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BUFFALO, NY- November 28, 2023 – A new #researchpaper was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 21, entitled, “1,5-anhydro-D-fructose induces anti-aging effects on aging-associated brain diseases by increasing 5’-adenosine monophosphate-activated protein kinase activity via the peroxisome proliferator-activated receptor-γ co-activator-1α/brain-derived neurotrophic factor pathway.”

5’-Adenosine monophosphate-activated protein kinase (AMPK) is a metabolic sensor that serves as a cellular housekeeper; it also controls energy homeostasis and stress resistance. Thus, correct regulation of this factor can enhance health and survival. AMPK signaling may have a critical role in aging-associated brain diseases. Some in vitro studies have shown that 1,5-anhydro-D-fructose (1,5-AF) induces AMPK activation. 

In this new study, researchers Kiyoshi Kikuchi, Shotaro Otsuka, Seiya Takada, Kazuki Nakanishi, Kentaro Setoyama, Harutoshi Sakakima, Eiichiro Tanaka, and Ikuro Maruyama from Kagoshima University investigated the effects of 1,5-AF on the AMPK/PGC-1α/BDNF pathway in multiple animal models of human aging-associated brain diseases.

“In the present study, we experimentally evaluated the effects of 1,5-AF on aging-associated brain diseases in vivo using an animal model of acute ischemic stroke (AIS), stroke-prone spontaneously hypertensive rats (SHRSPs), and the spontaneous senescence-accelerated mouse-prone 8 (SAMP8) model.”

In the AIS model, intraperitoneal injection of 1,5-AF reduced cerebral infarct volume, neurological deficits, and mortality. In SHRSPs, oral administration of 1,5-AF reduced blood pressure and prolonged survival. In the SAMP8 model, oral administration of 1,5-AF alleviated aging-related decline in motor cognitive function. Although aging reduced the expression levels of peroxisome proliferator-activated receptor-γ co-activator-1α (PGC-1α) and brain-derived neurotrophic factor (BDNF), the researchers found that 1,5-AF activated AMPK, which led to upregulation of the PGC-1α/BDNF pathway. 

“Our results suggest that 1,5-AF can induce endogenous neurovascular protection, potentially preventing aging-associated brain diseases. Clinical studies are needed to determine whether 1,5-AF can prevent aging-associated brain diseases.”

DOI - https://doi.org/10.18632/aging.205228

Corresponding authors - Kiyoshi Kikuchi - kikuchi_kiyoshi@kurume-u.ac.jp, and Ikuro Maruyama - maruyama-i@eva.hi-ho.ne.jp

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Keywords - aging, AMP-activated protein kinases, brain-derived neurotrophic factor, peroxisome proliferator-activated receptors, blood pressure

About Aging-US

Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

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Anti-Aging Effects of 1,5-Anhydro-D-Fructose on Brain Diseases via AMPK Activation

On this Episode 439 of Health Solutions, Shawn & Janet Needham R. Ph. discuss the carnivore diet with Dr. Shawn Baker who has been on the carnivore diet for over 7 years. 

Shawn Baker M.D. is the Co-Founder of Revero, orthopedic surgeon, world leading authority on treating disease with medical nutritional therapy, an Amazon best-selling author, world champion athlete, international speaker, podcast host, and consultant. Shawn is the Author Of The Best Selling Book On Amazon, The Carnivore Diet. Dr. Shawn Baker talks about his journey as a physician and the life-changing effects of nutrition on health, and has been a guest on the Joe Rogan podcast twice. His original episode with Joe Rogan has seen over 10 million views! 

00:00 - Start
00:23 - Dr. Baker’s Intro
01:26 - Dr. Baker’s Background
04:44 - Cholesterol
12:28 - Effectiveness of Statins
16:31 - Carnivore Diet Success Stories
19:45 - Benefits of Carnivore Diet
21:51 - Why Are We Sick?
22:44 - Getting People Healthy
25:00 - Diets Throughout History
27:27 - Diabetics & Big Food
30:15 - Dr. Baker on Joe Rogan
32:23 - Dr. Baker’s Passion
34:19 - Dr. Baker’s Contact Information
35:26 - Closing Comments

Episode Resources 
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EP 439: Dr. Shawn Baker Discussing the Carnivore Diet with Shawn & Janet Needham R. Ph.

