[Album] Aso Natsuko - Movement O

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Perfect-area complete!Single by Aso Natsuko from the album Movement of magicReleasedOctober 27, 2010GenreJ-popLabelLantisAso Natsuko Release ChronologyPreviousProgramming for non-fiction2nd Single (2009)NextEveryday sunshine line!4th Single (2010)Perfect-area complete! is the third single by Aso Natsuko. It was released on October 27, 2010, and peaked at #18 on the Oricon single chart.[1]
En 2008, elle chante comme les autres actrices de Mahō Sensei Negima! dans le générique au sein du trio pRythme, accompagnée de Kawase Yuri et Mukonoki Eri, elles sortiront 2 singles "Yuuki no Aji !" et "kIzuna", et un mini album nommé "pRythme O".
Gibbs, Hamish; Nightingale, Emily; Liu, Yang; Cheshire, James; Danon, Leon; Smeeth, Liam; Pearson, Carl AB; Grundy, Chris; Kucharski, Adam J; Eggo, Rosalind M; (2020)Detecting behavioural changes in human movement to inform the spatial scale of interventions against COVID-19. MedRxiv. DOI:
The discovery of the orexin system represents the single major progress in the sleep field of the last three to four decades. The two orexin peptides and their two receptors play a major role in arousal and sleep/wake cycles. Defects in the orexin system lead to narcolepsy with cataplexy in humans and dogs and can be experimentally reproduced in rodents. At least six orexin receptor antagonists have reached Phase II or Phase III clinical trials in insomnia, five of which are dual orexin receptor antagonists (DORAs) that target both OX 1 and OX 2 receptors (OX 2 Rs). All clinically tested DORAs induce and maintain sleep: suvorexant, recently registered in the USA and Japan for insomnia, represents the first hypnotic principle that acts in a completely different manner from the current standard medications. It is clear, however, that in the clinic, all DORAs promote sleep primarily by increasing rapid eye movement (REM) and are almost devoid of effects on slow-wave (SWS) sleep. At present, there is no consensus on whether the sole promotion of REM sleep has a negative impact in patients suffering from insomnia. However, sleep onset REM (SOREM), which has been documented with DORAs, is clearly an undesirable effect, especially for narcoleptic patients and also in fragile populations (e.g. elderly patients) where REM-associated loss of muscle tone may promote an elevated risk of falls. Debate thus remains as to the ideal orexin agent to achieve a balanced increase in REM and non-rapid eye movement (NREM) sleep. Here, we review the evidence that an OX 2 R antagonist should be at least equivalent, or perhaps superior, to a DORA for the treatment of insomnia. An OX 2 R antagonist may produce more balanced sleep than a DORA. Rodent sleep experiments show that the OX 2 R is the primary target of orexin receptor antagonists in sleep modulation. Furthermore, an OX 2 R antagonist should, in theory, have a lower narcoleptic/cataplexic potential. In the clinic, the situation
Parkinson's disease (PD) is a progressive neurodegenerative disorder. To date, most of the currently available therapies in PD target the dopaminergic system and none of these therapeutic approaches have been proven to modify the course of the disease. To various extents, these drugs can also cause motor and non-motor complications. A novel target, the adenosine A(2A) receptor (AA2AR), was recently identified, blockade of which may alleviate Parkinsonian symptoms, reduce motor fluctuations and potentially afford neuroprotection. This review is based on a PubMed search covering the relationship of the adenosine receptors and PD. The role of the AA2AR is reviewed and the results of preclinical investigations of antagonists are assessed. A synopsis of current drug development is provided, with a special focus on the pharmacokinetics and relevant clinical trials. The localization o

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