Dr. Amparo Santamaria describes a #research paper she co-authored that was #published in Volume 17, Issue 6 of Aging (Aging-US), titled “Enhancing oocyte activation in women with ovarian failure: clinical outcomes of the Stem Cell Regenera study using G-CSF mobilization of peripheral blood stem cells and intraovarian injection of stem cell factor-enriched platelet rich plasma in real-world-practice.”

DOI - https://doi.org/10.18632/aging.206274

Corresponding author -Amparo Santamaria - Amparo.santamaria@ivirma.com

Video interview - https://www.youtube.com/watch?v=oRFJNwnXZWI

Abstract

The study assesses the effectiveness and safety of the Stem Cell Regenera Treatment for oocyte activation in women with ovarian failure, including conditions such as Poor Ovarian Response (POR), Diminished Ovarian Reserve (DOR), and Premature Ovarian Insufficiency (POI). This retrospective observational study was conducted from January 2023 to December 2024 at the IVIRMA Alicante Clinics in Spain.

Women diagnosed with ovarian failure participated in the study, which involved mobilizing Hematopoietic Stem Cells from bone marrow into peripheral blood using granulocyte colony- stimulating factor (G-CSF). This was followed by an intraovarian injection of Stem Cell Factor- enriched Platelet Rich Plasma (SCFE-PRP).

The primary outcome measures were the rate of oocyte activation, leukocytes and stem cell count, and pregnancy rates. Oocyte activation was defined as an increase in total Antral Follicle Count of three or more follicles after treatment and/or at least a 20% rise in Anti-Müllerian Hormone levels. Safety was assessed based on adverse effects. Pregnancy rates were evaluated for both spontaneous gestation and following in vitro fertilization (IVF) treatment.

A total of 145 women participated: the overall activation rate was 68.28%, with 7.07% achieving spontaneous gestation and 14.14% achieving pregnancy following IVF. Mobilization of CD34+ cells was successful in all participants, with an average collection of 32.96 CD34+ cells/μl. No severe adverse effects were observed. The study concluded that the Stem Cell Regenera Treatment is effective and safe for oocyte activation in women with ovarian failure in real-world practice.

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Keywords - aging, Stem Cell Regenera, oocyte activation, ovarian regeneration, G-CSF, SCFE-PRP, ovarian failure

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Aging (Aging-US)

Behind the Study: Enhancing Oocyte Activation in Women with Ovarian Failure

On this episode of Let's Just Talk, host Kathryn Raaker welcomes two distinguished guests.

First, Dan Perkins, expert on politics and current events, joins the show to discuss two major legal developments. In the first segment, he explores the District Court’s effort to remove Planned Parenthood funding from a bill already passed by Congress and signed into law. In the second, he examines the legal challenge to birthright citizenship in the Los Angeles District Court, including a class-action lawsuit filed on behalf of newborns seeking reinstatement of certain funding. Known for his bold insights and the motto, “Political correctness isn’t always correct,” Dan brings his signature commentary to these pressing issues.

Our second guest, author Don Greco, shares his journey from a 33-year teaching career to becoming a successful novelist. Don introduces his latest book, Ghost Hawk, the final installment of The Youngstown Quintet. This historical novel offers a vivid narrative about the lives of American Indians in the 14th century.

Fairfax Radio Channel 37- Perkins-Greco- 7-15-2025-Lets Just Talk

On today's episode of Let's Just Talk with host Kathryn Raaker, our featured guest is acclaimed animated film director Ron Clements. Known for his iconic collaborations with John Musker, Ron co-directed beloved Disney classics including "Little Mermaid," "Aladdin," "The Princess and the Frog," and many more. His work on "Little Mermaid" and "Aladdin" helped usher in a new golden age for Disney animation in the late '80s and early '90s. Most recently, Ron served as one of the keynote speaker at the L. Ron Hubbard Writers and Illustrators Achievement Awards held on April 10th at the Taglyan Complex in Hollywood.
Our second guest, author Don Greco, shares his journey from a 33-year teaching career to becoming a successful novelist. Don introduces his latest book, Ghost Hawk, the final installment of The Youngstown Quintet. This historical novel offers a vivid narrative about the lives of American Indians in the 14th century. The Name of the Book is "The Ghost Hawk".

