Marshmallow. (lyrics)

When I was little Dad would tell me some jokes, and I’d laugh my head off
When I got older he would tell me some more, and I’d just roll my eyes
I grew up and my Daddy grew old, I’d see him at Christmas
He’d tell his jokes to the friends I brought home, and I’d just shake my head
And say, Dad you’re an embarrassment 

Chorus
Dad would tell one favorite joke
I’ll repeat it now, hope I don’t get it wrong, it went
“Last night I dreamed I ate a giant marshmallow
And when I woke up my pillow was gone”

Got the call that my Daddy was sick, went home to see him
He spent a month in the cancer wing, they weren’t sure he’d make it
The staff told me that every day, he’d visit the kids ward
And to those children Dad knew just what to say, so they’d laugh their heads off
Then he’d add “I’m here till Thursday, tip the nurses”

Repeat Chorus

Bridge
That day I saw a different man      
Respected Dad more than I ever had
At night I pledged I’d hug him, tell him that I loved him 
But in the morning they told me Dad was gone

I walked down to the children's ward, told ‘em Dad won’t be coming anymore
They asked who’ll show up to tell us daily jokes, I started to say I don’t know
But I took one look at those kids, and I told them this instead 
“Last night I dreamed I ate a giant marshmallow
And when I woke up my pillow was gone”

Marshmallow

BUFFALO, NY - April 15, 2025 – A new #research paper was #published in Oncotarget, Volume 16, on April 4, 2025, titled “Association between two single nucleotide polymorphisms of the Prostaglandin-Endoperoxide Synthase 1 and 2 genes and cell proliferative prostatic diseases in Lebanon."

The team of researchers led by first author Brock J. Sheehan and corresponding author Ruhul H. Kuddus, from Utah Valley University, discovered that a specific genetic variation in the PTGS2 gene is associated with a higher risk of benign prostate hyperplasia (BPH), a common condition in aging men. The study, which focused on Lebanese men, suggests that the C allele of the -765 G>C polymorphism in the PTGS2 gene may increase risk to this non-cancerous but problematic prostate condition. This finding could help identify men at greater risk earlier and lead to better treatment choices.

Benign prostate hyperplasia and prostate cancer are two common conditions that involve abnormal cell growth in the prostate gland. While prostate cancer is malignant and potentially life-threatening, BPH is a non-cancerous enlargement that can still significantly affect quality of life. Both conditions are widespread in older men, with BPH affecting over 70% of men above 60. Researchers have long suspected that inflammation-related genes may play a role in their development. In this study, the focus was to study PTGS1 and PTGS2, genes that help produce enzymes involved in inflammation.

Using DNA samples from 168 Lebanese men, including 61 with prostate cancer, 51 with BPH, and 56 healthy controls, the researchers analyzed two common gene variants. They found no link between the PTGS1 variant and either condition. However, the PTGS2 variant showed a strong association with BPH. Men carrying the C version of this gene were more than twice as likely to have BPH compared to those without it. While a similar trend was observed in men with prostate cancer, the results were less conclusive.

"The C allele of SNP-765G>C of the PTGS2 gene was significantly associated with an increased risk of BPH (OR = 2.30, p-value = 0.01)."

This is the first study to report a genetic link between the C allele of the -765 G>C polymorphism in the PTGS2 gene and BPH in Lebanese men. It builds on earlier findings that associated this gene variant with various cancers, including prostate, colon, and stomach cancers. Although based on a relatively small and specific population, the study offers new insight that could help improve genetic screening and guide prevention strategies.

The research also points to the potential benefits of COX-2 inhibitors—drugs already used to treat prostate conditions—which may be more effective for men with certain PTGS2 gene types. Further studies in larger and more diverse groups are needed to confirm these results and explore how this gene variant influences prostate disease. In the future, simple genetic tests could help identify men at higher risk before symptoms appear, allowing for earlier and more personalized care.

Continue reading: DOI: https://doi.org/10.18632/oncotarget.28710

Correspondence to: Ruhul H. Kuddus — ruhul.kuddus@uvu.edu

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MEDIA@IMPACTJOURNALS.COM

Gene Variant Linked to Benign Prostate Hyperplasia Risk in Lebanese Men

🎙️✨ O novo episódio do OncoPonto está imperdível!

Desta vez, discutimos sobre o câncer de pâncreas, um tema desafiador que tem avançado rapidamente graças à ciência e ao trabalho multidisciplinar.

Moderado pela Dra. Débora Curi, oncologista do Grupo SOnHe, o episódio traz uma conversa esclarecedora e cheia de insights com especialistas renomados:

Dr. Hugo Hammoud, cirurgião oncológico
Dr. Lucas Oliveira, cirurgião oncológico
Dr. Rafael Mello, cirurgião do aparelho digestivo

Entenda os desafios e os mais recentes avanços no tratamento e diagnóstico dessa doença.

