James 1:1-12. The current climate of our country appears to be one in which fear is the go-to response when we experience trials.

In this second study on the subject, Evangelist Jacob Holman returns to the first chapter of James to examine three additional ways that faith responds in life's trials.


Facing Trials with Faith (Part 2)

In this Knight Court discussion, the Team dissects the case that is on everyone's mind now: The Diddy Case!

Knight Court Dissects the Sean "Diddy" Combs Case

In this episode of "The Trial Lawyer's Handbook," litigation attorney Dan Small examines the challenges of preparing witnesses for trial, emphasizing the importance of honesty and addressing unfavorable facts in advance. Mr. Small shares his experience working with Billy Breen, a former drug trafficker turned government informant in the Appling County, Georgia, Racketeer Influenced and Corrupt Organizations (RICO) Act case. He details the process of building trust with witnesses, explains how financial incentives and personal history can impact testimony, and highlights the strategy of bringing out damaging information on direct examination. The episode offers practical insights into effective witness preparation and underscores the value of transparency and credibility in the courtroom.

Bring Out the Bad Stuff

Trance

In this essential episode of Parallax, Dr Ankur Kalra is joined by Dr Carolyn Ho, Professor of Medicine at Harvard Medical School and Medical Director of the Cardiovascular Genetics Program at Brigham and Women's Hospital, for a comprehensive discussion on how genetic testing is reshaping hypertrophic cardiomyopathy management.

The conversation explores the VANISH HCM trial results, which showed that valsartan can slow disease progression in young, asymptomatic individuals with early sarcomeric HCM. Dr Ho discusses how this evidence influenced the 2024 HCM guidelines and created new opportunities for disease-modifying therapy before clinical symptoms appear. The episode also examines emerging gene-based therapeutics, from current adeno-associated virus approaches to future CRISPR technologies that could address the underlying genetic causes of HCM.

Dr Ho addresses practical considerations for clinicians, including when to initiate genetic testing, how to manage family screening, and the promise of AI-assisted screening tools. The discussion highlights both current therapeutic options and the evolving landscape of precision medicine in inherited cardiovascular disease.

Questions and comments can be sent to "podcast@radcliffe-group.com" and may be answered by Ankur in the next episode. Host: @AnkurKalraMD and produced by: @RadcliffeCardio
Parallax is Ranked in the Top 100 Health Science Podcasts (#48) by Million Podcasts.

EP 139: The Genetic Revolution in HCM: Mapping Family Risk to Targeted Treatment

Mark 5:36 Records Jesus response to Jairus upon hearing that his daughter had died. Jesus told Jairus “Do not fear, only believe.”

In this study, evangelist Jacob Hudgins challenges us to choose Faith not Fear when we face hard circumstances in our lives.

Do Not Fear - Only Believe

In this episode of his "The Trial Lawyer's Handbook" podcast series, litigation attorney Dan Small talks about his experience prosecuting the Cammarata Organization while serving with the U.S. Department of Justice's (DOJ) Organized Crime Strike Force. Mr. Small explains how traditional organized crime groups struggled with the transition into drug trafficking, a business they once saw as off-limits. He details how the Cammarata group's excessive ambition and reliance on violence undermined their criminal enterprises, including failed international deals and brutal tactics that ultimately led to their downfall. This episode explores the realities of investigating organized crime, the economic principles underlying illegal enterprises and how prosecutors use evidence of violence to portray criminal organizations in court.

Too Dirty for Dirty Crime

Dive into the deep, hypnotic grooves of the Fargas Afro House Remix of Show Me Love by WizTheMc and bees & honey. Fargas brings a unique Afro House twist, blending pulsating percussion, warm basslines, and atmospheric synth textures, transforming the original into a soulful, dancefloor-ready journey.

This remix captures the essence of Afro-inspired house music while keeping the emotive core of the original track intact, making it perfect for late-night sets, beach sunsets, and those moments when the music takes you somewhere far beyond the room you’re in.

