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With 27 years in health insurance and a lifetime of witnessing his family navigate health challenges, Jason J. Paul's insights are unparalleled.

In 2020, his wife was diagnosed with a malignant brain tumor, altering his perspective on insurance, and driving his mission to assist consumers.

My friends, Insurance is crucial for safeguarding your financial health.

Listen and learn from Jason in this distinctive and enlightening conversation where you will discover what you did not know you needed to know.

http://www.karlsterling.com

570 WSYR "YOUR HEALTH MATTERS" Ep #10 Your Insurance Strategy Matters w/ Jason Paul

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                                           Fancy optimizing your health and living a longer and fuller life with plant-based recipes?Then this may be the book for you! Looking to adopt a healthy vegetarian diet this New Year but don’t know where to start?No worries, we’ve got you covered!Authors and leading plant-based nutrition experts Julieanna Hever and Ray Cronise have spent over a decade researching diet and nutrition, analyzing longevity studies, and helping their clients achieve sustainable, lasting health benefits by adopting a whole-food, plant-based diet.So what are you waiting for? Dive straight in

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This episode aired on April 21, 2024 on News Radio 570, WSYR

In this episode of "Your Health Matters," host Karl Sterling and guest Dr. Joe Barry discuss the critical links between obesity, inflammation, and cancer. They explore how fat cells contribute to inflammation and how a non-inflamed body can better prevent cancer by cleaning up precancerous cells. Dr. Barry introduces a new blood test from Greece that detects circulating cancer cells, providing an early warning system for cancer detection. The conversation also touches on the importance of lifestyle choices, such as diet and exercise, in cancer prevention. Additionally, Karl reflects on the value of free will and the power of human connection, emphasizing the need for community and genuine communication.

570 WSYR "YOUR HEALTH MATTERS" Ep #14: CANCER & CANCER SCREENINGS with Dr. Joe Barry

BUFFALO, NY- April 23, 2024 – A new #researchpaper was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 7, entitled, “The coupling between healthspan and lifespan in Caenorhabditis depends on complex interactions between compound intervention and genetic background.”

Aging is characterized by declining health that results in decreased cellular resilience and neuromuscular function. The relationship between lifespan and health, and the influence of genetic background on that relationship, has important implications in the development of pharmacological anti-aging interventions. 

In this new study, researchers Stephen A. Banse, E. Grace Jackson, Christine A. Sedore, Brian Onken, David Hall, Anna Coleman-Hulbert, Phu Huynh, Theo Garrett, Erik Johnson, Girish Harinath, Delaney Inman, Suzhen Guo, Mackenzie Morshead, Jian Xue, Ron Falkowski, Esteban Chen, Christopher Herrera, Allie J. Kirsch, Viviana I. Perez, Max Guo, Gordon J. Lithgow, Monica Driscoll, and Patrick C. Phillips from the University of Oregon, The State University of New Jersey (Rutgers), The Buck Institute for Research on Aging, and National Institute on Aging assessed swimming performance as well as survival under thermal and oxidative stress across a nematode genetic diversity test panel to evaluate health effects for three compounds previously studied in the Caenorhabditis Intervention Testing Program and thought to promote longevity in different ways – NP1 (nitrophenyl piperazine-containing compound 1), propyl gallate, and resveratrol. 

“Overall, we find the relationships among median lifespan, oxidative stress resistance, thermotolerance, and mobility vigor to be complex.” 

The researchers showed that oxidative stress resistance and thermotolerance vary with compound intervention, genetic background, and age. The effects of tested compounds on swimming locomotion, in contrast, are largely species-specific. In this study, thermotolerance, but not oxidative stress or swimming ability, correlates with lifespan. Notably, some compounds exert strong impact on some health measures without an equally strong impact on lifespan. 

“Our results demonstrate the importance of assessing health and lifespan across genetic backgrounds in the effort to identify reproducible anti-aging interventions, with data underscoring how personalized treatments might be required to optimize health benefits.”

DOI - https://doi.org/10.18632/aging.205743

Corresponding authors - Gordon J. Lithgow - glithgow@buckinstitute.org, Monica Driscoll - driscoll@dls.rutgers.edu, and Patrick C. Phillips - pphil@uoregon.edu

About Aging-US

Aging publishes research papers in all fields of aging research including but not limited, aging from yeast to mammals, cellular senescence, age-related diseases such as cancer and Alzheimer’s diseases and their prevention and treatment, anti-aging strategies and drug development and especially the role of signal transduction pathways such as mTOR in aging and potential approaches to modulate these signaling pathways to extend lifespan. The journal aims to promote treatment of age-related diseases by slowing down aging, validation of anti-aging drugs by treating age-related diseases, prevention of cancer by inhibiting aging. Cancer and COVID-19 are age-related diseases.

