In a universe stretched thin by eons, where stars have long faded and even atoms face their end, a single question remains: can intelligence find a way to outlast time itself?

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Credits:
Civilizations At The End Of Time:  Eternal Intelligence 
Episode 483; January 23, 2025
Written, Produced & Narrated by: Isaac Arthur
Edited by: Ludwig Luska
Graphics by: Jeremy Jozwik
Select imagery/video supplied by Getty Images 
Music Courtesy of Epidemic Sound http://epidemicsound.com/creator
Phase Shift, "Forest Night"
Chris Zabriskie, "Unfoldment, Revealment", "A New Day in a New Sector"
Stellardrone, "Billions and Billions"

Civilizations At The End Of Time: Eternal Intelligence (Narration Only)

ꍟꈤ꓄ꋪꂦꉣꌩ

Entropyvial (Prod. Manga13archive) (echo•frost)

[Lyrics]

Stoked the furnace, gears grind tight,
Knowledge burns, steam ignites.
Safety, pleasure, wisdom’s grace,
All born from the engine’s pace.
The cycle turns, the world moves on.


Flames of wisdom rise so high,
Scorch the furnace, burn the sky.
Order crumbles, chaos calls,
Ashes of ignorance blanket all.
Entropy reigns, no way to halt.


The second law, its fate is sealed,
Entropy grows, its truth revealed.
But greed blocks the vent, the heat won't fade,
Ignorance blinds, corruption degrades.
The sink is clogged, the system decays.


Flames of wisdom rise so high,
Scorch the furnace, burn the sky.
Order crumbles, chaos calls,
Ashes of ignorance blanket all.
Entropy reigns, no way to halt.


Carnot’s mind had seen the way,
No engine runs with heat to stay.
Perfection’s dream, an endless lie,
No fire lasts, no stars won’t die.


Cooling furnace, dying light,
Heat expands beyond our sight.
But greed still grows, refuses to die,
The sink is broken, smoke fills the sky.
The thermal death of all we’ve known.


Flames are fleeting, wisdom dies,
Engines fail, but we survive.
Purge the greed, expel the blind,
Keep the fire, fuel the mind.

Yet the keepers fade in time,
So carve the words, record the lines.
We will fade, but not in vain,
Until the fire dies in rain…

Wisdom-Age End

Carnot-Cycle's civilization

3. Entropy

Carl Cox - Entropy - The Leisurebowl, Stoke On Trent - 03-01-92

@c4reful @azkii1

(chew)
And I'm walking through the boneyard
Bitch I go hard, osprey in the backyard
Walk into the bone museum, tell me what do you see?
You could see it in a spiral, see it in a tree
Skeletal remains of a thousand wars
Drink the lifeblood, knowledge could be all yours
I could live a little more
Forest knocking at my door
I see birds when I kiss you
Favorite color's pink but it used to be blue
I reset my fucking mind, I reset my attitude
I'm just tryna observe, I'm not tryna intrude

(careful)
@skgpara19 we in our boneyard land we step right thru da crevice
yh im chillin wit my bro rn i dnt care bout nun of u faggots
Me angel olly kicked back in dis vc chew jus laggin
u culd get sliced up like sum chew rn if u wnna talk on me n my brethrin

I dnt get y u said dat tho we didnt do shit i guess u wnna b in da past tense
i wake up spin on da spot i dunno wht im doin i shuld go get active
I dunno y hes still around junshi wht da fk u doin jus lackin
u shuld go n better urself dunno y u sittin back jus slackin

Mel walk in da spot hello mnelo
got them man nervous jello
dunno y they talk up battles
them man need 2 give up let go

@skgpara19 in spot sk get thrown
dnt kno y they pree me @ all
dnt kno wht da fk goin on
dnt kno y i even try no more

boneyard feat careful prod azkii

you done did it now pal

this song was fun to make, i cannot lie

i made my own cover this time just to fit the occasion

ENTROPY

drones
filed like gravestones
bones
pave this road
independence broke
owned
life on loan
thrones
adorned by rotten corpse
the snakes still pass the torch over the sky

monoliths of ignorance shed no tears
on the wrists of innocence, ruled by fear

strings of lies that intertwine in your ear
deny the plight and buy some time the future's here

DRONES

The skyline flickers neon blue
Electric whispers come for you
Under the shadows they conspire
City's alive and breathing fire

We are the neon knights
We will not fall
Running on circuits breaking the walls
Through the static we ignite the fight
Light the night as the neon knights

Pixels bleed like a memory's cry
Chasing ghosts in a digital sky
In every spark we find our voice
The pulse of truth becomes our choice

