"it doesnt get better and it doesnt get easier"

"all i had was you"

Bojack Horseman x The Beginning - Flawed Mangoes (slowed & reverb)

BUFFALO, NY- October 16, 2024 – A new #review was #published in Oncotarget's Volume 15 on October 1, 2024, entitled, “Molecular chaperones: Guardians of tumor suppressor stability and function.”

As highlighted in the abstract of this paper, "tumor suppressor" describes a diverse set of genes typically involved in suppressing metastasis, but which can lead to tumorigenesis when loss-of-function mutations occur. Despite the varied structures and functions of tumor suppressor proteins, many share a common regulatory mechanism—they are "clients" of molecular chaperones, and they rely on an intracellular network of chaperones and co-chaperones to maintain their stability. Mutations in tumor suppressors that disrupt proper chaperoning prevent cells from maintaining sufficient protein levels for normal physiological function.

In their review, researchers Jennifer A. Heritz, Sarah J. Backe, and Mehdi Mollapour from SUNY Upstate Medical University and New York VA Health Care in Syracuse, New York, discuss the role of molecular chaperones Hsp70 and Hsp90 in maintaining the stability and functional integrity of tumor suppressors. They also detail the contributions of co-chaperones prefoldin, HOP, Aha1, p23, FNIP1/2, and Tsc1, as well as the chaperonin TRiC, to tumor suppressor stability.

“Overall, it is clear that oncogenesis can result from the dysregulation of tumor suppressor stabilization by chaperones.”

DOI - https://doi.org/10.18632/oncotarget.28653

Correspondence to - Mehdi Mollapour - mollapom@upstate.edu

Video short - https://www.youtube.com/watch?v=V5OFjeqaH3A

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Keywords - cancer, molecular chaperone, tumor suppressor, renal cell carcinoma, Birt-Hogg-Dubé (BHD) syndrome, TSC syndrome

About Oncotarget 

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Oncotarget is indexed and archived by PubMed/Medline, PubMed Central, Scopus, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science).

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MEDIA@IMPACTJOURNALS.COM

Oncotarget

Molecular Chaperones: Guardians of Tumor Suppressor Stability

TUMOR

Drs. Mehdi Mollapour, Jennifer Heritz, and Sarah Backe from SUNY Upstate Medical University (Syracuse, NY) discuss a review they co-authored that was published by Oncotarget in Volume 15, entitled, “Molecular chaperones: Guardians of tumor suppressor stability and function.”

DOI - https://doi.org/10.18632/oncotarget.28653

Correspondence to - Mehdi Mollapour - mollapom@upstate.edu

Video interview - https://www.youtube.com/watch?v=vEHmyemWgNo

Video transcript - https://www.oncotarget.net/2024/10/24/behind-the-study-molecular-chaperones-tumor-suppressor-stability/

Abstract

The term ‘tumor suppressor’ describes a widely diverse set of genes that are generally involved in the suppression of metastasis, but lead to tumorigenesis upon loss-of-function mutations. Despite the protein products of tumor suppressors exhibiting drastically different structures and functions, many share a common regulatory mechanism—they are molecular chaperone ‘clients’. Clients of molecular chaperones depend on an intracellular network of chaperones and co-chaperones to maintain stability. Mutations of tumor suppressors that disrupt proper chaperoning prevent the cell from maintaining sufficient protein levels for physiological function. This review discusses the role of the molecular chaperones Hsp70 and Hsp90 in maintaining the stability and functional integrity of tumor suppressors. The contribution of cochaperones prefoldin, HOP, Aha1, p23, FNIP1/2 and Tsc1 as well as the chaperonin TRiC to tumor suppressor stability is also discussed. Genes implicated in renal cell carcinoma development—VHL, TSC1/2, and FLCN—will be used as examples to explore this concept, as well as how pathogenic mutations of tumor suppressors cause disease by disrupting protein chaperoning, maturation, and function.

