On this April 1st Podcast Steven hosts his primo Omar Gonzalez & returning guest Freddy Morales.  The fellas talk about Texas heat, dancing horses, banda music, kids getting sick, going to the ER, blue chew & much more.

Episode #151 "My Last Podcast"

May 1, 2023

The Daily Mojo is 2 hours of news, commentary, comedy, and auditory deliciousness.

Now on Spreely TV!
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"Our 1000th Show!"

Birds aren't real! But this time, it's actually true. Hunter Biden may be facing the music today in Arkansas. Cattle mutilations should still be a topic of discussion. Body Integrity Disorder is now being lumped into LGTBQI - or whatever. Oh, and air pollution now causes heart problems - not the jab.

Plus, wait'll you hear which story is fake in Headlines! 

Thank you for supporting the Mojo 5-0 platform! We stand for the Constitution and individual responsibility. We especially love 1A &amp; 2A. Join us and help take our country back!
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Ep 050123: Our 1000th Show!

Synopsis: 
Sekar Kathiresan is the Co-Founder, CEO and Board Member of Verve Therapeutics, a clinical-stage biotechnology company developing gene editing medicines to treat patients with cardiovascular disease. Sekar discusses Verve’s work developing single-course, in vivo liver-directed gene editing medicines for patients with and at risk of cardiovascular disease and what the company pipeline looks like. He talks about the evolution of his pitch after years of experience with fundraising, how he approaches team building, and his perspective on why people are leaving academia for biotech. He also discusses what he’s learned about being a board member and what a good board for a pre-revenue biotech looks like.

Biography: 
Dr. Sekar Kathiresan is co-founder and CEO of Verve Therapeutics, a biotechnology company pioneering a new approach to the care of cardiovascular disease, transforming treatment from chronic management to single-course gene editing medicines. Dr. Kathiresan is a cardiologist and scientist who has focused his career on understanding the inherited basis for heart attack and leveraging those insights to improve the care of cardiovascular disease. Based on his groundbreaking discoveries in human genetic mutations that confer resistance to cardiovascular disease, Dr. Kathiresan co-founded Verve Therapeutics with a vision to create a pipeline of single-course, gene editing therapies focused on addressing the root causes of this highly prevalent and life-threatening disease. Today, Verve is advancing two initial programs that target PCSK9 and ANGPTL3, respectively – genes that have been extensively validated by Dr. Kathiresan and others as targets for lowering blood lipids, such as low-density lipoprotein cholesterol, which is a major driver of cardiovascular disease.

Prior to joining Verve, Dr. Kathiresan’s roles included director of the Massachusetts General Hospital (MGH) Center for Genomic Medicine, director of the Cardiovascular Disease Initiative at the Broad Institute and professor of medicine at Harvard Medical School. There, Dr. Kathiresan’s research laboratory focused on understanding the inherited basis for blood lipids and myocardial infarction. For his research contributions, he has been recognized by the American Heart Association with its highest scientific honor – a Distinguished Scientist Award and by the American Society of Human Genetics with the 2018 Curt Stern Award.

Dr. Kathiresan graduated summa cum laude with a B.A. in history from the University of Pennsylvania and received his M.D. from Harvard Medical School. He completed his clinical training in internal medicine and cardiology at MGH and his postdoctoral research training in human genetics at the Framingham Heart Study and the Broad Institute.

Single-course gene editing for cardiovascular disease, Sekar Kathiresan, Co-Founder & CEO, Verve Tx

Synopsis: 

Samir Ounzain is the CEO and Co-Founder of HAYA Therapeutics, a precision medicines company developing RNA-guided programmable therapeutics targeting the regulatory genome for serious health conditions including fibrosis. Samir discusses the current landscape as it relates to precision medicine and genomic medicine and what his team is hoping to achieve over the next year. He also talks about the evolution of his approach to fundraising and shares his thoughts on applying machine learning and AI at the intersection of biology. Finally, with a distributed team in both the US and Switzerland, he discusses the challenges that come with that, and how he approaches team building.

Biography: 

Samir Ounzain is a molecular biologist with over 15 years of experience exploring the dark matter of the genome and its roles in development and disease. Prior to founding HAYA Therapeutics, Samir was a Project Leader and Research Fellow at the Lausanne University Hospital (CHUV), where his research efforts directly led to the discovery of hundreds of novel heart-enriched lncRNAs, most notably the lncRNAs CARMEN, Meteor and Wisper.

