So that’s just all it is 
That’s what It’s meant to be 
A growth in front of you That brings the ending 
And if it follows suit It will keep on spreading 
Endless change Always Come from the deadly 

Adapt if you don’t like it, But please don’t try to fight it
It brings change in you, Whether you know or like it
show yourself love, And you’ll truly right it
But if the ride ends There’s another chance to ride it
You gotta take the chance 
The truth is in your hands
But next time, please stick to the plans
Stick to the truth, stick to yourself
And Watch your thoughts, they make your health

So that’s just all it is 
That’s what It’s meant to be 
A growth in front of you That brings the ending 
And if it follows suit It will keep on spreading 
Endless change Always Come from the deadly 

Get with the change or turn to the dust
It’s under your skin, waiting to bust
You can fight the way, but you won’t have luck
Change will come to you if youre safe and stuck 
Life will find a way, to show you whats up 
And it’ll grow fast thinking it’s not fast enough
By the time you notice, youre already fucked
You’re not in the future , isn’t that tough 

So that’s just all it is 
That’s what It’s meant to be 
A growth in front of you That brings the ending 
And if it follows suit It will keep on spreading 
Endless change Always Come from the deadly

Carson Or Carcinoma/Cancer (Nomi)

Is this a heart, or is it a hole?
Endless abyss or mi corazon
It can be hard to tell, sometimes I don’t know
Sometimes it’s obvious, they share the same home
There’s chaos in my heart, and blood inside my bones
There to show me love in things that I’ve never known
Right up to the edge, one more step to go
Just take a leap of faith, and see where you float

Show love to the pain who’s hurt and overgrown
A Shapeshifting fear of being unknown
But when you’re with me, you’re never alone
I live for chaos and love Choronzon

Is this a heart, or is it a hole?
Endless abyss or mi corazon
It can be hard to tell, sometimes I don’t know
Sometimes it’s obvious, they share the same home
There’s chaos in my heart, and blood inside my bones
There to show me love in things that I’ve never known
Right up to the edge, one more step to go
Just take a leap of faith, and see where you float

Corazon Or Choronzon (Mista X Ds)

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A new research paper was published in Oncotarget's Volume 14 on March 21, 2023, entitled, “Attenuation of cancer proliferation by suppression of glypican-1 and its pleiotropic effects in neoplastic behavior.”

Glypicans (GPC1-6) are associated with tumorigenic processes and their involvement in neoplastic behavior has been discussed in different cancer types. In this recent cancer-wide GPC expression study, researchers Fang Cheng, Victor Chérouvrier Hansson, Grigorios Georgolopoulos, and Katrin Mani from Lund University and Genevia Technologies used clinical cancer patient data in The Cancer Genome Atlas to reveal net upregulation of GPC1 and GPC2 in primary solid tumors. On the other hand, GPC3, GPC5 and GPC6 displayed lowered expression patterns compared to normal tissues. 

“[...] we identify and propose a mechanism where GPC1 interacts with extracellular matrix mediating signal transduction by mitogenic molecules involving TGF-β and p38 MAPK.”

Focusing on GPC1, the researchers conducted survival analyses of the clinical cancer patient data that revealed a statistically significant correlation between high expression of GPC1 and poor prognosis in 10 particular cancer types: bladder urothelial carcinoma, brain lower grade glioma, liver hepatocellular carcinoma, colon adenocarcinoma, kidney renal clear cell carcinoma, lung adenocarcinoma, mesothelioma, ovarian serous cystadenocarcinoma, uterine corpus endometrial carcinoma, and uveal melanoma. 

In vitro studies targeting GPC1 expression by CRISPR/Cas9 or siRNA or treatment with an anti-GPC1 antibody resulted in attenuation of proliferation of cancer cells from bladder carcinoma, glioma and hepatocellular carcinoma patients (T24, U87 and HepG2 cells). Further, GPC1 overexpression exhibited a significant and negative correlation between GPC1 expression and proliferation of T24 cells. Their attempt to reveal the mechanism through which downregulation of GPC1 leads to attenuation of tumor growth using systematic Ingenuity Pathway Analysis indicated that suppression of GPC1 results in ECM-mediated inhibition of specific pro-cancer signaling pathways involving TGF-β and p38 MAPK. The team also identified differential expression and pleiotropic effects of GPCs in specific cancer types. This emphasizes their potential as novel diagnostic tools and prognostic factors, and open doors for future GPC targeted therapy.

“It is plausible to measure circulating GPCs in serum, plasma or urine using a variety of methods including ELISA, urine cell sediments or exosome isolation [13, 24]. Further, detection and quantification of GPC1 by histopathological and immunohistochemical methods in tumor biopsies could be a new way to predict the biological outcome. The results of this investigation would also emphasize the potential of GPCs as novel tumor antigens, and open for GPC targeted immunotherapy. GPC targeted immunotherapy would be of high value, especially as we move into an era of precision and personalized cancer therapy.”

DOI: https://doi.org/10.18632/oncotarget.28388 

Correspondence to: Katrin Mani - katrin.mani@med.lu.se 

Keywords: Glypican-1, TCGA, bladder carcinoma, hepatocellular carcinoma, glioma

About Oncotarget

Oncotarget is a primarily oncology-focused, peer-reviewed, open access journal. Papers are published continuously within yearly volumes in their final and complete form, and then quickly released to Pubmed. On September 15, 2022, Oncotarget was accepted again for indexing by MEDLINE. Oncotarget is now indexed by Medline/PubMed and PMC/PubMed.

