BUFFALO, NY — July 1, 2025 — A new #research paper, featured on the #cover of Aging (Aging-US) Volume 17, Issue 6, was #published on June 4, 2025, titled “DoliClock: a lipid-based aging clock reveals accelerated aging in neurological disorders.”

This study, led by first author Djakim Latumalea from the National University of Singapore and Hanze University of Applied Sciences, with corresponding author Brian K. Kennedy from the National University of Singapore, introduces DoliClock, a biological aging clock based on lipid profiles in the human brain. The researchers found that individuals with autism, schizophrenia, and Down syndrome show signs of accelerated brain aging compared to individuals without these conditions. The discovery offers a new approach to measuring brain aging using lipid markers instead of traditional DNA-based methods.

The team developed DoliClock using lipidomic data from post-mortem prefrontal cortex samples. Lipids are fat-like molecules that play a key role in brain health. Changes in lipid patterns can reflect the biological age of brain tissue. The study focused on a specific class of lipids called dolichols, which increase gradually with age. The DoliClock model was trained to predict biological age by analyzing levels of dolichols and other lipid molecules. It accurately estimated brain age and revealed higher aging rates in individuals with neurological disorders.

One notable finding was a sharp increase in lipid profile variability—also known as entropy—around the age of 40. This suggests a disruption in lipid metabolism during midlife, possibly caused by changes in the mevalonate pathway, a critical biological process involved in producing lipids like cholesterol and dolichol. These disruptions may contribute to aging-related brain decline.

The study also found that dolichol levels could serve as reliable biomarkers of aging. Their consistent increase with age and strong influence on DoliClock’s predictions make them especially useful. In individuals with autism, schizophrenia, and Down syndrome, the clock indicated more advanced biological brain aging than expected, supporting the idea that these conditions are associated with premature aging.

DoliClock offers a new perspective in aging research, complementing existing biological clocks based on DNA or protein markers. Because it relies on lipids, it may detect aspects of aging that other tools cannot. While the current model is based on brain tissue samples, future research may examine whether similar lipid patterns can be identified in more accessible fluids such as blood or cerebrospinal fluid.

“These findings suggest that lipidomics can provide valuable insights into the molecular mechanisms of brain aging and neurological disorders.”

This study highlights the growing potential of lipidomics in the study of aging and neurological disorders. It opens the door to new biomarkers that could help researchers and clinicians better monitor brain aging and develop more targeted interventions for age-related and neurodevelopmental diseases.
DOI - https://doi.org/10.18632/aging.206266

Corresponding author - Brian K. Kennedy - bkennedy@nus.edu.sg

Video short - https://www.youtube.com/watch?v=-FEiyj9PjBE

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Aging (Aging-US)

New Lipid-Based Aging Clock Reveals Faster Brain Aging in Autism, Schizophrenia, and Down Syndrome

The provided text explores the revolutionary concept of biophotons, or ultra-faint photon emissions (UPEs), establishing them as a quantifiable light emitted by living organisms, which increases with stress or injury. A significant breakthrough in April 2025 involved the detection of light directly from the human brain, leading to photophilography as a new, cost-effective neuroimaging technique that correlates UPE output with brain electrical activity during tasks. Future implications include advanced brain mapping and identifying "biophoton fingerprints" for thought patterns, potentially diagnosing neurological issues. Dr. Jack Kruse's "Operational Consciousness" framework offers a theoretical underpinning, proposing that life and consciousness are fundamentally quantum processes fueled by entropy, with the brain acting as an "antenna" that utilizes structured water and iron to harness light and facilitate nonlocal communication via UPEs, emphasizing the importance of light exposure and cold thermogenesis for health.



DECENTRALIZED MEDICINE | Biophotons - The Brain's Luminous Secret (Audio Summary)

A new study published recently as the cover of Aging Volume 17, Issue 6, describes a new method to estimate how fast the brain is aging. By analyzing lipids, or fat molecules, in brain tissue, researchers from the National University of Singapore and Hanze University of Applied Sciences created a biological “clock” called DoliClock. This innovation highlights how conditions such as autism, schizophrenia, and Down syndrome are associated with accelerated brain aging.

Understanding Brain Aging

As people grow older, their brains naturally change. However, in many neurological disorders, these changes seem to appear earlier and progress more rapidly. Disorders like autism, schizophrenia, and Down syndrome reduce quality of life and contribute to premature death. Scientists have long searched for better ways to measure biological age in the brain to understand these processes and develop strategies to slow them down.