Feel the hum of the city’s veins
Electric blood burns through the chains
The rhythm’s rough but we embrace
The chaos charging through this place

We are the neon knights
We will not fall
Running on circuits breaking the walls
Through the static we ignite the fight
Light the night as the neon knights

When the darkness tries to drown the spark
We’ll burn brighter brighter than the dark
No turning back we’ll redefine
The endless dawn of our design

Crescendo of Light

Neon Knights

tracklist:
Aphex Twin: Analogue Bubblebath 1 (1991)
Future Sound Of London: Papua New Guinea (1991)
Urban Shakedown: Do It Now! (1992)
DJ Seduction: Hardcore Heaven (1992)
The Prodigy: Your Love (1991)
Hedgehog Affair: Second Rush (1992)
Kaotic Chemistry: Space Cakes (1992)
Kaotic Chemistry: Illegal Subs (1992)
Bizzy B: This One Is Computerised (1992)
The Prodigy: Charly (Trip Into Drum And Bass Version) (1992)
Nebula II: Athema (1991)
Tic Tac Toe: Ephemerol (1992)
Urban Shakedown: Some Justice (1991)
SL2: On A Ragga Tip (Version) (1992)
Leviticus: Burial (Lovers Rock Mix) (1994)
Phuture Assassins: Roots’N’Future (Reflections In Dub) (1993)
Dance Conspiracy: Dub War (Chapter One) (1992)
Cosmo And Dibs: Star Eyes (Remix) (1993)
Nebula II: C.O.D. Rider (1992)
The Prodigy: Out Of Space (1992)
Foul Play: Screwface (1993)
Power-Pill: Pac-Man (Ghost Mix) (1992)
Top Buzz: Living In Darkness (1992)
Shut Up And Dance Featuring Peter Bouncer: Raving I’m Raving (1992)
Aphex Twin: Polynomial-C (1992)

Conehead at Kallio Block Party 2024, ExH Stage

BUFFALO, NY — April 16, 2025 — A new #research paper was #published in Aging (Aging-US) Volume 17, Issue 3, on March 12, 2025, titled “DNA methylation entropy is a biomarker for aging.”

Researchers Jonathan Chan, Liudmilla Rubbi, and Matteo Pellegrini from the University of California, Los Angeles, led a study that discovered a new way to measure changes in DNA that can help predict a person’s age. This method focuses on how random certain chemical tags on DNA become over time. The team compared this new measurement, called methylation entropy, to existing methods and found it performed just as well—or even better. These findings support the idea that changes in our epigenetic information are closely linked to aging and could offer new tools for studying age-related diseases.

The study focused on DNA methylation, a process where chemical marks are added to DNA and help control which genes are turned on or off. Scientists have traditionally measured average methylation levels to estimate biological age using “epigenetic clocks.” This study, however, takes a different approach. The researchers used buccal swabs (cells from inside the cheek) from 100 individuals between ages 7 and 84 and applied targeted bisulfite sequencing techniques to measure methylation entropy across 3,000 regions of the genome.

Entropy in this context reflects how disordered or varied the methylation patterns are at certain sites on the DNA. The researchers discovered that as people age, the entropy of methylation at many locations changes in a reproducible way. Sometimes it increases, reflecting more random patterns, and sometimes it decreases, showing more uniformity. These shifts are not always tied to how much methylation is happening, which suggests entropy provides new information beyond what traditional methods can offer.

To test how well this new metric could predict age, the team used both statistical and machine learning models. They found that methylation entropy predicted age as accurately as traditional methods, and the best results came from combining entropy with other measurements like average methylation and a method called CHALM. These combined models were able to estimate age with an average error of just five years.

"[...] methylation entropy is measuring different properties of a locus compared to mean methylation and CHALM, and that loci can become both more or less disordered with age, independently of whether the methylation is increasing or decreasing with age."

This research supports the growing theory that aging is partly caused by a gradual loss of epigenetic information—the biological “instructions” that help keep our cells working properly. This insight also connects with recent studies suggesting that restoring this lost information might reverse some signs of aging. While more research is needed to study methylation entropy in other tissues, this work points to a more precise and powerful way to measure biological aging, which could influence the future of aging-related treatments and therapies.

