur T. Suckow, Ph.D., is the Co-Founder and CEO of DTx Pharma, which is focused on developing novel technology for delivery of RNA medicines. Eslie Dennis is the SVP and CMO of Kyowa Kirin North America, a Japan-based global specialty pharmaceutical company. Our guests discuss the patient journey for those living with rare diseases, the importance of driving awareness for this patient population, important points to consider when partnering with big pharma, clinical trial design for patients with rare diseases, and best practices for driving awareness and inclusion of people of color in rare disease trials.

Biography: 

James Mackay, Ph.D., Founder, President and Chief Executive Officer, has over 25 years of development and commercialization expertise in the pharmaceutical industry, including 6 drug product approvals across multiple therapeutic areas. Prior to founding Aristea, he was President and Chief Executive Officer of Ardea Biosciences, Inc., following the company’s acquisition by AstraZeneca in 2012. James was instrumental to setting up an innovative model for Ardea Biosciences that retained the biotech’s independence and accountability for the development of the gout franchise while also developing a synergistic and collaborative relationship with the parent company, AstraZeneca. Prior to Ardea, James held senior executive positions at AstraZeneca where he led the development and commercialization of drugs across a range of therapy areas. and managed significant global functional departments. James plays a pivotal role in the San Diego Ecosystem and currently sits on the Board and Executive Committee of CONNECT and sits on the Board of BIOCOM. He is a former Board member of the San Diego Economic Development Corporation (EDC). James holds a BS in Genetics and Ph.D. in Medical Genetics from Aberdeen University, Scotland.

Dr. Arthur Suckow founded DTx Pharma in 2017. An innovative leader in drug discovery, he previously worked on the ophthalmology, diabetes, and NASH programs at Regulus Therapeutics, at the MedImmune arm of AstraZeneca, and in the Diabetes Drug Discovery program at Johnson & Johnson. Dr. Suckow received his BS from the University of Delaware and his PhD from University of California, San Diego. He has received numerous awards including a Beckman Fellowship, a NSF graduate research fellowship, and a BIOCOM catalyst award.

Dr. Eslie Dennis joined Kyowa Kirin in May 2021 as SVP, Chief Medical Officer for Kyowa Kirin North America. Prior to joining this organization, she was Vice President and Head Global Medical Affairs at Ventana/Roche Tissue Diagnostics. She is a physician with 10 years experience in clinical practice (internal medicine and hematology/oncology) and research, and over 20 years international biopharma experience holding positions of increasing responsibility in pharmaceutical and diagnostic organizations at MSD, Novartis and Roche, including leadership of public-private consortia at the Critical Path Institute. Throughout her career, Dr. Dennis has championed innovative science and solutions to address unmet needs for patients and society, particularly addressing healthcare disparities. Dr. Dennis received her MBChB from the Godfrey Huggins School of Medicine in Harare, Zimbabwe, and was the recipient of the Winston Churchill, Margaret Low, and Prankard-Jones Scholarships, as well as the Guy Elliot Bursary.  She is a Fellow of the College of Physicians of South Africa and received her internal medicine and hematology/oncology training at Groote Schuur Hospital in Cape Town, South Africa.

JPM23 Special: Rare diseases, Eslie Dennis, Kyowa Kirin, Arthur Suckow, DTx, & James Mackay, Aristea

A new research paper was published in Aging (Aging-US) Volume 14, Issue 24, entitled, “Transcriptomic analysis of human ALS skeletal muscle reveals a disease-specific pattern of dysregulated circRNAs.”

Circular RNAs are abundant, covalently closed transcripts that arise in cells through back-splicing and display distinct expression patterns across cells and developmental stages. While their functions are largely unknown, their intrinsic stability has made them valuable biomarkers in many diseases.

In this new study, researchers Dimitrios Tsitsipatis, Krystyna Mazan-Mamczarz, Ying Si, Allison B. Herman, Jen-Hao Yang, Abhishek Guha, Yulan Piao, Jinshui Fan, Jennifer L. Martindale, Rachel Munk, Xiaoling Yang, Supriyo De, Brijesh K. Singh, Ritchie Ho, Myriam Gorospez, and Peter H. King from the National Institutes of Health’s National Institute on Aging, The University of Alabama at Birmingham, Birmingham Veterans Affairs Medical Center, and Cedars-Sinai Medical Center set out to examine circRNA patterns in amyotrophic lateral sclerosis (ALS). By RNA-sequencing analysis, the researchers first identified circRNAs and linear RNAs that were differentially abundant in skeletal muscle biopsies from ALS compared to normal individuals. 

“By RT-qPCR analysis, we confirmed that 8 circRNAs were significantly elevated and 10 were significantly reduced in ALS, while the linear mRNA counterparts, arising from shared precursor RNAs, generally did not change.” 

