Recent discoveries in #aging research reveal a powerful insight: the biological changes that lead to chronic #diseases begin far earlier than most people realize—often in midlife, well before symptoms appear. This early phase offers a valuable opportunity for prevention. As highlighted in a recent editorial by Marco Demaria, Editor-in-Chief of Aging and a researcher at the European Research Institute for the Biology of Ageing (ERIBA), University Medical Center Groningen, and the University of Groningen (RUG), the aging process itself – not just the diseases it produces – can and should be a primary focus of healthcare. 

The Problem with Traditional Medicine

While modern healthcare has extended lifespan and improved treatment for many diseases, it tends to be insufficient in addressing the complex needs of aging populations. Older individuals frequently experience multiple chronic conditions simultaneously, such as cardiovascular disease, diabetes, cancer, and neurodegenerative disorders. This state of multimorbidity complicates care, increases the use of multiple medications, and reduces quality of life. The dominant traditional healthcare system, which typically begins only after symptoms appear, is costly and insufficient for addressing the interconnected nature of these conditions.

A New Model for Healthcare: Insights from the Editorial

In his recent editorial, “Rethinking healthcare through aging biology,” published in Aging Volume 17, Issue 5, Dr. Demaria outlines a shift from disease-specific treatment to targeting the biological mechanisms of aging itself, a more integrated and forward-looking approach. He presents three evolving healthcare models.

Full blog - https://aging-us.org/2025/06/a-new-vision-for-healthcare-addressing-aging-before-disease-begins/

Paper DOI - https://doi.org/10.18632/aging.206262

Corresponding author - Marco Demaria - m.demaria@umcg.nl

Video short - https://www.youtube.com/watch?v=xR-16cjHnQY

Sign up for free Altmetric alerts about this article - 
https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206262

Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts

Keywords - aging, healthcare, senolytics, epigenetics, medical education

To learn more about the journal, please visit our website at https://www.Aging-US.com​​ and connect with us on social media at:

Facebook - https://www.facebook.com/AgingUS/
X - https://twitter.com/AgingJrnl
Instagram - https://www.instagram.com/agingjrnl/
YouTube - https://www.youtube.com/@AgingJournal
LinkedIn - https://www.linkedin.com/company/aging/
Bluesky - https://bsky.app/profile/aging-us.bsky.social
Pinterest - https://www.pinterest.com/AgingUS/
Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc

MEDIA@IMPACTJOURNALS.COM

Aging (Aging-US)

A New Vision for Healthcare: Addressing Aging Before Disease Begins

Friedrich Nietzsche's "Beyond Good and Evil," a work translated by Helen Zimmern, confronts long-held philosophical beliefs, notably those surrounding morality and truth, asserting that they frequently stem from ingrained biases rather than impartial logic. The text scrutinizes diverse philosophical viewpoints such as dogmatism and utilitarianism, while introducing Nietzsche's distinct ideas of master-morality and slave-morality to delineate contrasting ethical frameworks. Ultimately, the work delves into the character of the "free spirit" and the function of hardship in personal evolution, challenging conventional understandings of virtue and intellectual exploration.

FRIEDRICH NIETZSCHE | Beyond Good & Evil (Audiobook Summary)

The provided texts primarily explore the concept of "following through" and "finishing what you start," defining it as the transformation of intentions into reality through consistent effort. They identify common obstacles to completion, such as inhibiting tactics (e.g., procrastination, poor time management) and psychological roadblocks (e.g., fear of failure, perfectionism). The sources offer a range of practical strategies to overcome these challenges, including cultivating beneficial mindsets, establishing personal rules or "manifestos," employing techniques to combat procrastination and distractions (like singletasking and "don't-do" lists), and most importantly, implementing sustainable daily systems instead of relying solely on willpower. Various individuals are presented as examples to illustrate these principles, highlighting both successes and common pitfalls in the journey toward achieving goals.

