Welcome to the official debut of JAY'S JUNK, where Jay picks out the movie you've probably never heard of to review! Sure, he's done this before (and so has Sean), but now some are officially his!

This first selection is a movie called THE FIX. It's a tale about our future in which the air is unbreathable and rich corporations sell us the solution... until some drug dealing thieves get involved. It's weird; it's convoluted; but is it good? JAY'S JUNK will get to the bottom of it!

JAY'S JUNK: The Fix (2024) Review

BUFFALO, NY – June 9, 2025 – A new #research paper was #published in Volume 16 of Oncotarget on May 20, 2025, titled “Cigarette smoke and decreased DNA repair by Xeroderma Pigmentosum Group C use a double hit mechanism for epithelial cell lung carcinogenesis.”

In this study, led by first author Nawar Al Nasralla and corresponding author Catherine R. Sears, from the Division of Pulmonary, Critical Care, Sleep and Occupational Medicine, Indianapolis and the Richard L. Roudebush Veterans Affairs Medical Center, researchers investigated how cigarette smoke and reduced DNA repair capacity contribute together to the development of lung cancer. They found that when a critical DNA repair protein called XPC is decreased and lung cells are exposed to cigarette smoke, the combination causes extensive damage and significantly increases cancer risk.

Non-small cell lung cancer (NSCLC) develops through both genetic and environmental factors. This study focused on how cigarette smoke affects the body’s natural ability to repair DNA. The researchers studied the role of XPC, a protein essential for recognizing and repairing harmful DNA changes caused by tobacco smoke. They found that low levels of XPC — commonly seen in lung cancer patients — made lung cells less capable of repairing DNA. This made the cells unstable and more likely to become cancerous. These changes were most pronounced in normal lung cells, suggesting that the earliest stages of disease occur before cancer is even detected.

The findings support a “double hit” model, where both cigarette smoke and reduced DNA repair work together to drive cancer development. In laboratory experiments, normal lung cells with low XPC levels showed more damage and cell death after cigarette smoke exposure. By contrast, lung cancer cells were more resistant to smoke damage, even when XPC was low, indicating that critical changes had likely occurred earlier in the disease process.

“Our study suggests that cigarette smoke exposure leads to decreased XPC mRNA expression, exacerbates total and oxidative DNA damage, hinders NER, and may contribute to lung cancer development.”

The study also showed that DNA repair ability declined significantly in healthy cells after smoke exposure, but this effect was not seen in cancer cells. In addition, the researchers confirmed that XPC gene activity was lower in actual lung tumor tissue compared to nearby healthy lung tissue. This pattern was consistent across both adenocarcinoma and squamous cell carcinoma, the two main types of NSCLC.

These results add to our understanding of how lung cancer begins at the molecular level. By showing how cigarette smoke and reduced DNA repair combine to create genetic instability, the research points toward new strategies for prevention. A better understanding of XPC’s role could help identify high-risk individuals and inform future efforts to stop lung cancer before it begins.

DOI - https://doi.org/10.18632/oncotarget.28724

Correspondence to - Catherine R. Sears - crufatto@iu.edu

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Keywords - cancer, DNA repair, DNA damage, lung adenocarcinoma, squamous cell carcinoma, Xeroderma Pigmentosum Group C (XPC)

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Oncotarget

Cigarette Smoke and DNA Repair Deficiency Drive Lung Cancer Development

Kendrick Madruga - DNAluguel (ONOE Funk)

Módulo # 1 - Pregenómica: Introducción

1. Decodificándote: La revolución genómica y el futuro de la medicina personalizada

Sports Day (Raw)

"A genetic fire sale" -- that's the term used by J.B. Branch, Big Tech Accountability Advocate at Public Citizen, of the potential sale of the database of DNA of 15 million individuals involved in the bankruptcy sale of 23 and Me. Twenty-seven state attorney generals are also trying to block this sale, which involves not only individuals, but potential use of the data in extended family trees of those who had their DNA analyzed.

