BUFFALO, NY- October 23, 2024 – A new #editorial was #published in Oncotarget's Volume 15 on October 11, 2024, entitled, “Gene regulatory network and signalling pathway rewiring: How blood cancer cells shift their shapes to evade drug treatment.”

As highlighted in the paper, Acute Myeloid Leukemia (AML) is a complex and diverse disease caused by multiple mutations in genes that regulate transcription and growth. These mutations lead to extensive rewiring of the gene regulatory network (GRN), which alters the identity of hematopoietic stem and progenitor cells, ultimately blocking normal myeloid differentiation. A key feature of AML is the presence of mutations in growth factor receptor and signaling genes, such as FLT3, KIT, and RAS. Notably, FLT3 is one of the most commonly mutated genes in AML, with around 25% of cases showing an internal tandem duplication (ITD) that causes the receptor to remain constantly active.

In their paper, researchers Constanze Bonifer and Peter N. Cockerill from the Institute of Cancer and Genomic Sciences at the University of Birmingham, UK, and the Murdoch Children’s Research Institute, Royal Children’s Hospital in Melbourne, Australia, discuss recent publications from their group addressing this issue through a multi-omics study. The authors investigated how gene regulatory networks (GRNs) in FLT3-ITD patients were rewired compared to normal cells and in response to FLT3 inhibitor treatment. Several key findings stood out, including: 1)  Mapping of open chromatin regions revealed that patients initially responsive to FLT3 inhibition showed significant rewiring of their GRNs, forming new connections between transcription factors (TFs) and target genes, while non-responsive patients did not; 2) Chromatin immunoprecipitation (ChIP) experiments showed that drug treatment led to the loss of binding of RUNX1, the master regulator of hematopoiesis, and the MAP-Kinase (MAPK)-inducible TF AP-1; 3) Disruption of AP-1 binding via a dominant-negative version of the TF (dnFOS) also abolished RUNX1 binding at hundreds of sites, indicating that RUNX1 binding is AP-1 dependent; and 4) Inhibition of both AP-1 and RUNX1 led to a pronounced cell cycle block.

“In summary, drugs that target individual signalling pathways in AML often fail to stop proliferation malignant growth, due to the wide variety, redundancy and cross talk between multiple pathways regulating and differentiation.”

DOI - https://doi.org/10.18632/oncotarget.28662

Correspondence to - Constanze Bonifer - constanze.bonifer@mcri.edu.au

Video short - https://www.youtube.com/watch?v=5c_uT6aE36A

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Keywords - cancer, acute myeloid leukemia, gene regulatory networks, aberrant growth factor signaling, transcription, RUNX1/AP-1 axis

About Oncotarget 

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Oncotarget is indexed and archived by PubMed/Medline, PubMed Central, Scopus, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science).

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Oncotarget

How Blood Cancer Cells Rewire to Evade Drug Treatment

In this episode of “Financial Crime Matters”, Kieran talks with ACAMS colleague, Craig Timm, Senior Director of AML at ACAMS.
 
Craig and Kieran do a deep dive into the recent settlements by TD Bank with the US Department of Justice, the Federal Reserve Board, the Office of the Comptroller of the Currency, and the Financial Crimes Enforcement Network that resulted in more than $3 billion in monetary penalties, ongoing remediation and monitorships, as well as the prosecution of two bank insiders. With more individual prosecutions likely, Craig and Kieran layout the lessons for financial institutions from settlements and discuss how compliance professionals can protect themselves from culpability when their financial institutions go astray.

Parsing the TD Bank Prosecution and Regulatory Settlements, with Craig Timm

In this episode of Financial Crime Matters, Kieran sits down with Michael Grady, chief of the bank integrity unit at the U.S. Department of Justice Criminal Division during the ACAMS Assembly Vegas Conference in September.
 
Mike talks about the BIU’s remit to pursue criminal infractions at banks, payment service providers, cryptocurrency exchanges and other financial businesses subject to the Bank Secrecy Act. During their conversation, Mike discusses some specific cases involving institutions actively involved in breaking anti-money laundering, terror finance and sanctions laws, which pose a threat to national security.

Prosecuting Bank Insiders Gone Bad, with the DOJ’s Michael Grady

In this episode of “Financial Crime Matters,” Kieran talks with three individuals committed to exposing cryptocurrency scams and drawing attention to imprisoned investigative journalist Mech Dara, who is responsible for uncovering the horrific conditions and practices within Cambodian-based crypto fraud compounds. 
 
