"dizocilpine is the most frequently used uncompetitive NMDA receptor antagonist in animal models to mimic psychosis"

Glutamate is the brain's primary excitatory neurotransmitter. The channel is normally blocked with a magnesium ion and requires depolarization of the neuron to remove the magnesium and allow the glutamate to open the channel, causing an influx of calcium, which then leads to subsequent depolarization. Dizocilpine binds inside the ion channel of the receptor at several of PCP's binding sites thus preventing the flow of ions, including calcium (Ca2+), through the channel. Dizocilpine blocks NMDA receptors in a use- and voltage-dependent manner, since the channel must open for the drug to bind inside it.The drug acts as a potent anti-convulsant and probably has dissociative anesthetic properties, but it is not used clinically for this purpose because of the discovery of brain lesions, called Olney's lesions, in laboratory rats. Dizocilpine is also associated with a number of negative side effects, including cognitive disruption and psychotic-spectrum reactions. It inhibits the induction of long term potentiation and has been found to impair the acquisition of difficult, but not easy, learning tasks in rats and primates. Because of these effects of dizocilpine, the NMDA receptor pore blocker ketamine is used instead as a dissociative anesthetic in human medical procedures. While ketamine may also trigger temporary psychosis in certain individuals, its short half-life and lower potency make it a much safer clinical option. However, dizocilpine is the most frequently used uncompetitive NMDA receptor antagonist in animal models to mimic psychosis for experimental purposes.

Dizocilpine | 8A-PDHQ [ ion channel influx ] III.

PD-137889 | Flagship [ exodus / neurogenesis ] Ki [3H] TCP [a] 27 nM

merged 2 unfinished tracks from a while ago

https://soundcloud.com/dancinginrainfall/ripperdoc/s-0mzvgThsW4H
https://soundcloud.com/dancinginrainfall/despondent/s-AlK21syb7CO

yeah
slit right through my fingers
ill end this bitch why linger
feel weaker, always thinner
i said someone said

i cant feel this earth
cant make it all on myself
youll tap out when im in
i cannot feel this shit
so much on my head
bitch im feeling dead

feel so tense bitch im tongue tied
i cannot talk to anyone about you

suicide, heresy
bitch i dont feel good anyday
misery wont cease till i lay
wish i had u 2 talk to n my head

talk once imma spaz
slide once imma spaz
intuitive to my head
intuitive to my head

netrunner - despondent | amygdala

netrunner - swollen | infamous [ desire ]

feel stuck in this place
prod @dancinginrainfall s/o twin

this anhedonia is breakn my brain
tired of this ion wanna be awake
swear i wake up it always been the same shi
ion know nuthin else jus remember this
cant rest when i sleep i see they faces
hate how the game go yea its fuck this
brain always erodin im tired of it
hate feelin like this but yu learn2 love it
hate how im always so self-destructive
all i do now is sedate2 mitigate
walkin round for so long ion know my place
so inane so i been losin my way
shawty come2 me if yu feel lost we'll find a way
yea i swear2 god i'll help yu yea i'll find a way

i swear it's gotta work somehow
not gon let it fall now
gon make a way somehow

i got problems wit it
way yu[majority] look at me it's
fuckin wit my head nd
ion wanna feel this
do yu feel my lesions?
trauma time intention
always emotional rut
dwell on the gutter so done
hate like errything when i wake up i wish i was gone
dont need another death cycle no nooo
i dont need another death cycle no nooooo
i cant keep killin my egoooo.. :/

Sedate My Corrosion [prod Miseryprism]

down2 self-dissonancy
prod @dancinginrainfall w/ extra frm me

@searingthrume
ima carve my own way out
dont evn try2 doubt me, it wont work, no.
sinkin in this room, i feel like im on death row
sick of feelin like this, yea, ima choke.
fuck tha world, hate it all, tryna find a moat
all in tha distance now, like what happened??
feel so detached from like errything its maddening
[french]femme belle, why do this to me??
yur jus what i need
dont tell me that yur wary of me now???
im tired of breaking down.. :/
yea i feel so worthless as im spillin my guts
i aint fuckin wit it, no. im not fuckin wit it.
its fuckin wit my motions, ruin nervous system
realization set in.. so done, so done...

