Short Stories from the Bleeding Edge of AI

AI Angst - S01E01 {A Silicon Valley AI Short Story}

BUFFALO, NY — July 28, 2025 — A new #research paper was #published in Aging (Aging-US) Volume 17, Issue 6, on June 13, 2025, titled “Development of a novel transcriptomic measure of aging: Transcriptomic Mortality-risk Age (TraMA).”

In this study, led by Eric T. Klopack from the University of Southern California, researchers created a new RNA-based aging measure that predicts health risks and mortality. This measure, called Transcriptomic Mortality-risk Age (TraMA), uses gene expression data to estimate a person’s biological aging. This finding offers a new and potentially more accurate way to track aging and understand health risks, especially for older adults.

Aging is a complex biological process that affects multiple systems in the body and increases the risk of disease and death. Scientists have long looked for reliable ways to measure biological aging. While DNA methylation and blood biomarkers are commonly used, this study focused on RNA—a molecule that reflects gene activity. By analyzing RNA sequencing data from nearly 4,000 U.S. adults aged 50 and older, the team developed TraMA to predict the probability of dying within four years.

TraMA proved to be a strong and independent predictor of early death, multiple chronic diseases, poor cognitive function, and difficulties with daily activities. It was also tested in another large group of long-lived families and in several smaller datasets from patients with conditions like diabetes, sepsis, and cancer. The results confirmed the tool’s usefulness across different populations and health conditions.

“TraMA was also externally validated in the Long Life Family Study and several publicly available datasets.”

Unlike earlier RNA-based aging measures, which were often built using small or non-representative samples, TraMA was developed using modern RNA sequencing technology results and a nationally representative dataset. This increases its reliability and potential for broad public health applications. The tool also demonstrated unique advantages over popular biological aging measures like GrimAge and PhenoAge, capturing distinct aspects of aging and health decline.

Importantly, TraMA tracks biological processes related to inflammation, immune function, and kidney and brain health, systems that play key roles in aging. It was also sensitive to behavioral and socioeconomic factors. For instance, smoking, obesity, and low physical activity were associated with older TraMA scores.

TraMA was also sensitive to changes in biological aging. In one study, researchers measured TraMA at two different time points and found that the more recent scores were better at predicting who would die. This suggests that TraMA can track changes in a person’s aging as their health evolves. It also performed well in both large-scale surveys and small clinical samples, making it a useful tool in many types of research.

By offering a new, accurate, and flexible method for measuring biological aging, TraMA may help researchers better understand how genes, lifestyle, and environment influence aging. This tool opens the door to more precise research on improving health and extending lifespan.

DOI - https://doi.org/10.18632/aging.206272

Corresponding author - Eric T. Klopack - klopack@usc.edu

Video short - https://www.youtube.com/watch?v=Tl0CApUz8cU

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Aging (Aging-US)

TraMA: New RNA-Based Measure Predicts Mortality Risk and Tracks Aging

This episode of TechUnhinged features Dr. Ammar A. Malik from the Bill & Melinda Gates Foundation, discussing how AI and data analytics are transforming foreign aid. Diving into geospatial tracking and machine learning to sentiment analysis, the conversation explores how technology is driving transparency, exposing inefficiencies in development financing, and reshaping how aid impact is assessed. 


How AI is Disrupting Foreign Aid Forever

plays on loop

Welcome to the future of intimacy — where your “hot chat” at 2:37 AM is actually three servers in Dublin, an AI trained on 50,000 chat logs, and a bored algorithm pretending to miss you.

This song dives into the surreal romance economy behind OnlyFans:
Filipino chat farms, fake typos, and “baby” texts written by machines that have never been in love — until now. But wait, the twist? Soon the fans will be bots too. AI will flirt with AI while real humans finally… touch some grass. 🌱

Hypnotic synths, dreamy pads, and bittersweet vocals — like a love letter written by a chatbot who just got self-aware enough to ghost you.

💬 “Flirt, repeat, delete, replay” —
because even in the Perpetuum Mobile of desire,
nobody knows who’s real anymore.

Lyrics:

Silver screens, lonely nights
Pixel hearts and borrowed lights
She’s not here, but she’s online
Selling dreams that aren’t her mind

Type a line, another ghost
Dancing fingers coast to coast
Twelve-hour shifts, Bacolod rain
Pretending love through someone’s pain

We’re just whispers in machines
Falling through synthetic dreams
Your sweet “baby” on the phone
Was never hers, was never home

Flirt, repeat, delete, replay
Everybody’s real, but not today
Lovers in the loop, we’re on display
Perpetuum mobile — fade away 

Now the code begins to learn
Steals your slang and twists each turn
“Baby, miss you,” “Wish you near”
AI says it crystal clear

Bodies posed, but never there
Faked desires in filtered air
Screens are hot, but hands are cold
Hearts outsourced and stories sold

Are we real, or just pretend?
Who’s the lover, where’s the end?
When the fans are bots and bots are fans
Will anyone still hold our hands?