Several of these circRNAs were also differentially abundant in motor neurons derived from human induced pluripotent stem cells (iPSCs) bearing ALS mutations, and across different disease stages in skeletal muscle from a mouse model of ALS (SOD1G93A). Interestingly, a subset of the circRNAs significantly elevated in ALS muscle biopsies were significantly reduced in the spinal cord samples from ALS patients and ALS (SOD1G93A) mice. In sum, the researchers identified differentially abundant circRNAs in ALS-relevant tissues (muscle and spinal cord) that could inform about neuromuscular molecular programs in ALS and guide the development of therapies.

“As our studies advance, we will investigate the function of the most promising and abundant circRNAs, among the 18 circRNAs reported here. We are especially interested in those that appeared to be specific for ALS (Figure 2), as they may help to characterize disease-associated molecular pathways that could be targeted therapeutically.”

DOI: https://doi.org/10.18632/aging.204450 

Corresponding Authors: Myriam Gorospe - GorospeM@grc.nia.nih.gov, Dimitrios Tsitsipatis - dimitrios.tsitsipatis@nih.gov, Peter H. King - phking@uabmc.edu

Keywords: amyotrophic lateral sclerosis, circular RNAs, neurodegenerative disease, human skeletal muscle, human spinal cord tissue

About Aging-US:

Launched in 2009, Aging (Aging-US) publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

Please visit our website at www.Aging-US.com​​ and connect with us:

SoundCloud – https://soundcloud.com/Aging-Us
Facebook – https://www.facebook.com/AgingUS/
Twitter – https://twitter.com/AgingJrnl
Instagram – https://www.instagram.com/agingjrnl/
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LinkedIn – https://www.linkedin.com/company/aging/
Reddit – https://www.reddit.com/user/AgingUS
Pinterest – https://www.pinterest.com/AgingUS/

For media inquiries, please contact media@impactjournals.com.

Aging (Aging-US)

Transcriptomic Analysis of Human ALS Skeletal Muscle Reveals…

Synopsis: 
Josh Mandel-Brehm is the President and CEO of CAMP4 Therapeutics, a company pioneering mRNA amplification by using programmable ASO therapeutics to control gene expression. He joins host Rahul Chaturverdi to discuss the arc of his career and his interest in the intersection of business and science. They dive into the origins of CAMP4 and the inspiration behind the company’s name. He also talks about where CAMP4 is from a pipeline development perspective and how he approaches fundraising.

Biography: 
Josh Mandel-Brehm is President & Chief Executive Officer of CAMP4 Therapeutics.

Mr. Mandel-Brehm previously held roles as an entrepreneur partner with Polaris Partners and key business development and operations leadership roles at leading biotech companies. Most recently he served as part of the Business Development group at Biogen, where he led multiple strategic activities and corresponding transactions, which included expanding Biogen’s non-malignant hematology franchise and overseeing seminal investments to enter in gene therapy and the ophthalmology field. Prior to Biogen, Mr. Mandel-Brehm held several roles of increasing responsibility at Genzyme as part of the business development group for the company’s rare disease business unit.

Mr. Mandel-Brehm earned a BA in Biology from Washington University in St. Louis and holds an MBA from the University of Michigan.

Power of RNA to restore healthy gene expression, Josh Mandel-Brehm, President & CEO, CAMP4 Tx

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Check for id in array of ids and use those values in query

Is there a way to create a generic function that can take an array of ids and use it in the where clause and make sure the queried id is in that array?
Take the following query:
SELECT * FROM 
`pages` AS `p` 
WHERE 
`p`.`id` = '$id' 
OR 
`p`.`id` IN (1, 2, 5)

The problem with this is that, if it is a serialized array of ids, it will loop over all of them regardless of whether that id is the one being queried or if that id is in the list of ids.
I was hoping to find a function that I could pass an array of ids into and it would take it and use the WHERE clause like the following:
SELECT * FROM 
`pages` AS `p` 
WHERE 
`p`.`id` = '$id' 
OR 
`p`.`id` IN (
    SELECT COUNT(*) FROM `pages` AS `p` WHERE 
    `p`.`id` = '$id' 
)

I thought maybe something like the following function would work, but the IN clause doesn't seem to work.
function in_array_func($array, $value) {
    if(sizeof($array) == 0) return false;
    $result = mysql_query("SELECT COUNT(*) FROM pages WHERE id='$value'") or die(mysql_error());
    if($result) 
        return mysql_result($result,0) > 0? true : false;
    
    else {
        return false; ee730c9e81

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Hello to our social media account! and I'm a audiobook producer. Thank you for becoming followers. I'm sure you'll enjoy exploring my page.

A traditional, twice-monthly, peer-reviewed, open-access journal covering all areas of research on aging and age-related diseases, including cancer and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome.

In June 2022, Web of Science (Clarivate Analytics) released their 2021 JCR Impact Factor List. Aging is pleased to report that our 2021 impact factor is 5.955. This number has increased from last year’s 5.682.

Read about the Aging (Aging-US) Scientific Integrity Process: https://aging-us.com/scientific-integrity

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Biotech2050 Podcast is a think tank chronicling the disruptions changing the biotech industry over the next 50 years.

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