Nesta segunda-feira, 2 de setembro de 2024, a professora da Escola de Enfermagem da UFMG e líder do Observatório de Pesquisa e Estudos em Vacinação da Universidade (Opesv UFMG), Fernanda Penido, participou do programa Conexões. 

Ela abordou a pesquisa do Observatório, feita em parceria com a Secretaria de Saúde de Minas Gerais, que revelou que quase 46% dos jovens afirmaram já ter resistido, tido medo ou dúvidas se deveriam se vacinar, e mais de 21% já recusaram a administração dos imunizantes contra o HPV e contra a meningite.

Foi apurado também que mais de 55% do público não tem sequer conhecimento sobre as vacinas, apesar de quase 69% já terem recebido orientações sobre imunização na Unidade Básica de Saúde e cerca de 62% já terem sido orientados na escola. A investigação foi feita com quase mil crianças e adolescentes de Minas Gerais, entre 9 e 19 anos de idade.

Opesv UFMG: Quase metade dos jovens têm resistência, medo ou dúvida sobre vacinas de HPV e meningite

Humane Papillomviren (HPV) sind eine Gruppe von mehr als 200 Virustypen, von denen einige als Hochrisikotypen für die Entstehung von Krebserkrankungen gelten. Insbesondere sind sie die Hauptursache für die Entwicklung des Zervixkarzinoms, das zu den häufigsten Krebserkrankungen bei Frauen zählt. Infektionen mit Hochrisiko-HPV-Typen, wie HPV 16 und 18, können zur Bildung von präkanzerösen Zellveränderungen führen, die sich unbehandelt zu einem invasiven Karzinom entwickeln können. Eine frühzeitige Erkennung durch HPV-Screening sowie die Prävention durch eine Impfung bereits im Kindesalter sind entscheidende Maßnahmen zur Senkung des Erkrankungsrisikos.

Darüber spricht Dr. med. vet. Astrid Heinl, stellvertretende Chefredakteurin von Journal Onkologie, in der neuen Episode von O-Ton Onkologie mit Prof. Dr. rer. nat. Catharina Maulbecker-Armstrong. Sie lehrt an der Technischen Hochschule Mittelhessen in Gießen und forscht zu den Themen Gesundheitsökonomie, Prävention und Gesundheitsförderung.

Zur Folgen-Übersicht: https://bit.ly/3Tjq3Ur

Links:
-	https://www.thm.de/ges/fachbereich/profil/presse-2/masterthesis-von-karin-moser-auf-dem-deutschen-krebskongress-2022
-	https://www.ehealth-zentrum.de/
-	https://www.thm.de/ges/images/Flyer_KTE_netz.pdf
-	https://www.tagesschau.de/inland/gesellschaft/rueckgang-hpv-impfung-100.html
-	https://www.krebsinformationsdienst.de/
gebaermutterhalskrebs/risikofaktoren

O-TON Onkologie

Zervixkarzinom – die HPV-Impfung als Primärprävention

Najmuddin merupakan sebuah klinik pengobatan tradisional yang sudah berdiri sejak tahun 1985
hingga sekarang dan bertempat di kota Bandung. 
Campaka Bandung,Ciroyom Bandung,Dunguscariang Bandung,Garuda Bandung,Kebonjeruk Bandung,Maleber Bandung,Cibadak Bandung,Karanganyar Bandung,Karasak Bandung,Nyengseret Bandung

0812 - 1440 - 8050 Pengobatan HPV Ny. Djamilah Najmuddin Di Campaka Bandung

The HPV vaccine is offered to all young people aged 11–13 years in Scotland to protect them from cancers and genital warts caused by HPV infection.

Protect Yourself Against Cancers Caused By HPV

Dee and Kate chat with Adrienne the Yoni Nutritionist about fishy vaginas, which smells worse: foreskin smegma or vaginal discharge, and how to gently tell your sex partner that you have anal warts. Marshall Island Tony has a moral compass and UK listener calls in with a cautionary tale about Planet of the Apes. Sign up for the Sick and Wrong Patreon to hear the Second Show, SW archives, and the bonus minisode Serial Killer Star Signs.

S&W Episode 981: Something Fishy Going On

There's a new way to screen for cervical cancer with self-collection. People can take a sample of cells from their own vagina to test for HPV. The FDA recently approved this for use in providers offices. There's no pelvic exam stirrups or speculum involved. Research has shown that the results are just as accurate as when samples are collected by a clinician. Self-collection has the potential to expand testing to other healthcare settings and reach underscreened populations.

In this episode, we speak to Barbara Moscicki, MD, who has been involved in the research around HPV for decades to explain this new method to us, and how it might help us reach the goal of eliminating cervical cancer.


