Éxito de Los Prados, grupo argentino de gran éxito en los 70'.
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EXITOS INTERNACIONALES

COMO NO VOY A QUERERTE(M. Amuy)FREDDY NIKOLAI

BUFFALO, NY- December 11, 2024 – A new #research paper was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 21 on November 14, 2024, entitled, “Adolescents and young adults with sickle cell disease exhibit accelerated aging with elevated T-cell p16INK4a expression.”

Researchers Samuel R. Wilson, Natalia Mitin, Vanessa L. Ayer Miller, Andrew B. Smitherman, and Marcus A. Carden, from the University of North Carolina at Chapel Hill,  Sapere Bio, Campbell University, and Cogent Biosciences have discovered that young people with sickle cell disease (SCD) exhibit signs of accelerated biological aging compared to those without the disease. By measuring levels of p16INK4a, a key marker of cellular aging, the team found significantly higher levels in individuals with SCD. Remarkably, some participants showed biological aging equivalent to an additional 43 years. These findings suggest that SCD may drive faster aging in the body, offering new insights into the disease's long-term impact.

Sickle cell disease (SCD) is a genetic condition primarily affecting individuals of African or Mediterranean descent. While treatments have advanced, people with SCD often face significant health challenges, including complications that mimic the effects of aging.

Cellular aging, or senescence, occurs when cells stop dividing yet continue to send harmful signals that damage surrounding tissues. Researchers believe this process happens at an accelerated rate in people with SCD, underscoring the importance of finding ways to slow it down and mitigate its impact.

The study compared p16INK4a levels in 18 adolescents and young adults with SCD to 27 healthy people of the same age. The results showed that even the youngest participant with SCD had higher levels of this aging marker than anyone in the non-SCD group. 

“Our youngest participant, a 15-year-old with SCD, had a higher p16 expression than all the comparators, underscoring the early rise of p16 expression in this population.”

The researchers believe this faster aging could be caused by the chronic inflammation, lack of oxygen, and stress on the body associated with SCD. Along with managing the symptoms of the disease, SCD patients also face a higher risk of aging-related problems like organ damage and physical decline much earlier in life.

The findings suggest that measuring p16INK4a levels could help clinicians identify patients at risk for these problems earlier and offer targeted care. The study also opens the door to new treatments, such as drugs that aim to remove old, damaged cells. These therapies could potentially slow down the aging process.

Further research is essential to confirm these findings and to gain a deeper understanding of how to support SCD patients effectively. Larger, long-term studies could investigate whether therapies targeting cell aging can help prevent complications and improve the quality of life for individuals with SCD.

In conclusion, this study marks an important step in understanding how SCD accelerates aging and offers new ways to improve the lives of those living with the condition.

DOI - https://doi.org/10.18632/aging.206152

Corresponding author - Samuel R. Wilson - samuel.wilson@med.unc.edu

Video short - https://www.youtube.com/watch?v=QXVdxBikaqg

About Aging-US

The mission of the journal is to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population.

The journal aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.)

Please visit our website at https://www.Aging-US.com​​.

MEDIA@IMPACTJOURNALS.COM

Aging (Aging-US)

Accelerated Aging in Young Sickle Cell Patients Linked to Elevated T-cell p16INK4a

Imagine being 15 years old but having a body that shows signs of aging as if you are decades older. For some young people with sickle cell disease (SCD), this is a reality. A new study published in Volume 16, Issue 21 of Aging shows that SCD causes the body to age much faster than normal. The research not only explains why this happens but also points to new ways to help people with the disease live healthier, longer lives.

What Is Sickle Cell Disease?

SCD is a genetic condition that changes the shape of red blood cells. Instead of being round, like a doughnut, the cells become curved like a sickle (a farming tool). These misshapen cells struggle to move through blood vessels, often blocking blood flow and leading to pain, organ damage, and other health problems. Even with modern treatments, they can experience complications like those seen in older adults, such as weaker bones, frailty, and organ failure. In the study “Adolescents and young adults with sickle cell disease exhibit accelerated aging with elevated T-cell p16INK4a expression,” researchers wanted to understand why this happens and what it means for people with the disease.

Full blog - https://aging-us.org/?p=6372

Paper DOI - https://doi.org/10.18632/aging.206152

Corresponding author - Samuel R. Wilson - samuel.wilson@med.unc.edu

Video short - https://www.youtube.com/watch?v=QXVdxBikaqg

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Keywords - aging, sickle cell disease, p16, adolescents, young adults

About Aging-US

The mission of the journal is to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population.

