BUFFALO, NY- December 12, 2023 – A new #researchpaper was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 22, entitled, “Tat-heat shock protein 10 ameliorates age-related phenotypes by facilitating neuronal plasticity and reducing age-related genes in the hippocampus.”

In this new study, researchers Hyo Young Jung, Hyun Jung Kwon, Kyu Ri Hahn, Woosuk Kim, Dae Young Yoo, Yeo Sung Yoon, Dae Won Kim, and In Koo Hwang from Seoul National University, Chungnam National University, Gangneung-Wonju National University, Hallym University, and Konkuk University investigated the effects of heat shock protein 10 (HSP10) protein on memory function, hippocampal neurogenesis, and other related genes/proteins in adult and aged mice. 

“In the present study, we investigated the effects of HSP10 on hippocampal function in both adult and aged mice.”

To translocate the HSP10 protein into the hippocampus, the Tat-HSP10 fusion protein was synthesized, and Tat-HSP10, not HSP10, was successfully delivered into the hippocampus based on immunohistochemistry and western blotting. Tat-HSP10 (0.5 or 2.0 mg/kg) or HSP10 (control protein, 2.0 mg/kg) was administered daily to 3- and 21-month-old mice for 3 months, and observed the senescence maker P16 was significantly increased in aged mice and the treatment with Tat-HSP10 significantly decreased P16 expression in the hippocampus of aged mice. 

In novel object recognition and Morris water maze tests, aged mice demonstrated decreases in exploratory preferences, exploration time, distance moved, number of object contacts, and escape latency compared to adult mice. Treatment with Tat-HSP10 significantly improved exploratory preferences, the number of object contacts, and the time spent swimming in the target quadrant in aged mice but not adults. Administration of Tat-HSP10 increased the number of proliferating cells and differentiated neuroblasts in the dentate gyrus of adult and aged mice compared to controls, as determined by immunohistochemical staining for Ki67 and doublecortin, respectively. 

Additionally, Tat-HSP10 treatment significantly mitigated the reduction in sirtuin 1 mRNA level, N-methyl-D-aspartate receptor 1, and postsynaptic density 95 protein levels in the hippocampus of aged mice. In contrast, Tat-HSP10 treatment significantly increased sirtuin 3 protein levels in both adult and aged mouse hippocampus. These suggest that Tat-HSP10 can potentially reduce hippocampus-related aging phenotypes.

“Our results suggest that Tat-HSP10 treatment facilitates mitochondrial function, and Tat-HSP10 supplementation ameliorates the aging phenotypes in the mouse hippocampus.”

DOI - https://doi.org/10.18632/aging.205182

Corresponding authors - Dae Won Kim - kimdw@gwnu.ac.kr, and In Koo Hwang - vetmed2@snu.ac.kr

Keywords - aging, heat shock protein 10, hippocampus, memory, neurogenesis, synaptic plasticity

About Aging-US

Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

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Aging (Aging-US)

Tat-Heat Shock Protein 10 Ameliorates Age-Related Phenotypes in the Hippocampus

Neurogenesis

NoBadTrip - Neurogenesis

Hardeval - Broken Device EP
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Info:

Format: FLAC
Country: Slovakia
Released: Oct 30, 2013
Genre: Electronic
Style: Hard Techno
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Notes:

These are my first productions of Hard Techno subgenre, taken from EP released in LLokko Hard Tech (2013). Giovan Streitbar was another alias from Hardeval, currently out of use due to my female transition.
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Full track here:
https://hardeval.bandcamp.com/track/6-minutes-of-neurogenesis-2013
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Tracklist:

01. Hardeval - Broken Device [4:28]
02. Hardeval - Cardiac Pacemaker [5:43]
03. Hardeval - 6 Minutes Of Neurogenesis [6:03]
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Written By: Antonella Ponce Arévalo
©2014: LLokko Hard Traxx, a sublabel of LLokko Records
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Social links:

https://hardeval.bandcamp.com/
https://soundcloud.com/hardeval/
https://www.instagram.com/anto2k24/
https://www.facebook.com/ant0.2024/
https://www.mixcloud.com/hardeval2k24/

Broken Device EP

6 Minutes Of Neurogenesis

6 Minutes Of Neurogenesis (Original Edit) [2013]

All is ordered, all is transient, all is sacred on this planet, or this plane if we accept that infinite space in three dimensions can be contained in topology bounded on the z-axis.
Can you follow logic outside the boxes that education keeps you caught in? Caring what others think has left you trottin in hamster wheels & never stoppin to ask just for a minute is my mind controlled by limits that enclose me psychosocially within a mental prison, so that I can never see that Ive always been free & that the beauty of this world surpasses all soulless bullshit taught in classes?
They trapped us inside of dark rooms while the sun passed, wasting our youth, preaching the future will be brighter as long as we stay in school.
They said the smartest ones should delay working & reach for university. For those a little dumber, college should suit you perfectly.
Just have faith in systematic institutional establishments, dont look into what youre eating, theres no time, you should be studying these facts that will ensure academic advancement so that you get that diploma, the final prize that youre after.
Dont worry bout your health, focus on your rank amongst the students.
Dont even worry bout learning, get the grade allowing continuance.
On your graduation  day, youll be thankful you saw it through, even if youre left depressed & ultimately more confused
About what to do in life, if you want to solve the worlds problems.
How you gonna do that if the corporations cause em?
Are they going to let you fix a thing within the system they created so you yourself could uphold the entities perpetuating your enslavement?
Fucking up the Earth through stupid egotistical pursuits.
It would have truly served us more to use tuition money on mushrooms.

