BUFFALO, NY — August 12, 2025 — A new #research perspective was #published in Aging (Aging-US) on July 8, 2025, titled “Exercise as a geroprotector: focusing on epigenetic aging.”

In this perspective, led by Takuji Kawamura from Tohoku University, researchers reviewed existing evidence from scientific studies showing that regular exercise, physical activity, and fitness may influence epigenetic aging and potentially reverse it, offering a promising way to extend healthspan and improve long-term health.

Epigenetic aging refers to changes in the body’s DNA that reflect how quickly a person is aging at the molecular level. It is measured using epigenetic clocks, which analyze patterns of DNA methylation, a chemical modification that can affect gene activity. Unlike chronological age, which simply counts the number of years lived, epigenetic aging presents a more accurate picture of how well the body’s cells and tissues are functioning. This process is influenced by various factors, including lifestyle, and has become a powerful tool for studying aging.

This perspective highlights that while general physical activity, such as walking or doing household tasks, offers health benefits, structured exercise routines that are planned, repetitive, and goal-directed appear to have stronger effects on slowing epigenetic aging. Physical fitness, especially high cardiorespiratory capacity, is also closely associated with slower epigenetic aging.

The authors also discuss key findings from both human and animal studies. In mice, structured endurance and resistance training reduced age-related molecular changes in muscle tissue. In humans, multi-week exercise interventions demonstrated reductions in biological age markers in blood and skeletal muscle. One study found that sedentary middle-aged women reduced their epigenetic age by two years after just eight weeks of combined aerobic and strength training. Another study showed that older men with higher oxygen uptake levels, a key measure of cardiovascular fitness, had significantly slower epigenetic aging.

“These findings suggest that maintaining physical fitness delays epigenetic aging in multiple organs and supports the notion that exercise as a geroprotector confers benefits to various organs.”

The research also examines which organs benefit most from exercise. While skeletal muscle has been a central focus, new evidence shows that regular physical training may also slow aging in the heart, liver, fat tissue, and even the gut. In addition, Olympic athletes were found to have slower epigenetic aging than non-athletes, suggesting that long-term, intensive physical activity may have lasting anti-aging effects.

The authors call for further research to understand why some individuals respond more strongly to exercise than others and how different types of training influence aging in various organs. They also point out the importance of developing personalized exercise programs to maximize anti-aging benefits. Overall, the findings support the growing recognition that maintaining physical fitness is not only essential for daily health but may also serve as one of the most effective tools for slowing the body’s internal aging process.

DOI - https://doi.org/10.18632/aging.206278

Corresponding author - Takuji Kawamura - takuji.kawamura.b8@tohoku.ac.jp

Video short - https://www.youtube.com/watch?v=Wro3_wBovdE

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Aging (Aging-US)

Exercise May Slow Epigenetic Aging

Reporters and journalists face dangers just doing their jobs, and that's in the United States alone. We look at the Freedom Press Tracker at where reporters are facing danger within their own country.

The Reporter's Studio Episode 1 Kirstin McCudden

Can Americans learn to be civil to each other, or are we doomed to be divided by our politics? David Plazas was given the job of bringing people together after a contentious election. We'll find out how. 

The Reporter's Studio Episode 2 David Plazas

Local news remains the most trusted of all news outlets. But local news is hurting. Newsrooms at newspapers, television stations, and public media stations are shrinking. What could we lose? How do we save them? What must they do to evolve? 

The Reporter's Studio Episode 3 Kristin Hare

Can English-speaking news outlets find a way to reach Latin audiences? Well, it's tricky. Hugo Balta runs the Latino News Network, and he has some ideas on how to make it work. 

The Reporter's Studio Episode 4 Hugo Balta

There are all sorts of beats in journalism, but Brendan has probably the coolest. He covers space, as in outer space. Check out my conversation with Brendan about some of the cool stories he gets to cover.

The Reporter's Studio  Episode 7 Brendan Byrne

The guest host for today's show is Brad Bannon. Brad runs Bannon Communications Research, a polling, message development and media firm which helps labor unions, progressive issue groups and Democratic candidates win public affairs and political campaigns. His show, 'Deadline D.C. with Brad Bannon,' airs every Monday from 3-4pm ET.