Most existing methods for estimating biological age rely on genetic markers, such as DNA methylation, which are chemical modifications of DNA. While useful, these approaches may not fully capture the complexity of aging, especially in the brain. Lipids, which are essential components of brain cells and play important roles in energy storage and signaling, offer another perspective.

Full blog - https://aging-us.org/2025/07/doliclock-a-lipid-based-clock-for-measuring-brain-aging/

Paper DOI - https://doi.org/10.18632/aging.206266

Corresponding author - Brian K. Kennedy - bkennedy@nus.edu.sg

Video short - https://www.youtube.com/watch?v=-FEiyj9PjBE

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Keywords - aging, aging clock, down syndrome, autism, schizophrenia, dolichol

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DoliClock: A Lipid-Based Clock for Measuring Brain Aging

BUFFALO, NY — July 8, 2025 — As populations worldwide continue to age, understanding the mechanisms and manifestations of cognitive aging is increasingly urgent for science, medicine, and society. Age-related cognitive decline ranges from mild memory lapses to the onset of dementia, and is shaped by a complex interplay of molecular, cellular, systemic, and social determinants.

In this special collection, Aging (Aging-US) seeks to bring together cutting-edge research that spans the cellular and molecular underpinnings of cognitive aging with insights into the psychosocial, behavioral, and environmental factors that modulate its course. By integrating basic biology with translational and societal dimensions, this collection aims to foster a holistic understanding of how and why cognitive function changes with age—and what can be done to preserve it.

We welcome original research articles, reviews, and perspectives across model systems and human studies, particularly those that promote interdisciplinary insights and translational potential.

POTENTIAL TOPICS

Molecular and Cellular Mechanisms

-Senescence, inflammation, and neurodegeneration in cognitive decline
-Mitochondrial dysfunction and oxidative stress in aging neurons
-Neurovascular aging and blood-brain barrier integrity
-Single-cell and spatial transcriptomics of the aging brain
-mTOR, autophagy, and proteostasis in age-related cognitive impairment
-The role of glial cells (microglia, astrocytes) in brain aging

 Genetics and Biomarkers

-Genetic risk factors and epigenetic modifications associated with cognitive aging
-Biomarkers of cognitive resilience and vulnerability
-Neuroimaging and fluid-based biomarkers in aging populations

Interventions and Lifestyle Factors

-Cognitive benefits of caloric restriction, exercise, or senolytic therapies
-Preclinical and clinical trials targeting aging pathways to prevent cognitive decline
-Impact of sleep, nutrition, and metabolic health on cognition in older adults
-Use of cognitive strategies and compensatory techniques to maintain or enhance function in aging

Environmental and Social Contexts

-Impact of social isolation, education, and socioeconomic status on cognitive trajectories
-Lifelong cognitive reserve and its determinants
-Cross-cultural and demographic studies on aging and cognition
-Digital health tools for monitoring or enhancing cognitive function in the elderly

SUBMISSION DETAILS:

-Submission Deadline: March 31, 2026
-Manuscript Format: Please follow the journal’s submission guidelines
-Peer Review: All submissions will undergo a rigorous peer-review process
-Submission Link: https://aging.msubmit.net/cgi-bin/main.plex

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Now Accepting Submissions: Special Collection on Cognitive Aging

Tracklist: [148 BPM]
1.	Hypnoise - Unified Field (Ana Valeriano Remix)
2.	Alter Vu & Ana Valeriano - Anagram (UNR)
3.	Ana Valeriano & Neurology - The Hive (UNR)
4.	Neurology & Benedix - NN (UNR)
5.	Avan7 - Biological Connection (Original Mix)
6.	Ana Valeriano - Gosto Meio Roxo (Original Mix)
7.	Limbu & Brainlapse - NN  (UNR)
8.	Ana Valeriano - Cabron (Original Mix)
9.	Volcano On Mars - Connected (Original Mix)
10.	Ana Valeriano - Welcome (Original Mix)
11.	Ana Valeriano & Evocar - Oppenheimer (Original Mix)
12.	Hyperflex - Made of Light (Ana Valeriano & Cosmic Wolf Remix)
13.	Cosmic Wolf, Ana Valeriano, Alien Talk - Melded (Original Mix)
14.	Avan7 & Br1sa - Free Soul (Original Mix)
15.	Cosmic Wolf & Ana Valeriano - Hypnotic (Original Mix)
16.	Cosmic Wolf & Ana Valeriano - Wake Up (Original Mix)