Learning about HPV Self Collection with Barbara Moscicki, MD

There's a new way to screen for cervical cancer with self-collection. People can take a sample of cells from their own vagina to test for HPV. The FDA recently approved this for use in providers offices. There's no pelvic exam stirrups or speculum involved. Research has shown that the results are just as accurate as when samples are collected by a clinician. Self-collection has the potential to expand testing to other healthcare settings and reach underscreened populations.

In this episode, we speak to Jennifer S. Smith, PhD, who has been involved in the research around HPV for decades to explain this new method to us, and how it might help us reach the goal of eliminating cervical cancer.


Jennifer Smith and the Promise of HPV Self Collection

Les papillomavirus humains (HPV) sont des virus très contagieux qui se transmettent par contact intime. On estime qu’environ 80 % des femmes et des hommes y seront exposés au cours de leur vie. Dans certains cas, les infections aux papillomavirus peuvent être responsables de cancers.

Dans ce nouvel épisode, Dr Blanchi, infectiologue au #CHLeMans nous précise ce que sont les papillomavirus et comment s’en protéger, notamment grâce à la vaccination.

Prévention - #09 Les papillomavirus

قراءة صوتية لمقال "هل يمكن أن ينتقل فيروس الورم الحليمي عن طريق التقبيل؟" بصوت أحمد يوسف

لقراءة النص المكتوب، يمكنكم مطالعة: https://bit.ly/4hSkQgF

هل يمكن أن ينتقل فيروس الورم الحليمي عن طريق التقبيل؟

BUFFALO, NY - April 28, 2025 – A new #research paper was #published in Oncotarget, Volume 16, on April 24, 2025, titled “PD-L1 and FOXP3 expression in high-grade squamous intraepithelial lesions of the anogenital region."

Researchers Humberto Carvalho Carneiro, Rodrigo de Andrade Natal, José Vassallo and Fernando Augusto Soares from the Instituto D’Or de Pesquisa e Ensino and Rede D’Or studied early tissue changes caused by human papillomavirus (HPV) in the anal, vulvar, and penile regions. They found that high-grade pre-cancer lesions triggered stronger immune responses and showed higher levels of two immune-related markers, PD-L1 and FOXP3. These findings are important because they help explain how some HPV-related lesions progress to cancer while others heal on their own.

High-risk HPV is known to cause several types of anogenital cancers. Before these cancers appear, the virus often leads to abnormal tissue changes known as high-grade squamous intraepithelial lesions. Many of these lesions disappear without treatment, but some become cancer—especially in people with weakened immune systems. This study explored how immune activity may play a role in this progression.

The researchers examined tissue from 157 patients—95 males and 55 females—with either high-grade or low-grade HPV-related lesions. They found that T-regulatory cells, marked by the FOXP3 protein, were more common in high-grade lesions. These immune cells are known to suppress immune responses, which can allow infected or abnormal cells to grow. The team also found higher expression of PD-L1, a protein that helps cells evade immune detection, particularly in inflammatory immune cells.

"Dense inflammatory infiltrates and high counts of FOXP3+ cells were significantly more frequent in patients with HSILs than in those with LSILsHR (p = 0.04 and 0.02, respectively). HSILs also exhibited higher PD-L1 expression (padj < 0.01 and < 0.01 for the SP142 and 22C3 clones, respectively), based on the Poisson generalized linear model.”

These findings suggest that HPV may begin avoiding the immune system early in infection, even before cancer develops. The combination of high FOXP3 and PD-L1 levels may create a protective environment for infected cells, making them harder for the body to eliminate. This immune evasion may allow the lesions to remain and, over time, become cancerous.

The study also compared patients with and without HIV to assess whether immune health influenced the results. While those with compromised immune systems had more extensive lesions, PD-L1 and FOXP3 expression was also found in patients with healthy immune systems. This evidence shows that immune evasion by HPV can happen regardless of a person’s immune status.

Understanding how PD-L1 and FOXP3 function in early HPV-related lesions may help clinicians predict which lesions are more likely to become cancer. These insights could lead to new strategies for monitoring, treating, or preventing HPV-related precancerous lesions and cancer in the anogenital region. The study highlights how early immune system changes can play a key role in the development of HPV-related cancers.

DOI - https://doi.org/10.18632/oncotarget.28715

Correspondence to - Humberto Carvalho Carneiro - humberto.carneiro@rededor.com.br

Video short - https://www.youtube.com/watch?v=6d8G8TUbgYc

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To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us:

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MEDIA@IMPACTJOURNALS.COM

Oncotarget

Early Immune Evasion Found in HPV-Related Pre-Cancer Lesions of the Anogenital Region

Nőgyógyászati veszélyek a strand-, és fesztiválszezonkor, Dr. Holló Balázs - Manna Délelőtt Péter Petrával 2025. 07. 30.