Brad is first joined by Tim Karr, Senior of Director of Strategy and Communications at 'Free Press,' a nonpartisan organization fighting for your rights to connect and communicate.
The pair examines the increasingly disturbing trend of the mainstream media's capitulation to Trump and his administration.  This includes a discussion on Free Press's newly created 'Media Capitulation Index,' and a report that Tim authored on the way forward.  It's titled, "A More Perfect Media: Saving America’s Fourth Estate from Billionaires, Broligarchy and Trump."

Then, Brad is joined by Hadar Susskind, President and CEO of 'The New Jewish Narrative."  The organization's mission statement identifies their members as "American Jews, deeply rooted in the story of our people and the history of our struggle for peace and justice. In our narrative, peace and justice are the birthright of Israelis, of Palestinians, and of all people."

The two discuss the increasingly dire situation in Gaza, where the United Nation's Humanitarian Affairs Office says that food consumption has "declined to its lowest level since the onset of the war." They report that "nearly 90% of households have resorted to extremely severe coping mechanisms to feed themselves, including taking significant risks to obtain food and scavenging from garbage."  
Gaza health authorities also report that over 200 people have died of starvation since the war began 22 months ago, and that nearly half of them were children.


Brad writes a political column every Sunday for 'The Hill.'
He's on the National Journal's panel of political insiders and is a national political analyst for WGN TV and Radio in Chicago and KNX Radio in Los Angeles. You can read Brad's columns at www.MuckRack.com/Brad-Bannon. His handle on BlueSky is @bradbannon.bsky.social.   

(Image Credit: Free Press)

Leslie Marshall Show - 8/11/25 - Media Capitulation to Trump; Palestinian Children Dying of Starvation in Gaza

BUFFALO, NY - August 13, 2025 – A new #research paper was #published in Volume 16 of Oncotarget on July 29, 2025, titled “PCAIs stimulate MAPK, PI3K/AKT pathways and ROS-Mediated apoptosis in aromatase inhibitor-resistant breast cancer cells while disrupting actin filaments and focal adhesion.”

In this study, led by first author Jassy Mary S. Lazarte and corresponding author Nazarius S. Lamango from Florida A&M University College of Pharmacy and Pharmaceutical Sciences, researchers investigated a new class of compounds called polyisoprenylated cysteinyl amide inhibitors (PCAIs) as a potential treatment for aromatase inhibitor (AI) therapy resistant breast cancer. Aromatase inhibitors are a common treatment for estrogen receptor-positive (ER+) breast cancer, but many patients eventually develop resistance, leaving fewer therapeutic options.

The study focused on a PCAI compound called NSL-YHJ-2-27, which was tested in long-term letrozole-treated breast cancer cells (LTLT-Ca), an experimental model of AI therapy resistance. NSL-YHJ-2-27 activated two major signaling pathways, MAPK and PI3K/AKT. Although these pathways typically support cancer cell survival, their overstimulation by PCAIs led to increased oxidative stress, damaging the cells and inducing cell death by apoptosis. The compound also reduced levels of RAC1 and CDC42, proteins involved in maintaining cell shape and movement. These alterations resulted in cytoskeletal disruption and reduced structural integrity, making the cancer cells more vulnerable and less capable of spreading. Importantly, the effects of NSL-YHJ-2-27 persisted after the compound was removed, suggesting long-term control over AI resistant cancer cells may be possible.

“PCAIs inhibited cell proliferation and colony formation by 95% and 74%, respectively, increased active caspase 7 and BAX 1.5-fold and 56%, respectively. NSL-YHJ-2-27 (10 μM) induced LTLT-Ca spheroid degeneration by 61%.”

As a new class of targeted molecules, PCAIs represent an innovative approach distinct from traditional endocrine therapies. Their ability to affect multiple cellular mechanisms simultaneously makes them promising candidates for future drug development.

Overall, this study presents a promising new approach for treating AI therapy-resistant breast cancer. By targeting cellular pathways that support survival and mobility, PCAIs like NSL-YHJ-2-27 could provide a novel strategy to manage advanced or resistant forms of the disease. Further research, including in vivo studies and clinical trials, will be essential to confirm these findings and evaluate their therapeutic potential.