Please visit our website at https://www.Aging-US.com​​ and connect with us:

Facebook - https://www.facebook.com/AgingUS/
X - https://twitter.com/AgingJrnl
Instagram - https://www.instagram.com/agingjrnl/
YouTube - https://www.youtube.com/@AgingJournal
LinkedIn - https://www.linkedin.com/company/aging/
Pinterest - https://www.pinterest.com/AgingUS/
Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc

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Aging (Aging-US)

The Coupling Between Healthspan and Lifespan in Caenorhabditis Depends on…

BUFFALO, NY- April 24, 2024 – A new #researchpaper was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 7, entitled, “Using genetics and proteomics data to identify proteins causally related to COVID-19, healthspan and lifespan: a Mendelian randomization study.”

The COVID-19 pandemic poses a heavy burden on public health and accounts for substantial mortality and morbidity. Proteins are building blocks of life, but specific proteins causally related to COVID-19, healthspan and lifespan, have not been systematically examined. In this new study, researchers Jie V. Zhao, Minhao Yao, and Zhonghua Liu from The University of Hong Kong and Columbia University conducted a Mendelian randomization study to assess the effects of 1,361 plasma proteins on COVID-19, healthspan and lifespan, using large GWAS of severe COVID-19 (up to 13,769 cases and 1,072,442 controls), COVID-19 hospitalization (32,519 cases and 2,062,805 controls) and SARS-COV2 infection (122,616 cases and 2,475,240 controls), healthspan (n = 300,477) and parental lifespan (~0.8 million of European ancestry).

“We included both COVID-19 and healthspan and lifespan in the outcome, because COVID-19 which occurred in recent years reflects a new threat to longevity, whilst healthspan and lifespan reflect overall morbidity and mortality.”

The researchers identified 35, 43, and 63 proteins for severe COVID, COVID-19 hospitalization, and SARS-COV2 infection, and 4, 32, and 19 proteins for healthspan, father’s attained age, and mother’s attained age. In addition to some proteins reported previously, such as SFTPD related to severe COVID-19, the team identified novel proteins involved in inflammation and immunity (such as ICAM-2 and ICAM-5 which affect COVID-19 risk, CXCL9, HLA-DRA and LILRB4 for healthspan and lifespan), apoptosis (such as FGFR2 and ERBB4 which affect COVID-19 risk and FOXO3 which affect lifespan) and metabolism (such as PCSK9 which lowers lifespan). They found 2, 2, and 3 proteins shared between COVID-19 and healthspan/lifespan, such as CXADR and LEFTY2, shared between severe COVID-19 and healthspan/lifespan. Three proteins affecting COVID-19 and seven proteins affecting healthspan/lifespan are targeted by existing drugs.

“Our study provided novel insights into protein targets affecting COVID-19, healthspan and lifespan, with implications for developing new treatment and drug repurposing.”

DOI - https://doi.org/10.18632/aging.205711

Corresponding authors - Jie V. Zhao - janezhao@hku.hk, and Zhonghua Liu - zl2509@cumc.columbia.edu

Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts

About Aging-US

Aging publishes research papers in all fields of aging research including but not limited, aging from yeast to mammals, cellular senescence, age-related diseases such as cancer and Alzheimer’s diseases and their prevention and treatment, anti-aging strategies and drug development and especially the role of signal transduction pathways such as mTOR in aging and potential approaches to modulate these signaling pathways to extend lifespan. The journal aims to promote treatment of age-related diseases by slowing down aging, validation of anti-aging drugs by treating age-related diseases, prevention of cancer by inhibiting aging. Cancer and COVID-19 are age-related diseases.

Please visit our website at https://www.Aging-US.com​​ and connect with us:

Facebook - https://www.facebook.com/AgingUS/
X - https://twitter.com/AgingJrnl
Instagram - https://www.instagram.com/agingjrnl/
YouTube - https://www.youtube.com/@AgingJournal
LinkedIn - https://www.linkedin.com/company/aging/
Pinterest - https://www.pinterest.com/AgingUS/
Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc

MEDIA@IMPACTJOURNALS.COM

Identifying Proteins Causally Related to COVID-19, Healthspan and Lifespan

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This episode aired on Sunday, April 28, 2024 on News Radio 570 WSYR (and 106.9 FM). Your Health Matters with host, Karl Sterling.

Listen and learn as we dive into a discussion about exercise in relation to longevity, brain health, lifespan, health span, and qualtiy of life.

Time - it's the one thing we all share but often feel slipping away. On the podcast this week, we took a moment to reflect on its swift passage and the importance of making every second count. I shared my thoughts on why cherishing time helps us prioritize what truly matters in life and health. A reminder to live fully, with gratitude for each tick of the clock.

What's the connection between toe strength and your risk of falling? It might surprise you, as it did our listeners, that it's a crucial predictor! On "Your Health Matters," we not only discussed this fascinating fact but also demonstrated a simple exercise to test and improve your toe strength. A little focus on those toes could mean better balance and stability.

This week's conversation touched on something vital: the power of purpose. It's not just about losing weight or gaining muscle; it's the 'why' behind these goals that truly drives change. We delved into how understanding your motivations can be the key to a sustainable, healthier lifestyle. Inspirational stuff for anyone looking to transform their health journey.