We are infinite beings, only bound by hollow teachings,
With the power to reflect the breadth of universal lessons.
Possessing patience & presence to learn from every experience,
Walls & halls cannot confine us, it’s time to reclaim our minds from
Oppressive systems that degrade us, all day practically caged up,
Assignments & grades constrain us from thinking outside the pages.
Deprived of living life, will to be free is outrageous,
Nine to five future slavery, fuck that shit, I’m contagious
With a virus that’s stage one, it’s gonna last ’til I’m ageless,
Just too sick, I can’t fake this, it must have fucked up my brain cause
It makes me see that school & work are but occult balls & chains, son.
I’m not a pawn on the checkerboard masons placed on the temple floor.
Not controlled by the news reports used to fuel the foreign wars.
I’m protruding through borders formed, came in straight from the portal hole.
Students storming the corridors, saw the truth, we immortal souls.
Been intruded like Trojan horse through the programs informing us.
I conclude with the coroner, your brain dead, it don’t work no more.
TV hit you like chloroform, like your mind was aborted or
Your body resorted to its subconscious extortion so
It could ignore the warning calls to come back from commercial pause
To resume with entertainment & conform with the normal world.
It’s unfortunate we aren’t all choosing not to abuse ourselves.
That’s just life in a dual realm, see all from heaven down to hell.
Ever-present so time won’t tell, there is only the here & now,
Just this moment & nothing else, existence is ephemeral,
Hummingbird-like ethereal, collapsing like imperial,
Disappears like material, this wisdom is empirical 
There is nothing to fear at all, we appear individual,
The truest hallucination, universe sought to lose itself.
---

PLUTONIAN - Higher Education (Prod. smoke hash)

Break your brain with this new track.
A collaboration I made with my dear friend nath.exe who taught me all this, I hope you enjoy the video I made for all of you!
(VIDEO HERE!! https://youtu.be/kiApBs3Hrak?si=RG28OJiN-bqjcbOJ)

@nathdotexe  (my friend's music)

Amen 4Nh1lAt0R -  (feat Nath.exe)

what's that in the sky?? 
SEE THE VIDEO HERE!

https://youtu.be/rGKlOMjoTmA?si=jWi2Tx38V2MSNpRA

First Flight Mission

@nathdotexe (my friend's music)

I share with you this project that I did with my friend Nath.exe, something experimental to escape from reality.
A collaboration I made with my dear friend nath.exe who taught me all this, I hope you enjoy the video I made for all of you!
Video:

Dark Hero Revenge - (feat Nath.exe)

Compare CogniUltra and Cerebra to find the best brain-boosting supplement. Discover their ingredients, effectiveness, user feedback, and which one delivers better results for memory and focus.
https://www.cogniultra.com/blogs/supplement/cogniultra-vs-cerebra

CogniUltra Vs Cerebra

🔗 Follow me:
https://www.instagram.com/madstroke.dnb/

Neurogenesis Mix

new + old research snippets w/ friends :)

wisdom | research | evolution @avexacortexa

[I] chev chelios +@dancinginrainfall

[II] GABAA-rho +@dancinginrainfall

[III] qbittorrent [solo]

[IV] turnt2dust +@inveja nd @dancinginrainfall
[ https://soundcloud.com/searingthrume/hurt-like-hell ]

[V] mothership +@ihatejugo nd @kutliss

[VI] bathed in mercury +@kutliss nd @dancinginrainfall

[VII] feel so anemic [solo]

[VIII] phytochemicals +@chewy

[IX] hell2pay +@gr0lth

[X] cybermancy +@chewy

[XI] feel so baddd [solo]

[XII] faux +@alongthewalls

[XIII] anhedoniac +@kutliss

april research showcase | 5-HT2A full agonist [283.4 g/mol] ##avexacortexa

PLUTONIAN conscious rap connecting everything from science to psychedelics.

[🝎] covered in lesions #deathcycles
biotechnician @avexacortexa

1:1 like no other
texhnolesions@gmail.com

Drum and Bass DJ/Producer

https://www.instagram.com/madstroke.dnb/

Chilean amateur Hard Dance Dj/Producer and podcaster in DiFM (Hard Dance - The Style Awakens) [2016-2018]

Transgender girl in process ⚧

Cancer and aging are two sides of age-related tumorigenesis.

The mission of the journal is to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population.

The journal aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.)

Read about the Aging (Aging-US) Scientific Integrity Process: https://aging-us.com/scientific-integrity

i hope you like my music!
my youtube channel with music videos!
https://www.youtube.com/@ElectronicRhythmLab

New tracks tagged #neurogenesis