(Español) Ana Valeriano, nacida en Belo Horizonte, es una de las DJs femeninas más destacadas del trance psicodélico en Minas Gerais, con una personalidad fuerte que se refleja en su sonido característico.
Apasionada por la música, Ana siempre ha encarado su trabajo con creatividad, destacándose no solo por la autenticidad al expresar sus ideas, sino también por la importancia que le da a las sensaciones que transmite el sonido.
En su trayectoria musical, lanzó sus primeras canciones, alcanzando el prestigioso puesto número 1 en Beatport con su EP “Mystic Chants”, y participó en colaboraciones junto a otros artistas de renombre.
Sus sets transitan por las sutilezas del Full On y presentan repertorios cuidadosamente seleccionados, construyendo una atmósfera única y llevando la pista a momentos de intensa euforia y éxtasis.
Ana es representante del sello Maharetta Records, una influyente discográfica española que reúne a reconocidos artistas internacionales.

(Portugués) Ana Valeriano, nascida em Belo Horizonte, é uma das mais expressivas DJs femininas do trance psicodélico mineiro, com uma forte personalidade que se reflete em sua sonoridade marcante.
Apaixonada por música, Ana sempre encarou seu trabalho com criatividade, destacando-se não apenas pela autenticidade ao expressar suas ideias, mas também pela ênfase na importância das sensações transmitidas pelo som.
Na trajetória musical, lançou suas primeiras faixas, alcançando o prestigioso Top 1 no Beatport com seu EP "Mystic Chants", e participou de colaborações em lançamentos com outros artistas de renome.
Seus sets transitam nas nuances do Full On e apresentam repertórios bem selecionados, construindo uma atmosfera única e levando a pista a momentos de intensa euforia e êxtase.
Ana é representante do selo Maharetta Records, uma influente gravadora espanhola que reúne renomados artistas internacionais.

Ana Valeriano On
SoundCloud: @djanavaleriano
Redes Sociales: https://linktr.ee/djanavaleriano

Pulpa Music on
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It's Time to Psychedelic #0165 by ANA VALERIANO (BR)

Do you know you need to turn your attention away from technology, but find it difficult to do? Is your body and your nervous system asking for something different, more peaceful, and quieter?

Join Heather and the summer-night crickets for a meandering conversation about unplugging, tuning in to the earth, and nurturing your body and your world in new, simple, and very different ways.

Mentioned In This Episode
Unplug – Balancing the Ecosystem of Body, Neurology, Earth & Technology: heathernichols.com/unplug
The Generative Business Pods 6-Month Online Program: heathernichols.com/businesspods
Exploring the Sweetness of Silence – A Free Taste of the Generative Business Pods: heathernichols.com/silence

Heather's Links & Resources
Website: heathernichols.com
Facebook: facebook.com/heathernicholscf
Instagram: instagram.com/heatherknichols
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SoundCloud: soundcloud.com/heather-nichols-7
Telegram: heathernichols.com/telegram

Access Consciousness
AccessConsciousness.com/HeatherNichols

Episode 27 – Body, Neurology, Earth & Technology | Creation of Living Podcast

BUFFALO, NY — September 16, 2025 — A new #research paper was #published  in Volume 17, Issue 8 of Aging-US on August 6, 2025, titled “Age-related trends in amyloid positivity in Parkinson’s disease without dementia.”

In this study, led by first author Keiko Hatano and corresponding author Masashi Kameyama from the Tokyo Metropolitan Institute for Geriatrics and Gerontology in Japan, researchers found that patients with Parkinson’s disease (PD) diagnosed in their 80s showed a significantly higher rate of amyloid positivity—an indicator associated with Alzheimer’s disease—compared to those diagnosed at a younger age. Importantly, none of the participants had dementia. These findings suggest that older patients with PD may face a greater risk of future cognitive decline and could benefit from early screening for Alzheimer’s-related brain changes.

Amyloid-beta is considered a key marker of cognitive decline. While it is known that amyloid accumulation contributes to PD with dementia, its role in patients who have not developed cognitive problems remains less understood. This study aimed to explore how age influences amyloid buildup in people with PD who do not yet show signs of dementia.

