Get More Info: https://neurorisereviewsinfo.wordpress.com 

In today's fast-paced world, our brain often faces challenges in keeping up with the demands of our daily lives. To combat this, many people turn to nootropics, or "smart drugs," to improve their cognitive performance. One such nootropic is NeuroRise, a supplement that claims to enhance brain function, memory, and focus. In this article, we will explore what NeuroRise is, its ingredients, and whether it's worth trying.

What is NeuroRise?

NeuroRise is a nootropic supplement that claims to boost brain function, memory, and focus. It contains a blend of natural ingredients that are believed to enhance cognitive performance. The supplement is manufactured by a company called Vitality Now, which produces a range of health supplements.

Ingredients in NeuroRise

NeuroRise contains a blend of natural ingredients, including:

Bacopa Monnieri: This herb is believed to improve memory and cognitive function.

Ginkgo Biloba: This plant extract is known to enhance memory and focus.

L-Theanine: This amino acid is found in green tea and is known to reduce stress and anxiety while promoting relaxation.
Rhodiola Rosea: This plant is believed to improve mental performance, reduce fatigue, and enhance mood.

Vitamin B12: This vitamin is important for brain function and can help reduce fatigue and improve mood.

Does NeuroRise Work?

While NeuroRise's ingredients are believed to enhance cognitive function, it's essential to consider whether the supplement actually works. Unfortunately, there is limited scientific research on NeuroRise itself. However, some studies have looked at the effectiveness of the individual ingredients found in NeuroRise.

One study found that Bacopa Monnieri improved memory and cognitive function in older adults. Another study found that Ginkgo Biloba improved attention and memory in healthy adults. L-Theanine has been shown to reduce stress and anxiety, while Rhodiola Rosea has been found to enhance mood and cognitive performance. Vitamin B12 is known to improve brain function and reduce fatigue.

While the individual ingredients in NeuroRise have been shown to enhance cognitive function, there is no conclusive evidence that the supplement itself works. Additionally, results may vary from person to person, and it's important to remember that supplements are not a substitute for a healthy diet and lifestyle.

NeuroRise Reviews: Can This Nootropic Boost Your Brainpower?

Dr. Sandison confesses that when she first heard Dr. Dale Bredesen talk about his work reversing cognitive decline and Alzheimer's disease she was skeptical. But when she started to apply the Bredesen principles in her clinical work and saw just how meaningful the improvements were to patients' symptoms and quality of life, as she puts it: "...how do I do anything else with my life, but basically tell as many people who will listen that this is possible?" She then went on to found the first two residential care facilities for individuals with cognitive decline that are based on the Bredesen approach. She's published research on her clinical outcomes and is continuing to gather more data for publication. The information and inspiration she shares are relevant to anyone dealing with cognitive decline, caring for someone with cognitive decline, or even those of us who want to preserve and optimize cognitive function as we move through life. I found her report that environmental toxins were one of the most common findings among her patient population illuminating. - DrKF 

Head to <a href="https://www.drkarafitzgerald.com/fxme...">https://www.drkarafitzgerald.com/fxme...</a> for the transcription and all the resources.

Guest information
<ul>
 <li>Dr. Heather Sandison, ND, Author Reversing Alzheimer’s</li>
 <li><a href="https://www.drheathersandison.com/">https://www.drheathersandison.com/</a></li>
 <li>Email: drheathersandisonnd@gmail.com</li>
</ul>