W4CY-Clements-Greco- 7-17-2025 an W4VET 7-20-2025- Lets Just Talk

Tonight, Friday, July 18th, at 6 pm on The Brian Crombie Hour I interview ✅ Madelaine Drohan. ALL my 🎤 podcasts and 🎦 video casts can be accessed any time on my web site https://briancrombie.com which holds repository of all my shows. 📌 Journalist and historian Madelaine Drohan discusses her new book "He Did Not Conquer – Benjamin Franklin’s Failure to Annex Canada". She explores Franklin’s little-known efforts to bring Canada into the American fold—through a 1776 trip to Montreal and his role in the 1782 Treaty of Paris. Despite his ambitions, Canadian resistance and shifting priorities doomed the plan. Drohan draws parallels between Franklin’s failure and today’s U.S.–Canada relations, noting that the desire to annex Canada has surfaced repeatedly over the centuries. The conversation offers a compelling look at how a failed 18th-century strategy continues to echo in modern geopolitics.🎧 A must-listen for history buffs and policy watchers alike—tune in to hear Brian and Madelaine uncover a forgotten chapter of North American history.

📺 Videos: https://briancrombie.com/video-gallery
🎧 Podcasts: https://briancrombie.com/podcasts-the-brian-crombie-hour
📻 The Brian Crombie Hour airs nightly at 6 PM on Sauga960AM
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#BrianCrombieHour #MadelaineDrohan #HeDidNotConquer #BenjaminFranklin #CanadianHistory #USCanadaRelations #AmericanRevolution #HistoryPodcast #BookInterview #FranklinInCanada #CanadianPolitics #HistoricalNonFiction #AuthorInterview

Madelaine Drohan | Benjamin Franklin’s Attempt To Annex Canada

Sink your teeth into this episode of the Twilight Tonic! We're thrilled to host Melissa Dawn Harris, a leading vampire researcher and acclaimed author. Prepare for a captivating interview as Melissa shares her extensive knowledge, from ancient folklore to modern interpretations, offering a truly unique perspective on the vampire mythos. You won't want to miss this deep dive into the immortal world!

Unwrapping the Dark Gift with Melissa Dawn Harris

EC Nevin discusses the most meta murder mystery of them all! Episode 4 of My Bookcase Slays features A Novel Murder, a mystery lover's ultimate fantasy, and a charming British accent. Picture it: a  murder takes place at a crime fiction festival set in England cast with all the usual suspects and embellished with all the best tropes. Bonus feature: EC Nevin advises what wine pairs best with her debut novel. 

Learn more about GUEST EC Nevin: https://www.penguinrandomhouse.com/authors/2314249/e-c-nevin/
Learn more about HOST Melissa Westemeier: https://www.melwestemeier.com/

riverside_interview_ec nevin _ jul 22, 2025 001_melissa_westemeier'

Rattlesnakes, Secrets, and Suspense—A Conversation with author Cary J. Griffith
Author Cary J. Griffith joins the show to talk about Rattlesnake Bluff, a gripping outdoor mystery that begins with a chilling cold case and unravels into a deadly hunt for justice.
We dive into the inspiration behind U.S. Fish and Wildlife Agent Sam Rivers, his wolf hybrid Gray, and how a rare rattlesnake leads them straight into danger.
If you love cold cases, and wilderness justice—don’t miss this one!
Find out more about Cary: carygriffith.com/
To connect with me, visit: kathleendonnelly.com/


Cary Griffith, Rattle Snake Bluff, Ep. 3

Welcome friends and fellow philosophers to a Wild Isle author interview. In today's episode, I explore the inspirations, foundations, works, and philosophies of Brad Huestis, author of Ahab and The Big Bad.