Zeke Faux, author of “Number Go Up,” Danielle Keeton-Olsen, a freelance journalist based in Phnom Penh, and Erin West, Deputy District Attorney, Santa Clara County CA, discuss Dara’s treatment by the Cambodian government and its seeming indifference to fraud compounds that enslave tens of thousands and operate in plain sight, causing the financial ruin of millions around the world. During the podcast, Erin touches on the success law enforcement has had in recovering some victims’ money, Zeke calls on VASPs to do more to interdict crypto fraud funds, and Danielle identifies some of the organizations working for Dara’s release.

Standing Against "Pig-Butchering,"  with Zeke Faux, Danielle Keeton-Olsen and Erin West

Kicking off the podcast is news that TaxCalc has landed a major investment from private equity firm Symphony Technology Group (STG). Tom Herbert discusses TaxCalc’s history, what we know about STG, what’s next for TaxCalc and the state of the accounting software market. 

Richard Hattersley shares tales from his time at the Institute of Certified Bookkeepers (ICB) Summit. He tells all about how the event was, some of the big headlines like MTD, its focus on the future and what this means for bookkeeping. 

Lastly, Matthew Ord reveals some anti-money laundering (AML) woes, specifically Metro Bank which has been hit with a £16.7m fine for failing to monitor potential AML activities. The team questions why companies are still not using the right processes and procedures. 


No Accounting for Taste ep176: TaxCalc sold, ICB summit and Metro Bank fined

A lot has happened over the last year. Santa has been approached by multiple interested parties who are interested in licensing his software for their own projects and holidays, and now he even has a reformed partner who has identified several opportunities for improvements.

Christmas Special Pt. 4: New Partners & Licensing

Live-Mitschnitt meines Openings zu unserer zweiten Veranstaltung im MVZ-Wagner.

Die Umlandboys @ AML Goes MVZ II 15.11.24

With Christmas and New Year fast approaching, the AccountingWEB team reunites for their final podcast of 2024, reflecting on the year’s biggest stories.

They kick off with the 20-year Post Office scandal, which gained renewed attention in 2024 after the ITV drama Mr Bates vs The Post Office. The team discusses ongoing lessons and why it’s important to keep this issue in focus.

Next, they tackle HMRC’s pattern of U-turns, including this year’s reversals on double cab pickups and helpline cuts, sharing what these shifts reveal about HMRC’s direction.

The conversation turns to major anti-money laundering (AML) failures, such as Metro Bank’s £16.7m fine and the accountant who faked being an auditor for 34 years. The team questions why AML continues to be an issue and whether things will change. 

General election highlights and two budgets – Jeremy Hunt’s Spring Budget and Rachel Reeves’s inaugural Autumn Budget – also feature, with their impact being examined. 

Finally, Richard Hattersley and Tom Herbert share bold predictions for 2025, exploring where the accounting profession might head in the coming year.


No Accounting for Taste ep178: End of year round up

Neste Hora Local, a entrevista com Pedro Folgado, presidente da Oestecim, sobre o passe a 40 euros na região Oeste. Uma realidade depois de vários anos. As dificuldades de colocar em prática esta medida, os objetivos, o compromisso com a mobilidade verde a o ponto de situação quanto à aquisição da maioria do capital da Rodoviária do Oeste.
Ondem param as obras do 1º Direito no concelho de Azambuja
Hospital de Vila Franca com cirurgia inovadora no tratamento do cancro da mama e subsequente reconstrução mamária

Hora Local 18-12-2024

Ter uma carreira literária de mais de 50 anos é para poucos, mas esse é o caso do poeta e professor universitário Afonso Henriques Neto. O poeta, reconhecido por sua participação no movimento da poesia marginal, estreou na literatura com uma publicação independente, em 1972. Desde então, acumulou em sua carreira uma grande quantidade de livros, publicações e poemas, e perpassou os mais diversos cenários da poesia brasileira. Além de poeta, ele também é contista, romancista, tradutor, e professor do Instituto de Arte e Comunicação Social da Universidade Federal Fluminense (UFF), desde 1976. Mineiro nascido em Belo Horizonte, o escritor se tornou um membro da Academia Mineira de Letras em 2008, ocupante da cadeira 27, que anteriormente era de Paschoal Rangel. Neste ano de 2025, o escritor lança, pela editora francesa L’Harmattan, uma antologia poética bilíngue, que reúne poesias de 14 dos livros publicados pelo poeta desde a década de 70. Intitulada "Névoas de Sonho", a antologia traz poemas em português e francês e faz parte da Coleção Perspectivas Transculturais. 

