This week, Tim welcomes special guest Tate Dousette, the winner of the 2025 Open Contract Challenge: Speed Edition. Tate shares what it feels like to be published for the very first time, his passion for sci-fi, fantasy, and comics, and his upcoming Greek gods-inspired story set for release on Black Friday. The conversation also covers writing habits, creative influences, and the importance of community in building confidence as a new author.

The World of Myth Bits #337 - A First-Time Winner's Journey

Author DL Mitchell on Murder, Mayhem, and a Mischievous Parrot
Award-winning author DL Mitchell joins me to chat about her latest cozy mystery, Parrot Prose—a cozy mystery featuring quirky characters, a missing billionaire, a chaotic treasure hunt, and one very opinionated parrot. When this bird talks, people listen—and murderers better watch out!

From big-city animal hospitals to her current house call concierge veterinary practice, DL’s firsthand small animal veterinarian experiences enrich her mysteries with authentic insight into the human-animal bond. When she’s not writing or caring for pets, you might find her on a scuba adventure (though she admits to getting seasick), running trails, traveling with her espresso machine, or paddling on her inflatable SUP.

Join us for a fun conversation about writing, animals, and the delightful capers of a talking parrot!

For more about DL and Parrot Prose, visit: dlmitchellmystery.com
For more about my K-9 books, visit: kathleendonnelly.com


DL Mitchell, Parrot Prose, Ep. 6

Aiden Deacon from the University of Minnesota-Twin Cities, Minneapolis, discusses a research paper he co-authored that was published in Volume 16 of Oncotarget, titled “Dissecting the functional differences and clinical features of R-spondin family members in metastatic prostate cancer.”

DOI - https://doi.org/10.18632/oncotarget.28758

Correspondence to - Justin Hwang - jhwang@umn.edu

Video interview - https://www.youtube.com/watch?v=OXKhWWU1gnY

Abstract

This study investigates the R-spondin family of genes (RSPO1/2/3/4), a group of secreted proteins that act as Wnt regulators, and their subsequent role in advanced prostate cancer (PC). When evaluating transcriptomic data from primary and metastatic PC patients, we found that alterations in RSPO2 were more prevalent than in other RSPO family members or Wnt-regulating genes APC and CTNNB1. Further, we found that RSPO2 alterations in PCs were significantly associated with worse disease-free survival. Through our in silico modeling, RSPO2 exhibited strong positive associations with genes regulating epithelial-mesenchymal transition (EMT) and double-negative prostate cancer (DNPC), but had negative correlations with androgen receptor (AR) and AR-associated genes. Furthermore, 3D modeling of RSPO2 revealed structural differences between itself and other RSPOs. In cell lines, RSPO2 overexpression caused up-regulation of EMT pathways, including EMT-regulatory transcription factors ZEB1, ZEB2, and TWIST1. Conversely, this was not observed when CTNNB1 was overexpressed in the same models. These findings highlight that, in PC, RSPO2 functions as a unique member of the R-spondin family by promoting genes and signaling pathways associated with aggressive PC, and RSPO2 amplifications are associated with poor outcomes in PC patients.

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Keywords - cancer, RSPO2, prostate cancer, Wnt signaling, genomics, therapeutics

About Oncotarget 

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Oncotarget is indexed and archived by PubMed/Medline, PubMed Central, Scopus, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science).

To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us:

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Oncotarget

Oncotarget author interview: Aiden Deacon

Behind the Study: R-spondin Family Roles in Metastatic Prostate Cancer

Uncovering Buried Secrets—R. Weir on Cold Cases, Cults, and K-9 Heroes

Award-winning author R Weir joins me on the podcast to discuss his gripping new mystery, Justice For The Forgotten. In this mystery, retired police officer Donnie Steel and his loyal K-9 partner, Kogel, are hired to dig into a cold case murder—only to find themselves up against a powerful cult leader determined to keep dark secrets buried.
We chat about R’s inspiration for his newest series, how he creates his characters, and crafting page-turning suspense.
If you enjoy crime fiction filled with relentless investigators, unexpected twists, and unforgettable characters (human and K-9), you won’t want to miss this conversation. 

For more about R. Weir visit: rweirauthor.com/
For more about my K-9 books, visit: kathleendonnelly.com


Randy Weir, Justice For the Forgotten, Ep. 8

Federica Grosso from the  Institute for Genetic and Biomedical Research (IRGB) of the National Research Council (CNR) in Monserrato, Italy, describes a #research paper she co-authored that was #published in Volume 17, Issue 8 of Aging-US, entitled “Causal relationships between gut microbiome and hundreds of age-related traits: evidence of a replicable effect on ApoM protein levels.”