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Show Notes
<ul>
 <li>Reversing Alzheimer's by Dr. Heather Sandison :<a href="https://tinyurl.com/3hcywxxv">https://tinyurl.com/3hcywxxv</a></li>
 <li>Dr. Dale Bredesen: <a href="https://www.apollohealthco.com/dr-bre...">https://www.apollohealthco.com/dr-bre...</a></li>
 <li>Montreal Cognitive Assessment (MoCa): <a href="https://mocacognition.com/">https://mocacognition.com/</a></li>
 <li>Marama Residential Care Facility: <a href="https://www.maramaexperience.com/">https://www.maramaexperience.com/</a></li> 
 <li>Study: Observed Improvement in Cognition During a Personalized Lifestyle Intervention in People with Cognitive Decline: <a href="https://www.ncbi.nlm.nih.gov/pmc/arti...">https://www.ncbi.nlm.nih.gov/pmc/arti...</a></li>
 <li>Study: Precision Medicine Approach to Alzheimer’s Disease: Successful Pilot Project: <a href="https://www.ncbi.nlm.nih.gov/pmc/arti...">https://www.ncbi.nlm.nih.gov/pmc/arti...</a></li>
</ul>

DrKF Resources
<ul>
 <li>Podcast: Addressing Root Causes of Neurodegenerative Diseases with Dr. Dale Bredesen: <a href="https://tinyurl.com/3f2jchcm">https://tinyurl.com/3f2jchcm</a></li>
 <li>DrKF Clinic: Patient consults with DrKF physicians including Younger You Concierge: <a href="https://www.drkarafitzgerald.com/our-...">https://www.drkarafitzgerald.com/our-...</a></li>
 <li>Younger You Group Program: <a href="https://www.drkarafitzgerald.com/youn...">https://www.drkarafitzgerald.com/youn...</a></li>

Tackling Alzheimer's Disease Head On - the Inspiring Work of Dr. Heather Sandison

BUFFALO, NY- April 10, 2024 – A new #researchpaper was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 6, entitled, “Geraniol attenuates oxidative stress and neuroinflammation-mediated cognitive impairment in D galactose-induced mouse aging model.”

D-galactose (D-gal) administration was proven to induce cognitive impairment and aging in rodents’ models. Geraniol (GNL) belongs to the acyclic isoprenoid monoterpenes. GNL reduces inflammation by changing important signaling pathways and cytokines, and thus it is plausible to be used as a medicine for treating disorders linked to inflammation. In this new study, researchers Peramaiyan Rajendran, Fatma J. Al-Saeedi, Rebai Ben Ammar, Basem M. Abdallah, Enas M. Ali, Najla Khaled Al Abdulsalam, Sujatha Tejavat, Duaa Althumairy, Vishnu Priya Veeraraghavan, Sarah Abdulaziz Alamer, Gamal M. Bekhet, and Emad A. Ahmed from King Faisal University, Kuwait University, Center of Biotechnology of Borj-Cedria, Saveetha University, Alexandria University, and Assiut University examined the therapeutic effects of GNL on D-gal-induced oxidative stress and neuroinflammation-mediated memory loss in mice. 

“Life expectancy in the 21st century is rising, resulting in more age-related illnesses, such as memory impairment and Alzheimer’s disease. In this study, GNL was studied for its protective effect on D-gal-induced aging in mice.”

The study was conducted using six groups of mice (6 mice per group). The first group received normal saline, then D-gal (150 mg/wt) dissolved in normal saline solution (0.9%, w/v) was given orally for 9 weeks to the second group. In the III group, from the second week until the 10th week, mice were treated orally (without anesthesia) with D-gal (150 mg/kg body wt) and GNL weekly twice (40 mg/kg body wt) four hours later. Mice in Group IV were treated with GNL from the second week up until the end of the experiment. For comparison of young versus elderly mice, 4 month old (Group V) and 16-month-old (Group VI) control mice were used. 

“We evaluated the changes in antioxidant levels, PI3K/Akt levels, and Nrf2 levels. We also examined how D-gal and GNL treated pathological aging changes.”

Administration of GNL induced a significant increase in spatial learning and memory with spontaneously altered behavior. Enhancing anti-oxidant and anti-inflammatory effects and activating PI3K/Akt were the mechanisms that mediated this effect. Further, GNL treatment upregulated Nrf2 and HO-1 to reduce oxidative stress and apoptosis. This was confirmed using 99mTc-HMPAO brain flow gamma bioassays. 