RNA-guided programmable therapeutics for fibrosis, Samir Ounzain, CEO & Co-Founder, HAYA Tx

A new research paper was published in Aging (Aging-US) Volume 15, Issue 9, entitled, “Exogenous exposures shape genetic predisposition to lipids, Alzheimer’s, and coronary heart disease in the MLXIPL gene locus.”

In this new study, researchers Yury Loika, Elena Loiko, Fan Feng, Eric Stallard, Anatoliy I. Yashin, Konstantin Arbeev, Allison L. Kuipers, Mary F. Feitosa, Michael A. Province, and Alexander M. Kulminski from Duke University, University of Pittsburgh and Washington University School of Medicine examined associations of single nucleotide polymorphisms (SNPs) of the MLXIPL lipid gene with Alzheimer’s (AD) and coronary heart disease (CHD) and potentially causal mediation effects of their risk factors, high-density lipoprotein cholesterol (HDL-C) and triglycerides (TG) in two samples of European ancestry from the United States (US) (22,712 individuals 587/2,608 AD/CHD cases) and the United Kingdom Biobank (UKB) (232,341 individuals; 809/15,269 AD/CHD cases).

“Our results suggest that these associations can be regulated by several biological mechanisms and shaped by exogenous exposures.”

Two patterns of associations (represented by rs17145750 and rs6967028) were identified. Minor alleles of rs17145750 and rs6967028 demonstrated primary (secondary) association with high TG (lower HDL-C) and high HDL-C (lower TG) levels, respectively. The primary association explained ~50% of the secondary one suggesting partly independent mechanisms of TG and HDL-C regulation. The magnitude of the association of rs17145750 with HDL-C was significantly higher in the US vs. UKB sample and likely related to differences in exogenous exposures in the two countries. rs17145750 demonstrated a significant detrimental indirect effect through TG on AD risk in the UKB only (βIE = 0.015, pIE = 1.9 × 10−3), which suggests protective effects of high TG levels against AD, likely shaped by exogenous exposures. 

Also, rs17145750 demonstrated significant protective indirect effects through TG and HDL-C in the associations with CHD in both samples. In contrast, rs6967028 demonstrated an adverse mediation effect through HDL-C on CHD risk in the US sample only (βIE = 0.019, pIE = 8.6 × 10−4). This trade-off suggests different roles of triglyceride mediated mechanisms in the pathogenesis of AD and CHD.

“Finally, the results of this study suggest that genetic associations of SNPs from the MLXIPL gene locus with lipids, AD, and CHD are shaped by exogenous exposures. Further study of the related biological mechanisms can help to elucidate the related, modifiable risk factors.”

DOI - https://doi.org/10.18632/aging.204665

Corresponding authors - Yury Loika - yury.loika@duke.edu, and Alexander M. Kulminski - alexander.kulminski@duke.edu

Keywords - aging, MLXIPL, lipids, triglycerides, coronary heart disease, Alzheimer’s disease

About Aging-US

Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

Please visit our website at https://www.Aging-US.com​​ and connect with us:

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Media Contact
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Aging (Aging-US)

Factors Shape Genetic Predisposition to Lipids, Alzheimer’s and Heart Disease in MLXIPL Gene

Synopsis: 
Faraz Ali is the CEO of Tenaya Therapeutics, a clinical-stage biotechnology company with a mission to discover, develop and deliver potentially curative therapies that address the underlying causes of heart disease. Faraz discusses his non-traditional background as an electrical engineer before he found his passion for applying science and technology to healthcare problems. He talks about his experience working at Genzyme and what aspects from his time there he still carries with him today. Faraz also discusses his perspective on the application of genetic modalities, and his team’s work pursuing treatment for both rare and prevalent forms of heart disease. Finally, he talks about what it’s like being a first time CEO and his thoughts on team building.