Teste positivo para HPV - e agora? Vou ter tenho câncer? Vacina para HPV não é só pra adolescente? Eu já HPV, vale a pena vacinar? Para esclarecer essas e outras dúvidas, o âncora Jota Batista conversou com a ginecologista Arizla Maia, da IMUNOLÓGICA, nesta segunda-feira (27), no "Bora Imunizar", na Rádio Folha FM 96,7.

Como se proteger contra o HPV

In O-Ton Onkologie wird alles diskutiert, was mit Krebs zu tun hat – mit dem Fokus darauf, was für Medizinerinnen und Mediziner relevant ist: Wir berichten von Neuigkeiten zur Diagnostik und Therapie, stellen Wissenschaflterler:innen vor oder diskutieren praxisrelevante News von ausgewählten Kongressen. Der Podcast ist ein Projekt von Journal Onkologie und Medical Tribune Onkologie/Hämatologie aus der MedTriX Group. Wir sprechen alle 14 Tage mit Expert:innen aus der Onkologie und Hämatologie.

Das Team Onkologie sind Antje Blum, Chefredakteurin des Journal Onkologie, und ihre Stellvertreterin, Dr. Astrid Heinl, die beiden Chefredakteurinnen der Medical Tribune Onkologie/Hämatologie, Elisa Breuer und Dr. Judith Besseling sowie Jochen Schlabing, Teamleiter Onkologie in der MedTriX Group.

Den Podcast O-Ton Onkologie gibt es jeden zweiten Mittwoch auf den gängigen Podcast-Plattformen. Abonnieren Sie uns und machen Sie auch gerne Themenvorschläge. Kontakt zur Redaktion unter: o-ton-onkologie@medtrix.group

Mehr unter:
www.medical-tribune.de/o-ton-onkologie
www.journalonko.de/podcasts/liste

• MedTriX Group auf LinkedIn: www.linkedin.com/company/medtrix-group/
• Medical Tribune Deutschland auf LinkedIn: www.linkedin.com/showcase/medical-tribune-de/

Previously NHS Health Scotland, Public Health Scotland is Scotland’s lead agency for improving and protecting the health and wellbeing of all of Scotland’s people.

The Sex+Health podcast from the American Sexual Health Association covers all aspects of sexual health. Featuring interviews with medical professionals and experts in the field of sexuality, Sex+Health aims to offer information and resources to with the goal of helping people take charge of their sexual health and understand its importance to overall well being.

Oncotarget is a primarily oncology-focused, peer-reviewed, open access journal. Papers are published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Oncotarget is now indexed by MEDLINE, PubMed and PMC/PubMed.

Read about the Oncotarget Scientific Integrity Process: https://www.oncotarget.com/scientific_integrity/

THE WORLD’S SOURCE FOR ANTI-SOCIAL COMMENTARY

Sick and Wrong is your hearing aid into the dark, depraved, and dripping abscess that is contemporary existence. An enchanting mélange of social criticism, pointed observation, and well-deserved derision; Sick and Wrong is the pepto-bismol for society’s indigestion. In their critically acclaimed weekly podcast, award-winning broadcasters Dee Simon and Lance Wackerle discuss the most vile, disquieting, and oddly amusing news items for your listening pleasure.

“The most foul thing I have ever heard. I can’t believe people listen to this shit.” — Katy Perry

“Sick and Wrong is my new favorite podcast.” — Drew Barrymore

“My mom told me about this podcast.” — Neil Patrick Harris

“These guys have seen Brokeback Mountain one too many times.” — Bruce Campbell

As principais notícias de Pernambuco, do Brasil e do mundo resumidas e comentadas pela Folha PE através de podcasts diários.
Fone: 81 3425-5872

Écoutez le podcast du Centre Hospitalier du Mans.

موقع الحب ثقافة هو منصة للنقاش البناء حول الصحة الجنسية والإنجابية و الحب والعلاقات لمن يبلغ عمرهم 18 عام أو أكثر. من خلال هذه القناة، نعرض برامج من إنتاج منصتنا تناقش تلك الموضوعات.
تعمل المنصة في مصر من خلال مركز خدمات التنمية.

A Rádio UFMG Educativa é uma parceria entre a Universidade Federal de Minas Gerais (UFMG) e a Empresa Brasil de Comunicação (EBC), com transmissão de programação diária na frequência 104,5 FM, para a Região Metropolitana de Belo Horizonte, e on-line, pelo site http://ufmg.br/radio. Inaugurada em 6 de setembro de 2005, a emissora oferece uma programação diferenciada e alternativa aos formatos e gêneros musicais já existentes no mercado. Referência em produção radiofônica entre as rádios universitárias do país, a UFMG Educativa tem a missão de dar visibilidade à produção de conhecimento da Universidade, por meio da comunicação pública da ciência e do fomento à discussão constante de temas relacionados à educação e à cultura. A emissora está vinculada ao Centro de Comunicação da UFMG (Cedecom) e é composta pelos núcleos de Jornalismo, Operações e Programação.

New tracks tagged #hpv