Sweet Solid Strawberry Cream Pie

Strawberry Cheesecake

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BUFFALO, NY- October 16, 2024 – A new #review was #published in Oncotarget's Volume 15 on October 1, 2024, entitled, “Molecular chaperones: Guardians of tumor suppressor stability and function.”

As highlighted in the abstract of this paper, "tumor suppressor" describes a diverse set of genes typically involved in suppressing metastasis, but which can lead to tumorigenesis when loss-of-function mutations occur. Despite the varied structures and functions of tumor suppressor proteins, many share a common regulatory mechanism—they are "clients" of molecular chaperones, and they rely on an intracellular network of chaperones and co-chaperones to maintain their stability. Mutations in tumor suppressors that disrupt proper chaperoning prevent cells from maintaining sufficient protein levels for normal physiological function.

In their review, researchers Jennifer A. Heritz, Sarah J. Backe, and Mehdi Mollapour from SUNY Upstate Medical University and New York VA Health Care in Syracuse, New York, discuss the role of molecular chaperones Hsp70 and Hsp90 in maintaining the stability and functional integrity of tumor suppressors. They also detail the contributions of co-chaperones prefoldin, HOP, Aha1, p23, FNIP1/2, and Tsc1, as well as the chaperonin TRiC, to tumor suppressor stability.

“Overall, it is clear that oncogenesis can result from the dysregulation of tumor suppressor stabilization by chaperones.”

DOI - https://doi.org/10.18632/oncotarget.28653

Correspondence to - Mehdi Mollapour - mollapom@upstate.edu

Video short - https://www.youtube.com/watch?v=V5OFjeqaH3A

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Keywords - cancer, molecular chaperone, tumor suppressor, renal cell carcinoma, Birt-Hogg-Dubé (BHD) syndrome, TSC syndrome

About Oncotarget 

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Oncotarget is indexed and archived by PubMed/Medline, PubMed Central, Scopus, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science).

To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us:

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Oncotarget

Molecular Chaperones: Guardians of Tumor Suppressor Stability

Audio from my most recent video: https://www.youtube.com/watch?v=XoULSS0FKfM

Collab with : https://soundcloud.com/tr3n-motivation

Original Song: https://www.youtube.com/watch?v=7vAbLEzh1HU&pp=ygUJTmV4dCAyIG1l

TREN TWINS X NEXT 2 ME | GYM MOTIVATION | Feat. @Tr3n Motivation

Drs. Mehdi Mollapour, Jennifer Heritz, and Sarah Backe from SUNY Upstate Medical University (Syracuse, NY) discuss a review they co-authored that was published by Oncotarget in Volume 15, entitled, “Molecular chaperones: Guardians of tumor suppressor stability and function.”

DOI - https://doi.org/10.18632/oncotarget.28653

Correspondence to - Mehdi Mollapour - mollapom@upstate.edu

Video interview - https://www.youtube.com/watch?v=vEHmyemWgNo

Video transcript - https://www.oncotarget.net/2024/10/24/behind-the-study-molecular-chaperones-tumor-suppressor-stability/

Abstract

The term ‘tumor suppressor’ describes a widely diverse set of genes that are generally involved in the suppression of metastasis, but lead to tumorigenesis upon loss-of-function mutations. Despite the protein products of tumor suppressors exhibiting drastically different structures and functions, many share a common regulatory mechanism—they are molecular chaperone ‘clients’. Clients of molecular chaperones depend on an intracellular network of chaperones and co-chaperones to maintain stability. Mutations of tumor suppressors that disrupt proper chaperoning prevent the cell from maintaining sufficient protein levels for physiological function. This review discusses the role of the molecular chaperones Hsp70 and Hsp90 in maintaining the stability and functional integrity of tumor suppressors. The contribution of cochaperones prefoldin, HOP, Aha1, p23, FNIP1/2 and Tsc1 as well as the chaperonin TRiC to tumor suppressor stability is also discussed. Genes implicated in renal cell carcinoma development—VHL, TSC1/2, and FLCN—will be used as examples to explore this concept, as well as how pathogenic mutations of tumor suppressors cause disease by disrupting protein chaperoning, maturation, and function.

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Keywords - cancer, molecular chaperone, tumor suppressor, renal cell carcinoma, Birt-Hogg-Dubé (BHD) syndrome, TSC syndrome

About Oncotarget 

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Oncotarget is indexed and archived by PubMed/Medline, PubMed Central, Scopus, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science).