The researchers analyzed data from 89 individuals with PD and no signs of dementia. Participants were divided into two age-based groups: those diagnosed before age 73 (LOW group) and those diagnosed at age 73 or older (HIGH group). Using cerebrospinal fluid samples, they measured levels of amyloid-beta, a standard method for detecting early Alzheimer’s-related changes. The findings revealed that 30.6% of the older group tested positive for amyloid, compared to just 10.0% in the younger group.

“[…] we elucidated the prevalence of amyloid positivity in patients with PD without dementia, whose mean age at diagnosis was 80.2 years, using CSF Aβ42 levels.”

Interestingly, both age groups of Parkinson’s patients had a lower rate of amyloid positivity than cognitively normal individuals of the same age in the general population. This unexpected result suggests that PD may alter how amyloid accumulates in the brain, possibly shortening the phase in which amyloid builds up silently before symptoms appear. The authors suggest that amyloid buildup could accelerate the transition from healthy cognition to dementia in patients with PD. The study also observed age-related associations with other biological markers of Alzheimer’s disease, such as tau protein levels. 

As the global population continues to age and the number of older adults diagnosed with PD grows, identifying early warning signs of cognitive decline becomes increasingly important. These findings may help inform future screening approaches and support the development of therapies aimed at delaying or preventing dementia in people with Parkinson’s disease.

DOI - https://doi.org/10.18632/aging.206297

Corresponding author - Masashi Kameyama - kame-tky@umin.ac.jp

Abstract video - https://www.youtube.com/watch?v=AP8S9evzCJw

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Keywords - aging, amyloid positivity, Parkinson's disease without dementia, cerebrospinal fluid Aβ42

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Aging-US

Older Adults with Parkinson’s Disease Have Increased Brain Amyloid Without Dementia

This episode of VHHA’s Patients Come First podcast features Dr. Daniel Cohen, Chief of Neurology for Sentara Medical Group, for a conversation about his work, depression and mental health awareness, the importance of self care in mental wellness, which for Dr. Cohen includes DJing as a hobby, and more. Send questions, comments, feedback, or guest suggestions to pcfpodcast@vhha.com or contact on X (Twitter) (twitter.com/VirginiaHHA) or Instagram (www.instagram.com/virginiahha/) using the #PatientsComeFirst hashtag.

VHHA Patients Come First Podcast - Dr. Daniel Cohen

BUFFALO, NY — October 9, 2025 — A new #research paper was #published in Volume 17, Issue 9 of Aging-US on August 22, 2025, titled, “The impact of long-term social housing on biconditional association task performance and neuron ensembles in the anterior cingulate cortex and the hippocampal CA3 region of aged rats.”

The research team led by Anne M. Dankert from Providence College and University of North Carolina, Chapel Hill, showed that aged rats who lived in socially enriched environments throughout life retained better memory and cognitive flexibility than those housed alone. This study highlights the importance of social interaction in protecting the aging brain.

Cognitive decline, such as memory loss and reduced problem-solving ability, affects many people over the age of 65. While many factors contribute to age-related cognitive decline, this study suggests that one key factor may be surprisingly simple: long-term social connection. To explore how social interaction might influence memory performance and brain activity, the researchers designed a study using rats as a model for aging in humans.

“Cognitive decline and changes in neuronal activity are hallmarks of aging.”

They compared three groups of rats: young adults, aged rats housed alone, and aged rats housed socially in groups. All groups had access to the same physical enrichment, such as exercise and stimulating objects, but only some experienced lifelong social companionship. The team tested these animals on a complex memory challenge known as the biconditional association task, which requires animals to make context-based decisions—an ability that typically declines with age.

The results showed that aged rats living in social groups performed just as well as young adults on the memory task, while those housed alone showed significant impairments. Socially housed rats also made fewer working memory errors and required less effort to complete cognitive tasks, suggesting not only better performance but more efficient brain function. These benefits were not observed in aged rats who received only environmental enrichment without social interaction.

Brain imaging revealed additional differences between the groups. Socially housed aged rats showed increased activity in the hippocampus, particularly in the CA3 region, which plays a key role in forming and separating memories. In contrast, aged rats that lived alone had lower activity in this region, which may explain their poorer performance. Interestingly, socially housed rats also showed reduced overactivity in the anterior cingulate cortex—a brain area involved in attention and decision-making—suggesting a more balanced and efficient neural response.