Read the full paper: DOI: https://doi.org/10.18632/aging.206220

Corresponding author: Matteo Pellegrini - matteope@gmail.com

Sign up for free Altmetric alerts about this article - 
https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206220

Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts

Keywords: entropy, DNA methylation, aging, epigenetics, epigenetic clocks

To learn more about the journal, please visit our website at https://www.Aging-US.com​​ and connect with us on social media at:

Facebook - https://www.facebook.com/AgingUS/
X - https://twitter.com/AgingJrnl
Instagram - https://www.instagram.com/agingjrnl/
YouTube - https://www.youtube.com/@AgingJournal
LinkedIn - https://www.linkedin.com/company/aging/
Pinterest - https://www.pinterest.com/AgingUS/
Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc

MEDIA@IMPACTJOURNALS.COM

Aging (Aging-US)

DNA Methylation Entropy: A New Way to Track and Predict Aging

Entropy Explained

Pluperfect, by Dark Company.
From CD 1, 'SNAFU', of the triple CD album 'A for Acronym'.

PLUPERFECT
Tabletop toyset map of the world
Jigsaw planisphere, edges all curled
Worn out games book, puzzles all done
I looked inside to see what I'd won
I'd won a seat on the train to Strangeville
Or a place on the daily treadmill
I'd won a ticket to a 'no prize' win
Or a packet of bent penny pins

Mandelbrot paint set, infinity waits
Half finished painting of a garden gate
Last year's calender was there on the wall
I checked the dates, was I there at all?
I looked out the window, was I laying low
Or was I waiting for the Late Late Show
I couldn't figure out where I'd gone
But I must have done cos I lingered on

Sinewave eyeballs in a metal made head
Robotic vision that can see through lead
Nostradamus quatrains I could decode
Told me I was going into overload
Told me I'd lived twice every day
That I had to listen to what I'd say
Told me I'd had way too much fun
That I should have walked when I'd run

Lyrics by Peter Greatorex 4th November 2010.
Copyright ℗ 2010 D & G Music / Explicit Music.

Music by G. Davies/P. Greatorex.

This arrangement by Dark Company.

Vocals and rhythm guitar recorded at Wud Records Studio One, Exeter, 2015.
Everything else recorded at Wud Records Studio One, Europe, 2020.
Engineered, mixed and produced at Wud Records Studio One, Central Europe, 2024.

Cover Art:
“Bad Habits 1d” by Peter Greatorex
See: https://www.wudrecords.co.uk/artists/dark-company/original-artwork-by-peter-greatorex/original-artwork-by-peter-greatorex-gallery-1/

Copyright © 2025 Wud Records.

Performers:
‘Speedy’ Pete Greatorex – lead vocal
Zakk Black – lead and rhythm guitars
Maxx Damage – bass
Sven Stiglund – drums

Fun Facts:
* The lyrics for this song were written 4th November 2010.
* This is a song that Pete never sang a proper studio version of and his vocals were lifted from the demo and cleaned up a bit.
* Well, quite a lot actually. 🙂
* This song is mostly E7, D no 3rd and Asus4.
* Rhythm guitars by the Ice Maiden and Nicodemus.
* The lead guitar part at the start that was deemed reasonable was played on the Ice Maiden.
* There will be more lead guitar but it has not been recorded yet.

See also:
https://www.wudrecords.co.uk/artists/dark-company/
https://www.wudrecords.co.uk/artists/dark-company/a-for-acronym-cd-1-snafu/
https://linktr.ee/dark.company
https://www.explicitmusic.co.uk/lyrics-information/dark-company/a-for-acronym/pluperfect

A for Acronym CD 1: SNAFU

Pluperfect

Downloads

Dark Company: Pluperfect (alpha mix)

TEX4ROMMEX Records:
Artists:
onearmwolf 
SurrendaArmani!NTAKE
echo•frost
i730BLEEP!
Mvttbur
Mattmelodyb
wavematthew$Clan
AC300
2ToneMotorolaPhoneShawtyyy
BeaconSensi

i jus' upload subpar (i think) music lmao
aside from that, uh
listen if you want, this is just an archive of music i'm building
i jus be cookin up random ahh songs
if you wanna use em, just credit me, that's all i ask



digital footprint? what's that?

angel the fairy moth AKA The Unforgiving Sentinel

shoutout 2 @c4reful @azkii1

All songs are released into the public domain. 
Please feel free to download them.
No need to credit me, and you're even free to sell it if you like.
Hmm, but if you like it, I would love for you to help infected&spread my lyrics!
Link Free.  feel free to expose it anywhere you like.

I am a bacterium with mycolic acid on its surface.
I will damage your lungs.
And..... Smash commercialism.

Cancer and aging are two sides of age-related tumorigenesis.

The mission of the journal is to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population.

The journal aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.)

Read about the Aging (Aging-US) Scientific Integrity Process: https://aging-us.com/scientific-integrity

HYTKY is an established non-profit electronic music association located in Helsinki.