“Thus, our data suggested GNL as a promising agent for treating neuroinflammation-induced cognitive impairment.”

DOI - https://doi.org/10.18632/aging.205677

Corresponding authors - Peramaiyan Rajendran - prajendran@kfu.edu.sa, and Fatma J. Al-Saeedi - fatma.alsaeedi@ku.edu.kw

About Aging-US

Aging publishes research papers in all fields of aging research including but not limited, aging from yeast to mammals, cellular senescence, age-related diseases such as cancer and Alzheimer’s diseases and their prevention and treatment, anti-aging strategies and drug development and especially the role of signal transduction pathways such as mTOR in aging and potential approaches to modulate these signaling pathways to extend lifespan. The journal aims to promote treatment of age-related diseases by slowing down aging, validation of anti-aging drugs by treating age-related diseases, prevention of cancer by inhibiting aging. Cancer and COVID-19 are age-related diseases.

Please visit our website at https://www.Aging-US.com​​ and connect with us on social media.

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Aging (Aging-US)

Geraniol Attenuates Oxidative Stress and Cognitive Impairment in Mouse Aging Model

BUFFALO, NY- April 17, 2024 – A new #researchpaper was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 7, entitled, “The impact of continuous and intermittent ketogenic diets on cognitive behavior, motor function, and blood lipids in TgF344-AD rats.”

Studies suggest that ketogenic diets (KD) may improve memory in mouse models of aging and Alzheimer’s disease (AD). In this new study, researchers Jennifer M. Rutkowsky, Zabrisky Roland, Anthony Valenzuela, An B. Nguyen, Heui Hye Park, Natalie Six, Ilknur Dursun, Kyoungmi Kim, Pamela J. Lein, and Jon J. Ramsey from the University of California Davis and Istinye University determined whether a continuous or intermittent KD (IKD) enhanced cognitive behavior in the TgF344-AD rat model of AD. 

“[...] it remains to be determined whether long-term consumption of a ketogenic diet can mitigate declines in cognitive or motor behavior in a rat model of AD. Therefore, the current study aimed to determine whether a KD improves cognitive or motor behavior in the TgF344-AD rat.”

At 6 months-old, TgF344-AD and wild-type (WT) littermates were placed on a control (CD), KD, or IKD (morning CD and afternoon KD) provided as two meals per day for 2 or 6 months. Cognitive and motor behavior and circulating β-hydroxybutyrate (BHB), AD biomarkers and blood lipids were assessed. Animals on a KD diet had elevated circulating BHB, with IKD levels intermediate to CD and KD. 

TgF344-AD rats displayed impaired spatial learning memory in the Barnes maze at 8 and 12 months of age and impaired motor coordination at 12 months of age. Neither KD nor IKD improved performance compared to CD. At 12 months of age, TgF344-AD animals had elevated blood lipids. IKD reduced lipids to WT levels with KD further reducing cholesterol below WT levels. 

“[...] the IKD or KD did not improve motor coordination or spatial learning memory compared to the control diet. However, KD, and to a lesser extent IKD, mitigated elevations in plasma lipids in the TgF344-AD rats. Furthermore, the KD diet decreased plasma levels of total Tau in females.”

DOI - https://doi.org/10.18632/aging.205741

Corresponding author - Jennifer M. Rutkowsky - jrutkowsky@ucdavis.edu

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Keywords - aging, ketogenic diet, Alzheimer’s disease, cognitive behavior, motor function, lipids

About Aging-US

Aging publishes research papers in all fields of aging research including but not limited, aging from yeast to mammals, cellular senescence, age-related diseases such as cancer and Alzheimer’s diseases and their prevention and treatment, anti-aging strategies and drug development and especially the role of signal transduction pathways such as mTOR in aging and potential approaches to modulate these signaling pathways to extend lifespan. The journal aims to promote treatment of age-related diseases by slowing down aging, validation of anti-aging drugs by treating age-related diseases, prevention of cancer by inhibiting aging. Cancer and COVID-19 are age-related diseases.