Muscle strength isn't just for athletes; it's for everyone. In the latest podcast, we discussed the critical role muscle mass plays as we age. From reducing fall risk to improving mobility, preserving muscle is integral for longevity. Let's change the narrative on aging and strength - it's not an option, it's a necessity for a life well-lived.

BOOK OF THE WEEK: FOREVER STRONG by  @DrGabrielleLyon  
PODCAST OF THE WEEK:  @JockoPodcastOfficial  

Visit http://www.karlsterling.com

315-935-7488

570 WSYR "YOUR HEALTH MATTERS" Ep #15: Exercise for Longevity of the Brain & Body

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                                           Fancy optimizing your health and living a longer and fuller life with plant-based recipes?Then this may be the book for you! Looking to adopt a healthy vegetarian diet this New Year but don’t know where to start?No worries, we’ve got you covered!Authors and leading plant-based nutrition experts Julieanna Hever and Ray Cronise have spent over a decade researching diet and nutrition, analyzing longevity studies, and helping their clients achieve sustainable, lasting health benefits by adopting a whole-food, plant-based diet.So what are you waiting for? Dive straight in

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BUFFALO, NY- May 20, 2024 – Aging is a contributor at the 2024 Systems Aging Gordon Research Conference (GRC) on “Systems Modeling, Aging Biomarkers, and Longevity Interventions” — taking place from June 2–7, 2024, in Castelldefels, Barcelona, Spain.

“The conference will present recent advances in systemic rejuvenation, multi-omics approaches, applications of machine learning/artificial intelligence, and approaches for enhancing the chance of successfully translating basic research results to the clinic.” – GRC.org

Additionally, many Aging authors have been invited to speak and lead discussions at the 2024 Systems Aging GRC. Among them are distinguished members of Aging’s Editorial Board, including Steve Horvath, David Sinclair, Vera Gorbunova, Vadim Gladyshev, Guido Kroemer, and Anne Brunet.

“The program will include speakers from diverse fields who are united in their pursuit of pioneering longevity and rejuvenating interventions. The 2024 Systems Aging GRC also aims to present advanced approaches for identifying comprehensive interventions that alleviate age-related pathology.” – GRC.org

About Aging:

Aging publishes research papers in all fields of aging research, including but not limited to aging processes (from yeast to mammals), cellular senescence, age-related diseases (such as cancer and Alzheimer’s disease) and their prevention and treatment, anti-aging strategies and drug development, and, importantly, the role of signal transduction pathways in aging (such as mTOR) and potential approaches to modulate these signaling pathways to extend lifespan.

The journal aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.)

Aging is indexed by PubMed/Medline (abbreviated as “Aging (Albany NY)”), PubMed Central, Web of Science: Science Citation Index Expanded (abbreviated as “Aging‐US” and listed in the Cell Biology and Geriatrics & Gerontology categories), Scopus (abbreviated as “Aging” and listed in the Cell Biology and Aging categories), Biological Abstracts, BIOSIS Previews, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science).

Please visit our website at https://www.Aging-US.com​​ and connect with us:

SoundCloud - https://soundcloud.com/Aging-Us
Facebook - https://www.facebook.com/AgingUS/
X - https://twitter.com/AgingJrnl
Instagram - https://www.instagram.com/agingjrnl/
YouTube - https://www.youtube.com/@AgingJournal
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Aging Contributes to 2024 Systems Aging Gordon Research Conference

This episode aired on 5/19/24 on News Radio 570 WSYR.

Listen and learn from functional podiatrist / movement specialist extraorinairre, Dr. Emily Splichal about the important relationship betweem Walking Speed and Longevity.

http://www.karlsterling.com

570 WSYR "YOUR HEALTH MATTERS" Ep #18: Dr. Emily Splichal | Walking Speed & Longevity

A traditional, twice-monthly, peer-reviewed, open-access journal covering all areas of research on aging and age-related diseases, including cancer and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome.

Read about the Aging (Aging-US) Scientific Integrity Process: https://aging-us.com/scientific-integrity

Always learning, always growing, and always sharing with others, host Karl Sterling brings you conversations with extraordinary experts! We hope you enjoy our interviews.

Karl works as a neurorehabilitation specialist based in Syracuse, New York, and is the creator of the Parkinson’s Regeneration Training ® education program. While his extensive experience as a trainer includes working with a variety of populations, he primarily specializes in working with clients who have movement disorders such as Parkinson’s disease, MSA (Multiple System Atrophy), MS, Charcot-Marie-Tooth, Alzheimer’s, Epilepsy, Autism, and more.

Karl travels extensively throughout the United States and internationally as public speaker, keynote speaker, and educator in the movement disorder, human movement, and personal growth arenas. He is the Chief Operating Officer of Agile Human Performance, Inc and owner/CEO of PhysioChains LLC which currently offers Parkinson’s Regeneration Training ® courses worldwide.

In addition, Karl is the founder and president of the Parkinson’s Global Project, a foundation dedicated to funding research and helping people with Parkinson’s and other movement disorders all over the world.

New tracks tagged #healthspan