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EP 439: Dr. Shawn Baker Discussing the Carnivore Diet with Shawn & Janet Needham R. Ph.

Stilianos Efstratiadis, MD, an interventional cardiologist at Phelps Health discuss high blood pressure and cholesterol during American Heart Month.

High Blood Pressure and Cholesterol | Stilianos Efstratiadis, MD | Phelps Health

In this episode of "Health Matters," we delve into the intriguing relationship between Modafinil and blood pressure. Join us as we explore the science behind Modafinil's cognitive-enhancing properties and its potential impact on cardiovascular health. From understanding the basics of blood pressure to uncovering the nuances of Modafinil's effects, we'll provide you with essential insights to help you make informed decisions about your health. Whether you're considering Modafinil as a cognitive enhancer or simply curious about its effects, this episode is a must-listen. Tune in and stay informed about the intersection of Modafinil and blood pressure.

Learn More:https://healthnaturo.com/modafinil-blood-pressure/

Unlocking the Mystery: Modafinil and Blood Pressure

Blood Pressure

Today's episode is about blood pressure. It's not just something we avoid, it's essential for our circulatory system to function. We focus on hydrostatic pressure and work out a formula to to calculate resistance to flow. We also discuss coronary artery disease and why it is the leading cause of death in the world. Please feel free to email me with your questions and maybe I'll answer them in a future episode. minus55media@gmail.com

Episode 43 - Blood Pressure

Cardio Shield is an all-natural blood pressure formula that addresses the root cause of high blood pressure. Each serving of Cardio Shield, per Jerry, the creator, may increase healthy blood flow while lowering blood pressure and the risk of cardiovascular disease. Returning to the subject at hand, the culprit under question causes blood vessels to tighten, leading pressure to build up within them. This is also why nitric oxide levels in the body may be lower, preventing individuals from noticing a favourable shift in their blood measurements.

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ब्लड प्रेशर को जल्दी कैसे कम करें |How to reduce blood pressure quickly

A close relationship exists between the mind and the body. It is so far-reaching that it affects every cell of the body. This program discusses key aspects of this relationship and how it relates to common issues with our health.

Host: Kaysie Vokurka, Nutritionist & Lifestyle Medicine Practitioner
Guest: Jenifer Skues, Health Psychologist

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The healing influence of nature is being increasingly recognised. The benefits of light exposure, forest therapy, and green spaces are some highlights of this emerging area of research. This program explores some of the evidence for nature as medicine, possible mechanisms, exposure recommendations and practical suggestions.

Host: Kaysie Vokurka, Nutritionist & Lifestyle Medicine Practitioner
Guest: Dr Darren Morton, Educator, Author, Speaker, Lifestyle Medicine Expert

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Heart disease is the leading cause of death, but it doesn't have to be.  

In this episode, we sit down with Dr. Joel Kahn , "Americas Heart Doctor", to discuss the critical issue of heart disease, its connection to blood pressure, and the importance of regular checkups.  With over 30 million adults in the U.S. living with heart disease, it's more crucial than ever to monitor your health and ,make heart-healthy choices.  Dr. Kahn shares valuable insights on how diet, lifestyle, and routine checkups can play a key role in preventing heart disease.  

We also dive into alarming statistics, including the fact that heart disease is the leading cause of death for both men and women, claiming one in five lives.  Tune in for expert advice on how to protect your heart and live a longer, healthier life.

Shop blood pressure watches and wearable health monitoring devices at www.gmedwellness.com.  Be the CEO of your own health!  