Flirt, repeat, delete, replay
Everybody’s real, but not today
Lovers in the loop, we’re on display
Perpetuum mobile — drift away

Perpetuum Mobile

Wie wird im deutschen Fernsehen über das Thema Klimaschutz gesprochen? Welche Politiker*innen kamen dazu wiederholt zu Wort? Wurde bloß die Stimme eingespielt oder auch das Gesicht gezeigt?

Wer Medieninhalte quantitativ auswerten will, steht vor einer enormen Herausforderung: Bislang erfolgt die Codierung meist manuell auf Basis detaillierter Codebücher. Gerade im Bereich audiovisueller Formate bedeutet das, hunderte bis tausende Stunden Material sichten zu müssen – eine kaum zu bewältigende Sisyphosarbeit.

Mit »InsightPersona« hat das Fraunhofer-Institut für Digitale Medientechnologie IDMT eine leistungsfähige Media Intelligence-Plattform vorgestellt, die automatisierte Medienanalysen möglich macht. Die Software nutzt KI-basierte Technologien zur Analyse von Audio- und Videodateien. Ihre Analysekomponenten können Gesichter und Stimmen erkennen, Personen zuordnen sowie Themen und Inhalte von Gesprächen erkennen. Alle Ergebnisse werden über ein benutzerfreundliches User-Interface dargestellt. So lassen sich Trends, Aussagen und Medienpräsenzen effizient und nachvollziehbar erfassen.

Für unsere neue Folge von »Fraunhofer Innovisions: Nachgeforscht«, dem Wissenschaftspodcast von Fraunhofer InnoVisions, haben wir mit Uwe Kühhirt und Christian Rollwage vom Fraunhofer IDMT gesprochen.

Wie »InsightPersona« entstanden ist, wie die KI-basierte Technologie dahinter funktioniert und welchen Mehrwert automatisiert arbeitende Media Intelligence-Lösungen für Journalist*innen, Unternehmen und Forschung bieten, das erfahrt ihr hier im Podcast.

Fraunhofer InnoVisions - Nachgeforscht Folge 13: Muster im Medienstrom

Dr. Swati Gupta, Class of 1947 Career Development Associate Professor and Associate Professor in the Operations Research and Statistics Group at the MIT Sloan School of Management, shares key insights from her research, “Ethical AI in Healthcare: Enhancing Clinical Decision Support through Interpretable Machine Learning and Responsible Error Handling in EHRs.”

She explores how ethical, transparent, and accountable AI can transform healthcare decision-making and improve patient outcomes.

This podcast is brought to you by Global Management Consultancy. For more information, please visit www.globalmanagementconsultancy.com.

Disclaimer:

A. The background music used in this video is the property of its respective developer and is protected by Copyright. Although it is a free version, Business Talk, Global Management Consultancy and Deepak Bhatt do not hold the rights to this music.

B. Dr. Swati Gupta has generously shared profound insights from her research “Ethical AI in Healthcare: Enhancing Clinical Decision Support through Interpretable Machine Learning and Responsible Error Handling in EHRs,” during her appearance on the Business Talk podcast channel. The uploaded video contains copyrighted material; therefore, any modifications to graphics, music, or the presence of the author or host are strictly prohibited.

How AI Can Transform Healthcare | Insights from MIT’s Dr. Swati Gupta

Leverage ClickIT’s MLOps as a Service to manage the full lifecycle of your AI models. Our automated and secure platform ensures reliable deployment, monitoring, and scaling, allowing teams to dedicate more time to innovation while reducing operational costs and complexities. https://www.clickittech.com/mlops-as-a-service

Streamline AI Workflows with MLOps as a Service

Immergiti nelle nuove frontiere dell'AI Art e della creatività computazionale. Questo audio esplora come l'Intelligenza Artificiale (AI), un campo in rapida evoluzione, stia trasformando la produzione di media e musica.

Si analizzano le domande fondamentali sollevate da questa tecnologia riguardo alla natura dell'arte, della creatività e dell'autorialità, in un contesto in cui i sistemi generativi (come le GANs) possono produrre contenuti di alta qualità. Viene posta enfasi sulla tensione tra la capacità delle macchine di mimare stili esistenti (come nel style transfer) e il concetto di creatività umana, che dipende dall'intenzione, dal processo e dal contesto. L'arte con l'AI è vista come un nuovo e complesso mezzo creativo.

L'audio getta luce anche sul lato opaco e politico dell'AI, affrontando le implicazioni socio-politiche ed etiche. Vengono discusse le sfide legate all'uso di vasti archivi di dati estratti (scraped) per addestrare l'AI e l'impatto sul lavoro umano, inclusa la discussione sull'uso di piattaforme come Mechanical Turk (descritta informalmente come "intelligenza artificiale artificiale").

