A new study published recently as the cover of Aging Volume 17, Issue 6, describes a new method to estimate how fast the brain is aging. By analyzing lipids, or fat molecules, in brain tissue, researchers from the National University of Singapore and Hanze University of Applied Sciences created a biological “clock” called DoliClock. This innovation highlights how conditions such as autism, schizophrenia, and Down syndrome are associated with accelerated brain aging.

Understanding Brain Aging

As people grow older, their brains naturally change. However, in many neurological disorders, these changes seem to appear earlier and progress more rapidly. Disorders like autism, schizophrenia, and Down syndrome reduce quality of life and contribute to premature death. Scientists have long searched for better ways to measure biological age in the brain to understand these processes and develop strategies to slow them down.

Most existing methods for estimating biological age rely on genetic markers, such as DNA methylation, which are chemical modifications of DNA. While useful, these approaches may not fully capture the complexity of aging, especially in the brain. Lipids, which are essential components of brain cells and play important roles in energy storage and signaling, offer another perspective.

Full blog - https://aging-us.org/2025/07/doliclock-a-lipid-based-clock-for-measuring-brain-aging/

Paper DOI - https://doi.org/10.18632/aging.206266

Corresponding author - Brian K. Kennedy - bkennedy@nus.edu.sg

Video short - https://www.youtube.com/watch?v=-FEiyj9PjBE

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Keywords - aging, aging clock, down syndrome, autism, schizophrenia, dolichol

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Aging (Aging-US)

DoliClock: A Lipid-Based Clock for Measuring Brain Aging

BUFFALO, NY — July 8, 2025 — As populations worldwide continue to age, understanding the mechanisms and manifestations of cognitive aging is increasingly urgent for science, medicine, and society. Age-related cognitive decline ranges from mild memory lapses to the onset of dementia, and is shaped by a complex interplay of molecular, cellular, systemic, and social determinants.

In this special collection, Aging (Aging-US) seeks to bring together cutting-edge research that spans the cellular and molecular underpinnings of cognitive aging with insights into the psychosocial, behavioral, and environmental factors that modulate its course. By integrating basic biology with translational and societal dimensions, this collection aims to foster a holistic understanding of how and why cognitive function changes with age—and what can be done to preserve it.

We welcome original research articles, reviews, and perspectives across model systems and human studies, particularly those that promote interdisciplinary insights and translational potential.

POTENTIAL TOPICS

Molecular and Cellular Mechanisms

-Senescence, inflammation, and neurodegeneration in cognitive decline
-Mitochondrial dysfunction and oxidative stress in aging neurons
-Neurovascular aging and blood-brain barrier integrity
-Single-cell and spatial transcriptomics of the aging brain
-mTOR, autophagy, and proteostasis in age-related cognitive impairment
-The role of glial cells (microglia, astrocytes) in brain aging

 Genetics and Biomarkers

-Genetic risk factors and epigenetic modifications associated with cognitive aging
-Biomarkers of cognitive resilience and vulnerability
-Neuroimaging and fluid-based biomarkers in aging populations

Interventions and Lifestyle Factors

-Cognitive benefits of caloric restriction, exercise, or senolytic therapies
-Preclinical and clinical trials targeting aging pathways to prevent cognitive decline
-Impact of sleep, nutrition, and metabolic health on cognition in older adults
-Use of cognitive strategies and compensatory techniques to maintain or enhance function in aging

Environmental and Social Contexts

-Impact of social isolation, education, and socioeconomic status on cognitive trajectories
-Lifelong cognitive reserve and its determinants
-Cross-cultural and demographic studies on aging and cognition
-Digital health tools for monitoring or enhancing cognitive function in the elderly

SUBMISSION DETAILS:

-Submission Deadline: March 31, 2026
-Manuscript Format: Please follow the journal’s submission guidelines
-Peer Review: All submissions will undergo a rigorous peer-review process
-Submission Link: https://aging.msubmit.net/cgi-bin/main.plex

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Now Accepting Submissions: Special Collection on Cognitive Aging

