In this episode, podcast host Dr. Dwight Stoll talks with Dr. Emanuella Gionfriddo, associate professor in the Department of Chemistry at the University of Toledo, Ohio. Dr. Gionfriddo is an expert in bioanalysis and analyte extraction technologies, and works on both the development of new technologies, and the application of those technologies to contemporary analytical challenges. In their conversation, they discuss the origins of Dr. Gionfriddo’s interest in science, and several recent papers, including topics including extraction of neurotoxins from water, markers of hydraulic fracturing activity in wastewater, and development of thin-film extraction for improved performance of DNA amplification assays. Finally, Dr. Gionfriddo shares several pieces of advice for young and aspiring scientists.

Ep. 14: The more diverse is your toolbox, the more analytical problems you can solve

Current and future development of glucagon-like peptide-1 receptor agonists, more commonly referred to as GLP-1 RAs, or simply as GLP-1s, involves complexities not only in formulation but in all areas of early-phase drug development. Developing and refining preclinical models for early efficacy signals, developing and validating the bioanalytical assays necessary for quantitation, and designing the clinical studies that deliver the most robust data in this innovative therapeutic area are all key elements of a drug development program.

In this audiobook, we review the requirements for successful GLP-1 drug development, from the perspective of preclinical studies, clinical trials, manufacturing, and bioanalysis. Exclusive case studies are also presented.

Issue 42 — Managing the Complexities of Glucagon -like Peptide-1 Receptor Agonist Drug Development

Analytically Speaking, the podcast from LCGC and Spectroscopy magazines, addresses important issues in separation science and analytical spectroscopy. Topics include new analytical techniques, methods, and approaches; the latest trends; advances in instrument and software technology; practical solutions for specific applications; recent papers in the scientific literature and their applicability; challenges and solutions for data analysis and interpretation; analytical chemistry theory and fundamentals (from advanced research to tutorials and troubleshooting); and more. Our regular hosts are Dwight Stoll, PhD, a professor of chemistry at Gustavus Adolphus College in St. Peter, Minnesota, and Jerry Workman, PhD, a spectroscopist, noted author, and currently the Senior Technical Editor of Spectroscopy and LCGC. Dwight covers separation science and Jerry addresses spectroscopy related topics.

As an end-to-end CRO/CDMO, we have expert knowledge in all early stages of drug development, and we’re sharing that knowledge with you in The Altascientist: The Audiobook. 

Each issue is a deep dive into a specific area of early-phase drug development, providing insider tips, considerations, and case studies. 


Altasciences is a drug development solution company offering pharmaceutical and biotechnology companies a proven, flexible approach to preclinical and clinical pharmacology studies, including formulation, manufacturing, and analytical services.

New tracks tagged #bioanalysis