👉 Já disponível no Spotify e no Youtube do Grupo SOnHe!

Câncer de Pâncreas:Desafios e Avanços Recentes

Breast cancer survivors are living longer than ever, thanks to research and medical advances, but new studies suggest that some treatments may come with a hidden cost: accelerated aging. A recent study, titled “Accelerated aging associated with cancer characteristics and treatments among breast cancer survivors,” published in Aging (Aging-US), reveals that breast cancer and its treatments may speed up biological aging, with effects lasting up to a decade post-diagnosis.

Breast Cancer and Aging

Breast cancer is one of the most common cancers among women worldwide. Medical advancements have dramatically improved survival rates, making it one of the most treatable forms of cancer. Yet, many survivors report lasting symptoms like fatigue, memory issues, and reduced vitality that resemble accelerated aging. This pattern has led scientists to investigate whether treatments for breast cancer might be contributing to biological age acceleration.

Full blog - https://aging-us.org/2025/04/breast-cancer-treatments-hidden-impact-accelerated-aging-among-survivors/

Paper DOI - https://doi.org/10.18632/aging.206218

Corresponding author - Xiao-Ou Shu - xiao-ou.shu@vumc.org

Video short - https://www.youtube.com/watch?v=cfuyzVyDeHY

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Keywords - aging, accelerated aging, PhenoAge, breast cancer, survivors

Visit our website at https://www.Aging-US.com​​ and connect with us on social media at:

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MEDIA@IMPACTJOURNALS.COM

Aging (Aging-US)

Breast Cancer Treatment’s Hidden Impact: Accelerated Aging Among Survivors

Wink Martindale, the legendary radio and television icon, died in Rancho Mirage, California on Tuesday, April 15, 2025, at the age of 91. The king of game shows who was perhaps best known for hosting the beloved Tic-Tac-Dough and Gambit, had a remarkable 74-year career. He was surrounded by family and his beloved wife of 49 years, Sandra Martindale. &nbsp;  Wink was a longtime friend of CIA host and 9-time Emmy winner David Sams who sat down to interview him in 2019. We'd like to share this wonderful conversation between friends. Wink's legendary status as radio and TV host has taken him through many of the biggest phases of pop culture and he reveals his personal stories with Elvis Presley, Tony Bennett, Ed Sullivan and more. Hear from the iconic host of "Tic-Tac-Dough" and how the simplicity of a TV game show has power when applied to other areas of life. His influence has had a stunning ripple effect in Hollywood and beyond and his wife Sandy has been his anchor through the years.&nbsp;  &nbsp; Wink is survived by his wife Sandra, sister Geraldine, his daughters Lisa, Lyn and Laura and a large extended family full of grandchildren and great grandchildren, his honorary son Eric and his beloved Chihuahua Dude!&nbsp; &nbsp; #winkmartindale @WinkMartindaleGames

#273: WINK MARTINDALE - Stories from an iconic TV and radio career. A legend we will dearly miss and never forget..

HTYH wk 510 Eddie Brigati

HTYH wk 510 Sylvie Beljanski

Shivani tells her story of how she discovered she has a rare form of breast cancer and how it effected her life.

This podcast is sponsored by Prozis
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Ep #133 - From Fitness Athlete to Cancer Patient  - Shivani Vaghela

Burger and fries

"Jean Palmer contracted a deadly bone marrow cancer called, myeloma. Most people have a fear of dreadful diseases like this, and death.  But Jean put her hope and trust in God's love and power, no matter what. I had the privilege to chat with Jean shortly before she went home to be with Jesus."

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This radio programme has been sponsored by:

Frontline Cleaning, specialists in commercial & domestic cleaning.
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The Reality with the late Jean Palmer - No Fear

Author, Fitness, Mindset & Personal Development Coach with a key focus on lifestyle optimisation & life hacks.

Dudley Anderson was born and raised in Johannesburg, South Africa. After graduating from Bible College in 1990, God opened the way for Dudley to branch out into Christian radio. As a musician and worship leader he developed a heart for Christian music, which became the main thrust of his radio work in South Africa. 

 In 1996 God called Dudley and his family to the United Kingdom where he now works as a radio programme producer and presenter. Dudley also writes a FREE weekly e-mail devotional called, GodTracker, available at surereality.net

Dudley Anderson is married to Karen-Leigh and has two adult children, Kerryn and Ryan.

E-mail Dudley at dudley@surereality.net

Oncotarget is a primarily oncology-focused, peer-reviewed, open access journal. Papers are published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Oncotarget is now indexed by MEDLINE, PubMed and PMC/PubMed.

Read about the Oncotarget Scientific Integrity Process: https://www.oncotarget.com/scientific_integrity/

Cancer and aging are two sides of age-related tumorigenesis.

The mission of the journal is to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population.

The journal aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.)

Read about the Aging (Aging-US) Scientific Integrity Process: https://aging-us.com/scientific-integrity

New tracks tagged #cancer