Please visit our website at https://www.Aging-US.com​​ and connect with us:

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The Impact of Ketogenic Diets on Cognitive Behavior, Motor Function, and Blood Lipids

Living with anxiety and stress can be overwhelming, affecting not only your mental health but also your physical well-being. However, there are ways to manage these feelings and improve your quality of life. Matthew Danchak, a renowned expert in mental health, shares his top tips for coping with anxiety and stress.

Matthew Danchak Top Tips For Coping With Anxiety And Stress

BUFFALO, NY- June 25, 2024 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 11, entitled, “Associations of childhood, adolescence, and midlife cognitive function with DNA methylation age acceleration in midlife.”

Prior studies showed increased age acceleration (AgeAccel) is associated with worse cognitive function among old adults. In this new study, researchers Junyu Chen, Leah Moubadder, Elizabeth S. Clausing, Katrina L. Kezios, Karen N. Conneely, Anke Hüls, Andrea Baccarelli, Pam Factor-Litvak, Piera Cirrillo, Rachel C. Shelton, Bruce G. Link, and Shakira F. Suglia from Emory University, University of Nebraska, Columbia University, Public Health Institute, Washington, DC, and the University of California Riverside examined the associations of childhood, adolescence and midlife cognition with AgeAccel based on DNA methylation (DNAm) in midlife.

“To the best of our knowledge, this is the first study to show the association of cognition at younger age with midlife age acceleration, and associations between midlife age acceleration measures and cognitive function that are independent of childhood and adolescent cognition.”

Data are from 359 participants who had cognition measured in childhood and adolescence in the Child Health and Development study, and had cognition, blood based DNAm measured during midlife in the Disparities study. Childhood cognition was measured by Raven’s Progressive Matrices and Peabody Picture Vocabulary Test (PPVT). Adolescent cognition was measured only by PPVT. Midlife cognition included Wechsler Test of Adult Reading (WTAR), Verbal Fluency (VF), Digit Symbol (DS). AgeAccel measures including Horvath, Hannum, PhenoAge, GrimAge and DunedinPACE were calculated from DNAm. Linear regressions adjusted for potential confounders were utilized to examine the association between each cognitive measure in relation to each AgeAccel.

There are no significant associations between childhood cognition and midlife AgeAccel. A 1-unit increase in adolescent PPVT, which measures crystalized intelligence, is associated with 0.048-year decrease of aging measured by GrimAge and this association is attenuated after adjustment for adult socioeconomic status. Midlife crystalized intelligence measure WTAR is negatively associated with PhenoAge and DunedinPACE, and midlife fluid intelligence measure (DS) is negatively associated with GrimAge, PhenoAge and DunedinPACE. AgeAccel is not associated with VF in midlife.

“In conclusion, our study showed the potential role of cognitive functions at younger ages in the process of biological aging. We also showed a potential relationship of both crystalized and fluid intelligence with aging acceleration.”

DOI - https://doi.org/10.18632/aging.205943

Corresponding author - Junyu Chen - junyu.chen@emory.edu

Video short - https://www.youtube.com/watch?v=v7xiVCqVwPw

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The mission of the journal is to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population.

The journal aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.)

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Childhood, Adolescence, and Midlife Cognitive Function Linked to Age Acceleration in Midlife

BUFFALO, NY- October 8, 2024 – A new #research paper was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science), Volume 16, Issue 18 on September 18, 2024, entitled, “Determinants of cerebral blood flow and arterial transit time in healthy older adults.”

This research paper highlights that brain health deteriorates with age, particularly in terms of cerebral blood flow (CBF) and arterial transit time (ATT), key markers of brain vascular health. This decline can impair cognitive function and limit independence in later life—an issue that will affect many as the global population continues to age rapidly.

