Interview de Jeremy Jaspers par Hervé Laurent le jeudi 5 juin 2025 à Manifesta

2025-06-05_Jeremy_Jaspers_Manifesta

Dr. Stefanie Morgan joins Dr. Robert Dudley from AgelessRx to discuss a #research paper she co-authored that was #published in Volume 17, Issue 4 of Aging, entitled “Influence of rapamycin on safety and healthspan metrics after one year: PEARL trial results.”

DOI - https://doi.org/10.18632/aging.206235

Corresponding author - Stefanie L. Morgan - stefanie@agelessrx.com

Author interview - https://www.youtube.com/watch?v=2qlIiVh2OJs

Video short - https://www.youtube.com/watch?v=z5j2nyK2HZ8

Abstract

Design: This 48-week decentralized, double-blinded, randomized, placebo-controlled trial (NCT04488601) evaluated the long-term safety of intermittent low-dose rapamycin in a healthy, normative-aging human cohort. Participants received placebo, 5 mg or 10 mg compounded rapamycin weekly. The primary outcome measure was visceral adiposity (by DXA scan), secondary outcomes were blood biomarkers, and lean tissue and bone mineral content (by DXA scan). Established surveys were utilized to evaluate health and well-being. Safety was assessed through adverse events and blood biomarker monitoring.

Results: Adverse and serious adverse events were similar across all groups. Visceral adiposity did not change significantly (ηp2 = 0.001, p = 0.942), and changes in blood biomarkers remained within normal ranges. Lean tissue mass (ηp2 = 0.202, p = 0.013) and self-reported pain (ηp2 = 0.168, p = 0.015) improved significantly for women using 10 mg rapamycin. Self-reported emotional well-being (ηp2 = 0.108, p = 0.023) and general health (ηp2 = 0.166, p = 0.004) also improved for those using 5 mg rapamycin. No other significant effects were observed.

Conclusions: Low-dose, intermittent rapamycin administration over 48 weeks is relatively safe in healthy, normative-aging adults, and was associated with significant improvements in lean tissue mass and pain in women. Future work will evaluate benefits of a broader range of rapamycin doses on healthspan metrics for longevity, and will aim to more comprehensively establish efficacy.

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Keywords - aging, rapamycin, geroscience, longevity, healthspan

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Behind the Study: Rapamycin’s 1-Year Impact on Healthspan—PEARL Trial Results

Interview d'Olivier Chastaing, Directeur de la School Gallery Hervé Laurent le jeudi 5 juin 2025 à Manifesta

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Interview de Léna Brusset par Hervé Laurent le jeudi 5 juin 2025, à propos de l'exposition Marinette Cueco 

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"Dangerous Animals" had its world premiere in the Directors' Fortnight section of the 2025 Cannes Film Festival, where it received positive reviews for its brutal shark kills, handling of genre tone, and Jai Courtney's unhinged performance as the serial killer who feeds his victims to sharks and films them in the process. Courtney was kind enough to spend some time speaking with us about his experience making the film, which you can listen to below! Please be sure to check out the film, which is now playing in theaters from Independent Film Company. Thank you, and enjoy!

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Interview With "Dangerous Animals" Star Jai Courtney

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A podcast by NextBestPicture.com that reviews the latest film releases and discusses various topics within the world of film and the awards race.

Cancer and aging are two sides of age-related tumorigenesis.

The mission of the journal is to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population.

The journal aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.)

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