Still eating like you’re 25 and wondering why it’s not working anymore?
This episode is your wake-up call! 🙌
I’m breaking down how to eat smarter after 40—so you can boost your metabolism, support your hormones, and finally feel GOOD in your body again.

It’s time to stop fearing food and start fueling for strength, energy, and longevity. Let’s do this! 

#390 Eating Smarter After 40!

Morley Robbins joins me again to continue our discussion on Iron and hormones, including testosterone. Another fun conversation and I'm excited to welcome Morley back for PT3 in a few weeks ... let me know if you have any questions for him!
In this podcast episode you will learn;
A quick recap on low iron (ferritin) and anemia
Irons connection to hormone health
Do you need iron with heavy menstrual bleeding?
How adrenaline and estrogen dominance influence iron 
The copper IUD as a source of copper
Iron and metabolism for ATP production and understanding fatigue
Iron overload and its connection to hot flashes and night sweats (this answer is INSANE!)
And LOTS more!

Find our more about Morley and his work here;
https://therootcauseprotocol.com/abou...
https://www.instagram.com/therootcaus...

If you find these videos or the podcasts helpful or interesting and you want me to continue making them, you can support me in making these and the podcasts because they really do take a lot of time, especially where the research is involved. You can buy me a coffee, I will share the link in the description. I really appreciate those of you who have supported me already, I do love coffee. Thank you so much for your generosity.
https://buymeacoffee.com/cmhthanks

As always, please like, share and subscribe if you haven't already. Thank you! 

#369 PT2. Iron & hormones connection with Morley Robbins.

Exercise…Why do men get leaner-faster? Can women speed up their metabolism to burn fat/food/calories as fast as men? If yes- HOW?
www.maxfitnesscollege.com


Exercise…Why do men get leaner-faster...with Rowie McEvoy

The highly intelligent Carol Petersen is back to discuss Thyroid health but first...We apologize for some of the breaks in this conversation, we are both having issues with our WIFI but hopefully you still find this helpful. The podcast version has most of the breaks taken out, so will be clearer to listen to.
Thank you for understanding. :)
But this really is a fantastic very considered conversation around Thyroid health and hypothyroidism with Carol. 
👉In this episode you will learn;
The prevalence of hypothyroid in peri and post menopause
The symptoms you can experience
Testing thyroid and thyroid antibodies
How TSH misunderstandings is leading many people astray
TSH is a marker of inflammation
Estrogen and progesterone's impact on thyroid
Secondary hypothyroid as it relates to hypopituitarism 
Signs of hypopituitarism
Birth control and more!
We really hope you learn and enjoy this conversation. Apologies again for the WIFI issues. :)

Carol Petersen is an accomplished compounding pharmacist with decades of experience helping patients improve their quality of life through bio-identical hormone replacement therapy. She is the owner of ‪@thewellnessbydesignproject‬ and a force to be reckoned with when it comes to hormones. 
You can check her out here; 
Web - https://thewellnessbydesignproject.com/
Take charge of your health radio show - https://www.wbai.org/program.php

If you find these videos or the podcasts helpful or interesting and you want me to continue making them, you can support me in making these and the podcasts because they really do take a lot of time, especially where the research is involved. You can buy me a coffee, I will share the link in the description. I really appreciate those of you who have supported me already, I do love coffee. Thank you so much for your generosity.
https://buymeacoffee.com/cmhthanks

As always, please like share, and subscribe if you haven't already. We appreciate you! :)

#374 Hypothyroid prevalence, Thyroid antibodies, TSH misconceptions, Hypopituitarism with Carol Petersen.

In this podcast episode I had a great conversation with the very funny Patrick Sullivan CEO and Co-founder of Jigsaw Health. We discussed the life behind Jigsaw health and what drives their creations - products and hilarious content. We also covered;
- Restless legs syndrome and cramping
- Magnesium deficiencies and needs
- Magnesium deficiency symptoms 
- Magnesium types
- Migraines and adrenal fatigue
- The need for electrolytes and adequate hydration
And lots more. We hope you really enjoy this conversation and look forward to reading your feedback in the comments. :)