To learn more about Oncotarget, visit https://www.oncotarget.com and connect with us:

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Oncotarget

Attenuation of Cancer Proliferation by Suppression of Glypican-1

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BUFFALO, NY- September 20, 2023 – A new editorial paper was published in Oncotarget's Volume 14 on September 15, 2023, entitled, “Potential repurposing of DPP4 inhibitors for target therapy resistance in renal cell carcinoma.”

In their new editorial, researchers Kuniko Horie and Satoshi Inoue from Saitama Medical University and Tokyo Metropolitan Institute for Geriatrics and Gerontology discuss renal cell carcinoma (RCC) — a major adult kidney cancer, which is often incidentally discovered as an asymptomatic disease on imaging in the developed countries. RCC has the most fatal disease among urological cancers, as a recent 5-year relative survival rate in the U.S. (2009–2015) is less than 80%. While RCC is known as a cancer resistant to chemo- and radio-therapies, the prognosis of RCC has been remarkably improved after the clinical application of tyrosine kinase inhibitors (TKIs) and immunotherapy. 

The rationale for the efficacy of TKIs in RCC is mainly based on the angiogenetic status, particularly in clear cell RCC (ccRCC) that is the most common type of RCC (70–75% of RCC), in which the loss of function mutation of Von Hippel-Lindau (VHL) tumor suppressor gene activates hypoxia inducible factor (HIF) and vascular endothelial growth factor (VEGF) pathways. The first-line TKIs that predominantly target VEGF receptor (VEGFR) and platelet-derived growth factor receptor (PDGFR) (e.g., sunitinib and sorafenib) have been clinically used since late 2000s, and the second-line TKIs such as cabozantinib, which targets more receptor tyrosine kinases including MET and TAM kinases as well as VEGFR, have been further applied to the treatment of advanced RCC since early 2010s in which the first-line TKIs are ineffective.

“In our recent study, we established a panel of patient-derived ccRCC spheroid cultures with the enhancement of cancer stemness gene signature including DPP4 [9]. Focusing on TKI sunitinib sensitivity, we demonstrated that DPP4 inhibition increased sunitinib efficacy in DPP4-high RCC spheroids and DPP4 was upregulated in sunitinib-resistant RCC cells.”

DOI - https://doi.org/10.18632/oncotarget.28463

Correspondence to - Satoshi Inoue -  sinoue07@gmail.com

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Keywords - cancer, renal cell carcinoma (RCC), tyrosine kinase inhibitor (TKI), Dipeptidyl peptidase IV (DPP4), drug resistance, drug repurposing

About Oncotarget 

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us:

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DPP4 Inhibitors for Target Therapy Resistance in Renal Cell Carcinoma

Neste episódio do Uro-Oncologia Prática os oncologistas Denis Jardim e Diogo Assed Bastos debatem o tema: "Sequenciamento atual de terapias para o Carcinoma Urotelial metastático".

Uro-Oncologia Prática 53 - Sequenciamento atual de terapias para o Carcinoma Urotelial metastático

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angels surround (p. sorrow bringer & doublemydose)
produced primarily by @sorrow_bringer and I was inspired by his beautiful track "carcinoma" - So I went in on the beat and added 50% doublemydose <3

LMK IF YOU LIKE THIS or my EDM instrumentals more - I'll do what's wanted next!

FOLLOW/SUPPORT:
linktr.ee/doublemydose

new music video:

150bpm - Amin

LYRICS:
You could call me crazy well why would I want to conform?
Isolated Ideation shrouded from the sun in dark I'm born
Drom the sun I'm damaged
Lupus running rampant
No I can't stand it
God it's like
You fucking planned this!
I'm so vacant from this planet
It's like you fucking planet
So damaged
I'm so damaged vacant from this planet!
I've succumbed to every fear
Like no one wants me near?
No oh

Why do angels carry me so easily through this apathy?
It's unreal to me
Show me what to live for
I don't anymore
What's left to explore
To others I'm just simply ignored

Why do angels carry me so easily through this apathy?
It's unreal to me
Show me what to live for
I don't anymore
What's left to explore
To others I'm just simply ignored

angels surround (p. sorrow bringer & doublemydose)

In this episode of Lung Cancer Considered, host Dr. Narjust Florez moderates a discussion about adenosquamous cell carcinoma of the lung, from diagnosis, treatment, and outcomes in this group of patients.

When two worlds collide: Adenosquamous histology

Oncotarget is a primarily oncology-focused, peer-reviewed, open access journal. Papers are published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Oncotarget is now indexed by MEDLINE, PubMed and PMC/PubMed.

Read about the Oncotarget Scientific Integrity Process: https://www.oncotarget.com/scientific_integrity/

ŴǏŤČĦ ŤŘÂP
witch trap atmospheric wave trap lord 🌊 guitarist, singer, jack of all sins

ON STREAMING ASAP

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Dr. Stephen Liu and Dr. Narjust Florez host Lung Cancer Considered, the podcast of The International Association for the Study of Lung Cancer (IASLC). IASLC is the only global organization dedicated solely to the study of lung cancer and other thoracic malignancies. Founded in 1974, the association's membership includes more than 6,500 lung cancer specialists across all disciplines in over 100 countries, forming a global network working together to conquer lung and thoracic cancers worldwide. The association also publishes the Journal of Thoracic Oncology, the primary educational and informational publication for topics relevant to the prevention, detection, diagnosis and treatment of all thoracic malignancies. Visit www.iaslc.org for more information.

Lung Cancer considered is funded in part by AstraZeneca, Daiichi Sankyo, Inc., and Takeda

New tracks tagged #carcinoma