DOI - https://doi.org/10.18632/oncotarget.28759

Correspondence to - Nazarius S. Lamango - nazarius.lamango@famu.edu

Video short - https://www.youtube.com/watch?v=8xQEilloO9Q

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Keywords - cancer, PCAIs, ROS, MAPK, PI3K/AKT, LTLT-Ca cells

To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us:

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Oncotarget

New Compound Disrupts Survival Pathways in Aromatase Inhibitor-Resistant Breast Cancer Cells

BUFFALO, NY — August 14, 2025 — A new #research paper was #published in Volume 17, Issue 7, of Aging (Aging-US) on July 3, 2025, titled “Frailty associates with respiratory exacerbations and mortality in the COPDGene cohort.”

In this study, led by first author Eleanor Kate Phillips from Brigham and Women’s Hospital and corresponding author Dawn L. DeMeo from Brigham and Women’s Hospital and Harvard Medical School, researchers investigated how frailty impacts lung health and survival in individuals with a history of cigarette smoking. They found that frailty raises the risk of lung attacks and death, even in smokers with preserved lung function. This result shows why all current and former smokers should be checked for frailty.

Frailty is a condition that makes the body more vulnerable to illness, especially in older adults. This study focused on more than 2,600 adults with a history of heavy smoking, many of whom showed no signs of lung damage on standard tests. At the second follow-up visit, participants were categorized as robust, prefrail, or frail and followed for about three years. Researchers tracked how often they experienced respiratory attacks, such as episodes of severe coughing or breathlessness, and whether they survived during that period.

“COPDGene is a cohort study of individuals aged 45–80 with a minimum 10 pack-year smoking history.”

The results showed that people who were frail had a three- to five-fold higher chance of developing serious or frequent respiratory attacks compared to those who were robust. These risks were not limited to people with chronic lung disease. In fact, many frail participants with normal lung function still faced a significantly higher chance of lung attacks and death. Even those in the “prefrail” stage, a milder form of frailty, were more likely to experience health complications.

The research team also found that frailty was associated with an accelerated pace of biological aging, measured using a DNA-based test called DunedinPACE. This supports the idea that frailty may reflect deeper biological changes in the body that go beyond what traditional lung function tests can detect. These findings challenge the idea that standard lung tests can rule out future respiratory complications in people with a history of smoking. 

Altogether, the study shows that simple frailty checks could help identify early health problems, allowing for timely interventions that may prevent hospitalizations and potentially save lives. The study suggests that frailty screening may be a valuable tool in public health efforts to reduce respiratory disease and improve outcomes for aging adults.

DOI - https://doi.org/10.18632/aging.206275

Corresponding author - Dawn L. DeMeo - redld@channing.harvard.edu

Video short - https://www.youtube.com/watch?v=G1XQhQN6PQ8

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Keywords - aging, frailty, cigarette smoking, respiratory exacerbations, COPD, epigenetic aging

To learn more about the journal, please visit our website at https://www.Aging-US.com​​ and connect with us on social media at:

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Frailty Linked to Higher Risk of Respiratory Complications and Death in Smokers