Nesta quarta-feira, 22 de janeiro de 2025, o poeta Afonso Henriques Neto foi o convidado de apresentadora Michelle Bruck, para um bate-papo no programa Universo Literário, da Rádio UFMG Educativa.

Afonso Henriques Neto lança antologia poética bilíngue, em português e francês

Na Convenção Arruda 2035, o presidente da Câmara de Arruda dos Vinhos, Carlos Alves, focou que os idosos terão de ser uma prioridade no concelho nos próximos anos , com reforço do apoio domiciliário.
Na Área Metropolitana de Lisboa, já foram atribuidas 4700 casas no âmbito do PRR, o que corresponde a 19 por cento das habitações candidatadas


Rádio Valor Local Notícias 05-02-2025

Insurance professionals should remain alert to the following suspicious behaviors, which may indicate money laundering or terrorist financing activities!

FIND OUT: https://insights.searchbug.com/insurance-red-flags-to-watch-out-for-777798020159
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#aml #amlinsurance #kyc #fraudalert #fraudwarnings #antimoneylaundering

Anti-Money Laundering in Insurance: 9 Fraud Red Flags to Watch Out For

Dr. Tim Naddy, VP of Finance for the Savannah Bananas, talks Entertainment and Passion.

Savannah Bananas' Website: https://thesavannahbananas.com/
Savannah Bananas' Instagram: https://www.instagram.com/thesavbananas/

Last Call Baseball T-Shirts: https://last-call-baseball-shop.fourthwall.com/collections/all
Last Call Baseball Instagram: https://www.instagram.com/lastcallbaseball/
Last Call Baseball Bluesky: https://bsky.app/profile/lastcallbaseball.bsky.social
Intro and Outro Music: DeCarlo
Podcast Logo Artist Instagram: https://www.instagram.com/regan_vasconcellos/




186 - Dr. Tim Naddy

Erik Vingelen - COVID-19 AML Resource Challenges

Steve Gurdak, Group Supervisory of the Northern Virginia Financial Initiative discusses the work of his SAR Review team, the importance of law enforcement collaboration when working SARS and the importance of SAR narratives.

Steve Gurdak -The importance of SAR narratives

Beyond IP, the role of geolocation data in combating AML and fraud. John Byrne sits down with David Briggs, CEO and Co-Founder of GeoGuard and GeoComply, to discuss the limitations of IP addresses and the role that advanced geolocation data can play in AML and in fighting other types of financial fraud, FinCEN’s recent guidance on encouraging innovative responses to COVID-19 fraud, and how to improve the BSA/AML data analysis infrastructure.

David Briggs - The Challenges with Geolocation Data

In this episode of AML Conversations, John sits down with Sara Crowe, Strategic Initiatives Director, Financial Systems for the Polaris Project. Sara leads Polaris’s efforts to partner with the financial services industry to implement a comprehensive and industry-wide strategy to intervene in the crime of human trafficking. This initiative aims to 1) disrupt human trafficking businesses on a global scale by using existing financial system structures and processes (such as anti-money laundering and economic sanctions frameworks) to decrease the profitability of sex and labor trafficking while increasing the risk to traffickers; 2) shift financing practices to reward businesses with good labor conditions; and 3) bolster financial resiliency of vulnerable populations and trafficking survivors through financial inclusion initiatives. 
 
During their discussion, John and Sara cover issues related to the crimes of human trafficking during the pandemic, the value of partnering with the financial sector and how to get engaged in any of a variety of projects supporting the detection and prevention of human trafficking.

Sara Crowe: Human Trafficking Issues During the Pandemic

In this episode of AML Conversations, John Byrne interviews David Stewart, Director, Financial Services Industry, Fraud & Security Intelligence Practice for SAS Institute Inc. David has spent many years in the AML/Financial Crime space and his insight is sought by many in our community.

During their discussion, John and David discuss the impact of the COVID-19 pandemic on his global team, how he sees compliance after the “new normal” and the recent SAS paper, “What is next- generation AML?.” The paper delves into issues such as innovation, model governance and how to manage AML and fraud.

David Stewart: Compliance After the "New Normal"

In the second episode of our AML Conversations series with members of IRSCI, John Byrne sits down with Greg Monahan, IRS Supervisory Special Agent of the Cyber Crimes Unit and Chris Janczewski, IRS Special Agent in the Pittsburgh office. 