Tracklist: [148 BPM]
1.	Hypnoise - Unified Field (Ana Valeriano Remix)
2.	Alter Vu & Ana Valeriano - Anagram (UNR)
3.	Ana Valeriano & Neurology - The Hive (UNR)
4.	Neurology & Benedix - NN (UNR)
5.	Avan7 - Biological Connection (Original Mix)
6.	Ana Valeriano - Gosto Meio Roxo (Original Mix)
7.	Limbu & Brainlapse - NN  (UNR)
8.	Ana Valeriano - Cabron (Original Mix)
9.	Volcano On Mars - Connected (Original Mix)
10.	Ana Valeriano - Welcome (Original Mix)
11.	Ana Valeriano & Evocar - Oppenheimer (Original Mix)
12.	Hyperflex - Made of Light (Ana Valeriano & Cosmic Wolf Remix)
13.	Cosmic Wolf, Ana Valeriano, Alien Talk - Melded (Original Mix)
14.	Avan7 & Br1sa - Free Soul (Original Mix)
15.	Cosmic Wolf & Ana Valeriano - Hypnotic (Original Mix)
16.	Cosmic Wolf & Ana Valeriano - Wake Up (Original Mix)

(Español) Ana Valeriano, nacida en Belo Horizonte, es una de las DJs femeninas más destacadas del trance psicodélico en Minas Gerais, con una personalidad fuerte que se refleja en su sonido característico.
Apasionada por la música, Ana siempre ha encarado su trabajo con creatividad, destacándose no solo por la autenticidad al expresar sus ideas, sino también por la importancia que le da a las sensaciones que transmite el sonido.
En su trayectoria musical, lanzó sus primeras canciones, alcanzando el prestigioso puesto número 1 en Beatport con su EP “Mystic Chants”, y participó en colaboraciones junto a otros artistas de renombre.
Sus sets transitan por las sutilezas del Full On y presentan repertorios cuidadosamente seleccionados, construyendo una atmósfera única y llevando la pista a momentos de intensa euforia y éxtasis.
Ana es representante del sello Maharetta Records, una influyente discográfica española que reúne a reconocidos artistas internacionales.

(Portugués) Ana Valeriano, nascida em Belo Horizonte, é uma das mais expressivas DJs femininas do trance psicodélico mineiro, com uma forte personalidade que se reflete em sua sonoridade marcante.
Apaixonada por música, Ana sempre encarou seu trabalho com criatividade, destacando-se não apenas pela autenticidade ao expressar suas ideias, mas também pela ênfase na importância das sensações transmitidas pelo som.
Na trajetória musical, lançou suas primeiras faixas, alcançando o prestigioso Top 1 no Beatport com seu EP "Mystic Chants", e participou de colaborações em lançamentos com outros artistas de renome.
Seus sets transitam nas nuances do Full On e apresentam repertórios bem selecionados, construindo uma atmosfera única e levando a pista a momentos de intensa euforia e êxtase.
Ana é representante do selo Maharetta Records, uma influente gravadora espanhola que reúne renomados artistas internacionais.

Ana Valeriano On
SoundCloud: @djanavaleriano
Redes Sociales: https://linktr.ee/djanavaleriano

Pulpa Music on
Instagram: www.instagram.com/pulpamusic
Facebook: www.facebook.com/pulpa.music
YouTube: www.youtube.com/pulpamusic
SoundCloud: @pulpa_music

It's Time to Psychedelic #0165 by ANA VALERIANO (BR)

Do you know you need to turn your attention away from technology, but find it difficult to do? Is your body and your nervous system asking for something different, more peaceful, and quieter?

Join Heather and the summer-night crickets for a meandering conversation about unplugging, tuning in to the earth, and nurturing your body and your world in new, simple, and very different ways.

Mentioned In This Episode
Unplug – Balancing the Ecosystem of Body, Neurology, Earth & Technology: heathernichols.com/unplug
The Generative Business Pods 6-Month Online Program: heathernichols.com/businesspods
Exploring the Sweetness of Silence – A Free Taste of the Generative Business Pods: heathernichols.com/silence

Heather's Links & Resources
Website: heathernichols.com
Facebook: facebook.com/heathernicholscf
Instagram: instagram.com/heatherknichols
YouTube: youtube.com/@heathernicholscf
SoundCloud: soundcloud.com/heather-nichols-7
Telegram: heathernichols.com/telegram

Access Consciousness
AccessConsciousness.com/HeatherNichols

Episode 27 – Body, Neurology, Earth & Technology | Creation of Living Podcast

BUFFALO, NY — September 16, 2025 — A new #research paper was #published  in Volume 17, Issue 8 of Aging-US on August 6, 2025, titled “Age-related trends in amyloid positivity in Parkinson’s disease without dementia.”

