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CONNECT WITH YOUR PAST TO DISCOVER YOUR PURPOSE AND FIND A FULFILLING CAREERIs it time for a career change? You deserve a career that serves your deepest needs, uses your innate gifts, and helps you feel your best. In The Inner Compass Process, Danielle Roessle shows you how your childhood is a doorway to your true self – your inner compass – and guides you to discover your values, skills, and natural talents.This newfound awareness helps you clarify your career direction so you can find fulfillment in work and life. This book will help you: • Revisit childhood memories and learn the surprising ways that they shaped who you are today and who you want to be tomorrow. • Identify your four core values and recognize if an employer shares your values. • Clarify the natural gifts that motivate you in your career. • Visualize your ideal workday and identify career options that align with your needs. • Get clear on whether you want to change your job, career, employer, industry, or start a business, and then create an action plan to achieve your goals.You will come away with the self-awareness and practical skills to make the career change that’s right for you.DANIELLE ROESSLE is a licensed clinical social worker (LCSW), certified career coach, and the founder of Inner Compass Coach. She has helped hundreds of clients make successful career changes through The Inner Compass Process. Find her at innercompasscoach.com."
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On the boat returning from Samoa, Mead met her second husband, Reo Fortune, a New Zealander headed to Cambridge, England, to study psychology. They were married in 1928, after Mead's divorce from Luther Cressman. They traveled together to Pere, a small village on the island of Manus, in what was then the Admiralty Islands and is now part of Papua New Guinea. Mead wanted to study the thought processes of children in preliterate cultures and asked the children of Pere to prepare drawings for her. On the trip she collected approximately 35,000 pieces of children's artwork. Contrary to prevailing thought, she discovered that what is considered childlike in thought varies according to the emphases of the culture. In a culture such as Manus, where the supernatural permeates everyday life, Mead found that children showed no particular interest in the supernatural in their drawings. They focused instead on realistic depictions of the world around them. She published her findings in Growing Up in New Guinea (1930), a book written for a general audience. But, as with her Samoan research, she also published a technical monograph on Manus for her peers entitled titled Kinship in the Admiralty Islands (1934).
It is well-established that cancer treatment substantially increases the risk of long-term adverse health outcomes among childhood cancer survivors. However, there is limited research on the underlying mechanisms. To elucidate the pathophysiology and a possible causal pathway from treatment exposures to cardiometabolic conditions, we conducted epigenome-wide association studies (EWAS) to identify the DNA methylation (DNAm) sites associated with cancer treatment exposures and examined whether treatment-associated DNAm sites mediate associations between specific treatments and cardiometabolic conditions.
In childhood cancer survivors, cancer treatment exposures are associated with DNAm patterns present decades following the exposure. Treatment-associated DNAm sites may mediate the causal pathway from specific treatment exposures to certain cardiometabolic conditions, suggesting the utility of DNAm sites as risk predictors and potential mechanistic targets for future intervention studies.
Progress in cancer treatment has dramatically improved the 5-year survival following a childhood cancer diagnosis to more than 85% between 2010 and 2016 [1]. Thus, the population of childhood cancer survivors has grown rapidly and is estimated to exceed 500,000 persons in the USA [2]. Unfortunately, the treatment of childhood malignancies is associated with long-term morbidity and mortality [3,4,5,6,7]. Mounting evidence suggests that reduced physical activity, muscular weakness, metabolic derangements, and cognitive declines are common problems among adults treated for childhood malignancies [7,8,9,10,11]. Furthermore, premature cellular senescence, sterile inflammation, and mitochondrial dysfunction resulting from a primary cancer diagnosis or treatment-related toxicity may contribute to adverse health outcomes [12]. Accordingly, survivors of childhood cancer often develop treatment-related late effects with 60% to more than 90% of survivors experiencing one or more long-term chronic health conditions (CHCs) [13], an approximately 2-fold greater burden of CHCs than community controls [4]. Treatment-related adverse health outcomes encompass a broad range of CHCs [4, 14, 15], hospitalizations [16], premature frailty [17], and early mortality [14]. Some of the most commonly observed CHCs among survivors include obesity [18, 19], diabetes mellitus [20], cardiovascular diseases

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