Biography: 
Faraz Ali, MBA, is the CEO of Tenaya Therapeutics, a clinical-stage biotechnology company with a mission to discover, develop and deliver potentially curative therapies that address the underlying causes of heart disease. He was most recently Chief Business Officer at REGENXBIO, where he had accountability for corporate development, commercial planning, portfolio strategy, alliance management and corporate communications. Prior to that, Mr. Ali was a Vice President at bluebird bio, where he was responsible for new product planning, program management, patient advocacy and external affairs. He also held roles of increasing global commercial leadership at Genzyme Corporation, where he helped launch multiple first-in-class enzyme replacement therapies for rare diseases. He started his career at General Electric, including technical roles at GE Healthcare and business assignments at GE Corporate. Mr. Ali received his MBA from Harvard Business School and his B.S. from Stanford University. He was appointed to the Board of Directors for The Alliance for Regenerative Medicine (ARM), the leading international advocacy organization dedicated to realizing the promise of regenerative medicines and advanced therapies, in 2022.

BIO Special: Advancing heart disease treatment, Faraz Ali, CEO, Tenaya Therapeutics

Glenn and Dr. Aiena discuss heart disease

TMHC Heart Disease 060823

On this Podcast Steven gives an update on his health & talks about his road to recovery from heart failure due to having Myocarditis.  He also speaks about the California Assembly Bill AB316 that was recently vetoed by California Governor Gavin Newsom.

Episode #175 "Don't call it a comeback"

On this Podcast Steven Hosts new guest to the show Sam Hermisillo.  Sam talks about her weight loss journey losing 175lbs in one year.  An inspirational Podcast you don't want to miss.

The views, information or opinions expressed in the YouTube Channel and Podcast are solely the views of the individuals involved and by no means represent absolute facts. Opinions expressed by the host and guests can change at any time.

Episode #188 "New Year New Me"

Nearly 48% of Black women and 44% of Black men have some form of heart disease. The rate of heart disease is also higher in the growing middle and upper-class Black community than in White Americans with similar socioeconomic status.  Why is this happening?  Statistics show that Black people have higher rates of high blood pressure, obesity and diabetes – common conditions that increase the risk of heart disease.  Genetic factors also add to these higher rates, as do societal factors, such as gaps in income and education.  Discrimination and health care access can have a profound impact on treatment and health outcomes.  Education and awareness are just the beginning.  

Equal Hope hosts, Equal Health. Tune in to hear how health experts and Equal Hope clients are working to address and eliminate health disparities in Chicago.

Equal Hope can help you obtain free mammograms, cervical screens, and a medical home, as well as COVID testing and vaccination. Equal Hope can also help you get a referral for emergency services (like food assistance, help with your utilities or your rent). 

Sign up at EqualHope.org or call Equal Hope at 312-942-3368.
Equal Hope is excited to announce that they have cancer support resources for patients, caregivers and providers on equalhope.org.  Search through the patient handout resources and links to learn more about getting help for and addressing needs and concerns.  For providers, there are various training and screening tools to use in research or practice.

Heart Health & the Black Community 1-6-24

praphitproductions.com

Tonight, Liam is mad, Khaled is lazy, and Diddy is in trouble... again.

Music and Shiiii_2/27/24 - BUMBACLARTS!

On this 200th Podcast & historic milestone, Steven hosts his childhood friends Freddy Morales & Terry Diggs.  The guys reflect on the past, talk about the now, & analyze the future.


The views, information or opinions expressed in the YouTube Channel and Podcast are solely the views of the individuals involved and by no means represent absolute facts. Opinions expressed by the host and guests can change at any time.

Episode #200 "Consistency"

On this Episode 449 of Health Solutions, Shawn & Janet Needham R. Ph. discuss hormone replacement therapy and the myths that go along with it. 

00:00 - Start
01:21 - Defining Hormones
03:15 - Misinformation from WHI Study
09:55 - Progesterone and Estrogen
13:03 - Benefits of Progesterone for Sleep
15:25 - Blood Clots
16:40 - Breast Cancer
22:03 - Heart Disease
22:55 - Do Your Own Research
24:38 - Testosterone
27:29 - Testosterone and Strokes
32:29 - Listener Comment / Drugs for Sleep
33:44 - Birth Control Pills
36:23 - Listener Comment / Aging and Hormones
39:25 - Listener Comment / Marijuana and Sleep Aids
44:35 - Listener Comment / Hormones and Diets
49:59 - Listener Comment / More on Marijuana
51:18 - Listener Comment / Microdosing
52:30 - Effects of Cortisol on Sleep
55:34 - Resources and Contact
57:28 - Free Market Healthcare
58:02 - Closing Comments

EP 449: Discussing Hormone Replacement Therapy with Shawn & Janet Needham R. Ph.

