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Kieran talks with Daniel Stipano, partner at Davis Polk & Wardwell and a 30-year veteran of the Office of the Comptroller of the Currency, about the unfolding requirements of the Corporate Transparency and AML Acts and their impact on law enforcement, and financial as well as non-financial institutions.

Dan also weighs in on the current court challenges to the CTA, particularly the recent Federal court ruling that declared it unconstitutional, what the Financial Crime Enforcement Network’s latest rule-makings mean, and what the long-awaited revised customer due diligence rule might look like.

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This Financial Crime Matters episode is sponsored by:

SymphonyAI - www.symphonyai.com

Making Sense of U.S. Anti-Financial Crime Measures, with Daniel Stipano

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BUFFALO, NY- March 25, 2024 – A new #research paper was #published in Oncotarget's Volume 15 on March 14, 2024, entitled, “ABT199/venetoclax synergism with thiotepa enhances the cytotoxicity of fludarabine, cladribine and busulfan in AML cells.”

ABT199/venetoclax, an inhibitor of the pro-survival BCL-2 protein, has improved AML treatment. Its efficacy in hematopoietic stem cell transplantation (HSCT), when combined with other chemotherapeutic drugs, has not been thoroughly investigated. In this new study, researchers Benigno C. Valdez, Bin Yuan, David Murray, Jeremy L. Ramdial, Uday Popat, Yago Nieto, and Borje S. Andersson from The University of Texas MD Anderson Cancer Center and the University of Alberta demonstrate the synergistic cytotoxicity of ABT199/venetoclax with the DNA alkylator thiotepa (Thio) in AML cells. 

“The results may provide relevant information for the design of clinical trials using these drugs to circumvent recognized drug-resistance mechanisms when used as part of pre-transplant conditioning regimens for AML patients undergoing allogenic HSCT.”

Cleavage of Caspase 3, PARP1 and HSP90, as well as increased Annexin V positivity, suggest potent activation of apoptosis by this two-drug combination; increased levels of γ-H2AX, P-CHK1 (S317), P-CHK2 (S19) and P-SMC1 (S957) indicate an enhanced DNA damage response. Likewise, the increased level of P-SAPK/JNK (T183/Y185) and decreased P-PI3Kp85 (Y458) suggest enhanced activation of stress signaling pathways. These molecular readouts were synergistically enhanced when ABT199/venetoclax and Thio were combined with fludarabine, cladribine and busulfan. 

The five-drug combination decreased the levels of BCL-2, BCL-xL and MCL-1, suggesting its potential clinical relevance in overcoming ABT199/venetoclax resistance. Moreover, this combination is active against P53-negative and FLT3-ITD-positive cell lines. Enhanced activation of apoptosis was observed in leukemia patient-derived cell samples exposed to the five-drug combination, suggesting a clinical relevance. 

“The results provide a rationale for clinical trials using these two- and five-drug combinations as part of a conditioning regimen for AML patients undergoing HSCT.”

DOI - https://doi.org/10.18632/oncotarget.28563

Correspondence to - Benigno C. Valdez - mbalasik@yahoo.com

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Keywords - cancer, acute myeloid leukemia, aml, pre-transplant regimens, venetoclax, thiotepa, busulfan

About Oncotarget 

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.
Oncotarget is indexed and archived by PubMed/Medline, PubMed Central, Scopus, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science).

To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us:

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Oncotarget

ABT199/Venetoclax Synergism With Thiotepa in Acute Myeloid Leukemia (AML) Cells

Myelodysplastische Neoplasien (MDS) gehören mit einer Inzidenz von 4-5 pro 100.000 Einwohner:innen zu den häufigsten malignen hämatologischen Erkrankungen. Das Risiko, innerhalb von 2 Jahren an einer akuten myeloischen Leukämie (AML) zu erkranken, liegt bei ca. 30%. Welchen Patient:innen droht ein Übergang von MDS zu AML? Wie unterscheidet sich die Therapie von Hochrisiko- und Niedrigrisiko-MDS? Und inwieweit können neue zielgerichtete Therapieansätze die Prognose bei MDS verbessern? Diese und weitere Fragen klärt Dr. med. vet. Astrid Heinl, stellvertretende Chefredakteurin des Journal Onkologie, im Gespräch mit Prof. Dr. med. Haifa Kathrin Al-Ali, Direktorin des Krukenberg-Krebszentrums Halle.

Zur Folgen-Übersicht: medical-tribune.de/o-ton-onkologie

Weiterführende Informationen:
https://www.umh.de/portraets/prof-dr-med-haifa-kathrin-al-ali
https://www.umh.de/
https://forschung-sachsen-anhalt.de/pl/al-ali-116846
https://www.journalonko.de/news/lesen/mds-ergebnisse-commands-studie-luspatercept
https://www.journalonko.de/podcasts/abspielen/ash-2022-klassifikation-diagnostik-therapie-aml

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Join ACFCS and Elizabeth Callan, a FinCrime and Sanctions SME with Symphony AI Financial Services, as we hit the highlights of major pending financial crime regulations in the U.S., discuss their impact for compliance programs, and provide advice on how you can prepare now to get out ahead of these changes.