@sinefelt
everything's breaking apart
u been all up on my buttons
like ur tryna whip a damn push 2start
u been playin w my heart
can't tell if u mean harm
either way u cld keep ur mouth shut
bitch shut the fuck up
don't play that card
can't tell what i shouldn't be taking
u know that shit 2 n use it
i shoulda known tho, that's my fault
u waved plenty flags ur putrid

i know i'm not the only one
discounted me, we're done
i just wanna sit down
roll up quick
n nvr go see the sun

damn
i think that i might b losing it
i wonder if u felt the same
if u did i couldn't imagine it
u wouldn't be playing these games

at least i don't think so
can't let me miss your ringtone
if i do it's game over
if i do then u won
bitch pls shut the fuck up
stop lying u don't worry bout me tons

always spills out「+sinefelt nd miseryprism」

An elite hacker cell attacks The Corporation, which retaliates using their own private hacker army

Cyberpunk scene

.. so much4 that .
prod me nd @dancinginrainfall

i swear2 gawd
yea i cant keep goin on like this
before i met yu i aint feel a thing
carbon bond baby tell me if yu feel that
wasnt lyin when i said i think i need that
yu agonize my bonds, its that magic
turnin my head2 soup
seepin in my heart, chains gettn cut thru
feel yu get me the depth is insanity
2:2 swear her mind feel so close2 me
pull me out the fuckery, pull me outta errything
rlly hope yu feel the same wayyy
way we talk like erryday does sumn2 my brain
hope yu get what the fuk i been sayinnn
swear it b that magic k, yea that magic k

agonize my heart
agonize my bonds
agonize me
tell me whatchu want
nevr want yu gone
love what yu do to my chemistry
only one that i want
think yur jus what i need
see all these other folks?
they could never get me

agonize my bonds.. ♡♡「+miseryprism」##1:1

"Spirit War" - Prod. 2025 by Netrunner // Preview

Spirit War

2 much carbon bionic goddamn whip
bitch i doubt i will i feel again
got 2 geeked up bitch ill never feel again
every week is the goddamn same
not even finna trip
in that shit like cateleya
nightingale my face 
shoutout my bro veja
u a  corporate not no major
this bitch im in love with damn anesthesia
so enamored with the rain
bring me to fantasia
never gave a shit
walk up in this bitch geek tf up
got this k on me, im talking 3 Oxo PCE
bring me to goddamn fantasia

flying in this bitch going mach speeds into the unknown
rolling hard as fuck bitch im fully off my dome
eat this this .76 we dont see eye 2 eye
no no u cant follow where my go
i cant understand what u saying
i cant even see u
i just wanna see u
hollowpoint bullets make his ass see through
fly innat bitch in that fucking rain
dipyanone in my goddamn system
too much drugs i need 
too much in my lungs
never coming down no no

fantasia | galliano | dipyanone  ( miseryprism )

The streets are dead. This is cyber turf now.

Digital Blood ain’t a track                           It’s a fucken transmission. From payloads to proxies, this is the new age grind where nerds move silent and code hits louder than any Glock ever could. Forget gold chains haha             This is root access. No bling, no drip, just digital vengeance and encrypted trauma masked behind a terminal window.

Written in fire, laced in grief, and aimed straight at a world full of flexed-up fuckwits.

This is your warning shot.
The nerds aren’t playing nice anymore.