PETER HOLLINS | Finish What You Start (Audiobook Summary)

Liver cancer, especially hepatocellular carcinoma (HCC), remains a major health concern worldwide. In Latin America, the situation becomes more difficult due to limited access to advanced treatments and the high prevalence of underlying liver diseases. A recent research paper, published in Volume 16 of Oncotarget by researchers from Argentina, Brazil, Chile, and Colombia, offers valuable insights into how patients in the region respond to a widely used immunotherapy regimen. This real-world study explores both the effectiveness of treatment and the risks of immune-related side effects.

Understanding Hepatocellular Carcinoma: Why It is So Difficult to Treat

Hepatocellular carcinoma is often diagnosed at an advanced stage and frequently occurs in people with pre-existing liver conditions such as cirrhosis. Standard treatments like surgery or local therapies are not always possible in these cases. In recent years, the combination of two drugs—atezolizumab and bevacizumab—has shown promise in extending survival. However, most of the evidence comes from controlled clinical trials that may not represent the realities faced by healthcare providers and patients in Latin America.

The Study: Immunotherapy for Hepatocellular Carcinoma in Latin America

In a multicenter study titled “Immune-mediated adverse events following atezolizumab and bevacizumab in a multinational Latin American cohort of unresectable hepatocellular carcinoma,” led by Leonardo Gomes da Fonseca from Hospital das Clínicas, Universidade de São Paulo, Brazil, and Federico Piñero from Hospital Universitario Austral, Argentina, researchers aimed to fill that gap. The study included 99 patients with advanced HCC from Argentina, Brazil, Chile, and Colombia. All patients received the combination of atezolizumab and bevacizumab. The main objectives were to assess how frequently immune-related side effects, known as immune-related adverse events (irAEs), occurred and whether these events affected overall survival.

Full blog - https://www.oncotarget.org/2025/07/02/immunotherapy-safety-for-hepatocellular-carcinoma-in-latin-america-insights-from-a-real-world-study/

Paper DOI - https://doi.org/10.18632/oncotarget.28721

Correspondence to - Federico Piñero - fpinerof@cas.austral.edu.ar

Video short - https://www.youtube.com/watch?v=gk3oQwzIC-E

Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28721

Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/

Keywords - cancer, liver cancer, immunotherapy, adverse events, immunology, real-world 

To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us:

Facebook - https://www.facebook.com/Oncotarget/
X - https://twitter.com/oncotarget
Instagram - https://www.instagram.com/oncotargetjrnl/
YouTube - https://www.youtube.com/@OncotargetJournal
LinkedIn - https://www.linkedin.com/company/oncotarget
Pinterest - https://www.pinterest.com/oncotarget/
Reddit - https://www.reddit.com/user/Oncotarget/
Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh

MEDIA@IMPACTJOURNALS.COM

Oncotarget

Immunotherapy Safety for Hepatocellular Carcinoma in Latin America: Insights from a Real-World Study

This extensive collection of excerpts delves into the philosophy of mind, exploring various theories and key thinkers who have shaped its discourse over the last 90 years. The text highlights the foundational challenges, such as understanding how subjective conscious experiences arise from physical processes, and discusses historical perspectives like Cartesian dualism, which posits a fundamental separation of mind and body. It then examines prominent naturalistic approaches, including logical behaviorism, which attempts to define mental states purely by observable behavior, and the identity theory of mind, asserting that mental states are directly reducible to brain states. Furthermore, the source extensively covers functionalism, a view suggesting mental states are defined by their functional roles, allowing for multiple physical realizations, and the Representational Theory of Mind, which models thinking as a computational process involving mental representations. The conversation goes on to critiques and alternative frameworks such as embodied cognition, which highlights the critical role of the body and environment in forming the mind, and anomalous monism. This argument argues that the psychological is irreducible despite its physical basis. Finally, it touches on the "hard problem" of consciousness and the continuous search for a naturalistic explanation.



Key Thinkers in the Philosophy of Mind (Audiobook Summary)

This academic text explores the "Global Workspace theory" of consciousness, drawing heavily on a "theater metaphor" where conscious contents are like actors on a stage, broadcast to an unconscious "audience" of brain networks. It examines the relationship between conscious and unconscious processes through various experiments, including those involving memory, perception, and problem-solving, highlighting how conscious awareness is a limited capacity system that grants access to a vast array of unconscious knowledge and skills. The text also discusses the brain's role in shaping conscious experience, including the function of the thalamus and the impact of brain damage on context and perception. Ultimately, it argues for the functional importance of consciousness in learning, adapting to reality, and guiding voluntary actions, challenging the view that it is merely an epiphenomenon.