The journal aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.)

Please visit our website at https://www.Aging-US.com​​ and connect with us:

Facebook - https://www.facebook.com/AgingUS/
X - https://twitter.com/AgingJrnl
Instagram - https://www.instagram.com/agingjrnl/
YouTube - https://www.youtube.com/@AgingJournal
LinkedIn - https://www.linkedin.com/company/aging/
Pinterest - https://www.pinterest.com/AgingUS/
Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc

MEDIA@IMPACTJOURNALS.COM

Accelerated Aging in Young People with Sickle Cell Disease

A MEXICO ...CON AMOR

MI VIEJO(Piero)FREDDY NIKOLAI

Tradução 
Intro 
A vadiazinha ela falou que me conhece
Eu não te conheço então tira mão do meu b**


MsK

A vadiazinha ela falou que me conhece 
Eu não te conheço então tira mão do meu beck 
Eu sou da north ela veio me dá da west 
Eu sou perigoso ela não conhece os mlk
Vaso gamo igual gama em KitKat
Ela me chupo e eu flexionando cashh
Minha conta gordao e você chorando igual mlk 
Tenho filhos em todo mundo vê se você não se esquece
(Juro eu achava que você não era assim mas tu revelou as caras, mas isso foi bom so mostrou que eu não precisava confiar em vadias falsas)
Tenho design em mim design em todos os cantos
Você foi um x1 comigo e ainda saiu sangrando
Me sinto um hella guns com armas atras dos panos
Não te conheço vadia, vou te passar uma missão e só chegar atirando.

from north to west

SCD w/ Skeem [rav3nz]

In Folge #157 des E-Commerce Dudes Podcasts sprechen Daniel Höhnke und Tim Schestag über die großen Themen der Woche im digitalen Handel – mit einem besonderen Fokus auf die Shoptalk Europe 2025 in Barcelona und den wichtigsten News der Woche.

Daniel berichtet frisch von der Shoptalk Europe, die vergangene Woche in Barcelona stattfand. Die Messe gilt als das führende Event für Innovationen im europäischen Handel und vereint über 4.500 Entscheider, Tech-Player und Marken aus mehr als 70 Ländern. Daniel schildert, warum gerade deutsche Teilnehmer enorm vom internationalen Austausch profitieren können: Von exklusiven Networking-Möglichkeiten, Einblicken in die neuesten Retail-Trends bis hin zu direkten Kontakten mit den wichtigsten Köpfen der Branche – Shoptalk Europe bietet einen einmaligen Rahmen, um das eigene Business zukunftssicher aufzustellen und neue Impulse für den deutschen Markt mitzunehmen.

News der Woche:
- Shopware Community Day abgesagt: Aufgrund der Entschärfung von drei Blindgängern aus dem Zweiten Weltkrieg musste der Shopware Community Day in Köln kurzfristig abgesagt werden. Die Sicherheit der Teilnehmer stand an erster Stelle, ein neuer Termin wird gesucht. Teile des Programms sollen in den nächsten Wochen digital nachgeholt werden.

- Google Ads in AI Overviews: Google testet aktuell, wie Anzeigen in den neuen AI-gestützten Suchergebnissen (AI Mode & AI Overviews) ausgespielt werden. Damit werden künftig noch mehr Werbeplätze in KI-generierten Antworten verfügbar sein – ein Gamechanger für das Suchmaschinenmarketing.

- ChatGPT als Top-5-Website: ChatGPT ist mittlerweile eine der fünf meistbesuchten Websites weltweit, mit über 5 Milliarden Besuchen pro Monat. Die rasante Entwicklung zeigt, wie sehr KI-basierte Tools den Alltag und die digitale Wirtschaft durchdringen.

- AI-SEO für Shopify Stores: Wer möchte, dass der eigene Shopify-Shop in ChatGPT, Perplexity & Co. gefunden wird, muss gezielt die richtigen Bots zulassen und Inhalte für LLMs optimieren. Ein Leitfaden zeigt, wie Shops für die KI-Suche fit gemacht werden können.