SC msgs blocked. Contact: info@wudrecords.co.uk
UK/EU indie label founded 1984. Eclectic, outsider, progrock composition and musicianship. Demos, oddities, archives, unfinished works appear here. Downloads from Bandcamp. We tweet all reposts. Wud! You have just been wudded. ;-)

We're very sorry but we're unable to reply to SC messages. We can read them but cannot reply. Please email info@wudrecords.co.uk instead. We answer most emails within a week.

ACTIVE ARTISTS:
Flicker, Dark Company, Pok the Bard, The Bastard Sons of Dennis

LEGACY ARTISTS:
Alchemeon, Clonk!, Dr Watson, The Ug Brothers, Alien Heat, Rough Terrain, The Subterraineans, The Addled Eggs, The Masters of Drone, Laughing Sun, Wud, Lemming Meringue, Sirius Rising, Now, Fooog Dinboffin and the Release, Mark Drower and the Everyones

ARCHIVE ARTISTS:
Andromeda, Critical Error, Dayglow, Demon Groove Lizards, Ember, Fruit Bats, Goodstaff, Guarana, Murdock, Prism, Pyg, Recluse, Search Party, Spacegoats, Stephen Yates, The Chillun, Watershed

* For DIY musicians:

Looking to grow your fanbase? Here's a proven strategy for success. It's a bit time-consuming at first because you need to work at it often. However, the awesome results will make it worth your while:

http://www.wudrecords.co.uk/miscellaneous/be-discovered-on-social-media

That article was published in March 2017. While some of the links may no longer work, the theory absolutely will. Try it for yourself!

* Unfortunately...

Due to brexshit, broken britain, rip-off britain, corruption, lies and bias in the media, bigotry, racism, intolerance, polarisation, the fact that some of our family members would not be allowed to remain post-brexit, state-sponsored child trafficking (yes, that's right, we said it - it's pretty shocking, start reading from here if you don't believe it: https://forced-adoption.com/), an increasing sense of frustration and exasperation, and general total weariness of being treated with nothing but derision, ignorance and contempt by the entire shebang since the early 80s, we decided enough was enough and moved our entire operation from brexeter in the uk to begin our grand brexodus in 2017. We are now brefugees, living in brexile very near the border of the Czech Republic, Austria and Germany. If you live in (the crumbling remains of) the uk, do yourself a favour and leave. The upgrade in life quality will blow your mind.

* What do we stand for as a label?

We support all independent musicians who are doing something we find interesting. Our team members all have formal music education qualifications.

We are against corporate brainwash muzak, their puppet friends in the mass media, and many other corporate activities. We will fight their desecration of music until either it stops or we die. 

We believe in helping others in the face of corrupt laws and a broken system. We are pro democracy, green energy and free speech.

We're politically liberal. We cannot support the republicans, maga or gun violence in the usa. We don't see there's any real difference, other than in name, between the christian far right in the USA and the taliban in Afghanistan.

In the uk we are broadly pro LibDem/Green/Labour/SNP. We are VERY anti-tory, bnp, ukip, and any of their friends and associates. We have no trust at all in the uk right wing press monopoly and the bbc. Beware the bbc and its claims of neutrality. It is the propaganda mouthpiece of the tory party. It even charges a propaganda tax called the licence fee. But we like Test Match Special and Radio 6, so does that make us hypocrites...? Hmm.

We support independence for Scotland, Wales, Northern Ireland and Cornwall. We support the individual and the underdog. We are anti-putin and his war, and pro-Ukraine.

Please notice the careful use of capitals. Capital letters imply respect!

We're only interested in the colour of your soul. Not your skin, hair or socks.

We like cricket! Most of us support Somerset County Cricket Club.

EVERY FRI & SAT

DJ Mixes from the biggest Liverpool DJ's & Venues from Merseyside & a few beyond!

Club Nights, Reunions, Festivals, Weekenders, Events

Got any old mix tapes/Flyers from Liverpool/North West England? get in touch with us

Full mixes could be added at any time!!!

https://twitter.com/oldskoolpool

Beat Uploads Are on Hold Until Further Notice due to label and contract deals as of MAR2024
-PM For Rap Beats 
-All EDM is strictly a Preference that I have a deep passion for
-Ask for any style and i'll deliver :)

"All that I want in this life is the chance to do my thing"
~Forever Remember Me By My Music~


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Rap: Beats/Custom Beats Available, PM For Details
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If any track is used, credit me. Credit where credit is due.

Love ya'll, help me chase my dreams🤍

New tracks tagged #entropy