buzz-6-11-25-J-B-Branch

Módulo # 1 - Pregenómica: Introducción a experimentos que llevaron al descubrimiento del DNA

2. Descifrando el plan de la vida: Los experimentos que desenmascararon el ADN

Módulo # 1 - Pregenómica: Experimento Casero Desveló el Secreto Genético - Hershey y Chase - 1952

5. La Batidora de la Vida: Cuando un experimento casero desveló el secreto genético - Hershey y Chase

Módulo # 2 - Postgenómica: Sobre el proyecto ENCODE (Encyclopedia of DNA Elements)

9. ENCODE: Más allá de los genes - Descubriendo los secretos de nuestro ADN “oscuro”

Módulo # 2 - Postgenómica: Sobre el Proyecto Internacional HapMap

11. Descifrando nuestras diferencias: Cómo el proyecto HapMap revolucionó la investigación genética

Listener-sponsored, volunteer-powered, noncommercial community radio broadcasting to south-central Wisconsin at 89.9 FM and online at wortfm.org via our studios in Madison. 

We provide an outlet for communication, education, free expression, entertainment, training and access for the purpose of sharing music, information, news, and cultural experiences, and strive to give people underrepresented elsewhere in traditional media a voice. 

NOTE: Most of the content posted at this time are news stories or talk shows. 

MUSICIANS:  We NEVER look on our SoundCloud for music submissions, so it's not a very efficient way to contact us. Please go to www.wortfm.org and click on Music --> Music Submissions for our submission info and guidelines. Thanks and we look forward to hearing your music!

Oncotarget is a primarily oncology-focused, peer-reviewed, open access journal. Papers are published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Oncotarget is now indexed by MEDLINE, PubMed and PMC/PubMed.

Read about the Oncotarget Scientific Integrity Process: https://www.oncotarget.com/scientific_integrity/

Here’s a little story about a trio of janitors. 
Might have heard they worked at a well-known film school.
They picked up a few things other than trash. 
They might hate your movie, or if drunk think it’s cool.
Every now and then they get together for a lunch break. 
Trash talk some movie, or TV, or streaming.
Rodney and Jason and Sean – they all clean halls. 
If you listen close you can hear kids screaming: Film School Janitors!

2024 Music "Aries Beats - Escape" is is under a Creative Commons (CC BY-SA 3.0) license. 
2019 Music from YouTube Audio Library [Aka YAL]
2019 Music provided by RFM: https://youtu.be/8BkqPryqA5Q
2018 Music: https://www.instagram.com/jaelaredd/ 
NCU Theme Music from YouTube Audio Library [Aka YAL]
High School Hero · Silent Partner: https://www.youtube.com/watch?v=iguumobmY_4

At your local top-tier film-and-TV school, these three lurk the halls… sweeping… scrubbing…mopping…

What you drop, they pick up.  But that’s not all they’re picking up.

You see, after twenty years of cleaning up after film students, they’ve learned something – most movies are garbage.

So whenever their lunch breaks align, they catch up on the latest Hollywood has to offer.

In between taking out the trash, they’re talking trash.

Rodney – Sean – Jason… They are The Film School Janitors

Dear Universe. Please stop all war on planet Earth and give all humans Peace now 🙏🏽

Thanks a centillion for ALL the support. I love you all for helping me in so many ways with what I've loved doing for 38 years, making music. This is a human made list of life dives. I'd happily explain any process to you if you wish or are wondering something about TBD. Just ask, I'm Carl and I love sharing what I've discovered and learned especially in the songs themselves. I see songs as one of the finest ways to learn something and bolt your truth to on any subject in a direct yet maybe less imposing manner as your singing it and making it mellifluous. It's hard to sing what you feel is a lie so in my view writing truly honest lyrics and making them songs can be a mini thesis for you on any subject.

No AI here...

New tracks tagged #dna