DOI - https://doi.org/10.18632/aging.206293

Corresponding author - Serena Sanna - serena.sanna@cnr.it

Video interview - https://www.youtube.com/watch?v=qYg42_gn_pw

Abstract

In the past 20 years, the involvement of gut microbiome in human health has received particular attention, but its contribution to age-related diseases remains unclear. To address this, we performed a comprehensive two-sample Mendelian Randomization investigation, testing 55130 potential causal relationships between 37 traits representing gut microbiome composition and function and age-related phenotypes, including 1472 inflammatory and cardiometabolic circulating plasma proteins from UK Biobank Pharma Proteomic Project and 18 complex traits. A total of 91 causal relationships remained significant after multiple testing correction (false discovery rate p-value <0.05) and sensitivity analyses, notably two with the risk of developing age-related macular degeneration and 89 with plasma proteins. The link between purine nucleotides degradation II aerobic pathway and apolipoprotein M was further replicated using independent genome-wide association study data. Finally, by taking advantage of previously reported biological function of Faecalibacterium prausnitzii we found evidence of regulation of six proteins by its function as mucosal-A antigen utilization. These results support the role of gut microbiome as modulator of the inflammatory and cardiometabolic circuits, that may contribute to the onset of age-related diseases, albeit future studies are needed to investigate the underlying biological mechanisms.

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Keywords - aging, causal inference, aging, gut microbiome, inflammatory proteins, age-related macular degeneration

To learn more about the journal, please visit our website at https://www.Aging-US.com​​ and connect with us on social media at:

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Aging-US

Behind the Study: Gut Microbiome Links to Age-Related Traits and ApoM Protein

In this episode of the Longevity & Aging Series, Girish Harinath from AgelessRx joins host Dr. Evgeniy Galimov to discuss a research paper he co-authored in Volume 17, Issue 4 of Aging-US, titled “Influence of rapamycin on safety and healthspan metrics after one year: PEARL trial results.”

DOI - https://doi.org/10.18632/aging.206235

Corresponding author - Stefanie L. Morgan - stefanie@agelessrx.com

Video interview - https://www.youtube.com/watch?v=7-NvskI8Ve0

Longevity & Aging Series - https://www.aging-us.com/longevity

Abstract

Design: This 48-week decentralized, double-blinded, randomized, placebo-controlled trial (NCT04488601) evaluated the long-term safety of intermittent low-dose rapamycin in a healthy, normative-aging human cohort. Participants received placebo, 5 mg or 10 mg compounded rapamycin weekly. The primary outcome measure was visceral adiposity (by DXA scan), secondary outcomes were blood biomarkers, and lean tissue and bone mineral content (by DXA scan). Established surveys were utilized to evaluate health and well-being. Safety was assessed through adverse events and blood biomarker monitoring.

Results: Adverse and serious adverse events were similar across all groups. Visceral adiposity did not change significantly (ηp2 = 0.001, p = 0.942), and changes in blood biomarkers remained within normal ranges. Lean tissue mass (ηp2 = 0.202, p = 0.013) and self-reported pain (ηp2 = 0.168, p = 0.015) improved significantly for women using 10 mg rapamycin. Self-reported emotional well-being (ηp2 = 0.108, p = 0.023) and general health (ηp2 = 0.166, p = 0.004) also improved for those using 5 mg rapamycin. No other significant effects were observed.

Conclusions: Low-dose, intermittent rapamycin administration over 48 weeks is relatively safe in healthy, normative-aging adults, and was associated with significant improvements in lean tissue mass and pain in women. Future work will evaluate benefits of a broader range of rapamycin doses on healthspan metrics for longevity, and will aim to more comprehensively establish efficacy.

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Keywords - aging, rapamycin, geroscience, longevity, healthspan

To learn more about the journal, please visit our website at https://www.Aging-US.com​​ and connect with us on social media at:

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Longevity & Aging Series (S3, E6): Girish Harinath

Dr. Leonard Egede, Dr. Rebekah Walker, and Dr. Obinna Ekwunife from the Department of Medicine at the University of Buffalo, NY, describe their #research paper #published in Volume 17, Issue 8 of Aging-US, entitled “Longitudinal relationship between social and CVD risk factors in older adults with prediabetes: the HRS 2006-2016.”
#interview #authorinterview #aging #prediabetes #cardiovascular #health #openaccess #openscience #peerreviewed #journal #publication #publishing #meded

DOI - https://doi.org/10.18632/aging.206308

Corresponding author - Leonard E. Egede - legede@buffalo.edu

Video interview - https://www.youtube.com/watch?v=1MSTk3GQAGA

Video transcript - https://aging-us.net/2025/10/08/behind-the-study-social-and-cardiovascular-risk-factors-in-older-adults-with-prediabetes/

Abstract

Background: This study examines how multiple social risk factors influence cardiovascular disease (CVD) risk control over time in older adults with prediabetes using a nationally representative cohort.

Methods: Data from the Health and Retirement Study (HRS) included 5,086 U.S. adults aged 50+ with prediabetes. Five social risk domains (economic stability, environment, education, healthcare, and social context) were examined as independent variables, while CVD risk factors included glycemic control (HbA1c), systolic blood pressure (SBP), and cholesterol ratio (total cholesterol/high-density lipoprotein). Mixed-effects models assessed relationships between social risk factors and CVD outcomes, adjusting for age, gender, race, and marital status.