Together, they discuss the impact of cybercrime both in the US and abroad. Additionally, John and Chris go through two major cases, one on a group selling child pornography for Bitcoin, and another investigation that resulted in prosecution of a Chinese money launderer. These agents also offer “red flag indicators” for financial institutions to spot cyber threats, discuss the importance of IRS partnering with other agencies, and working with the private sector.

Greg Monahan & Chris Janczewski: IRSCI on Cybercrime

CO-founder and resident of https://soundcloud.com/aml_jena

Max Bauner aka "Die Umlandboys" started DJying 2015. What was only a hobby for a long time evolved to Club-DJing in the recent time. He likes a great variety of Techno stiles from slow Psy-Techno to (Hard) Trance and modern Hardtechno.
"Stumpf ist Trumpf" ("blunt is trump")

Last Gig‘s :
28/03/2025 AML goes MVZ III
15/11/2024 AML goes MVZ II - Cafe Wagner - Jena
27/0972024 "3 Jahre AML" @ Zapata Bar - Jena
29/05/2024 AML @ Miite Techno - Rosenkeller Jena
22/03/2024 AML goes MVZ - Cafe Wagner - Jena
08/03/2024 Tanzstation Zapata Bar - Jena
19/01/2024 AML Zapata Bar - Jena
25/11/2023 "C:RAVE X Gabber Industries Berlin" MVZ - Jena
29/09/2023 "2 Jahre AML" Zapata Bar - Jena
19/08/2023 "Schnell und draußen" Open Air (AML X S.O.D) - Jena
28/04/2023 AML "Trancy Acid Night" Zebra - Weimar
04/02/2023 Radio Elctronica Radio OKJ Jena
20/01/2023 AML Zapata Bar - Jena
24/09/2022 S.O.D X AML Krämpfergarten - Erfurt
05/08/2022 AML ON 1.4 Zapata Bar - Jena

Oncotarget is a primarily oncology-focused, peer-reviewed, open access journal. Papers are published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Oncotarget is now indexed by MEDLINE, PubMed and PMC/PubMed.

Read about the Oncotarget Scientific Integrity Process: https://www.oncotarget.com/scientific_integrity/

AML Conversations is dedicated to inform professionals and those interested in anti-money laundering about conversations happening in the government, private sector, and internationally. Throughout the series John Byrne, AML RightSource Vice Chairman, will interview industry experts or participate in live programming or panel discussions related to the industry.

In this podcast series, Kieran Beer (Chief Analyst at ACAMS) interviews the movers and shakers of the anti-financial crime world. 

Listen for fast-paced conversations about the latest financial scandal to hit newsstands, and insights on trending Financial Crime topics. 
 
Have something you’d like to hear covered? Email Kieran on podcasts@acams.org and tell us what matters to you. You can also follow Kieran on twitter www.twitter.com/kieranbeer

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Join me for baseball, drinks, and everything under the sun.

Join Expero's team of tech experts as they discuss best practices and lessons learned from the battlefield of consulting. Hosts and guests draw from a deep well of experience working with custom software products, supply chain optimization systems, biotech manufacturing workflows, financial service modernization efforts, and everything in between.

Searchbug® is a professional online service to find and investigate people, businesses, addresses and phone numbers. Searchbug® is used by collections agents, consumer credit specialists, investigators and other professionals to verify information on their customers and trace current contact information for hard-to-find people.  Many businesses use searchbug to <a href="http://www.searchbug.com/batch/phone-number.aspx">identify phone number</a> info and conduct customer <a href="http://www.searchbug.com/batch/">list cleaning</a>.

A Rádio UFMG Educativa é uma parceria entre a Universidade Federal de Minas Gerais (UFMG) e a Empresa Brasil de Comunicação (EBC), com transmissão de programação diária na frequência 104,5 FM, para a Região Metropolitana de Belo Horizonte, e on-line, pelo site http://ufmg.br/radio. Inaugurada em 6 de setembro de 2005, a emissora oferece uma programação diferenciada e alternativa aos formatos e gêneros musicais já existentes no mercado. Referência em produção radiofônica entre as rádios universitárias do país, a UFMG Educativa tem a missão de dar visibilidade à produção de conhecimento da Universidade, por meio da comunicação pública da ciência e do fomento à discussão constante de temas relacionados à educação e à cultura. A emissora está vinculada ao Centro de Comunicação da UFMG (Cedecom) e é composta pelos núcleos de Jornalismo, Operações e Programação.

New tracks tagged #aml