In their paper, researchers Jack Feron, Katrien Segaert, Foyzul Rahman, Sindre H. Fosstveit, Kelsey E. Joyce, Ahmed Gilani, Hilde Lohne-Seiler, Sveinung Berntsen, Karen J Mullinger, and Samuel J. E. Lucas from the University of Birmingham, University of Agder, and University of Nottingham aimed to identify modifiable determinants of CBF and ATT in healthy older adults (n = 78, aged 60–81 years). They also investigated the relationship between CBF, ATT, and cognitive function in older adults. 

The researchers hypothesized that markers of superior general health—such as higher cardiorespiratory fitness, handgrip strength, and grey matter volume, or lower age, BMI, and blood pressure—would be associated with greater CBF and shorter ATT.

Results from multiple linear regressions revealed that a higher BMI was associated with lower global cerebral blood flow (CBF) (β = −0.35, P = 0.008) and longer global arterial transit time (ATT) (β = 0.30, P = 0.017). Additionally, global ATT increased with age (β = 0.43, P = 0.004), while higher cardiorespiratory fitness was linked to longer ATT in the parietal (β = 0.44, P = 0.004) and occipital (β = 0.45, P = 0.003) regions. However, neither global nor regional CBF or ATT were associated with processing speed, working memory, or attention.

“In conclusion, preventing excessive weight gain may help attenuate age-related declines in brain vascular health.”

DOI - https://doi.org/10.18632/aging.206112

Corresponding author - Jack Feron - j.feron@bham.ac.uk

Video short - https://www.youtube.com/watch?v=QpS4kK273os

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The mission of the journal is to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population.

The journal aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.)

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Cerebral Blood Flow and Arterial Transit in Older Adults

BUFFALO, NY — August 26, 2025 — A new #research paper was #published in Volume 17, Issue 7 of Aging (Aging-US) on July 21, 2025, titled “Association of DNA methylation age acceleration with digital clock drawing test performance: the Framingham Heart Study.”

In this study, led by first author Zexu Li from the Department of Anatomy and Neurobiology at Boston University Chobanian and Avedisian School of Medicine, and corresponding author Chunyu Liu from Boston University Chobanian and Avedisian School of Medicine and Boston University School of Public Health, researchers found that individuals with signs of faster biological aging had lower scores on a digital cognitive test taken seven years later. The findings suggest that the rate at which a person ages at the molecular level may be associated with how well their brain functions as they grow older.

Using data from the Framingham Heart Study, the researchers examined the relationship between biological aging and cognitive health. They used DNA methylation (DNAm) patterns—chemical changes that occur in the DNA with aging, known as epigenetic aging—to estimate biological age acceleration, and used the digital Clock Drawing Test (dCDT) to assess cognitive performance. The dCDT is a computerized version of a traditional pen-and-paper test that evaluates memory, thinking speed, and motor control. It provides an overall score and measures performance in specific areas such as spatial reasoning and movement.

Among 1,789 participants, higher levels of epigenetic age acceleration were associated with significantly lower cognitive scores, particularly those over age 65. Of all the epigenetic aging markers examined, the DunedinPACE measure showed the strongest association with reduced brain function in both younger and older adults. Other measures, such as Horvath and PhenoAge, were associated with lower scores only in older adults. Key areas affected included motor skills and spatial reasoning.

The researchers also studied blood-based protein markers used in an aging measure called GrimAge. Two proteins, PAI1 and ADM, were closely associated with lower cognitive scores, especially in older individuals. These results suggest that declines in brain and motor functions may reflect broader aging-related changes throughout the body.

“Digital cognitive measures displayed stronger associations with most DNAm aging metrics among older compared to younger participants, likely to reflect the cumulative and nonlinear age influences on both brain health and DNAm.”

This study supports the idea that epigenetic age may be a more accurate predictor of cognitive decline than chronological age. The dCDT, which is easy to use, automated, and more precise than traditional tools, may help detect early signs of brain aging. When combined with DNAm measures, it could become a valuable part of regular health screenings.