In this study, led by first author Keiko Hatano and corresponding author Masashi Kameyama from the Tokyo Metropolitan Institute for Geriatrics and Gerontology in Japan, researchers found that patients with Parkinson’s disease (PD) diagnosed in their 80s showed a significantly higher rate of amyloid positivity—an indicator associated with Alzheimer’s disease—compared to those diagnosed at a younger age. Importantly, none of the participants had dementia. These findings suggest that older patients with PD may face a greater risk of future cognitive decline and could benefit from early screening for Alzheimer’s-related brain changes.

Amyloid-beta is considered a key marker of cognitive decline. While it is known that amyloid accumulation contributes to PD with dementia, its role in patients who have not developed cognitive problems remains less understood. This study aimed to explore how age influences amyloid buildup in people with PD who do not yet show signs of dementia.

The researchers analyzed data from 89 individuals with PD and no signs of dementia. Participants were divided into two age-based groups: those diagnosed before age 73 (LOW group) and those diagnosed at age 73 or older (HIGH group). Using cerebrospinal fluid samples, they measured levels of amyloid-beta, a standard method for detecting early Alzheimer’s-related changes. The findings revealed that 30.6% of the older group tested positive for amyloid, compared to just 10.0% in the younger group.

“[…] we elucidated the prevalence of amyloid positivity in patients with PD without dementia, whose mean age at diagnosis was 80.2 years, using CSF Aβ42 levels.”

Interestingly, both age groups of Parkinson’s patients had a lower rate of amyloid positivity than cognitively normal individuals of the same age in the general population. This unexpected result suggests that PD may alter how amyloid accumulates in the brain, possibly shortening the phase in which amyloid builds up silently before symptoms appear. The authors suggest that amyloid buildup could accelerate the transition from healthy cognition to dementia in patients with PD. The study also observed age-related associations with other biological markers of Alzheimer’s disease, such as tau protein levels. 

As the global population continues to age and the number of older adults diagnosed with PD grows, identifying early warning signs of cognitive decline becomes increasingly important. These findings may help inform future screening approaches and support the development of therapies aimed at delaying or preventing dementia in people with Parkinson’s disease.

DOI - https://doi.org/10.18632/aging.206297

Corresponding author - Masashi Kameyama - kame-tky@umin.ac.jp

Abstract video - https://www.youtube.com/watch?v=AP8S9evzCJw

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Keywords - aging, amyloid positivity, Parkinson's disease without dementia, cerebrospinal fluid Aβ42

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Aging-US

Older Adults with Parkinson’s Disease Have Increased Brain Amyloid Without Dementia

This episode of VHHA’s Patients Come First podcast features Dr. Daniel Cohen, Chief of Neurology for Sentara Medical Group, for a conversation about his work, depression and mental health awareness, the importance of self care in mental wellness, which for Dr. Cohen includes DJing as a hobby, and more. Send questions, comments, feedback, or guest suggestions to pcfpodcast@vhha.com or contact on X (Twitter) (twitter.com/VirginiaHHA) or Instagram (www.instagram.com/virginiahha/) using the #PatientsComeFirst hashtag.

VHHA Patients Come First Podcast - Dr. Daniel Cohen

BUFFALO, NY — October 9, 2025 — A new #research paper was #published in Volume 17, Issue 9 of Aging-US on August 22, 2025, titled, “The impact of long-term social housing on biconditional association task performance and neuron ensembles in the anterior cingulate cortex and the hippocampal CA3 region of aged rats.”

The research team led by Anne M. Dankert from Providence College and University of North Carolina, Chapel Hill, showed that aged rats who lived in socially enriched environments throughout life retained better memory and cognitive flexibility than those housed alone. This study highlights the importance of social interaction in protecting the aging brain.

Cognitive decline, such as memory loss and reduced problem-solving ability, affects many people over the age of 65. While many factors contribute to age-related cognitive decline, this study suggests that one key factor may be surprisingly simple: long-term social connection. To explore how social interaction might influence memory performance and brain activity, the researchers designed a study using rats as a model for aging in humans.

“Cognitive decline and changes in neuronal activity are hallmarks of aging.”

They compared three groups of rats: young adults, aged rats housed alone, and aged rats housed socially in groups. All groups had access to the same physical enrichment, such as exercise and stimulating objects, but only some experienced lifelong social companionship. The team tested these animals on a complex memory challenge known as the biconditional association task, which requires animals to make context-based decisions—an ability that typically declines with age.