Results: The sample had an average age of 68.6 years, with 60.2% female, and 70.97% identifying as non-Hispanic Black. Average HbA1c was 5.7, SBP 129.4, and cholesterol ratio 3.85. Limited education was consistently associated with increased CVD risk—HbA1c (β = 0.03, 95% CI: 0.01–0.06, p < 0.001), SBP (β = 4.34, 95% CI: 2.96–5.71, p < 0.001), and cholesterol ratio (β = 0.08, 95% CI: 0.01–0.16, p < 0.05) —in the fully adjusted model. Medication cost-related non-adherence was significantly associated with higher HbA1c levels (β = 0.03, 95% CI: 0.002–0.06, p < 0.05). Difficulty paying bills and lack of health insurance were both significantly associated with higher cholesterol levels (β = 0.03, 95% CI: 0.002–0.06, p < 0.05) and (β = 0.22, 95% CI: 0.15–0.30, p < 0.001), respectively.

Conclusions: Social risk factors, particularly limited education, significantly impact CVD risk in older adults with prediabetes.

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Keywords - aging, prediabetes, social determinants of health, health equity, cardiovascular health, population health

To learn more about the journal, visit https://www.Aging-US.com​​ and connect with us on social media at:

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MEDIA@IMPACTJOURNALS.COM

Behind the Study: Social and Cardiovascular Risk Factors in Older Adults with Prediabetes

Paul Goldstein, law professor and author of the novel "Errors and Omissions," talks about the struggle that the main character has with alcohol and about the twist in the book where Wall Street was behind the Hollywood blacklisting era.  The full interview from a 2006 episode of "Conversations On The Coast with Jim Foster" can be heard now wherever you get your podcasts.

Errors and Omissions by Paul Goldstein

Allegra Goodman, author of the novel "Intuition," talks about the pressure that scientists in the book face in order to fund their important research projects at their independent science labs.  The full interview from a 2006 episode of "Conversations On The Coast with Jim Foster" can be heard now wherever you get your podcasts.  Photo: allegragoodman.com.

Intuition by Allegra Goodman

Linda Gordon, American Historian and Author of "Dorothea Lange: A Life Beyond Limits," talks about how photographer Dorothea Lange helped show that documentary photography could also be art, and also discusses Lange's unique ability to capture her subject's natural state.  The full interview from a 2009 episode of "Conversations On The Coast with Jim Foster" can be heard now wherever you get your podcasts.

Dorothea Lange A Life Beyond Limits by Linda Gordon

In the latest episode of the State of the Arts Podcast, host filmmaker and writer Des Doyle chats with Catherine Doyle, internationally bestselling and award-winning author of The Dagger and the Flame, The Rebel And The Rose and The Storm Keeper trilogy.

Produced in partnership with Film Ireland and supported by Fís Éireann/Screen Ireland through the Screen Stakeholders Funding Scheme, the State of the Arts series explores the creative processes, industry challenges, and new opportunities that both Irish and international creatives face in today’s ever-evolving artistic landscapes.

In this conversation, Doyle shares insights into her creative journey - from inspirations, to the practical aspects of building emotionally rich, imaginative worlds for young readers, to writing Romantasy books with the City Of Fantome trilogy and  co-authoring the bestselling Twin Crowns trilogy. She discusses her journey, becoming successful, and gives helpful insight into how she managed to pen 13 books in a decade.

Follow the journey of State of the Arts here: https://www.instagram.com/sotapod/

Read more about this episode here: https://www.filmireland.net/state-of-the-arts-podcast-bestselling-author-catherine-doyle-with-host-des-doyle

State of the Arts: Bestselling Author Catherine Doyle (The Dagger and the Flame) with host Des Doyle

Joe Gores, author of "Glass Tiger," discusses an excerpt of the novel in which an assassination was attempted on a newly-elected President, and how American politics changed over the years in how many elected officials stay in public office for their entire lives.  The full interview from a 2006 episode of "Conversations On The Coast with Jim Foster" can be heard now wherever you get your podcasts.

Glass Tiger by Joe Gores

Oncotarget is a primarily oncology-focused, peer-reviewed, open access journal. Papers are published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Oncotarget is now indexed by MEDLINE, PubMed and PMC/PubMed.

Read about the Oncotarget Scientific Integrity Process: https://www.oncotarget.com/scientific_integrity/

Aging-US is dedicated to advancing our understanding of the biological mechanisms that drive aging and the development of age-related diseases. Our mission is to serve as a platform for high-quality research that uncovers the cellular, molecular, and systemic processes underlying aging, and translates these insights into strategies to extend healthspan and delay the onset of chronic disease.

Read about the Aging (Aging-US) Scientific Integrity Process: https://aging-us.com/scientific-integrity

Authors from around the world discuss their book with host Jim Foster. "Conversations On The Coast with Jim Foster" aired for over two decades on radio stations in the San Francisco Bay Area.

Covering all things cinema on the island of Ireland.

The Authors on the Air Global Radio Network is an international digital media corporation featuring  podcasts, book reviewers and conference media coverage..  Our content is available on audio and video platforms in 153 countries.

New tracks tagged #authorinterview