- Shopify Catalog API & Perplexity: Shopify hat still und leise seine neue Catalog API gelauncht – Perplexity AI ist der erste Partner. Damit können KI-Anwendungen in Echtzeit auf Produktdaten aller Shopify-Stores zugreifen. Das verändert, wie Produkte künftig online gefunden und gekauft werden.

- Amazon testet humanoide Lieferroboter: Amazon plant den Test von humanoiden Robotern für die Paketzustellung. Mit speziellen KI-Systemen sollen die Roboter künftig Pakete autonom ausliefern – ein weiterer Schritt in Richtung automatisierter Logistik.

Daniel: www.linkedin.com/in/daniel-hoehnke/
Tim: www.linkedin.com/in/tim-schestag/

#157 Lohnt sich die Shoptalk Europe? + die NdW

idk but i do know i love Lucas Rocco Sorleto luv u always xoxo @JD

just another memory

In this episode of Parallax, Dr Ankur Kalra speaks with Dr Benjamin A D’Souza, Associate Professor of Medicine at the University of Pennsylvania and Section Chief of Cardiac Electrophysiology at Presbyterian Medical Center. Together, they explore the challenges of mitigating sudden cardiac death and the evolving role of guideline-directed medical therapy in optimising patient outcomes.

Dr D’Souza reflects on current strategies for risk assessment and prevention, highlighting the importance of medical therapy, careful monitoring and timely use of defibrillators. He stresses that management must be tailored to individual patients, with decisions guided by evidence, imaging and multidisciplinary collaboration.

The conversation also turns to women’s cardiac health and representation in electrophysiology. Dr D’Souza highlights the persistent under-enrolment of women in clinical trials and their lower access to ablation and device therapy. He stresses the need for inclusive trial design, mentorship and acknowledgement of systemic bias to improve equity in cardiovascular care.

This series is supported by ZOLL and is intended for Health Care Professionals.

EP 143: GDMT Optimisation: Mitigating SCD Risk and Addressing Women’s Cardiac Health

Canción de la autoría de Marco Aurelio, excelente cantante y compositor chileno.

AMOR POR TI (Marco Aurelio)FREDDY NIKOLAI

https://www.instagram.com/reel/DKzKIUSAnjj/?utm_source=ig_web_copy_link&igsh=MzRlODBiNWFlZA==

Aging-US is dedicated to advancing our understanding of the biological mechanisms that drive aging and the development of age-related diseases. Our mission is to serve as a platform for high-quality research that uncovers the cellular, molecular, and systemic processes underlying aging, and translates these insights into strategies to extend healthspan and delay the onset of chronic disease.

Read about the Aging (Aging-US) Scientific Integrity Process: https://aging-us.com/scientific-integrity

Artista chileno de dilatada trayectoria, intérprete. De música internacional, músico, cantautor, actor. Sus inicios ocurrieron en Stgo., allá por los años 60’ en las radios de la capital.
En 2106, la SCD le otorgó la medalla por “50 años de trayectoria Artística.

Der E-Commerce Dudes Podcast ist dein wöchentlicher Begleiter in die Welt des Online-Handels. Moderiert von Daniel Höhnke und Tim Schestag, bietet der Podcast seit 2018 spannende Einblicke in aktuelle Trends und Entwicklungen im E-Commerce. Von praxisnahen Tipps für Unternehmer über tiefgehende Analysen bis hin zu innovativen Ideen - hier erfährst du alles, was du wissen musst, um im digitalen Handel erfolgreich zu sein. Egal, ob du gerade erst startest oder bereits ein etablierter Händler bist, die E-Commerce Dudes liefern wertvolle Inhalte und inspirierende Gespräche, die dich weiterbringen. Hör rein und entdecke, wie du deinen E-Commerce auf das nächste Level bringen kannst!

‘Parallax’ (/ˈparəlaks/)-noun: the effect whereby the position or direction of an object appears to differ when viewed from different positions. Join Ankur Kalra, MD as he shows you a different side to cardiovascular care, management and science. Listen to Ankur’s conversations with legendary cardiologists, critical reviews of key congresses and late-breaking trials, and concise summaries. Published every second Monday of the month, this is your fix of reliable updates on all things cardiology by someone from a non-traditional background, who is always trying to look at it from new angles! Dear cardiologists, we want to make this podcast about you, and for you! Please email us critical thoughts, comments and questions for Ankur at podcast@radcliffe-group.com.

New tracks tagged #SCD