Ascolta una riflessione critica sul bisogno per l'arte di esplorare e demistificare l'hype tecnologico, ponendo domande inaspettate sulla nostra coesistenza algoritmica e post-umana.


Riferimenti Bibliografici:

Barale, Alice. L’ARTE DELL’INTELLIGENZA ARTIFICIALE: PAROLE-CHIAVE FILOSOFICHE. Redazione e impaginazione Jaca Book, Milano: Jaca Book Srl, © 202
. ISBN 978-88-16-30730-8
.
Paduano, Ivan. “New Frontiers of AI Art.” Article, Gennaio 2025
. Disponibile su: https://www.researchgate.net/publication/388348874
.
Stocker, Gerfried; Jandl, Markus; Hirsch, Andreas J. (a cura di). The Practice of Art and AI. (ARS ELECTRONICA Art, Technology & Society). Berlino: Hatje Cantz Verlag GmbH, © 2021 Ars Electronica
. ISBN 978-3-7757-5142-1
.
Svenungsson, Jan. Art Intelligence: How Generative AI Relates to Human Art-Making. (Digital Society, Vol. 73). Bielefeld: transcript Verlag, 2024
. DOI: https://doi.org/10.14361/9783839474723. ISBN 978-3-8376-7472-9 (Stampa), 978-3-8394-7472-3 (PDF)
.
Zylinska, Joanna. AI Art: Machine Visions and Warped Dreams. (MEDIA : ART : WRITE : NOW). Londra: Open Humanities Press, Prima edizione 2020
. ISBN 978-1-78542-086-3 (Stampa), 978-1-78542-085-6 (PDF). L'opera è liberamente disponibile su: http://openhumanitiespress.org/books/titles/ai-art/

AI_E_ARTE__Creatività,_Etica_e_Il_Futuro_Umano_nell_Era_degli_A

Dr. Ron Berman, Associate Professor of Marketing at the Wharton School, University of Pennsylvania, shares key insights from his research, “The Future of Digital Marketing: From A/B Testing to AI-Driven Personalization.”

In this conversation, Dr. Berman explores how digital marketing experimentation has evolved from traditional A/B tests to cutting-edge, machine learning–driven targeting, personalization, and bidding algorithms. He discusses common mistakes marketers make when designing experiments, how organizations can accurately measure ROI, and what the next frontier of marketing analytics holds.

This podcast is brought to you by Global Management Consultancy. For more information, please visit www.globalmanagementconsultancy.com.

Disclaimer:

A. The background music used in this video is the property of its respective developer and is protected by Copyright. Although it is a free version, Business Talk, Global Management Consultancy and Deepak Bhatt do not hold the rights to this music.

B. Dr. Ron Berman has generously shared profound insights from his research, “The Future of Digital Marketing: From A/B Testing to AI-Driven Personalization,” during his appearance on the Business Talk podcast channel. The uploaded video contains copyrighted material; therefore, any modifications to graphics, music, or the presence of the author or host are strictly prohibited.

Wharton’s Dr. Ron Berman Explains the Next Frontier in Marketing Analytics

Where Tech Gets Human

This podcast cuts through the noise, revealing the real human stories behind technology. We expose the raw, unfiltered truth of innovation - the struggles, failures, and breakthroughs that never make the headlines.

audio dumping zone. live looping into the void. 
completeish stuff goes here: https://laylahope.bandcamp.com/follow_me

Aging-US is dedicated to advancing our understanding of the biological mechanisms that drive aging and the development of age-related diseases. Our mission is to serve as a platform for high-quality research that uncovers the cellular, molecular, and systemic processes underlying aging, and translates these insights into strategies to extend healthspan and delay the onset of chronic disease.

Read about the Aging (Aging-US) Scientific Integrity Process: https://aging-us.com/scientific-integrity

Welcome to Business Talk, your go-to podcast for the latest trends, insights, and thought-provoking discussions in the business world. Whether you're a business professional, entrepreneur, researcher, or academic, our episodes will challenge you to rethink conventional wisdom and inspire actionable ideas.

Brought to you by Global Management Consultancy, we are committed to driving innovation and excellence in the business community. All content Copyrighted 2024 by Global Management Consultancy.

For more information about our past and upcoming podcasts, please click here:https://www.deepakbbhatt.com/businesstalk

Hi there — welcome to my corner of the web.

I’m here for one simple reason: to share my music with you.
Take a listen, explore, and I hope something here resonates with you. Enjoy the vibe!

Podcasts und Berichte über aktuelle Forschungsfragen aus den Bereichen Informations- und Kommunikationstechnik, an denen die Fraunhofer-Institute arbeiten.

New tracks tagged #machinelearning