BUFFALO, NY- February 27, 2024 – A new #research paper was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 3, entitled, “The anti-aging effect of vitamin D and vitamin D receptor in Drosophila midgut.”

Adult stem cells are pivotal for maintaining tissue homeostasis, and their functional decline is linked to aging and its associated diseases, influenced by the niche cells’ environment. Age- and cancer-related reduction of vitamin D and its receptor levels are well documented in human clinical studies. However, the mechanisms through which the vitamin D/vitamin D receptor (VitD/VDR) pathway contributes to anti-aging and extends life expectancy are not well understood. In this new study, researchers Joung-Sun Park, Hyun-Jin Na and Yung-Jin Kim from Pusan National University and Korea Food Research Institute aimed to determine the protective role of the vitamin D/vitamin D receptor pathway in differentiated enterocytes (ECs) during intestinal stem cell (ISC) aging. 

“This study aimed to determine the protective role of VitD/VDR in differentiated ECs during ISC aging using the adult Drosophila intestine model.”

By utilizing a well-established Drosophila midgut model for stem cell aging biology, the researchers revealed that vitamin D receptor knockdown in ECs induced ISC proliferation, EC death, ISC aging, and enteroendocrine cell differentiation. Additionally, age- and oxidative stress-induced increases in ISC proliferation and centrosome amplification were reduced by vitamin D treatment. In conclusion, this study provides direct evidence of the anti-aging role of the VitD/VDR pathway, involving protecting ECs during aging, and provides valuable insights for exploring the molecular mechanisms underlying enhanced healthy aging in Drosophila.

“Our findings suggest a direct evidence of the anti-aging role of the vitamin D/vitamin D receptor pathway and provides insights into the molecular mechanisms underlying healthy aging in Drosophila.”

DOI - https://doi.org/10.18632/aging.205518

Corresponding author - Joung-Sun Park - dreamjs78@pusan.ac.kr

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Keywords - aging, Drosophila, vitamin D, vitamin D receptor, anti-aging, intestinal stem cell

About Aging-US

Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

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Aging (Aging-US)

The Anti-aging Effect of Vitamin D and its Receptor in Drosophila Midgut

Wasted on a...(nother human)

A healthy set of teeth is not merely the result of brushing daily. Many aspects of our overall lifestyles are also involved. This program looks at how lifestyle affects key dental issues including decay, tooth alignment, and grinding.

Host: Kaysie Vokurka, Nutritionist & Lifestyle Medicine Practitioner
Guest: Dr Berenice Cheng, Dentist & Public Health Practitioner

Lifestyle Dentistry - YLAM230009

WHAT ABOUT FAKE VITAMINS? PODCAST https://mealbetix.com/take-back-your-health-podcast

#fakevitamins #syntheticvitamins #artificialvitamins

WHAT ABOUT FAKE VITAMINS?

Vitamin D is the subject of a lot of controversy right now after the Endocrine Society made new recommendations in June 2024 suggesting that routine screening for vitamin D was not necessary, and routine supplementation was not beneficial for the average person. Today I'm looking into how they came up with this recommendation and what hundreds of studies have shown over the years, to put this recommendation in context. Everyone agrees that vitamin D is critical for life and no one is suggesting that we don't need it, but questions remain around whether we need to take a supplement or if we can find it naturally, and if so, whether we need to measure blood levels and what the optimal blood level should be.

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MultipleSklerose

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В ударе

Winter und Morbus Crohn – eine Kombination, die mich jedes Jahr wieder herausfordert. Vielleicht kennst du das auch: Müdigkeit, Unruhe, ein träger Darm, schlechter Schlaf oder ein geschwächtes Immunsystem. Der Körper reagiert anders als im Sommer – und manchmal fühlt es sich an, als wäre alles aus dem Gleichgewicht geraten.

In dieser Folge spreche ich über genau die eine Sache, die für mich im Winter den größten Unterschied macht: Balance. Ich zeige dir, wie ich meine Energie zurückhole, was mir hilft, wenn mein Darm rebelliert, und warum kleine Gegengewichte oft den größten Unterschied machen.

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#206 Die eine Sache, die mir im Winter mit Morbus Crohn am meisten hilft

In this informative podcast episode, we provide valuable insights into detecting and addressing deficiencies in these crucial nutrients. Discover the importance of iron and vitamin D for your health and learn how to take charge of your well-being by booking an appointment for a comprehensive testing process.

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Edit of the track "Roaring 20’s" by Jamback.
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Note: Non-commercial edit. The original track "Roaring 20’s" belongs to Jamback.

JAMBACK - ROARING 20'S (Vitamind Edit)

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Cancer and aging are two sides of age-related tumorigenesis.

The mission of the journal is to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population.

The journal aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.)

Read about the Aging (Aging-US) Scientific Integrity Process: https://aging-us.com/scientific-integrity

Willkommen beim ‘Ich und mein Crohn’ Podcast – Dein wöchentlicher Begleiter für ein erfülltes Leben trotz CED. Ich, Kai Flockenhaus, teile als Industriekaufmann, Sozialarbeiter, systemischer Coach und vor allem als Betroffener, meine persönlichen Einsichten und professionellen Ratschläge, um Dir zu helfen, Morbus Crohn oder Colitis Ulcerosa nicht nur zu managen, sondern ihnen mutig zu begegnen. Mit über 14 Jahren Erfahrung zeige ich Dir, wie Du schnell wieder die Kontrolle gewinnst und ein selbstbestimmtes Leben führen kannst. Jeden zweiten Freitag ab 5:00 Uhr erwarten Dich inspirierende Geschichten und praktische Tipps, die Deinen Alltag erleichtern. Lass uns gemeinsam diesen Weg gehen!
 

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Adrian Korin aka the baddest in the music game

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Content is for informational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your health care provider with any questions you have regarding a medical or mental health condition, and before undertaking any diet, dietary supplement, exercise, or other health program.

New tracks tagged #VitaminD