"it doesnt get better and it doesnt get easier"

"all i had was you"

Bojack Horseman x The Beginning - Flawed Mangoes (slowed & reverb)

TUMOR

Drs. Mehdi Mollapour, Jennifer Heritz, and Sarah Backe from SUNY Upstate Medical University (Syracuse, NY) discuss a review they co-authored that was published by Oncotarget in Volume 15, entitled, “Molecular chaperones: Guardians of tumor suppressor stability and function.”

DOI - https://doi.org/10.18632/oncotarget.28653

Correspondence to - Mehdi Mollapour - mollapom@upstate.edu

Video interview - https://www.youtube.com/watch?v=vEHmyemWgNo

Video transcript - https://www.oncotarget.net/2024/10/24/behind-the-study-molecular-chaperones-tumor-suppressor-stability/

Abstract

The term ‘tumor suppressor’ describes a widely diverse set of genes that are generally involved in the suppression of metastasis, but lead to tumorigenesis upon loss-of-function mutations. Despite the protein products of tumor suppressors exhibiting drastically different structures and functions, many share a common regulatory mechanism—they are molecular chaperone ‘clients’. Clients of molecular chaperones depend on an intracellular network of chaperones and co-chaperones to maintain stability. Mutations of tumor suppressors that disrupt proper chaperoning prevent the cell from maintaining sufficient protein levels for physiological function. This review discusses the role of the molecular chaperones Hsp70 and Hsp90 in maintaining the stability and functional integrity of tumor suppressors. The contribution of cochaperones prefoldin, HOP, Aha1, p23, FNIP1/2 and Tsc1 as well as the chaperonin TRiC to tumor suppressor stability is also discussed. Genes implicated in renal cell carcinoma development—VHL, TSC1/2, and FLCN—will be used as examples to explore this concept, as well as how pathogenic mutations of tumor suppressors cause disease by disrupting protein chaperoning, maturation, and function.

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Keywords - cancer, molecular chaperone, tumor suppressor, renal cell carcinoma, Birt-Hogg-Dubé (BHD) syndrome, TSC syndrome

About Oncotarget 

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Oncotarget is indexed and archived by PubMed/Medline, PubMed Central, Scopus, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science).

To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us:

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MEDIA@IMPACTJOURNALS.COM

Oncotarget

Behind the Study: Molecular Chaperones & Tumor Suppressor Stability

BUFFALO, NY - November 12, 2024 – A new #review was #published in Oncotarget's Volume 15 on November 7, 2024, entitled “Understanding the interplay between extracellular matrix topology and tumor-immune interactions: Challenges and opportunities.”

This comprehensive review by researchers Yijia Fan, Alvis Chiu, Feng Zhao, and Jason T. George from Texas A&M University, Rice University, and MD  Anderson Cancer Center sheds light on how the structural properties of the extracellular matrix (ECM) within tumors impact immune cell behavior and influence the effectiveness of cancer immunotherapies. The ECM, a network of proteins surrounding cells, often transforms in cancer, becoming denser and more aligned. These changes create physical barriers that can prevent immune cells, especially T cells, from effectively accessing and attacking tumors, thereby limiting the success of immunotherapies.

The team emphasizes the role of specific ECM configurations, known as Tumor-Associated Collagen Signatures (TACS), in cancer progression and immune evasion. TACS1 and TACS2 patterns create "immune deserts" around tumors, limiting immune cell movement and preventing T cells from recognizing and attacking cancer cells, which is essential for successful immunotherapy. In advanced stages, TACS3 aligns ECM fibers in ways that both promote tumor spread and create additional barriers, further obstructing immune cell access to the tumor.

These insights lead the way for ECM-targeted therapies designed to modify these barriers, potentially transforming “cold” (immune-non-responsive) tumors into “hot” (immune-responsive) ones, thereby improving immune cell infiltration and enhancing treatment outcomes. 

“Understanding the complex interplay is relevant for developing more accurate model of tumor evasion and the identification of corresponding therapeutic intervention.”


The review highlights advanced computational models that simulate interactions between the ECM, immune cells, and tumors, offering valuable insights for developing ECM-targeted therapies. These models illustrate how modifying ECM properties could enhance immune cell migration and function, potentially overcoming immune resistance and expanding the effectiveness of immunotherapies.

