The ketogenic (keto) diet has surged in popularity, with many touting its weight loss and metabolic benefits. However, some individuals—particularly those following a low-carb, high-fat regimen—experience a significant rise in LDL cholesterol, a phenomenon now known as the Lean Mass Hyper-Responder (LMHR) phenotype. What does this mean for cardiovascular risk?
In this episode, Chadi is joined by three of the lead investigators of the KETO-CTA study, recently published in The American Journal of Clinical Nutrition. They break down their findings on how the keto diet affects coronary plaque formation and what it could mean for LMHR individuals.
This is Part 1 of a two-part series. Next week, Chadi brings in a contrasting perspective on the study’s conclusions.
A must-listen series for anyone interested in the intersection of diet, cholesterol, and cardiovascular health.
View the KETO-CTA study.
https://www.sciencedirect.com/science/article/pii/S2772963X25001036

Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/

Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Part 1: The Keto Heart Study

In this episode of CEPR’s Unpacking the Court series, we sit down with Hayley Brown, Research Associate at CEPR, to unpack the Dobbs v. Jackson Women’s Health Organization decision and its disproportionate effects on reproductive rights for people with disabilities.  We also discuss the Acheson Hotels LLC v. Laufer ruling and its threat to enforcement of the Americans with Disabilities Act (ADA). We explore how the Court’s pivot toward 'originalism' has undermined bodily autonomy and civil rights, the unique barriers disabled individuals face under new abortion restrictions, and what state- and community-driven strategies can do to defend inclusive justice.

Unpacking the Court Series: Dobbs v. Jackson Decision (Part 3 of 3)

Last week, Chadi and researchers explored the KETO-CTA study, which investigated the effects of the ketogenic diet on coronary plaque formation in Lean Mass Hyper-Responders (LMHR), or individuals who experience significant LDL cholesterol elevations on low-carb diets.
This week, the other side of the conversation is presented.

A leading cardiologist joins the show to critically examine the KETO-CTA study findings, questioning their clinical significance and broader applicability. What do these results really mean for cardiovascular risk in the general population? Should elevated LDL in the context of good metabolic health be treated the same as traditional hyperlipidemia?

This episode dives into the nuances of lipidology, the role of LDL in atherosclerosis, and the complexity of applying study findings to real-world patients.

Whether you're a clinician, researcher, or just interested in the science behind diet and heart health, this conversation is essential listening.

View the KETO-CTA study.
https://www.sciencedirect.com/science/article/pii/S2772963X25001036

Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/

Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Part 2: The Keto Heart Study

This week, editors Peter Suderman, Katherine Mangu-Ward, Nick Gillespie, and Matt Welch critique President Donald Trump's proposed tax legislation and its fiscal irresponsibility, discuss the national deficit and credit rating downgrade, examine the media and political cover-up of former President Joe Biden's cognitive decline, and highlight the broader consequences of institutional failure and partisan denial.

0:00—"Big beautiful bill" breakdown

2:21—The MAGA (Money Account for Growth and Advancement) baby account boondoggle

13:54—SALT cap debate and wealthy blue state subsidies

19:12—Proposed Medicaid cuts and "fiscal illusions"

23:02—Moody's Ratings downgraded the U.S. credit rating system. Does this matter?

27:09—The Supreme Court takes up birthright citizenship and nationwide injunctions

34:41—Who pays tariffs? Trump vs. Walmart

40:24—Listener question: Is the economic inequality data bad?

46:09—What did we know about Biden's health and when did we know it?

48:24—How the media didn't responsibly report on Biden's health

1:01:04—Weekly cultural recommendations

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The GOP Budget Is Big, Bloated, B.S.

Former FDA Commissioner Robert Califf returns to the show for an in-depth discussion on the integration of artificial intelligence into regulatory processes, including how AI is currently being used—and should be used—in drug and medical device approvals, the detection and review of fraudulent data, and clinical decision support systems. He also explores the boundaries between algorithmic automation and human judgment, emphasizing the importance of maintaining transparency, accountability, and trust in an increasingly data-driven regulatory landscape.

Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/

Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

AI in Regulatory Processes With Robert Califf

In recognition of World Elder Abuse Awareness Day (June 15), hosts Payal Nanavati and Savanna Williams talk to Jen Mika about best practices that providers should keep in mind to combat elder abuse, neglect, and exploitation.

This podcast episode features the following speakers:
-Jen Mika is a counsel in Crowell’s DC office and is considered a leading authority on Elder Law in the District of Columbia. Jen was the District of Columbia’s first prosecutor solely focused on investigating and prosecuting financial exploitation of elders and vulnerable adults.

Payers, Providers, and Patients – Oh My!: World Elder Abuse Awareness Day

Dena Marrinucci, PhD, co-founder and COO of Truvian Health, joins the show to discuss her mission to transform blood diagnostics through a point-of-care device that delivers rapid, actionable results. She shares the origin story of founding Truvian in 2015—coincidentally just weeks before the Theranos exposé—and reflects on navigating industry skepticism in the post-Theranos landscape. Marrinucci also outlines the company’s FDA submission process, the importance of empowering immediate patient-provider decision-making, and what the initial panel of 30+ lab tests offers for routine care, among so much more.

Read the article on the Truvian Health blood test.
https://www.newsweek.com/truvian-lab-company-blood-test-device-theranos-health-care-1997422

Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/

Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Changing the Blood Diagnostic Industry With Dena Marrinucci

A quick roundup episode of major news and health policy developments from The American Journal of Managed Care. 

Managed Care Cast News Roundup: June 17, 2025

Dr. Vivek Subbiah returns for another edition of Vivek’s Takes, offering his expert insights on the standout science from the 2025 ASCO Annual Meeting. He breaks down key developments including trispecific antibodies, the growing role of radioligand therapies, a new standard of care in small cell lung cancer, and paradigm-shifting data in adjuvant therapy for colorectal cancer. The discussion also highlights a long-term exercise intervention, adjuvant vaccine studies, ctDNA and MRD integration, resistance mechanisms, artificial intelligence, and other emerging trends shaping the future of oncology.

Check out Chadi’s website for all Healthcare Unfiltered episodes and other content. www.chadinabhan.com/

Watch all Healthcare Unfiltered episodes on YouTube. www.youtube.com/channel/UCjiJPTpIJdIiukcq0UaMFsA

Vivek’s Takes: ASCO 2025

Gastropsychiatrist Eva Szigethy, MD, PhD, and Benjamin Cohen, MD, Cleveland Clinic, discuss quality of life improvement in terms of behavioral health and inflammatory bowel disease (IBD).

Addressing the Physical, Psychological Complexity of IBD Through Coordinated Care

Crowell & Moring LLP is an international law firm with approximately 550 lawyers representing clients in high-stakes litigation and arbitration, regulatory, and transactional matters. The firm is internationally recognized for its representation of Fortune 500 and emerging companies as well as its ongoing commitment to pro bono service, diversity, value-based billing, and legal project management.

Founded in 1968, Reason is the planet's leading source of news, politics, and culture from a libertarian perspective. Our podcast offerings include:

The Reason Roundtable
Every Monday, the libertarian editors of the magazine of “Free Minds and Free Markets”—Matt Welch, Nick Gillespie, Katherine Mangu-Ward, and Peter Suderman—discuss and debate the week’s biggest stories and what fresh hell awaits us all.

The Reason Interview with Nick Gillespie
Want to know what comes next in politics, culture, and libertarian ideas? Reason’s Nick Gillespie hosts relentlessly interesting interviews with the activists, artists, authors, entrepreneurs, newsmakers, and politicians who are defining the 21st century.

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Reason presents a libertarian-themed debate series recorded monthly before a live audience in New York City. Moderated by former Barron's Economics Editor Gene Epstein, the Soho Forum features Nobel prize winners, radical thinkers, and other public intellectuals facing off over the future of bitcoin, veganism, sex work, illegal drugs, electric vehicles, abortion, robotics, government debt, and other controversial topics.

Healthcare Unfiltered is an honest, raw, timely podcast tackling any and all topics in healthcare that affect stakeholders. Dr. Chadi Nabhan uses his dynamic conversational skills to challenge his guests to address controversial and important topics. He also brings on world renowned experts to discuss clinical advances in medicine.

New tracks tagged #health care