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#hormones #hormonereplacementtherapy #hormonebalance #hormone #hormonebalancing #hormoneimbalance #cortisol #aging #diets #diet #microdosing #birthcontrol #birthcontrolpills #testosterone #heartdisease #cancer #stroke #bloodclot #progesterone #estrogen #podcastshow #podcast #podcastguest #optimalhealth #healthfreedom #MedicalFreedom #medicaleducation 
#medicalcare #HealthCare #PriceTransparency #freemarket #Liberty #FitAfter50 #FitOver50 #fitover40 #fitafter40 #Boise #IdahoFalls #Tricities #SiouxFalls #Wenatchee 
#EducateAndEmpower #NeedhamHealthSolutions #TeamNeedham #ShawnNeedham #HealthSolutions #MosesLakeProfessionalPharmacy #MLRX #SickenedTheBook #ShawnNeedhamRPh #ThinkOutsideTheSystem #OptimalHealthMatters #ItsTime

~
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EP 449: Discussing Hormone Replacement Therapy with Shawn & Janet Needham R. Ph.

Chest pain of any kind can make people fear the worst—they may think they’re having a heart attack. But, is it? Dr. Ronald Fields, cardiologist at Trinity Health Mid-Atlantic Medical Group goes behind the science and explains the functions of the heart and how to tell the difference.

Beyond the Stethoscope

Is It a Heart Attack or Panic Attack?

S1E8: The Truth About Heart Attacks

This interview first aired on Wednesday the 19th of June, 2024 on ONE FM 98.5 Shepparton.

One FM fill-in breakfast announcer Plemo chats with Will Adams from the Shepparton Adviser who gives us an update about what's making news around the region.

Listen to One FM Breakfast live on weekday mornings from 6am-9am.

Contact the station on admin@fm985.com.au or (+613) 58313131

The ONE FM 98.5 Community Radio podcast page operates under the license of Goulburn Valley Community Radio Inc. (ONE FM) Number 1385226/1.

PRA AMCOS (Australasian Performing Right Association Limited  and Australasian Mechanical Copyright Owners Society) that covers Simulcasting and Online content including podcasts with musical content, that we pay every year. This licence number is 1385226/1.

Weekly News Wrap with Will Adams of the Shepparton Adviser

Experience the Take Back Your Health Podcast
https://mealbetix.com/take-back-your-health-podcast

#heartdisease

WHERE DOES HEART DISEASE COME FROM? PODCAST

Saving women’s lives by eliminating health disparities in IL.

Beyond the Stethoscope dives into the many service lines and specialties at Trinity Health Mid-Atlantic. Our list of guests includes front line physicians, executives and colleagues to give listeners different perspectives of what goes on around our health system that serves the Greater Philadelphia area and Delaware. Margie Zimmerman hosts Beyond the Stethoscope.

A traditional, twice-monthly, peer-reviewed, open-access journal covering all areas of research on aging and age-related diseases, including cancer and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome.

Read about the Aging (Aging-US) Scientific Integrity Process: https://aging-us.com/scientific-integrity

One FM Community Radio Station airs a range of programs, including  "Ethnic Programs"  (in languages other than English), specialist interview programs such as "Shepplife" and health programs (So Much More)which are podcast here.  We also podcast a range of local sports programs as part of our Super Saturday Sports Show.  
Goulburn Valley Community Radio Station  Inc. (One FM 98.5) podcast site operates under APRA AMCOS (Australasian Performing Rights Association and Australasian Mechanical Copyright Owners Society) and ACMA (Australian Communications Media Authority) Licence Number  1385226/1.

The programs are recorded and first aired at One FM 98.5 Community Radio Station in Shepparton (Victoria, AUSTRALIA), and produced with the assistance of the Community Broadcasting Foundation or the National Ethnic and Multicultural Broadcasters' Council.

All intro and outro music for So Much More podcasts are taken from Beneplacito Boogaloo composed by Terry Barbossa and Matt Holland.

The world is a crazy place. We try to make a little sense of it.

Biotech2050 Podcast is a think tank chronicling the disruptions changing the biotech industry over the next 50 years.

Boldly Empowering 30s ~ 60s+ to Take Charge of Their Health. Bio Identical Hormone Balancing. Medical Freedom. Optimal Health Tips. 25+ yrs as Cash Only Compounding Pharmacists. Twice weekly Live Podcast.

On a journey to discover who I am and what I want to leave behind.

New tracks tagged #heartdisease