Free Download

WizTheMc, bees & honey - Show Me Love (Afro House Remix)

In this episode of "The Trial Lawyer's Handbook," litigation attorney Dan Small explores the complicated dynamics of using informants in organized crime cases. Drawing from his prosecution of Sam Cammarata, Mr. Small explains how informants can both help and hinder investigations, especially when they manipulate their insider status for personal gain. He discusses the challenges prosecutors face in building persuasive arguments using informant testimony, tactics defense lawyers use to cast doubt on informant credibility and strategies that help reveal the truth in court. This episode offers insights into the delicate balance required to pursue justice when relying on those closest to criminal activity.

"I Was Just Playing a Role"

In this essential episode of Parallax, Dr Ankur Kalra welcomes Dr Shelley Zieroth, Professor of Medicine, clinician-scientist, and advanced heart failure and transplant cardiologist in Winnipeg, Canada. As we mark the 10-year anniversary of the landmark EMPA-REG OUTCOME trial, Dr Zieroth provides a comprehensive update on how SGLT2 inhibitors have revolutionized cardiovascular care.

Dr Zieroth takes us through the remarkable journey from the initial 2015 trial that transformed SGLT2 inhibitors from anti-diabetic agents into cardiovascular powerhouses, delivering highly significant reductions in cardiovascular death and heart failure hospitalization. She explores how these medications have become fundamental pillars of cardio-kidney-metabolic medicine, with evidence spanning the entire ejection fraction spectrum.

Dr Zieroth discusses prescribing these agents in heart failure - including the straightforward 10-mg daily dosing, monitoring strategies, and crucial patient selection criteria. She shares insights from the recent EMPULSE trial on safe in-hospital initiation, addresses important considerations for diabetic patients, and highlights key contraindications like indwelling catheters that clinicians must recognize.

Beyond the basics, Dr Kalra and Dr Zieroth examine the evolving role of SGLT2 inhibitors in valvular disease and diastolic dysfunction, tackle the ongoing reimbursement challenges across different healthcare systems, and discuss the critical importance of multidisciplinary collaboration in the cardio-kidney-metabolic space. They also look ahead to exciting combination therapies on the horizon that promise to further advance heart failure prevention and treatment.

Questions and comments can be sent to "podcast@radcliffe-group.com" and may be answered by Ankur in the next episode.

Host: @AnkurKalraMD and produced by: @RadcliffeCardio
Parallax is Ranked in the Top 100 Health Science Podcasts (#48) by Million Podcasts.

EP 141: From EMPA-REG to Clinical Practice: Mastering SGLT2 Inhibitors in Modern Cardiology

BOOKINGS: me@richiefargas.com 

Welcome! I’m a London-based Artist, creating music inspired by African culture.

SEND ME TUNES: richiefargas@gmail.com

The church of Christ at Fairview Park is a group of Christians committed to following just the Bible in all that we say and do. Our goal is to be a local church like those found in the pages of the New Testament. Our collective worship and work reflect this focus.  

Our weekly uploads are Bible lessons presented by Fairview Evangelists.  We invite you to study the Bible with us.

Like those found in the pages of the New Testament, the Fairview Park church is completely independent of all other churches. The elders have authority over this congregation (Heb 13:7, 17; 1 Pet 5:1-4) and they answer only to Jesus – not any other church or body.

We would love for you to join us for worship. If you have any questions about what we do or concerns about whether we are following the New Testament, we sincerely encourage you to contact us.

‘Parallax’ (/ˈparəlaks/)-noun: the effect whereby the position or direction of an object appears to differ when viewed from different positions. Join Ankur Kalra, MD as he shows you a different side to cardiovascular care, management and science. Listen to Ankur’s conversations with legendary cardiologists, critical reviews of key congresses and late-breaking trials, and concise summaries. Published every second Monday of the month, this is your fix of reliable updates on all things cardiology by someone from a non-traditional background, who is always trying to look at it from new angles! Dear cardiologists, we want to make this podcast about you, and for you! Please email us critical thoughts, comments and questions for Ankur at podcast@radcliffe-group.com.

New tracks tagged #TRIAL