There’s been growing interest in exploring the potential of psychedelics to treat neuropsychiatric conditions. Onsero Therapeutics is part of a growing list of companies that are developing therapies that target the 5-HT2A serotonin receptor, the receptor to which several of psychedelics bind, and one that has been clinically validated in a number of psychiatric conditions. The company believes the therapies it’s developing have the potential to provide the treatment benefits of these substances without their better-known effects. We spoke to Tim Piser, chief scientific officer of Onsero, about the case for these drugs to treat conditions like mood disorder, how it’s developing its experimental therapies so they don’t induce effects, and why he believes benefits of these drugs can exist independently of them packing a psychedelic punch.

Treating Psychiatric Conditions with Tripless Psychedelics

Today we’re talking about sleep deprivation and glymphatics with Vivek Jain, MD, Associate Professor of Medicine in the Division of Pulmonary, Critical Care & Sleep Medicine at GW and Director of GW Center for Sleep Disorders.  

The glymphatic system is a network of vessels that clear waste from the central nervous system, brain, and spinal cord, mostly during sleep.  Once thought not to exist, this lymphatic system may be disrupted in and contribute to some diseases of the brain.

Dr. Jain is a graduate for the All India Institute of Medical Sciences in New Delhi, India. He did his residency in Internal Medicine and fellowship in Pulmonology and Critical Care Medicine at the University of Missouri Hospital & Clinics, Columbia, Missouri.

Dr. Jain’s research on various aspects of sleep disorders has been published in more than dozens or peer-reviewed scholarly journals and numerous books. He lectures nationally and internationally on the topics of obstructive sleep apnea and heart disease.

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Related Content

GW Center for Sleep Disorders
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Transcript
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This podcast features the song “Follow Your Dreams” (freemusicarchive.org/music/Scott_Ho…ur_Dreams_1918) by Scott Holmes, available under a Creative Commons Attribution-Noncommercial (01https://creativecommons.org/licenses/by-nc/4.0/) license.

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Disclaimer: The content and information shared in GW Integrative Medicine is for educational purposes only and should not be taken as medical advice. The views and opinions expressed in GW Integrative Medicine represent the opinions of the host(s) and their guest(s). For medical advice, diagnosis, and/or treatment, please consult a medical professional.

Sleep Deprivation and Glymphatics

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Welcome to GW Integrative Medicine, a podcast about using an integrative approach to disease prevention and health promotion. We look forward to sharing the latest news and research on Integrative Medicine – where the best practices of conventional medicine and evidence-based complementary medicine meet. This podcast is brought to you by the Office of Integrative Medicine and Health, the George Washington University School of Medicine and Health Sciences,  in collaboration with the university's Integrative Medicine Programs and the IMPACT Initiative.

New tracks tagged #mood disorders