Links and references;
 @JigsawHealthTV  
1) Jigsaws St. Patricks Day Skit - https://youtu.be/hgTZvua9DMY?si=YU3xVjjF61RlO4PM
2) Get some mag relief music video - https://www.jigsawhealth.com/blogs/news/get-some-magrelief-music-video
3) Patricks 5 Favorite ways to get Magnesium - https://drive.google.com/file/d/1aC6cvP5aL8H7qbVlqSa5CASdA2MaRrpa/view?usp=sharing
4) 14 Drugs That Deplete Magnesium by Suzy Cohen, RPh
https://www.jigsawhealth.com/blogs/news/drug-muggers-suzy-cohen-magnesium
5) Magnesium Deficiency Checklist:
https://www.jigsawhealth.com/blogs/news/a-quick-selftest-for-magnesium-deficiency
6) Scottsdale Magnesium Study summary:
https://www.jigsawhealth.com/pages/scottsdale-magnesium-study
PubMed link - https://pubmed.ncbi.nlm.nih.gov/29425476/
7) NEW: Rock Bottom Podcast — Health horror stories that inspire:
https://rockbottompod.com/
8) Follow Patrick on X: 
https://x.com/realPatrickJr
9) Jigsaw Health on Instagram - https://www.instagram.com/jigsaw_health

Thank you so much for listening. And if you find these conversations helpful, please like, share and subscribe. Your subscription helps me get on more awesome guests like Patrick, so you can learn from their knowledge and experience. :)

#375 Restless leg syndrome, magnesium requirements, and hydration with Patrick Sullivan Jr | Jigsaw Health.

shut upp

BUFFALO, NY — June 12, 2025 — A new #research paper was #published in Aging (Aging-US) Volume 17, Issue 5, on May 3, 2025, titled “APOE genotype and biological age impact inter-omic associations related to bioenergetics.”

In this study, led by first author Dylan Ellis and corresponding author Noa Rappaport from the Institute for Systems Biology, researchers discovered that different versions of the APOE gene—particularly ε2 and ε4—are linked to metabolic patterns associated with aging and Alzheimer’s disease risk. Both variants were linked to increased levels of diacylglycerols, a type of fat molecule connected to insulin resistance and inflammation, suggesting shared disruptions in how the body regulates energy.

The research team analyzed data from over 2,200 adults without an Alzheimer’s diagnosis, exploring how APOE genotypes influence biological age, a measure of health that reflects how quickly or slowly someone is aging at a cellular level. They found that the same metabolic disturbances seen in ε2 carriers were also present in people considered biologically older, revealing unexpected overlap between genetic risk and aging-related metabolic changes.

To examine these connections in more detail, the researchers used a multi-omics approach, combining blood-based metabolism and protein data, gut bacteria analysis from stool samples, and clinical chemistry data. This method allowed them to map how genetic differences and biological aging affect the body’s energy systems. They observed altered connections between glucose metabolism, inflammatory markers, and key molecules that play roles in energy production, indicating early disruptions that could contribute to age-related diseases.

One of the study’s surprising findings was that the ε2 variant, usually associated with longer life and reduced Alzheimer’s risk, showed metabolic traits similar to those found in insulin-resistant individuals. This suggests that ε2 may carry metabolic disadvantages earlier in life, with its protective effects becoming more pronounced later. Conversely, ε4—linked to greater Alzheimer’s risk—may exert its influence based on interactions with lifestyle factors like diet, sex, and overall health status.

“‘Omics association patterns of ε2-carriers and increased biological age were also counter-intuitively similar, displaying significantly increased associations between insulin resistance markers and energy-generating pathway metabolites.”

By identifying these shared biological signatures, this study offers a new framework for understanding how genes and metabolism work together to influence aging. These findings could support more personalized health strategies aimed at delaying biological aging and reducing the risk of chronic diseases. As aging populations grow worldwide, understanding these pathways is essential to improving healthspan.

DOI - https://doi.org/10.18632/aging.206243

Corresponding author - Noa Rappaport - noa.rappaport@isbscience.org

Video short - https://www.youtube.com/watch?v=75hZQoO5U0U

Sign up for free Altmetric alerts about this article - 
https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206243

Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts

Keywords - aging, apolipoprotein E (APOE), biological age, metabolism, Alzheimer’s disease (AD), insulin resistance

To learn more about the journal, please visit our website at https://www.Aging-US.com​​ and connect with us on social media at:

Facebook - https://www.facebook.com/AgingUS/
X - https://twitter.com/AgingJrnl
Instagram - https://www.instagram.com/agingjrnl/
YouTube - https://www.youtube.com/@AgingJournal
LinkedIn - https://www.linkedin.com/company/aging/
Bluesky - https://bsky.app/profile/aging-us.bsky.social
Pinterest - https://www.pinterest.com/AgingUS/
Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc

MEDIA@IMPACTJOURNALS.COM

Aging (Aging-US)

APOE Gene Variants Linked to Metabolic Signatures of Aging and Alzheimer's Risk

Why does eating more not fix the severe weight loss seen in some cancer patients, and what can be done about it?