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Keywords - cancer, molecular chaperone, tumor suppressor, renal cell carcinoma, Birt-Hogg-Dubé (BHD) syndrome, TSC syndrome

About Oncotarget 

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Oncotarget is indexed and archived by PubMed/Medline, PubMed Central, Scopus, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science).

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MEDIA@IMPACTJOURNALS.COM

Behind the Study: Molecular Chaperones & Tumor Suppressor Stability

BUFFALO, NY - November 12, 2024 – A new #review was #published in Oncotarget's Volume 15 on November 7, 2024, entitled “Understanding the interplay between extracellular matrix topology and tumor-immune interactions: Challenges and opportunities.”

This comprehensive review by researchers Yijia Fan, Alvis Chiu, Feng Zhao, and Jason T. George from Texas A&M University, Rice University, and MD  Anderson Cancer Center sheds light on how the structural properties of the extracellular matrix (ECM) within tumors impact immune cell behavior and influence the effectiveness of cancer immunotherapies. The ECM, a network of proteins surrounding cells, often transforms in cancer, becoming denser and more aligned. These changes create physical barriers that can prevent immune cells, especially T cells, from effectively accessing and attacking tumors, thereby limiting the success of immunotherapies.

The team emphasizes the role of specific ECM configurations, known as Tumor-Associated Collagen Signatures (TACS), in cancer progression and immune evasion. TACS1 and TACS2 patterns create "immune deserts" around tumors, limiting immune cell movement and preventing T cells from recognizing and attacking cancer cells, which is essential for successful immunotherapy. In advanced stages, TACS3 aligns ECM fibers in ways that both promote tumor spread and create additional barriers, further obstructing immune cell access to the tumor.

These insights lead the way for ECM-targeted therapies designed to modify these barriers, potentially transforming “cold” (immune-non-responsive) tumors into “hot” (immune-responsive) ones, thereby improving immune cell infiltration and enhancing treatment outcomes. 

“Understanding the complex interplay is relevant for developing more accurate model of tumor evasion and the identification of corresponding therapeutic intervention.”


The review highlights advanced computational models that simulate interactions between the ECM, immune cells, and tumors, offering valuable insights for developing ECM-targeted therapies. These models illustrate how modifying ECM properties could enhance immune cell migration and function, potentially overcoming immune resistance and expanding the effectiveness of immunotherapies.

The authors also suggest that targeting ECM structure could significantly enhance the effectiveness of immunotherapy, especially for cancers like breast, pancreatic, and ovarian, which often feature dense ECM regions. By reshaping the ECM, such treatments could enable immune cells to access previously unreachable tumor areas, presenting a promising strategy to combat tumors that are resistant to standard therapies.

In conclusion, the review underscores the need for continued research into ECM-focused strategies, which could support more integrated approaches to cancer treatment. By targeting the ECM’s physical barriers and immune evasion mechanisms, these strategies hold promise for improving outcomes in difficult-to-treat cancers.

DOI - https://doi.org/10.18632/oncotarget.28666

Correspondence to - Jason T. George - jason.george@tamu.edu

Video short - https://www.youtube.com/watch?v=7Wm-SMLJadk

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MEDIA@IMPACTJOURNALS.COM

Extracellular Matrix and Tumor-Immune Interactions: Challenges & Opportunities

[Slashy the femboy fucker]
Imma fuck a femboy and it’s gon be sweet 
And I fucking love it when he’s worrying bout my sheets 
Baby boy don’t worry afterwards I’ll get it cleaned 
So let’s go do whatever and I know we both some freaks 

So 
Imma fuck a femboy 
Imma fuck a femboy 
Imma fuck a femboy
Imma fuck a femboy 

And I’ll fucking love it 
And I know he’ll love it 
Daddy issues makin it easier for the cutting 
Mommy issues makin it easier for all the cuffing 
Stuff you like a turkey while my dick is all ur stuffing 