2024: A Review of Pivotal Changes in U.S. AML Regulations

It’s been a busy year so far with FinCEN releasing two NPRMs that would bring AML regulations to two sectors of the U.S. economy, residential real estate and registered investment advisers, which have not been subject to these regulations in the past.

What does all this mean for these sectors and AML/FinCrime programs? Join ACFCS and Elizabeth Callan, AML and FinCrime Risk and Compliance Expert with Symphony AI Financial Services, as they hit the highlights of these pending rules, discuss their impact for AML/FinCrime professionals and programs, and provide advice on how you can prepare now to get ahead of these changes.

Speaker:
Elizabeth Callan, AML & FinCrime Risk Management & Compliance Expert, SymphonyAI Financial Services

2024: A Review of Pivotal Changes in U.S. AML Regulations & Cutting-Edge Solutions

In an interview conducted at the NFT.NYC conference in New York, David Berlind engages in a conversation with Amy Kalnoki, the COO and co-founder of Bitwave. Bitwave is essentially an accounting solution that bridges the gap between an organization's traditional financial recordkeeping systems (e.g., NetSuite, Quickbooks, etc.) and its implementations of blockchain. The net effect, Kalnoki claims, is an automated consolidation of all financials (fiat and cryptocurrency) into one single source of truth in a way that's designed to simplify both financial recordkeeping and tax compliance. This arrangement overcomes the inability of traditional financial systems to cope with the complexities of cryptocurrency recordkeeping. 

Creating a single source of truth when public blockchains are involved is a highly nuanced process. Different organizations engage with different public blockchains for a variety of applications that involve different financial patterns. For example, whereas some organizations transact in certain cryptocurrencies as a part of their e-commerce workflows, other organizations rely on a public blockchain for non-payment-related applications that require crypto-based payment of a blockchain's service fees. In those and other use cases, organizations end up keeping some amount of crypto in their treasuries, and the tax implications connected to that activity are non-trivial. According to Kalnoki, it's not just fungible token activity that businesses must keep an eye on. Now, with businesses increasingly discovering the transformative power of non-fungible tokens (NFTs) to drive new or improved business outcomes – Kalnoki cites ticketing and gaming as two such applications – trying to track all blockchain-related financials using extemporaneous methods is not an option (which explains why Kalnoki was speaking at a conference about NFTs). 

The conversation shifts to regulatory challenges, focusing on IRS regulation 6050I, which aims to treat crypto transactions over $10,000 as cash equivalents, necessitating detailed reporting. It's a rare example of where a small shred of regulatory clarity exists such that businesses (and solution providers like Bitwave) can work with blockchain in observance of certain legal guardrails. But a dearth of such regulatory clarity is still problematic for most American businesses. As the gears of blockchain law and policy-making have essentially ground to a halt in Washington, DC, organizations are holding, back on their blockchain applications for fear of waking up one morning on the wrong side of the law.  Kalnoki acknowledges the need for more clarity in order to foster compliance and, ultimately, innovation. 

Finally, Kalnoki invites viewers to attend Bitwave's Enterprise Digital Assets Summit in Nashville (July 2024), where the conversation will address the challenges and solutions to business adoption of blockchain amid regulatory uncertainty.

To watch the video version of this podcast or read its full-text transcript, go to:
https://blockchainjournal.com/interview/bitwave-looks-ease-accounting-complexities-arise-enterprise-adoption-nfts

The video can also be watched on Blockchain Journal's YouTube Channel at:
https://www.youtube.com/watch?v=7nHeqppkXa8

For information about Bitcoin2024, please visit:
https://bitcoin2024.b.tc/2024

Bitwave Looks to Ease Accounting Complexities That Arise From Enterprise Adoption of NFTs

BUFFALO, NY- April 10, 2024 – A new #researchpaper was #published in Oncotarget's Volume 15 on April 8, 2024, entitled, “Exploring the role of GHRH antagonist MIA-602 in overcoming Doxorubicin-resistance in acute myeloid leukemia.”

Acute myeloid leukemia (AML) is characterized by the rapid proliferation of mutagenic hematopoietic progenitors in the bone marrow. Conventional therapies include chemotherapy and bone marrow stem cell transplantation; however, they are often associated with poor prognosis. Notably, growth hormone-releasing hormone (GHRH) receptor antagonist MIA-602 has been shown to impede the growth of various human cancer cell lines, including AML. In this new study, researchers Simonetta I. Gaumond, Rama Abdin, Joel Costoya, Andrew V. Schally, and Joaquin J. Jimenez from the University of Miami, Florida Atlantic University and Veterans Affairs Medical Center, Miami examined the impact of MIA-602 as monotherapy and in combination with Doxorubicin on three Doxorubicin-resistant AML cell lines, KG-1A, U-937, and K-562. 

“Given the role of GHRH in multiple cancer types, it is possible that GHRH antagonists may offer an alternative treatment approach for AML as well as drug-resistant AML, which may circumvent the side effects associated with standard chemotherapy.”