To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us:

Facebook - https://www.facebook.com/Oncotarget/
X - https://twitter.com/oncotarget
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Reddit - https://www.reddit.com/user/Oncotarget/
Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh

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Behind the Study: Molecular Chaperones & Tumor Suppressor Stability

We are happy to inform you guys that "Sleepless Nights" is Official OUT on SoundCloud and YouTube for now (soon on other platforms)
Hosted and organized by Hexa Vibes,we made it through blood and sweat to present you this track along with the news of our collab being 3rd ranked 😀 

Stalk this big guy @saffroniumusic
https://linktr.ee/saffroniumusic

My socials
https://linktr.ee/lieselottedubz

Stalk him as well...It is the host after all :)
https://linktr.ee/hexavibes

#dubstep #melodictearout #tearout

Saffronium & Lieselotte - Sleepless Nights [RCC #1]

trh0
https://soundcloud.com/titusrho
https://twitter.com/titusrho
https://instagram.com/titusrh0
https://trho.de

RocCyJoes
@roccyjoes
https://hearthis.at/roccyjoes
https://roccyjoes.de

PAN p.m. (Original Mix)

trh0
https://soundcloud.com/titusrho/
https://twitter.com/titusrho
https://www.instagram.com/titusrh0/
https://trho.de

RocCyJoes
https://@roccyjoes
https://hearthis.at/roccyjoes/
https://roccyjoes.de

Odd Translation (Original Mix)

YOUTUBE FULL VOD HERE: https://youtu.be/BiTDfC94rgQ?si=Z3fY2qNwPC_8Du0W&t=11037

xChillphil @ RCC | 1.17.25

The one at the cycle track 🚴
A weird but cool location...

==TRACKLIST==

[00:00] Machine - Off The Cuff
[06:10] Rising Sons - Body & Soul
[09:55] Omni Trio - Trippin' On Broken Beats (Carlito Mix)
[13:20] Kenny Larkin - Loop 2 (Alex Reece Remix)
[17:31] King Kooba - Wing It
[22:39] Jazz Cartel - Expand
[26:38] Fallen Angels - Biophonic
[30:23] Mijk van Dijk with Humate - Waterdrop
[32:17] Bounty Killaz - Killa Instinct (Alex Reece Remix)
[36:45] 45 Roller - Saturday Night Roller (ft Shy FX)
[39:32] BLIM & Clinical - Morain
[41:46] Incognito - Barumba (Daniel Maunick's Mix)
[43:53] T-Power - 33rd Parallel
[44:54] Janet Jackson - Go Deep (Roni Size Remix)
[46:00] Future Cut - Dainjah
[47:40] Mefjus - Blitz
[51:51] Special Request - Stairfoot Lane Bunker (Minor Science Remix)
[55:39] Don Lemon @donlemons - Yidaki Steppa
[58:58] Sonic & Silver - Rocket Launcher
[1:05:07] Paradox - Orion
[1:06:24] Artsea @iamartsea - The Retreat
[1:09:22] Accidental Heroes - Precinct 13
[1:14:31] Moresounds - Shut Up
[1:15:59] The Game Shop - One More Time

https://linktr.ee/ravecity
https://linktr.ee/superjimz

RCC v4 _ Super Jim Z (DnB Set) | 2025.06.09

Soundcloud of RealCommentatorsCommunity (RCC)

Oncotarget is a primarily oncology-focused, peer-reviewed, open access journal. Papers are published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Oncotarget is now indexed by MEDLINE, PubMed and PMC/PubMed.

Read about the Oncotarget Scientific Integrity Process: https://www.oncotarget.com/scientific_integrity/

bookings: thexchillphil@gmail.com
producer // irl & vr dj ⁄⁄ 140 dub ⁄⁄ bass ⁄⁄ techno ⁄⁄ 
28/he/him
https://linktr.ee/xchillphil

★ [GDZ009] ★
https://goddezz.bandcamp.com/track/on-the-air
★ [fuckreality06] ★
https://smallville-records.bandcamp.com/album/fuck-reality-06-super-jim-z

Released on
@extraspicysydney
@grclabel
@thefinestfufu
@goddezztemple
@fuck-reality-1
@philthtrax
@tooflezmuzik
@saucetraxx
@donk-world

A&R @cosmic-beach 🏝🌏

contact: roccyjoes.technomusic \ gmail.com

New tracks tagged #rcc