Ahab: a Hockey Story:
https://a.co/d/2qosPGH

The Big Bad:
https://a.co/d/cge7GMD

Follow Brad Huestis:
https://www.facebook.com/brad.huestis
https://www.linkedin.com/in/brad-huestis-a61a7273/

MarQuese's Links:
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https://marquesedliddle.substack.com/

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Wild Isle Author Interview with Brad Huestis

Dr. Joan A. Friedman, psychotherapist, twin, and author of "The Same but Different: How Twins Can Live, Love, and Learn to Be Individuals," talks about how it is possible that love and resentment can happen at the same time between twins.  The full interview from a 2015 episode of "Conversations On The Coast with Jim Foster" can be heard now wherever you get your podcasts.  Photo: joanafriedmanphd.com.   

The Same but Different by Dr. Joan A. Friedman

Alan Furst, author of "Dark Voyage," talks about what it meant for those aboard a Dutch ship who suddenly found themselves aboard a "tramp freighter" when it was taken over by Britain on the eve of World War 2.  The full interview from a 2004 episode of "Conversations On The Coast with Jim Foster" can be heard now wherever you get your podcasts.

Dark Voyage by Alan Furst

This week, Tim welcomes special guest Tate Dousette, the winner of the 2025 Open Contract Challenge: Speed Edition. Tate shares what it feels like to be published for the very first time, his passion for sci-fi, fantasy, and comics, and his upcoming Greek gods-inspired story set for release on Black Friday. The conversation also covers writing habits, creative influences, and the importance of community in building confidence as a new author.

The World of Myth Bits #337 - A First-Time Winner's Journey

Author DL Mitchell on Murder, Mayhem, and a Mischievous Parrot
Award-winning author DL Mitchell joins me to chat about her latest cozy mystery, Parrot Prose—a cozy mystery featuring quirky characters, a missing billionaire, a chaotic treasure hunt, and one very opinionated parrot. When this bird talks, people listen—and murderers better watch out!

From big-city animal hospitals to her current house call concierge veterinary practice, DL’s firsthand small animal veterinarian experiences enrich her mysteries with authentic insight into the human-animal bond. When she’s not writing or caring for pets, you might find her on a scuba adventure (though she admits to getting seasick), running trails, traveling with her espresso machine, or paddling on her inflatable SUP.

Join us for a fun conversation about writing, animals, and the delightful capers of a talking parrot!

For more about DL and Parrot Prose, visit: dlmitchellmystery.com
For more about my K-9 books, visit: kathleendonnelly.com


DL Mitchell, Parrot Prose, Ep. 6

Nora Gallagher, author of "Changing Light," talks about her love of New Mexico and the wide variety of cultures who lived in Los Alamos during the creation of the first atomic bomb.  The full interview from a 2007 episode of "Conversations On The Coast with Jim Foster" can be heard now wherever you get your podcasts.  Photo: noragallagher.org.

Changing Light by Nora Gallagher

Aiden Deacon from the University of Minnesota-Twin Cities, Minneapolis, discusses a research paper he co-authored that was published in Volume 16 of Oncotarget, titled “Dissecting the functional differences and clinical features of R-spondin family members in metastatic prostate cancer.”

DOI - https://doi.org/10.18632/oncotarget.28758

Correspondence to - Justin Hwang - jhwang@umn.edu

Video interview - https://www.youtube.com/watch?v=OXKhWWU1gnY

Abstract

This study investigates the R-spondin family of genes (RSPO1/2/3/4), a group of secreted proteins that act as Wnt regulators, and their subsequent role in advanced prostate cancer (PC). When evaluating transcriptomic data from primary and metastatic PC patients, we found that alterations in RSPO2 were more prevalent than in other RSPO family members or Wnt-regulating genes APC and CTNNB1. Further, we found that RSPO2 alterations in PCs were significantly associated with worse disease-free survival. Through our in silico modeling, RSPO2 exhibited strong positive associations with genes regulating epithelial-mesenchymal transition (EMT) and double-negative prostate cancer (DNPC), but had negative correlations with androgen receptor (AR) and AR-associated genes. Furthermore, 3D modeling of RSPO2 revealed structural differences between itself and other RSPOs. In cell lines, RSPO2 overexpression caused up-regulation of EMT pathways, including EMT-regulatory transcription factors ZEB1, ZEB2, and TWIST1. Conversely, this was not observed when CTNNB1 was overexpressed in the same models. These findings highlight that, in PC, RSPO2 functions as a unique member of the R-spondin family by promoting genes and signaling pathways associated with aggressive PC, and RSPO2 amplifications are associated with poor outcomes in PC patients.