The in vitro results revealed a significant reduction in cell viability for all treated wild-type cells. Doxorubicin-resistant clones were similarly susceptible to MIA-602 as the wild-type counterpart. Their in vivo experiment of xenografted nude mice with Doxorubicin-resistant K-562 revealed a reduction in tumor volume with MIA-602 treatment compared to control. 

“Our study demonstrates that these three AML cell lines, and their Doxorubicin-resistant clones, are susceptible to GHRH antagonist MIA-602.”

DOI - https://doi.org/10.18632/oncotarget.28579

Correspondence to - Simonetta I. Gaumond - sxg1204@miami.edu

Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/

Keywords - cancer, leukemia, AML, resistance, growth hormone-releasing hormone, MIA-602

About Oncotarget 

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Oncotarget is indexed and archived by PubMed/Medline, PubMed Central, Scopus, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science).

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Exploring the Role of MIA-602 in Overcoming Doxorubicin-resistance in Acute Myeloid Leukemia

Acute myeloid leukemia (AML) is a cancer characterized by the rapid growth of abnormal white blood cells that accumulate in the bone marrow and interfere with the production of normal blood cells. ABT199, also known as venetoclax, is a targeted therapy that inhibits the BCL-2 protein, which is often overexpressed in AML cells and contributes to their survival. By blocking this protein, venetoclax can trigger apoptosis, or programmed cell death, in cancer cells. Thiotepa, a DNA alkylating agent, has been used in conditioning regimens for hematopoietic stem cell transplantation (HSCT) but its combination with ABT199/venetoclax has not been thoroughly explored, until now.

In a new study, researchers Benigno C. Valdez, Bin Yuan, David Murray, Jeremy L. Ramdial, Uday Popat, Yago Nieto, and Borje S. Andersson from The University of Texas MD Anderson Cancer Center and the University of Alberta investigated a promising new approach to AML therapy by combining multiple drugs to enhance cytotoxic effects on AML cells. On March 14, 2024, their new research paper was published in Oncotarget’s Volume 15, entitled, “ABT199/venetoclax synergism with thiotepa enhances the cytotoxicity of fludarabine, cladribine and busulfan in AML cells.”

Full blog - https://www.oncotarget.org/2024/04/11/synergistic-effects-of-drug-combinations-targeting-aml-cells/

Paper DOI - https://doi.org/10.18632/oncotarget.28563

Correspondence to - Benigno C. Valdez - mbalasik@yahoo.com

Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28563

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Keywords - cancer, acute myeloid leukemia, aml, pre-transplant regimens, venetoclax, thiotepa, busulfan

About Oncotarget 

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Oncotarget is indexed and archived by PubMed/Medline, PubMed Central, Scopus, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science).

To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us:

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Synergistic Effects of Drug Combinations Targeting AML Cells

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Ein Fokus liegt zudem auf der jüngeren Generation – so sprechen wir in dieser Staffel zum Beispiel mit der Jungen DGHO und stellen neue Berufsbilder wie den Clinician Scientist vor.

Das Team Onkologie sind Antje Blum, Chefredakteurin des Journal Onkologie, und ihre Stellvertreterin, Dr. Astrid Heinl, die beiden Chefredakteurinnen der Medical Tribune Onkologie/Hämatologie, Elisa Breuer und Dr. Judith Besseling sowie Jochen Schlabing, Teamleiter Onkologie in der MedTriX Group.

Den Podcast O-Ton Onkologie gibt es alle 14 Tage mittwochs auf den gängigen Podcast-Plattformen. Abonnieren Sie uns und machen Sie auch gerne Themenvorschläge. Kontakt zur Redaktion unter: o-ton-onkologie@medtrix.group

Mehr unter:
https://www.medical-tribune.de/o-ton-onkologie
https://www.journalonko.de/podcasts/liste

• Twitter MT Onkologie • Hämatologie: https://twitter.com/MT_Onkologie
• MedTriX Group auf LinkedIn: https://www.linkedin.com/company/medtrix-group/
• Medical Tribune Deutschland auf LinkedIn: https://www.linkedin.com/showcase/medical-tribune-de/

The world's leading source of information for enterprises and businesses looking to use blockchain as an application platform for digital transformation, business innovation, customer engagement, and industry disruption.

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Oncotarget is a primarily oncology-focused, peer-reviewed, open access journal. Papers are published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Oncotarget is now indexed by MEDLINE, PubMed and PMC/PubMed.

Read about the Oncotarget Scientific Integrity Process: https://www.oncotarget.com/scientific_integrity/

In this podcast series, Kieran Beer (Chief Analyst at ACAMS) interviews the movers and shakers of the anti-financial crime world. 

Listen for fast-paced conversations about the latest financial scandal to hit newsstands, and insights on trending Financial Crime topics. 
 
Have something you’d like to hear covered? Email Kieran on podcasts@acams.org and tell us what matters to you. You can also follow Kieran on twitter www.twitter.com/kieranbeer

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New tracks tagged #aml