Made me finish quick oh my god boy can u stay
I’ll be loving everything about you that you hate 
Let’s keep up the cardio and don’t you forget 
That my semen is ur meal plan and u just ate 

So 
Imma fuck a femboy 
Imma fuck a femboy 
Imma fuck a femboy 
Imma fuck a femboy 

[Tumor the femboy fucker]
its blinding here
and I want a boy so much
mirror mirror can u tell me what is wrong?
It replied if your fine inside im not
cuz I need a fucking twink inside my heart
wanna fuck a skinny boy and moan all night
can you tell me if I can nut here
yeah your ass its so fucking tight
if you scream ill shut you up alright

fuck them white hoes yeah I love bros
if I am honest I would rather fuck a twink 
than some bitch thats dishonest

and she wanna fucking see me but she has a whole ass pussy and I want some fucking penis cuz I love all of my bussy
and im gone
look in the corner ill lick your thong
and im fucking with your tears yeah they growing shlong
and I want a fucking femboy to suck on my cock
and ill cum inside their bussy when they gripping my cock

Slashy + Tumor - Femboys (prod. Okayjml)

(Prod. Peril)

feel like I'm deaf I don't hear a word you're saying >:3

Confess

mylasttcup + V8dareal556 - tumor [DREAMTHUGEXCLUSIVE]

This podcast discusses an updated systematic review of the literature and provides new recommendations for the role of Stereotactic Radiosurgery in the treatment of adult patients with Vestibular Schwannoma. 

Brad Elder, MD
Isabelle Germano, MD

Radiosurgery (SRS) and Radiation Therapy for Vestibular Schwannoma Update: A CNS Guidelines Podcast

40 minutes ago
Read article here => https://healthsolvtions.blogspot.ch/lutenol+tumor+in+eye+treatment

Reviews tumor in eye treatment
Best tumor in eye treatment
Suplement tumor in eye treatment
tumor in eye treatment for Men
tumor in eye treatment for Women

Best Tumor In Eye Treatment Reviews

DJ TUMOR'S FIRST OFFICIAL SONG @pigly-34893863

Spongetastic Speed

una rola asi bien ardida por somos bien sigmas chads y basados 

This Is End

prod. sickboi

Wake up spinning in and out of my head
I wanna break down telling you get out of my head
I swear I cut off all the things attached to my sins
so why am I still just a fucking dork in my head?

Im feeling so empty, numb in my bed
I need my SSRI's
so close to leaving my head maybe SUNNY is my life
close myself trapped in my dream living like OMORI
im corny when im trapped in the scene don't even bother asking...

Dream Space

🔮 NOWA ERA: MATTEO/X 🔥
Z popiołów przeszłości narodził się ktoś nowy 🌙

Everything I do is for God's glory.

A bunch of custom video game type themes. I also do some video game remixes and instrumentals for songs I've written or that others have written and asked me to make music for.

New Background Logo by O-P ( ℗᷏͛ )

O-P ( ℗᷏͛ ) Channel: https://soundcloud.com/opstellar

Chase Your Dream 👊🏾
DreamthugExclusive@gmail.com
For hosting or other inquiries email or dm on ig

Oncotarget is a primarily oncology-focused, peer-reviewed, open access journal. Papers are published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Oncotarget is now indexed by MEDLINE, PubMed and PMC/PubMed.

Read about the Oncotarget Scientific Integrity Process: https://www.oncotarget.com/scientific_integrity/

The CNS' suite of complimentary podcasts cover CNS journal articles from Neurosurgery and Operative Neurosurgery, as well as CNS Guidelines, Controversies in Neurosurgery, Optimizing Neurosurgical Practice, CNS Partner Podcasts and the CNS Leadership Institute. Podcasts are available on Apple, SoundCloud, Spotify and YouTube.

Blah Blah Blah

If u listen to my music I hope u enjoy it :)

New tracks tagged #Tumor