In this 'Ask Me Anything' episode, Dr Hui-Ling Ou, Programme Manager for the Pancreatic Cancer and Cancer Immunology Programmes at the CRUK Cambridge Centre, speaks with researchers from the Cancer Cachexia Action Network (CANCAN): Dr Claire Connell (University of Cambridge and Cambridge University Hospitals NHS Foundation Trust), Dr David Lewis (CRUK Scotland Institute), and Dr Tobias Janowitz (Cold Spring Harbor Laboratory).

Together, they unpack what cancer-associated cachexia is, why it's so devastating for patients, and how scientists are working to understand and reverse this syndrome. The guests share how their research, spanning metabolism, imaging, immunology, and clinical studies, is bringing fresh insights and hope to a problem that affects quality of life for so many.

This thought-provoking discussion shines a light on the collaborative efforts driving progress against one of cancer's most challenging complications.

Ask me anything about cancer

Ask me anything about... the science of cancer-associated cachexia

What do you most want to know about pancreatic cancer and cancer-associated cachexia?

In this special episode, we bring you a recording of a live 'Ask Me Anything (AMA)' event hosted by the CRUK Cambridge Centre Pancreatic Cancer Programme for World Pancreatic Cancer Day 2024.

A multidisciplinary and international panel of experts, including clinicians, researchers, nurses, dietitians and physiotherapists, answer thoughtful questions from the public about pancreatic cancer, cachexia and the latest research and care approaches. Topics range from understanding the biology of these diseases to managing symptoms and improving quality of life.

The discussion sheds light on the progress being made and the ongoing challenges in improving outcomes for people affected by these conditions.

Ask me anything about... cachexia research and management

Fast Metabolism...How to get and keep one? What works, what works faster, what wastes your time; when you want to burn energy fast?
www.maxfitnesscollege.com


Fast Metabolism...How to get and keep one

The Earn That Body Podcast is here to give you fitness, nutrition and health information you can put into play right away.

Proverbs 18:21 "Death and life are in the power of the tongue, and those who love it shall eat of its fruit."
It is my hope that my podcast and these conversations bring you insight and the tools to take responsibility for your health and hormones, so that you may live your best life AND fulfill your life's purpose with determination and happiness. Please like and subscribe if you are enjoying my content. :)

If you are considering reaching out, I work with high-achieving motivated people in a 1:1 position to optimize their health and life through a science backed holistic approach. This includes personalized nutrition and hormone therapy, 360° sleep improvement, strategic supplementation, movement and more.📝📊🧬

Don't be afraid to say Hi sometime!
support@chemainesmodelhealth.com or on Facebook and Instagram - I swear I do respond! ;)

Aging-US is dedicated to advancing our understanding of the biological mechanisms that drive aging and the development of age-related diseases. Our mission is to serve as a platform for high-quality research that uncovers the cellular, molecular, and systemic processes underlying aging, and translates these insights into strategies to extend healthspan and delay the onset of chronic disease.

Read about the Aging (Aging-US) Scientific Integrity Process: https://aging-us.com/scientific-integrity

The Cancer Research UK Cambridge Centre unites over 1,000 world-leading biologists, chemists, physicists, engineers, mathematicians, computer scientists, clinicians, nurses and allied healthcare professionals from across Cambridge, UK to tackle cancer from every angle.

Our mission is to end death and disease caused by cancer through research, treatment and education. We are detecting cancer at its earliest stage and are developing personalised treatments for every patient through facilitating new collaborations and driving the translation of new scientific discoveries into clinical applications to improve patient care. By working together across a range of different disciplines, our members are breaking down the barriers between the laboratory and the clinic, enabling patients to benefit from the latest innovations in cancer science.

New tracks tagged #metabolism