The Theatre of Consciousness | A Brain Model (Audiobook Summary)

This excerpt from Erwin Schrödinger's "My View of the World" explores profound philosophical questions about consciousness, the self, and our perception of reality, bridging scientific thought with ancient Vedantic philosophy. Schrödinger questions the common assumption of a singular, external world causing universal sense-impressions, proposing instead that the apparent agreement between individual "consciousness spheres" is established through language and shared experience, rather than an independent material reality. He delves into the concept of "supra-individual memory" to suggest a continuity of consciousness across generations, arguing that consciousness itself is tied to "learning in organic substance", where "becoming is conscious, being unconscious." Ultimately, the text posits that the perceived multiplicity of consciousness is a "false construction," leading to the Vedantic vision that all conscious beings are fundamentally "numerically one," a mystical yet deeply ethical perspective that finds parallels in modern scientific thought.



Erwin Schrödinger | My View of the World (Audiobook Summary)

A new study published recently as the cover of Aging Volume 17, Issue 6, describes a new method to estimate how fast the brain is aging. By analyzing lipids, or fat molecules, in brain tissue, researchers from the National University of Singapore and Hanze University of Applied Sciences created a biological “clock” called DoliClock. This innovation highlights how conditions such as autism, schizophrenia, and Down syndrome are associated with accelerated brain aging.

Understanding Brain Aging

As people grow older, their brains naturally change. However, in many neurological disorders, these changes seem to appear earlier and progress more rapidly. Disorders like autism, schizophrenia, and Down syndrome reduce quality of life and contribute to premature death. Scientists have long searched for better ways to measure biological age in the brain to understand these processes and develop strategies to slow them down.

Most existing methods for estimating biological age rely on genetic markers, such as DNA methylation, which are chemical modifications of DNA. While useful, these approaches may not fully capture the complexity of aging, especially in the brain. Lipids, which are essential components of brain cells and play important roles in energy storage and signaling, offer another perspective.

Full blog - https://aging-us.org/2025/07/doliclock-a-lipid-based-clock-for-measuring-brain-aging/

Paper DOI - https://doi.org/10.18632/aging.206266

Corresponding author - Brian K. Kennedy - bkennedy@nus.edu.sg

Video short - https://www.youtube.com/watch?v=-FEiyj9PjBE

Sign up for free Altmetric alerts about this article - 
https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206266

Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts

Keywords - aging, aging clock, down syndrome, autism, schizophrenia, dolichol

To learn more about the journal, please visit our website at https://www.Aging-US.com​​ and connect with us:

Facebook - https://www.facebook.com/AgingUS/
X - https://twitter.com/AgingJrnl
Instagram - https://www.instagram.com/agingjrnl/
YouTube - https://www.youtube.com/@AgingJournal
LinkedIn - https://www.linkedin.com/company/aging/
Bluesky - https://bsky.app/profile/aging-us.bsky.social
Pinterest - https://www.pinterest.com/AgingUS/
Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc

MEDIA@IMPACTJOURNALS.COM

DoliClock: A Lipid-Based Clock for Measuring Brain Aging

The provided texts collectively explore the **fundamental principles of quantum mechanics**, such as **wave-particle duality**, **superposition**, and **quantum entanglement**, which profoundly **challenge classical physics** by introducing a **probabilistic nature to reality**. They detail the **historical development of quantum theory**, highlighting key experiments like the **double-slit experiment** and contributions from figures like **Einstein, Bohr, and Heisenberg**. Furthermore, the sources cover the **significant technological applications** derived from quantum mechanics, including **modern electronics**, **quantum computing**, and **quantum cryptography**, while also discussing **future implications** such as the **unification of physics**, a deeper **understanding of the universe**, and emerging fields like **quantum biology**. Finally, the texts touch upon the **philosophical debates** surrounding quantum reality, particularly the **Copenhagen** and **Many-Worlds interpretations**, emphasizing the **active role of observation** in shaping quantum outcomes.