Overall, the findings provide strong evidence that faster biological aging is associated with cognitive decline. This research may lead to better ways of identifying and monitoring brain health in aging populations.

DOI - https://doi.org/10.18632/aging.206285

Corresponding author - Chunyu Liu - liuc@bu.edu

Video short - https://www.youtube.com/watch?v=4hyjDqnPs8w

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Faster Biological Aging Linked to Cognitive Decline in Older Adults

Dr. Rayna Hirst a clinical psychologist and cannabis researcher at Palo Alto University joins us to discuss her research measuring the cognitive effects of medicinal and recreational cannabis.

                              

Rayna Hirst Ph.D. Researching Cognitive Effects of Cannabis 03/02/2018

Podcast นี้เป็น podcast ที่จะพาทุกคนไปรู้จักกับจักรวาลภายในตัวเราเองตามทฤษฎีของนักจิตวิทยาชาวสวิส คาร์ล กุสตาฟ ยุง เราจะค่อยๆ ดำดิ่งลงไปในโลกภายในของตัวเองที่กว้างขวางประหนึ่งเป็นจักรวาลอันใหญ่โต เพื่อให้เราได้รู้จักตัวเองในระดับที่ลึกซึ้งขึ้นและเข้าใจความเป็นมนุษย์อย่างแท้จริง

จุดเด่นของคนประเภท ISTJ & ISFJ/ EP3 Introverted Sensing (Si)/ "สมุดโน้ตของพลอย"

Matthew Danchak, a passionate individual with a decade of nursing experience dedicated to mental health advocacy. Matthew Danchak's love for cats and dogs reflects his nurturing nature, adding a compassionate touch to his character. Matthew Danchak extensive professional background in nursing attests to his unwavering commitment to healthcare. Photography is not just a hobby but a passion for Matthew, who has documented over 1000 waterfalls across the globe. Balancing a caring profession with an adventurous spirit, Matthew brings a unique blend of empathy, resilience, and a love for exploration to his multifaceted life.

Welcome to New Frontiers in Functional Medicine, Longevity & Epigenetics™ where I interview the best minds in functional medicine to discuss the science and research behind medicine, longevity, epigenetics, and so much more. Expect thought-provoking ideas, new research, lots of clinical pearls for practitioners, and step-change information for clinicians and patients. Join us! ~DrKF  

Copyright © 2025 by KF Education and Consulting, LLC
All Rights Reserved

The Cannabis Connection hosted by Christopher Carr provides stimulating conversation with professionals, regulators, researchers, and experts striving to demystify common misconceptions about Cannabis. Our radio broadcast educates and opens a dialogue surrounding the potential Cannabis has to heal ailments, but also our society from a social and economic standpoint. Carr's professional mission is to educate the public on Cannabis stewardship, science, policy, industry, and research. An adviser for Santa Cruz County and Executive Committee Member for Community Prevention Partners, Carr also serves as a Guest Lecturer at Cabrillo College, College of Botanical Healing Arts, and judge for both High Times Cup and The Emerald Cup. Carr represents Santa Cruz in the greater Cannabis Community and has positive rapport with the leading activists in Sacramento and Emerald Triangle. Rooted in the ethics of Compassionate Use Act while engaging the leading minds of the ever evolving California Cannabis Industry, Carr serves the community shaping a local Cannabis movement that reflects the values of Santa Cruz through leadership and compassion.

Aging-US is dedicated to advancing our understanding of the biological mechanisms that drive aging and the development of age-related diseases. Our mission is to serve as a platform for high-quality research that uncovers the cellular, molecular, and systemic processes underlying aging, and translates these insights into strategies to extend healthspan and delay the onset of chronic disease.

Read about the Aging (Aging-US) Scientific Integrity Process: https://aging-us.com/scientific-integrity

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