Dr. Kennard Herring is an optometrist who is the owner of “Nostalgic Eyecare” in Philadelphia. Dr. Herring has participated in several vision screenings and community service ventures in the Greater Philadelphia Area. Dr. Herring joins the show to talk about his motive for opening Nostalgic Eyecare, and to further discuss the services it has to offer.

The Source w/ Andrea Lawful-Sanders | Dr. Kennard Herring - 3.18.24

Dede has a conversation with the 2023 Optometry Student Challenge winners, delving into their experiences with the challenge and exploring what aspects of starting their career excite them the most. Learn more at https://abboptical.com/practitioner-resources/dedetalks

Episode 26: Dede talks with the 2023 Optometry Student Challenge Poster Winners

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Optometry, a duo composed of John Tejada and March Adstrum, offer vintage vibes & ethereal electronics on Palette Recordings with 'Comets.'

Read more: https://whenwedip.com/2024/10/premiere-optometry-palette-recordings/

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Premiere: Optometry - Comets [Palette Recordings]

BUFFALO, NY- November 13, 2024 – A new #research paper was #published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science), on October 25, 2024, Volume 16, Issue 20, titled, ”Canonical ligand-dependent and non-canonical ligand-independent EphA2 signaling in the eye lens of wild-type, knockout, and aging mice.“

Researchers from the School of Optometry and Vision Science Program at Indiana University have uncovered important new insights into how the aging affects the eye lens and contributes to cataract formation, a condition impacting millions worldwide. This study focuses on the EphA2 protein, traditionally associated with cancer, which researchers have now identified as essential for maintaining the lens’s clarity and function as it ages.

Cataracts are the leading cause of blindness worldwide, primarily affecting older adults, yet the precise biological mechanisms behind their formation remain unclear. This research sheds light on the role of the EphA2 protein receptor in the eye lens, revealing that it operates through two distinct signaling pathways: a canonical (ligand-dependent) and a non-canonical (ligand-independent) pathway. By studying various groups of mice, including those lacking the EphA2 protein receptor and its ligand partner ephrin-A5, scientists observed how these signaling pathways change with age, affecting the organization and maturation of lens cells.

Researchers Jenna L. Horner, Michael P. Vu, Jackson T. Clark, Isaiah J. Innis, and Catherine Cheng observed that EphA2’s canonical signaling, which organizes lens cells, remains stable in aging lens tissue, particularly in epithelial cells. They found that the non-canonical signaling pathway—previously associated primarily with aggressive cancer cells—increases with age in normal lens cells. This increase suggests that non-canonical signaling plays a crucial role in helping lens fiber cells mature and maintain their structure over time.

“Here, we report that canonical ligand-mediated EphA2 activation is restricted to the lens epithelial cells and show the first evidence of physiological non-canonical EphA2 activity in a normal tissue.”

This understanding could lead to new therapies targeting EphA2 to delay or prevent cataracts.

In conclusion, this study represents a significant advance in understanding the cellular mechanisms behind lens aging and cataract development, potentially paving the way for new non-surgical cataract treatments.

DOI - https://doi.org/10.18632/aging.206144

Corresponding author - Catherine Cheng - ckcheng@iu.edu

Video short - https://www.youtube.com/watch?v=3ScKLgOxQvA

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Keywords - aging, fiber cells, epithelial cells, Y588, Y589, S897, phosphorylation, maturation, ephrin

About Aging-US

The mission of the journal is to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population.

The journal aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.)

Please visit our website at https://www.Aging-US.com​​ and connect with us:

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Aging (Aging-US)

EphA2 Signaling in Eye Lens Aging: Wild-Type, Knockout, and Aging Mice

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Fitting specialty lenses is as much an art as it is a science.

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On this When We Dip Radio channel, we features awesome premieres, free newbies and some of our favourite podcasts from amazing artists.

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Aging-US is dedicated to advancing our understanding of the biological mechanisms that drive aging and the development of age-related diseases. Our mission is to serve as a platform for high-quality research that uncovers the cellular, molecular, and systemic processes underlying aging, and translates these insights into strategies to extend healthspan and delay the onset of chronic disease.

Read about the Aging (Aging-US) Scientific Integrity Process: https://aging-us.com/scientific-integrity

WURD Radio is the only African-American owned and operated talk radio station in Pennsylvania, and one of few in the country. Taking a multimedia approach – on-air, online and in the community – WURD is widely recognized as the pulse of the African-American community locally, regionally, and nationally. From mayoral races to presidential elections, from the street corner to the corner suite, WURD has tackled the hard issues as an influential, respected and powerful voice in the marketplace.

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New tracks tagged #optometry