The results showed that aged rats living in social groups performed just as well as young adults on the memory task, while those housed alone showed significant impairments. Socially housed rats also made fewer working memory errors and required less effort to complete cognitive tasks, suggesting not only better performance but more efficient brain function. These benefits were not observed in aged rats who received only environmental enrichment without social interaction.

Brain imaging revealed additional differences between the groups. Socially housed aged rats showed increased activity in the hippocampus, particularly in the CA3 region, which plays a key role in forming and separating memories. In contrast, aged rats that lived alone had lower activity in this region, which may explain their poorer performance. Interestingly, socially housed rats also showed reduced overactivity in the anterior cingulate cortex—a brain area involved in attention and decision-making—suggesting a more balanced and efficient neural response.

This research provides new insight into how lifelong social experiences shape brain health during aging. While earlier studies have shown that physical activity and cognitive stimulation help preserve cognitive function, this study identifies social interaction as an independent and powerful protective factor. The findings are consistent with human studies showing that older adults who remain socially active tend to experience slower cognitive decline and stronger brain function.

Overall, these results emphasize that brain aging is not inevitable but may be influenced by our social environments. This research suggests that fostering lifelong social connections could be a critical, low-cost strategy to protect memory and mental flexibility in older adults.

DOI - https://doi.org/10.18632/aging.206310

Corresponding author - Anne M. Dankert - adankert@unc.edu

Abstract video - https://www.youtube.com/watch?v=poNnPz1ti6Q

https://www.aging-us.com/

MEDIA@IMPACTJOURNALS.COM

Lifelong Companionship Protects Aging Rat Brains from Cognitive Decline

As people age, it is common to experience some memory lapses or slower thinking. Although this is often a normal part of aging, it can still affect a person’s quality of life. Scientists have been investigating ways to slow or prevent cognitive decline, and growing evidence points to the potential role of social interaction.

Recently, a study using rats found that long-term social connection may help protect the brain from age-related memory decline. This work, titled “The impact of long-term social housing on biconditional association task performance and neuron ensembles in the anterior cingulate cortex and the hippocampal CA3 region of aged rats,” was recently published in Aging-US (Volume 17, Issue 9).

Full blog - https://aging-us.org/2025/10/how-long-term-social-connection-supports-brain-health-and-memory-in-aging/

Paper DOI - https://doi.org/10.18632/aging.206310

Corresponding author - Anne M. Dankert - adankert@unc.edu

Abstract video - https://www.youtube.com/watch?v=poNnPz1ti6Q

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Keywords - aging, aging, environmental enrichment, working memory, complex cognition, immediate early genes

To learn more about the journal, please visit our website at https://www.Aging-US.com​​ and connect with us on social media at:

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How Long-Term Social Connection Supports Brain Health and Memory in Aging

BUFFALO, NY — November 3, 2025 — A new #research paper featured on the #cover of Volume 17, Issue 10 of Aging-US was #published on October 20, 2025, titled “Brain region-specific and systemic transcriptomic alterations in a human alpha-synuclein overexpressing rat model.”

In this study, led by first author Vivien Hoof and corresponding author Thomas Hentrich from Saarland University, Germany, researchers investigated how excess alpha-synuclein—a protein linked to Parkinson’s disease—affects gene activity in different brain regions and the gut. They found that early, region-specific gene disruptions may contribute to the appearance of disease, with some effects also detected in the gut. These early molecular changes could serve as biomarkers for Parkinson’s and point to new directions for treatment.

Alpha-synuclein accumulates in the brains of individuals with Parkinson’s disease and other age-related neurological conditions known as synucleinopathies. To better understand this process, the research team used a genetically modified rat model that overexpresses human alpha-synuclein. They studied gene expression in the striatum, cortex, and cerebellum—three key brain regions involved in movement and cognition—and analyzed how these changes evolved with age. 

“Transcriptomic analyses were performed on gene and transcript level of striatal, frontocortical, and cerebellar tissue in 5- and 12-month-old transgenic (BAC SNCA) and wild type rats […]”

The results showed that gene alterations appeared earlier and were more pronounced in young rats, particularly in the striatum and cortex, before any visible signs of disease manifested. This early disruption challenges the common belief that gene alterations gradually increase with age and suggests that early-life molecular changes may be critical in disease development.

