Today we are talking with Jordan Squair and Mark Anderson about their September 2023 paper published in the journal Science: “Recovery of walking after paralysis by regenerating characterized neurons to their natural target region”. The work is akin to the first gardeners figuring out how to make plants grow. But instead of plants, it's injured neurons. Squair and Anderson are both highly accomplished scientists who also happen to be best friends. They work together with Gregoire Courtine’s group and NeuroRestore at the...

More info: https://u2fp.org/get-educated/curecast/episode-97.html

Designing the Cure Garden (Episode 97)

Cuzin Blowy X Aura - Atoms & Neurons
Prod. by RUCCI
VibeOneFour ENT.

Atoms & Neurons (Cuzin Blowy X Aura)

Can random mutations actually produce the complex molecular machines in our body like the ATP synthase motor that spins faster than a jet engine? How many of these tiny turbines power our cells every day? Which technology company based their new computer chip on the human brain because of its brilliant design? Can our thoughts be weighed? Stayed tuned for a fascinating look at our human body.

Evolutionary Quandaries - ATP's Molecular Mastery - 2408

BUFFALO, NY- August 13, 2024 – A new #research perspective was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science), Volume 16, Issue 14 on July 19, 2024, entitled, “Lipid accumulation drives cellular senescence in dopaminergic neurons.”

As highlighted in the Abstract of this perspective, Parkinson’s disease (PD) is an age-related movement disorder caused by the loss of dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc) of the midbrain. However, the underlying causes of this DA neuron loss in PD are unknown, and there are currently no effective treatments to prevent or slow neuronal loss or the progression of related symptoms. 

In their perspective, researchers Taylor Russo and Markus Riessland from Stony Brook University found that artificially inducing GluCer accumulation leads to cellular senescence of DA neurons. This suggests that lipid aggregation plays a crucial role in the pathology of PD by driving senescence in these vulnerable neurons.

“Here, we discuss the relevance of the age-related aggregation of lipids as well as the direct functional link between general lipid aggregation, cellular senescence, and inflammaging of DA neurons.”

Additionally, they propose that the expression of a cellular senescence phenotype in the most vulnerable neurons in PD can be triggered by lysosomal impairment and lipid aggregation. 

“Importantly, we highlight additional data that perilipin (PLIN2) is significantly upregulated in senescent DA neurons, suggesting an overall enrichment of lipid droplets (LDs) in these cells.”

DOI - https://doi.org/10.18632/aging.206030

Corresponding author - Markus Riessland - markus.riessland@stonybrook.edu

Video short - https://www.youtube.com/watch?v=CsBthdwpdGg

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Keywords - aging, lipids, cellular senescence, Parkinson’s disease, glucosylceramides, lysosomes, neuroinflammation

About Aging-US

The mission of the journal is to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population.

The journal aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.)

Please visit our website at https://www.Aging-US.com​​ and connect with us:

Facebook - https://www.facebook.com/AgingUS/
X - https://twitter.com/AgingJrnl
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LinkedIn - https://www.linkedin.com/company/aging/
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MEDIA@IMPACTJOURNALS.COM

Aging (Aging-US)

Lipid Accumulation Drives Cellular Senescence in Dopaminergic Neurons

Uncover the power of neuroscience in market research. Learn how analyzing brainwaves and leveraging big data can unlock deeper consumer insights, predict behavior, and create more effective marketing strategies.

Link : https://maction.com/brainwaves-and-big-data-neuroscience-in-market-research/

Brainwaves And Big Data - Neuroscience In Market Research

In this audio version of "Trading Silicon Neurons: Final Sparks in the Quest for Computing," - https://www.linkedin.com/pulse/trading-silicon-neurons-finalsparks-quest-computing-luke-gray-js4gc

We explore the exciting intersection of silicon-based technology and biological neurons in the quest for advanced computing solutions. 

Discover how innovations in quantum computing and neural networks are reshaping our understanding of data processing and energy efficiency. 

Join us as we discuss the future of technology, the potential of combining silicon and biological systems, and what this means for industries across the board.

Trading Silicon For Neurons  FinalSpark's Quest To Revolutionize Computing

SChitzophrenic ARchive NUmber 69, SEizure

A new study involving elderly rhesus monkeys suggests that metformin, widely used to regulate blood sugar, might also slow cognitive decline. While this research is ongoing this could be a game changer in how doctors approach neurodegenerative diseases. Let's ask today's big question, can we slow down brain aging? 


Question Your World - Can we slow down brain aging?

It gets you going in the morning, it gives you antioxidants, it can even be used to make bricks and roads. I’m talking about the all powerful and magical thing most of us need every single day…COFFEE! But can it also reduce the addictive effects of alcohol?

Question Your World - Can coffee reduce the addictive effects of alcohol?

In this episode, Edd Hall discusses the latest cybersecurity developments shaking up the digital world. From sophisticated MFA bypass techniques to Microsoft’s massive July Patch Tuesday addressing 130 vulnerabilities, Edd breaks down what security teams need to know. He also covers major data breaches at Nippon Steel Solutions and Bitcoin Depot, ransomware disruptions at Ingram Micro, a critical flaw in ServiceNow, and urgent patches from Ivanti, Fortinet, and Splunk. Plus, the mysterious shutdown of the notorious SatanLock ransomware group raises questions about what might come next. Don’t miss this essential roundup for staying ahead in cybersecurity.

MFA Bypasses, Microsoft Patch Tuesday, and Major Breaches Shake Industry

The Daily HEAL Security Dispatch Podcast is a leading source for up-to-the-minute news and deep insights in the realm of healthcare cybersecurity and threat intelligence. 

At the heart of HEAL Security's vision is the commitment to equipping organizations and individuals with rapid, contextually rich cybersecurity updates, establishing itself as a pivotal force in unifying practice and data against the ingenious tactics of criminal and malicious entities. HEAL Security is fervently devoted to constructing a robust resource and community that champions the defense of the healthcare sector against the growing cyber threats from organized crime groups and antagonistic nation-states. Our core focus encompasses the protection of vital IT infrastructures, the security of sensitive patient and clinical information, the safeguarding of critical healthcare systems, and the assurance of continuous, undisturbed patient care services.

For a wealth of life changing information visit:  3abnaustralia.org.au/radio/listen 

3ABN (Three Angels Broadcasting Network) Australia Radio is the "Mending Broken People Network," broadcasting Christian content 24/7.

Here, I dive into the fascinating world of marketing, language, and technology. As a passionate marketer and content creator, I explore how powerful words can shape narratives and influence audiences.
Join me as I transform articles into engaging podcast discussions, sharing insights on effective communication strategies and the psychology behind marketing. Whether you're a seasoned pro or just starting out, there's something here for everyone.
Tune in for thought-provoking content that will inspire you to rethink your approach to marketing and storytelling. Let’s embark on this journey together!
Don’t forget to check out my articles for deeper insights!

Aging-US is dedicated to advancing our understanding of the biological mechanisms that drive aging and the development of age-related diseases. Our mission is to serve as a platform for high-quality research that uncovers the cellular, molecular, and systemic processes underlying aging, and translates these insights into strategies to extend healthspan and delay the onset of chronic disease.

Read about the Aging (Aging-US) Scientific Integrity Process: https://aging-us.com/scientific-integrity

Unite 2 Fight Paralysis exists to unite and empower the international spinal cord injury community to cure paralysis through advocacy, education, and support for research. Get Educated and Get Involved.

New tracks tagged #neurons