This research provides new insight into how lifelong social experiences shape brain health during aging. While earlier studies have shown that physical activity and cognitive stimulation help preserve cognitive function, this study identifies social interaction as an independent and powerful protective factor. The findings are consistent with human studies showing that older adults who remain socially active tend to experience slower cognitive decline and stronger brain function.

Overall, these results emphasize that brain aging is not inevitable but may be influenced by our social environments. This research suggests that fostering lifelong social connections could be a critical, low-cost strategy to protect memory and mental flexibility in older adults.

DOI - https://doi.org/10.18632/aging.206310

Corresponding author - Anne M. Dankert - adankert@unc.edu

Abstract video - https://www.youtube.com/watch?v=poNnPz1ti6Q

https://www.aging-us.com/

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Lifelong Companionship Protects Aging Rat Brains from Cognitive Decline

As people age, it is common to experience some memory lapses or slower thinking. Although this is often a normal part of aging, it can still affect a person’s quality of life. Scientists have been investigating ways to slow or prevent cognitive decline, and growing evidence points to the potential role of social interaction.

Recently, a study using rats found that long-term social connection may help protect the brain from age-related memory decline. This work, titled “The impact of long-term social housing on biconditional association task performance and neuron ensembles in the anterior cingulate cortex and the hippocampal CA3 region of aged rats,” was recently published in Aging-US (Volume 17, Issue 9).

Full blog - https://aging-us.org/2025/10/how-long-term-social-connection-supports-brain-health-and-memory-in-aging/

Paper DOI - https://doi.org/10.18632/aging.206310

Corresponding author - Anne M. Dankert - adankert@unc.edu

Abstract video - https://www.youtube.com/watch?v=poNnPz1ti6Q

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Keywords - aging, aging, environmental enrichment, working memory, complex cognition, immediate early genes

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How Long-Term Social Connection Supports Brain Health and Memory in Aging

Heather has been creating dynamic change in people’s lives for over 20 years. Her potent, spacious presence invites you to say YES to the brilliant life that is waiting for you on the other side of choice.

Aging-US is dedicated to advancing our understanding of the biological mechanisms that drive aging and the development of age-related diseases. Our mission is to serve as a platform for high-quality research that uncovers the cellular, molecular, and systemic processes underlying aging, and translates these insights into strategies to extend healthspan and delay the onset of chronic disease.

Read about the Aging (Aging-US) Scientific Integrity Process: https://aging-us.com/scientific-integrity

I genuinely believe in the potential of music to facilitate personal growth, foster meaningful connections, and cultivate shared experiences. My mission centers on producing dynamic musical works, both in the booth and studio, as an effective medium for storytelling, spiritual exploration, and the creation of deep emotional bonds.


+ Life Long Musical Professional & Enthusiast | Creative Entrepreneur | Music Producer | Club DJ | Event Production, Management, and Design Specialist | Electrician | Graphic Designer | Barber & Comedian 
+ Academic Background Master of Arts in Arts and Media, Audio Production, Media Management, Psychology, Mathematics, Sciences, and Business.   

**UNIFI MUSIC LLC**
NYC-Based Record Label, Music Production & Artist Management
At UNIFI MUSIC LLC, we aim to cultivate a creative and collaborative ecosystem for emerging musicians, artists, and producers. We are dedicated to educating up-and-coming artists to help them reach their highest potential while providing them the means to release music on all essential platforms. Our goal is to create an inspiring and lasting impact on the music industry. Music, dance, and storytelling are fundamental parts of the human experience. Art inspires, helps us find purpose, and fosters meaningful, lifelong connections..

Website - https://bio.site/anelo
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Pulpa Music es una productora de eventos con base en Buenos Aires, Argentina.
Dedicada a la música electrónica, se enfoca en los géneros Psytrance, Progressive Psytrance & Full On.
Fue fundada en el año 2017 por EarthNoise (Arg), y desde su creación ha logrado consagrar el evento que realiza año tras año como la fiesta más esperada de cada verano, siendo en formato outdoor, se caracteriza como festival al celebrarse todos los años en el mes de Diciembre, mes en el que originalmente nació esta fiesta.

Artistas - Team Pulpero 2025
- EarthNoise https://soundcloud.com/earthnoisemusic
- Zaratustra https://soundcloud.com/zaratustrapsytrance
- 1000oK https://soundcloud.com/miloka1
- Gmey https://soundcloud.com/gonza-mey
- Agus Casanova https://soundcloud.com/ac_arg

Booking: pulpamusic.producciones@gmail.com

New tracks tagged #neurology