The researchers also found that many gene expression changes were unique to individual brain regions. However, they identified a set of genes that were consistently affected across all brain regions and the gut. This suggests that the disease may begin to affect the entire body—not just the brain—long before symptoms become noticeable.

Several of the shared genes are involved in synaptic signaling and inflammation—processes known to be altered in Parkinson’s. Others are linked to dopamine production and neuronal plasticity, indicating potential early efforts by the brain to compensate for the harmful effects of the alpha-synuclein buildup.

Overall, this study provides a detailed view of how alpha-synuclein affects gene networks early in the disease process. Understanding these changes may help identify biomarkers and develop targeted therapies before irreversible brain damage occurs.

DOI - https://doi.org/10.18632/aging.206331

Corresponding author - Thomas Hentrich - thomas.hentrich@uni-saarland.de

Abstract video - https://www.youtube.com/watch?v=Yl6AfVchkb0

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Keywords - aging, alpha-synuclein, transgenic rat model, different brain regions, transcriptome analysis

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Alpha-Synuclein Triggers Early Gene Expression Changes in Parkinson’s Disease Model

Synucleinopathies are a group of age-related neurological disorders, including Parkinson’s disease, dementia with Lewy bodies, and multiple system atrophy. Most individuals are not diagnosed until these diseases have significantly progressed, as early symptoms, such as a reduced sense of smell, subtle cognitive or motor changes are too vague to serve as reliable indicators. 

To uncover specific biological signs that appear earlier and clearly point to the disease process, researchers from Saarland University developed a study titled “Brain region-specific and systemic transcriptomic alterations in a human alpha-synuclein overexpressing rat model,” featured as the cover Aging-US, Volume 17, Issue 10.

Full blog - https://aging-us.org/2025/11/alpha-synuclein-overexpression-in-rats-reveals-early-clues-to-synucleinopathies/

Paper DOI - https://doi.org/10.18632/aging.206331

Corresponding author - Thomas Hentrich - thomas.hentrich@uni-saarland.de

Abstract video - https://www.youtube.com/watch?v=Yl6AfVchkb0

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Keywords - aging, alpha-synuclein, transgenic rat model, different brain regions, transcriptome analysis

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Alpha-Synuclein Overexpression in Rats Reveals Early Clues to Synucleinopathies

In this episode, we get an update on Anti-Amyloid therapies and ARIA, along with the new POC tool to help physicians navigate these therapeutics and how they may impact patients in the emergency department. We talk with Dr. Christina Shenvi who introduced us to ARIA earlier in the year and now we have more evidence and a POC tool.

Supported by Eli Lilly, USA

Anti-Amyloid Therapies and ARIA - Highlighting the Pearls of the POC Tool with Dr. Christina Shenvi

The second mix, and the first one of the year!
Mixed with traktor pro 4 and midi controllers.

Tracklist:
1. Psygeneration & DropKeeper - Addicted Stan
2. Ned Flangers - Rezzurekt
3. Neurology - Rythem Manipulation
4. Stereoxide & Unlimited - Delayed Flight
5. Alter Vu & Lante - Language
6. Wood Warden - Future Shamans 2.0 
7. Gandhabba & Synthetik Chaos - Casual Healing
8. Act One- Your Bass or Mine
9. Twisted Perception - Are you Ian 
10. Fohat - Dancing Elves

Art: TAS Visuals
I dont own any of these tracks or artworks, all the rights goes to thier respective owners.

January 2026 - Night Full-On/Twilight Mix

The February mix for your listening pleasure!
Mixed with traktor pro 4 and midi controllers.

Tracklist:
1. Twisted Perception - Gourmet Shit
2. Zzbing - Flapjacks
3. Aum Shanti & Makolly - Eternal Connections
4. Hypnospores & LabRat - Thcfx
5. Neurology - Lost World of Maya
6. Wooden Ships - Thought Forms
7. Light Vision & Unlimited - Heavy Weights
8. Ion - No Mind
9. Synthetik Chaos - Saiko Ticos
10. The Horrids - Rocker Deluxe

Art: TAS Visuals
I dont own any of these tracks or artworks, all the rights goes to thier respective owners.