The authors also suggest that targeting ECM structure could significantly enhance the effectiveness of immunotherapy, especially for cancers like breast, pancreatic, and ovarian, which often feature dense ECM regions. By reshaping the ECM, such treatments could enable immune cells to access previously unreachable tumor areas, presenting a promising strategy to combat tumors that are resistant to standard therapies.

In conclusion, the review underscores the need for continued research into ECM-focused strategies, which could support more integrated approaches to cancer treatment. By targeting the ECM’s physical barriers and immune evasion mechanisms, these strategies hold promise for improving outcomes in difficult-to-treat cancers.

DOI - https://doi.org/10.18632/oncotarget.28666

Correspondence to - Jason T. George - jason.george@tamu.edu

Video short - https://www.youtube.com/watch?v=7Wm-SMLJadk

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Extracellular Matrix and Tumor-Immune Interactions: Challenges & Opportunities

[Slashy the femboy fucker]
Imma fuck a femboy and it’s gon be sweet 
And I fucking love it when he’s worrying bout my sheets 
Baby boy don’t worry afterwards I’ll get it cleaned 
So let’s go do whatever and I know we both some freaks 

So 
Imma fuck a femboy 
Imma fuck a femboy 
Imma fuck a femboy
Imma fuck a femboy 

And I’ll fucking love it 
And I know he’ll love it 
Daddy issues makin it easier for the cutting 
Mommy issues makin it easier for all the cuffing 
Stuff you like a turkey while my dick is all ur stuffing 

Made me finish quick oh my god boy can u stay
I’ll be loving everything about you that you hate 
Let’s keep up the cardio and don’t you forget 
That my semen is ur meal plan and u just ate 

So 
Imma fuck a femboy 
Imma fuck a femboy 
Imma fuck a femboy 
Imma fuck a femboy 

[Tumor the femboy fucker]
its blinding here
and I want a boy so much
mirror mirror can u tell me what is wrong?
It replied if your fine inside im not
cuz I need a fucking twink inside my heart
wanna fuck a skinny boy and moan all night
can you tell me if I can nut here
yeah your ass its so fucking tight
if you scream ill shut you up alright

fuck them white hoes yeah I love bros
if I am honest I would rather fuck a twink 
than some bitch thats dishonest

and she wanna fucking see me but she has a whole ass pussy and I want some fucking penis cuz I love all of my bussy
and im gone
look in the corner ill lick your thong
and im fucking with your tears yeah they growing shlong
and I want a fucking femboy to suck on my cock
and ill cum inside their bussy when they gripping my cock

Slashy + Tumor - Femboys (prod. Okayjml)

(Prod. Peril)

feel like I'm deaf I don't hear a word you're saying >:3

Confess

mylasttcup + V8dareal556 - tumor [DREAMTHUGEXCLUSIVE]

This podcast discusses an updated systematic review of the literature and provides new recommendations for the role of Stereotactic Radiosurgery in the treatment of adult patients with Vestibular Schwannoma. 

Brad Elder, MD
Isabelle Germano, MD

Radiosurgery (SRS) and Radiation Therapy for Vestibular Schwannoma Update: A CNS Guidelines Podcast

40 minutes ago
Read article here => https://healthsolvtions.blogspot.ch/lutenol+tumor+in+eye+treatment

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Everything I do is for God's glory.

A bunch of custom video game type themes. I also do some video game remixes and instrumentals for songs I've written or that others have written and asked me to make music for.

New Background Logo by O-P ( ℗᷏͛ )

O-P ( ℗᷏͛ ) Channel: https://soundcloud.com/opstellar

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Oncotarget is a primarily oncology-focused, peer-reviewed, open access journal. Papers are published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Oncotarget is now indexed by MEDLINE, PubMed and PMC/PubMed.

Read about the Oncotarget Scientific Integrity Process: https://www.oncotarget.com/scientific_integrity/

The CNS' suite of complimentary podcasts cover CNS journal articles from Neurosurgery and Operative Neurosurgery, as well as CNS Guidelines, Controversies in Neurosurgery, Optimizing Neurosurgical Practice, CNS Partner Podcasts and the CNS Leadership Institute. Podcasts are available on Apple, SoundCloud, Spotify and YouTube.

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If u listen to my music I hope u enjoy it :)

New tracks tagged #Tumor