Quantum Physics for Beginners (Audiobook Summary)

Scientists have uncovered a promising new strategy to weaken cancer cells’ natural defense mechanisms, potentially making chemotherapy more effective. In a study published in Volume 16 of Oncotarget, researchers identified the protein PRDX1 as a key player in helping tumors resist treatment. By targeting this protein, they propose a novel way to combat aggressive, treatment-resistant cancers.

Understanding Why Some Cancers Resist Treatment

Chemotherapy works by damaging the DNA of cancer cells, forcing them to self-destruct. However, many cancers develop robust repair systems that fix this damage, allowing the tumor to survive and grow. A central component of this repair machinery is a protein called ATM, which acts like a first responder in the cell, detecting DNA damage and coordinating its repair.

In ovarian cancer and other aggressive tumors, high levels of ATM have been associated with poor survival rates and resistance to chemotherapy.

The Study: How PRDX1 Protects Cancer Cells

The study, titled “PRDX1 protects ATM from arsenite-induced proteotoxicity and maintains its stability during DNA damage signaling,” was led by first author Reem Ali and corresponding author Dindial Ramotar from Hamad Bin Khalifa University in Qatar, in collaboration with researchers from the University of Nottingham in the UK. 

Full blog - https://www.oncotarget.org/2025/07/14/prdx1-identified-as-key-to-chemotherapy-resistance-in-cancer-cells/

Paper DOI - https://doi.org/10.18632/oncotarget.28720

Correspondence to - Dindial Ramotar - dramotar@hbku.edu.qa

Video short - https://www.youtube.com/watch?v=suOhF7mPlNQ

Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28720

Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/

Keywords - cancer, redox signaling, homologous recombination, protein interaction, cell cycle, protein modification

To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us:

Facebook - https://www.facebook.com/Oncotarget/
X - https://twitter.com/oncotarget
Instagram - https://www.instagram.com/oncotargetjrnl/
YouTube - https://www.youtube.com/@OncotargetJournal
LinkedIn - https://www.linkedin.com/company/oncotarget
Pinterest - https://www.pinterest.com/oncotarget/
Reddit - https://www.reddit.com/user/Oncotarget/
Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh

MEDIA@IMPACTJOURNALS.COM

PRDX1 Identified as Key to Chemotherapy Resistance in Cancer Cells

Oncotarget is a primarily oncology-focused, peer-reviewed, open access journal. Papers are published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Oncotarget is now indexed by MEDLINE, PubMed and PMC/PubMed.

Read about the Oncotarget Scientific Integrity Process: https://www.oncotarget.com/scientific_integrity/

Cancer and aging are two sides of age-related tumorigenesis.

The mission of the journal is to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population.

The journal aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.)

Read about the Aging (Aging-US) Scientific Integrity Process: https://aging-us.com/scientific-integrity

I genuinely believe in the potential of music to facilitate personal growth, foster meaningful connections, and cultivate shared experiences. My mission centers on producing dynamic musical works, both in the booth and studio, as an effective medium for storytelling, spiritual exploration, and the creation of deep emotional bonds.


+ Life Long Musical Professional & Enthusiast | Creative Entrepreneur | Music Producer | Club DJ | Event Production, Management, and Design Specialist | Electrician | Graphic Designer | Barber & Comedian 
+ Academic Background Master of Arts in Arts and Media, Audio Production, Media Management, Psychology, Mathematics, Sciences, and Business.   

**UNIFI MUSIC LLC**
NYC-Based Record Label, Music Production & Artist Management
At UNIFI MUSIC LLC, we aim to cultivate a creative and collaborative ecosystem for emerging musicians, artists, and producers. We are dedicated to educating up-and-coming artists to help them reach their highest potential while providing them the means to release music on all essential platforms. Our goal is to create an inspiring and lasting impact on the music industry. Music, dance, and storytelling are fundamental parts of the human experience. Art inspires, helps us find purpose, and fosters meaningful, lifelong connections..

Website - https://bio.site/anelo
Label - https://UnifiMusicRecords.com
Email - Promo@UnifiMusic.info

New tracks tagged #Summary