February 2026 - Night Full-On/Twilight Mix

The ALS treatment landscape is shifting faster than ever, with emerging clinical trial data and advances in gene‑targeted therapies reshaping how healthcare professionals think about disease management and patient support. Now, with encouraging new results from clinical trials and the growing influence of AI‑driven drug discovery, Richard S. Bedlack, MD, PhD, of Duke University School of Medicine, and chair of i3 Health's activity, "Slowing Disease Progression and Optimizing Quality of Life for Patients with ALS, returns to highlight the latest developments that are already informing clinical practice—and bringing renewed optimism to both clinicians and the patients they serve.

Click here to view the full activity and claim your free credit: https://bit.ly/4qbRoXh

Additional Advances in ALS Research and Clinical Trials With Richard S. Bedlack, MD, PhD, MS

In this episode, we review advancements in migraine care and the standardization that can help physicians and other practitioners take the pain out of managing this condition, treating and preventing symptoms. 

https://drive.google.com/file/d/1YqEz5Ih_lmOnAk7nJsddfu8uXb3dYVjr/view?usp=sharing

Supported by Pfizer

Case Study: Standardized Protocol and Treatment of the Migraine Patient in the ED

Let's explore the concept of the entropic brain, a framework that describes how the brain can shift between organized and disorganized or chaotic states. We know that psylocibin temporarily increases this entropy, allowing the brain to break out of rigid activity patterns to access new ways of perceiving and processing information. In this episode, we talk about how brain entropy reflects the variability of our neural activity and thought patterns. We discuss how a shift in entropy can open the door to insights, emotional breakthroughs, and greater psychological flexibility.

Authors: Jake Rockandel, Eve Racette

Email: thinktwicepodcast@outlook.com 
Instagram: @thinktwice_podcast
LinkedIN: Think Twice Podcast
Patreon: https://www.patreon.com/ThinkTwicePodcast 

Disclaimer: Think Twice is a podcast for general information and entertainment purposes only. The content discussed in the episodes does not reflect the views of the podcast committee members or any institution they are affiliated with. The use of the information presented in this podcast is at the user’s own risk and is not intended to replace professional healthcare services. 

57 : Embracing Chaos : The Entropic Brain

Какво не знаем за мозъка и нервната система? Как да ги запазим по-дълго здрави, и кои са основните заболявания и вредни навици?

Отговорите в разговора ни с чл.-кор. проф. д-р Николай Габровски, началник на Клиниката по неврохирургия на УМБАЛСМ "Н. И. Пирогов", зам.-директор на медицнската дейност на УМБАЛСМ "Н. И. Пирогов", и председател на Фондация „Съвет за мозъчно здраве“.

Приятно гледане и слушане!

Последвай ни и в:

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https://www.youtube.com/@LegendiBG
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Apple Podcasts: https://podcasts.apple.com/bg/podcast/legendi-legends/id1538275381
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Георги Харизанов
Веселин Вълчев

Легенди / Legends
Българският подкаст

“Здраве” еп.32: Мозък и нервна система. Проф. Николай Габровски, УМБАЛСМ "Н.И.Пирогов"

Patty and Brian interview Dr. Robert Friedland about his second book, 99 Lessons in Critical Thinking.

#256 Critical Thinking for Everyone! | Robert Friedland | 99 Lessons in Critical Thinking | 3-19-26

BUFFALO, NY — March 23, 2026 — A new #research paper was #published in Volume 18 of Aging-US on March 12, 2026, titled “Blood biochemical and gut microbiotic neural network models forecasting human biological age.”

Led by Anastasia A. Kobelyatskaya from the Russian Clinical Research Center for Gerontology, Pirogov Russian National Research Medical University, and the Institute of Biology of Aging and Healthy Longevity Medicine with Preventive Medicine Clinic, Petrovsky Russian Research Centre of Surgery — with corresponding author Alexey Moskalev from the Institute of Biology of Aging and Healthy Longevity Medicine with Preventive Medicine Clinic, Petrovsky Russian Research Centre of Surgery — the study builds a gender-specific biochemical model (seven routine clinical markers, e.g., cystatin-C, IGF-1, DHEAS, plus sex-specific sets) and a microbiota model (45 species measured by full-length 16S sequencing). Both models were trained and tested on the same 637-person dataset and achieved mean absolute errors of around six years and R² values above 0.8.

The team emphasised interpretability: they applied SHapley Additive exPlanations (SHAP) to convert each model from a “black box” into a more interpretable tool, showing how individual predictors (for example, DHEAS, cystatin-C, NT-proBNP in the blood model, and species such as Blautia obeum in the microbiota model) shift predicted age in years for a given individual. The biochemical clock yielded a small (clinically accessible) predictor set (7 markers) to ease clinical translation, while the microbiota clock used a 45-species signature and highlighted microbiome taxa whose abundance gradients correlate with predicted microbiotic age.