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Watch Peter's Principles TV Show every Tuesday & Thursday on Astound Network 2pm ET & every Saturday & Sunday on Roku & Apple TV @DBTV Network 8:30am ET


Matters of the Heart:  Preventing Heart Disease with Dr. Joel Kahn

In this episode, Dr. Enam Abood delves deep into the global benchmarks for typical blood pressure ranges and variations observed in different countries. Investigate the significant factors that contribute to these differences and the impact of age and overall health on assessing blood pressure levels.

The Harley Street Doctor - Produced by the Harley Street Health Centre

Blood Pressure - Global Standards & Variations Explained by Dr Enam Abood

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On this Podcast Steven talks about his recent visit to the emergency room which led to a stay at the hospital for life threatening health issues. 

Episode #236 "Potassium, the silent killer"

BLOOD PRESSURE CONTROL

For a wealth of life changing information visit:  3abnaustralia.org.au/radio/listen 

3ABN (Three Angels Broadcasting Network) Australia Radio is the "Mending Broken People Network," broadcasting Christian content 24/7.

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Aging is dedicated to advancing our understanding of the biological mechanisms that drive aging and the development of age-related diseases. Our mission is to serve as a platform for high-quality research that uncovers the cellular, molecular, and systemic processes underlying aging, and translates these insights into strategies to extend healthspan and delay the onset of chronic disease.

Read about the Aging Scientific Integrity Process: https://aging-us.com/scientific-integrity

Peter and his wife, Joyce share tips on health & fitness, nutrition, spiritual growth, relationships, and mental well-being. This podcast explores ways to channel your passions, natural born talents, values and beliefs into living your purpose.

Peter N. Nielsen at the early age of 15 was diagnosed with Crohn’s disease. The challenge of having Crohn’s began his lifelong journey to physical and spiritual health. Overcoming his challenges led him to winning over 50 bodybuilding awards, including: 2x Mr. International Universe and 5x Mr. America titles. Peter N. Nielsen is the creator and host of the syndicated TV and Radio show Peter’s Principles, which has impacted hundreds of thousands of lives. In 2001, after his second near death experience due to Crohn’s disease, Peter vowed to help inspire and empower as many people as he could to become a better version of themselves through his Peter’s Principles lifestyle. These Principles include improved health, importance of eating a clean diet, exercise and overall well-being. Peter now offers a worldwide platform with well over 120 million potential viewers and his shows are seen and heard in over 100 countries. He is an author of six published books, including his latest release, Soul Strength. Peter is the national spokesman for the Crohn’s and Colitis Foundation of America. He is a world-renowned fitness guru who holds an ISSA Master’s Degree Certified in Nutrition and Exercise Science. In 2016, Peter helped launch Clean Planet Foods, which delivers clean, protein packed, convenient meals with a meal plan to your doorstep. Peter has owned, and operated, health and fitness clubs as well as physical therapy clinics. He has been a personal trainer and life coach, with an elite clientele. As a life coach, he speaks all over the world as a keynote speaker. Peter was voted Trainer of the Year by Self Magazine and Muscle & Fitness.

"Anatomy & Physiology - Bit by Bit" is not only intended for college students taking A&P, it's for anyone who is interested in how the human body is structured and how it functions. Where students are concerned, the goal is "B or better." Whether you're interested in nursing, physical therapy, physician assistant, radiography, etc, a B or better should be the goal to be competitive with other students in your field. Hopefully, these short, pointed discussions will help you understand what you need to be successful. Feel free to email me questions at minus55media@gmail.com.

Boldly Empowering 30s ~ 60s+ to Take Charge of Their Health. Bio Identical Hormone Balancing. Medical Freedom. Optimal Health Tips. 25+ yrs as Cash Only Compounding Pharmacists. Twice weekly Live Podcast.

On a journey to discover who I am and what I want to leave behind.

Harley Street Health Centre is a Private GP clinic that offers both walk-in & same-day appointments. Located in central London just a short walk from Oxford Circus station. They have a team of highly trained GP's who are passionate about helping patients whatever their needs.

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