Show me the way to make you happy I actually wrote for superstar Mariah Carey in the believe that I will be probably main composer concerning her career and along with that Janet and Michael Jackson.In the end of 1985 two lesbians one my former fiancee with NPD father its about small AFD Nazis  following to her owner of MBB later called EADS militär then Airbus Militär ( today ) You know Tiger Eurocopter,Eurofighter Typhoon last but not least engines of Ariane spave in main house at Ottobrunn near to Munich seperated from me in a way which costs my full stipendium at private school Obermenzinger Gymnasium where son of Israel Ariel Sharon was sitting in my class.My fiabncee seperated 10 minutes before of a internal test.With those results it was over for me in year 12 ,1 of Kollegstufe.The I had to take an extrem hard bacalaureat A-level Abitur at Theresien Gymnasium longer broader deeper which is possible al years for somebody in Bavaria.My Abitur present was cousine Brenda of best of the year of Harward president Bill clinton also Jazzer and Democrats in Germany SPD ) In 1986 the beged me to work in a restaurant with lewadership of a friend of mine Claudia Mandel.She also quite nice said to me forgett Karin she has hairs on her teeth.You cant detect this now cause you are stoned with her.But forget her....I gues she was rich and tried to help.Music career.In that restaurant also worked some big celebrities ( greetings) and daughter of chief of Nestle Europe Mauscher who wanted to flirt in rush hour...I was approximatelly evrything there apart from steaks.concerning the bar Iwas pretending that im Antialkoholic...( I drink not much) worst paying.But my comrade was operasinger Patricia there ma of Mariah Carey.She said they told her Im simply best talent.She has a team but she is looking for a further main composer.she will come next week from Brooklyn visiting her here....Little Mariah accepted my name change to her official label Maria with h and Carey following to her real pa.But she had no demo,no contract and she said without Micro ( U47 or U87)  I will not sing.And I said then you must marry Tommy Mottola founder of Sony Music I will not follow under the bridge of Brooklyn waiting for your demo.Sing 3 octaves are enought.I have never heard 5 octaves ( rather seldom in history with her Milisma today a bit standard since her...But we had contact.In the end I heard that she is trans gender....Cause of my personal history and Im perfectly tender and normal it seems as fake to me too dagerous.Im straight no fake.Walter Afanassief took my place who was actually producer too in that time.But im certainly better as composer...I did a lot and its more everlasting then avry song of Mariah Careys team apart from Hero and Butterfly at least...Till rtoday I dont know if she was realy friend...First album Vision of Love was made 4 years long without me.Prisoner,Somedays ,Vision of love 3 number one songs and best Sent from up above Nr 2.But this rest crew was thrown out even selling 16 million of records produced by Tommy Mottola himself.cover is rather angry Mariah Carey at the front and precisely my Mariah Carey in our restaurant clothes with one change : A U87Neumann micro !  ( ?!? ) Im everlasting.But Walter Afanassief was certainly good enough to make money...best work Tell him with Celine Dion and Barbra Streisand.For some tracks I need a good singer actually...And Mariah is fearing me how it semms even if Im best for her career too.I have realy a lot of this style...but better and deeperas Mariah ( 220 Million sold records..) Thats life ! This is not the offcial recording but near to the final version as Instrumental Version.Sincerly Oliver frederic Dieck O.F.D - short Oli from Munich genius of the century

showmethewaytomakeyouhappy-instrumental-hiphop-balad-byOFD2025

Hallo fans and co musicians :  Im O.F.D - Oliver Frederic Dieck the music composer .This is my real documents name. Looking like 40 thosedays I mcomposing since my 11 year successfully.Meanwhile I did almost evrything rock jazz,pop ,hiphop.But since 1988 its enough for everlasting new classic music as next Beethoven.I had a lot of terroristical enemies since my youth actualy strict east jews argumenting with second world war even if I almost dont know my one waffen SS tank leading pa breading bull being bymyself chief of SPD democrats youth  (till 1990 )  at Munich Bavaria Germany universities with extreme A level Abitur.....An affront for them as well as that im normal hetero with pretty high Iq.Freud is mad.No drugs necessary.But a woman...familly...Here you wil not find payed official versions of mine.I m a label too.But for free enough to evaluate in all styles 2.Oli More of mine at  -www.o-f-d.de,www.o-f-d.com,www.cartooner.de,http://aurora.o-f-d.com,www.complete-this.com,www.diemusikkritik.de,www.helpful-contacts.net,www.generalartsblog.com and www.instagram.com/o.f.d Join me ! oliver

Oncotarget is a primarily oncology-focused, peer-reviewed, open access journal. Papers are published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Oncotarget is now indexed by MEDLINE, PubMed and PMC/PubMed.

Read about the Oncotarget Scientific Integrity Process: https://www.oncotarget.com/scientific_integrity/

Aging-US is dedicated to advancing our understanding of the biological mechanisms that drive aging and the development of age-related diseases. Our mission is to serve as a platform for high-quality research that uncovers the cellular, molecular, and systemic processes underlying aging, and translates these insights into strategies to extend healthspan and delay the onset of chronic disease.

Read about the Aging (Aging-US) Scientific Integrity Process: https://aging-us.com/scientific-integrity

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