“As the proposed models possess both global and local explainability, they hold future potential for application in monitoring the effectiveness of various interventions in clinical trials.”

The authors note limitations and next steps: the cohort was restricted to a Caucasian population, and the microbiota model requires sequencing resources that may limit immediate clinical rollout. They call for external validation in larger, ethnically diverse cohorts, prospective testing to link model predictions to health outcomes, and application of the explainable models to monitor responses in intervention trials (for example, lifestyle, diet, or drug studies) where a change in predicted biological age would be an early, interpretable signal of benefit.

DOI - https://doi.org/10.18632/aging.206360

Corresponding author - Alexey Moskalev - amoskalev@med.ru

Abstract video - https://www.youtube.com/watch?v=wg3YEwXMKWY

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Keywords - aging, biological age, blood biochemistry, gut microbiome, neural network

To learn more about the journal, please visit https://www.Aging-US.com​​ and connect with us on social media at:

Bluesky - https://bsky.app/profile/aging-us.bsky.social
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MEDIA@IMPACTJOURNALS.COM

New Blood- and Microbiome-Based Neural Networks Forecast Human Biological Age

i3 Health’s mission is to enhance the proficiency of the interprofessional healthcare team by providing evidence-based, fair-balanced CME/NCPD/CPE-approved activities that address identified professional practice gaps and unmet educational needs.

Get your critical thinking caps on! ‘Think Twice’ discusses controversial topics in the field of neuroscience with the goal of bringing more nuance and rigor to mainstream media. We’ll take you past the headlines by breaking down relevant neuroscience topics, interviewing experts in the field and overcoming misinformation/disinformation with evidence-based content. This podcast is run by a small group of graduate students at the Centre for Neuroscience Studies at Queen’s University. We hope to bring down barriers to the dissemination of scientific information, give early-career neuroscientists a voice, and foster a culture of entertaining and accessible science communication.

Heather has been creating dynamic change in people’s lives for over 20 years. Her potent, spacious presence invites you to say YES to the brilliant life that is waiting for you on the other side of choice.

ACEP Frontline, hosted by Dr. Ryan Stanton, features in-depth conversations on the hottest topics in emergency medicine and critical care.

Forward Radio is independent, listener-sponsored, volunteer-powered, grassroots community radio WFMP-LP Louisville, Kentucky. We have been broadcasting at 106.5fm and live-streaming at forwardradio.org since April 9, 2017. Please donate at forwardradio.org to keep us on-air. It costs $42/day to keep this programming coming your way.

Aging-US is dedicated to advancing our understanding of the biological mechanisms that drive aging and the development of age-related diseases. Our mission is to serve as a platform for high-quality research that uncovers the cellular, molecular, and systemic processes underlying aging, and translates these insights into strategies to extend healthspan and delay the onset of chronic disease.

Read about the Aging-US Scientific Integrity Process: https://aging-us.com/scientific-integrity

Hi, I'm Michel and i like to record DJ mixes in my free time. I have been DJing since 2011 at home and shortly after at local venues. At the moment i'm doing  a monthly mix series of 10 songs and who knows what the future will bring.

For contact, DM me right here on Soundcloud!

Pulpa Music es una productora de eventos con base en Buenos Aires, Argentina.
Dedicada a la música electrónica, se enfoca en los géneros Psytrance, Progressive Psytrance & Full On.
Fue fundada en el año 2017 por EarthNoise (Arg), y desde su creación ha logrado consagrar el evento que realiza año tras año como la fiesta más esperada de cada verano, siendo en formato outdoor, se caracteriza como festival al celebrarse todos los años en el mes de Diciembre, mes en el que originalmente nació esta fiesta.

Artistas - Team Pulpero 2026
- EarthNoise https://soundcloud.com/earthnoisemusic
- Zaratustra https://soundcloud.com/zaratustrapsytrance
- 1000oK https://soundcloud.com/miloka1
- Gmey https://soundcloud.com/gonza-mey
- Xzeke https://soundcloud.com/dj_xzeke

Booking: pulpamusic.producciones@gmail.com

Българският подкаст - The Bulgarian podcast

New tracks tagged #neurology