MagooZla - Digital Blood

@ihatejugo  +  a little from me
@avexacortexa 1:1 llike no other

so geeked i cant function
bitch dont ask me nothing
i cannot finish something
up that qbz he running
up that qbz where you wrong
762 leave him stump
no no no no no
goddamn
stab this bitch dont care bout nothing
i could hear his heartbeat jumping
up n his house we breaking in n running
regardless how many men
sicario walk in like im cataleya
walk in, netrun
i cant feel a damn thing
primidone in my fucking body in my bloodstream
i cant feel my self
tell that bitch i need u, more than o-dsmt
tell her take rip off her jeans
iv up that O-PCE
10 lines of amphetamine
high off ephenidine
goddamn bitch you cannot
get up on my level
300 black out take his knees
take ur nails and make make me bleed

i look right back, ion give no mind
kill yourself boy u needa die
jiggas got me out my mind
he talking shit i cannot mind
wake up walk like Frankenstein
need more drugs to metabolize

never felt anything, nothing
pop 10 percocets im not even stumbling
girl i cant pick a substance with u
got me stunting, im higher n higher
never found meaning, nothing
tell that boy, yeah i got u something
with a bad white bitch she give her mind
she want more i dont got time
fuck out my face talking dont waste my goddamn time
burn him when he see the heavy carbon in my ride
i dont even pickup my damn line ion even
talk that way i fuck him up
up that rifle if i must
1:1 like no other
dont know who to trust, got my brothers
im so geeked up i cant fathom
its so perfect, while your over
F-17475 in my goddamn mind
so many pills up in my body i feel like no other
my only fear is being sober
bad ass bitch come over
i walk like korshunova or pivarova
fingers deep up in that bitch
told her leave her friends right over
sniffing percs while that bitch over
dont sip codeine that shit weak as fuck

nail me to the fucking ground
i cant feel a fucking thing
i wanted u to drop that lie, u were everything
need to be heavily tranquilized,  just dont rescue me
dont care im not even shy, i cant ever breath
im not waking up if i dont got no more drugs to eat
girl you know i can even tell, that u follow me
lately i dont even give a fuck, cant tell what i think
i feel dead alive cause i made u leave

netrunner  - backlash | like no other  [  jugowickd ]

netrunner - cocaine | mephedrone

Avexa Cortexa Pharmeceutical & Biotech Research Facility

Wisdom Research Evolution

|  @avexacortexa
|  @traumacatalyst

1:1

 [  https://miseryprism.bandcamp.com/   ]

[🝎] covered in lesions #deathcycles
architect @avexacortexa⠀╮
⠀+ +@inverseinterpolate⠀╯

inquiries - texhnolesions@gmail.com

1:1 — like no other

We ain’t normal, we’re human.
In the age of drip fed loops, normality is synthetic. Humanity is the glitch. I Hate Labels is the reminder.
A digital ghost shouting back through the static. We create from chaos, not for clout. Every track is a crack in the feed, a space to reflect, to breathe, to wake up. This isn’t normal music. It’s human noise.

Avexa Cortexa Research Facility
@avexacortexa
Wisdom Research Evolution

1:1

One man army production, bleeding Beats for the human mind & Soul... We Are All Born Under One Star 🫶🏾 One Love🫶🏾 Beatport: https://www.beatport.com/label/netrunner/116394

I produce, mix and master my songs. Constantly releasing tracks from the mothership.

You will find a variety of genres blended into my own unique style: Electronic RnB, Liquid Drum N Bass, Retro Wave, Hip Hop, Electronic, Freestyle, Quad, Miami Bass, Rhythm & Quad

U can find my ALIAS here for #UndergroundHipHop https://soundcloud.com/abnorm_76

Stay healthy and thanks for listening to my music! 

Netrunner Spotify Artist: https://open.spotify.com/intl-de/artist/6fAbN3N19dVpbxg95XCEnO?si=Ns07Mz9-RFCa8hc_KehLWA

Merch: https://www.etsy.com/de/shop/NetrunnersGeekShop
Contact: realakumaryu@gmail.com

New tracks tagged #netrunner