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Keywords - cancer, RSPO2, prostate cancer, Wnt signaling, genomics, therapeutics

About Oncotarget 

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Oncotarget is indexed and archived by PubMed/Medline, PubMed Central, Scopus, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science).

To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us:

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Oncotarget

Oncotarget author interview: Aiden Deacon

Behind the Study: R-spondin Family Roles in Metastatic Prostate Cancer

Elizabeth Gilbert, author of "Eat, Pray, Love: One Woman's Search for Everything Across Italy, India and Indonesia," talks about the importance of pleasure and devotion in life and the need for a steady balance to keep them strong.  The full interview from a 2007 episode of "Conversations On The Coast with Jim Foster" can be heard now wherever you get your podcasts.  Photo: elizabethgilbert.com.

Eat Pray Love by Elizabeth Gilbert

Uncovering Buried Secrets—R. Weir on Cold Cases, Cults, and K-9 Heroes

Award-winning author R Weir joins me on the podcast to discuss his gripping new mystery, Justice For The Forgotten. In this mystery, retired police officer Donnie Steel and his loyal K-9 partner, Kogel, are hired to dig into a cold case murder—only to find themselves up against a powerful cult leader determined to keep dark secrets buried.
We chat about R’s inspiration for his newest series, how he creates his characters, and crafting page-turning suspense.
If you enjoy crime fiction filled with relentless investigators, unexpected twists, and unforgettable characters (human and K-9), you won’t want to miss this conversation. 

For more about R. Weir visit: rweirauthor.com/
For more about my K-9 books, visit: kathleendonnelly.com


Randy Weir, Justice For the Forgotten, Ep. 8

Carol Gilligan, psychologist and author of the novel "Kyra," talks about how the main character in the novel redefines the 'structure' in her therapy in order to get to the real truth behind events in her life.  The full interview from a 2008 episode of "Conversations On The Coast with Jim Foster" can be heard now wherever you get your podcasts.

Kyra by Carol Gilligan

Kathryn Raaker hosts a nationally syndicated magazine format radio program on AM/FM, Internet streaming, and on her free iTunes App. The show features topics for today’s audience. Whether it is a guest talking about the newest technology, politics, health, or other topics, it is all about informing her listeners. Kathryn has been in broadcasting for almost 30 years and is featured on the Wilkins Radio Networks, Fairfax Radio Network, W4Cy & W4Vet Networks, and WVFR AM out of Pittsburg. So tune into "Let’s Just Talk! Radio" to be informed and entertained!

Oncotarget is a primarily oncology-focused, peer-reviewed, open access journal. Papers are published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Oncotarget is now indexed by MEDLINE, PubMed and PMC/PubMed.

Read about the Oncotarget Scientific Integrity Process: https://www.oncotarget.com/scientific_integrity/

Aging-US is dedicated to advancing our understanding of the biological mechanisms that drive aging and the development of age-related diseases. Our mission is to serve as a platform for high-quality research that uncovers the cellular, molecular, and systemic processes underlying aging, and translates these insights into strategies to extend healthspan and delay the onset of chronic disease.

Read about the Aging (Aging-US) Scientific Integrity Process: https://aging-us.com/scientific-integrity

Authors from around the world discuss their book with host Jim Foster. "Conversations On The Coast with Jim Foster" aired for over two decades on radio stations in the San Francisco Bay Area.

The Authors on the Air Global Radio Network is an international digital media corporation featuring  podcasts, book reviewers and conference media coverage..  Our content is available on audio and video platforms in 153 countries.

Brian Crombie has 20 years of corporate experience, a depth of knowledge in all facets of finance, strategic planning and corporate / business development for a wide breadth of companies in several industries. Brian has deep political, community and charitable involvement as well.

New tracks tagged #authorinterview