"Groundhog" is a musical reflection on the repetitive patterns of daily life, from the monotony of routine actions to the cycle of work and home. It's a powerful and thought-provoking work, that captures the mundanity of modern life.

Groundhog

A new editorial paper was published in Oncotarget's Volume 14 on July 20, 2023, entitled, “Multiclonality of ER expression in DCIS – Implications for clinical practice and future research.”

Estrogen receptor (ER) expression is not routinely evaluated in ductal carcinoma in situ (DCIS). This may be because the prognostic role of ER in DCIS was unclear until the UK/ ANZ DCIS trial in 2021 showed that lack of ER expression in DCIS was associated with a greater than 3-fold risk of ipsilateral recurrence. This was the largest (to date) case-control study nested in a DCIS randomized trial. 

The meticulous study design eliminated treatment allocation bias as well as treatment-related confounding. This was also the first-ever study to show that ER expression in DCIS is multi-clonal — having very important clinical and research implications. A small proportion of otherwise ER-positive DCIS also contained carcinoma in situ (CIS) duct/s that completely lacked ER expression. 

“This admixture of clearly ER-positive and ER-negative ducts is not the same as heterogeneity in ER expression and I labeled such DCIS cases as multiclonal DCIS even if just one CIS duct in the entire section lacked ER expression.”

In his new editorial, Dr. Mangesh A. Thorat from Guy's and St Thomas' NHS Foundation Trust, Queen Mary University of London and King's College London discusses this study in greater detail, the clinical implications of ER status in DCIS, the potential for avoiding overtreatment and undertreatment based on ER expression, and the importance of simple clinical observations in research.

“In summary, ER is a strong and independent prognostic biomarker in DCIS and our novel clonal method is a more accurate method to assess ER status in DCIS.”

DOI - https://doi.org/10.18632/oncotarget.28450

Correspondence to - Mangesh A. Thorat -  thoratmangesh@gmail.com; m.thorat@qmul.ac.uk

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Keywords - cancer, ductal carcinoma in situ (DCIS), invasive breast cancer, ER, recurrence, clonality

About Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

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Oncotarget

Multiclonality of Estrogen Receptor Expression in Ductal Carcinoma in Situ (DCIS)

Dr. Mangesh A. Thorat from Guy’s Hospital in London, Queen Mary University of London, and King’s College London, describes a recent #editorial he authored that was #published by Oncotarget in Volume 14, entitled, “Multiclonality of ER expression in DCIS – Implications for clinical practice and future research.”
 #author #interview #authorinterview #researcher #cancer #cancerresearch #breastcancer #research #recurrence #clonality #ductalcarcinoma #ER #openaccess #openscience  #peerreview  #journal  #publication #meded #publishing #researcher #video

DOI - https://doi.org/10.18632/oncotarget.28450

Correspondence to - Mangesh A. Thorat -  thoratmangesh@gmail.com; m.thorat@qmul.ac.uk

Video interview - https://www.youtube.com/watch?v=TGeiFcKjbaQ

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Keywords - cancer, ductal carcinoma in situ (DCIS), invasive breast cancer, ER, recurrence, clonality

About Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us:

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Facebook - https://www.facebook.com/Oncotarget/
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18009220957

ER Expression Multiclonality in DCIS: Clinical & Future Insights

PDF Holistic Cancer Care: An Herbal Approach to Reducing Cancer Risk, Helping Patients Thrive during Treatment, and Minimizing Recurrence

link here : https://centerofsound.blogspot.com/?oak=1635863732

Recipes from the Herbalist?s Kitchen Rosemary Gladstar?s Medicinal Herbs A Beginner?s Guide Body Into Balance Christopher Hobbs?s Medicinal Mushrooms The Essential Guide More from Storey Publishing Experiment with 110 original recipes for scrumptious snacks, entr?es, drinks, and desserts that are specially designed to meet the body?s needs for comfort, nourishment, energy, and support through seasonal changes. In this introductory guide, Rosemary Gladstar shows you how easy it can be to make your own herbal remedies for life?s common ailments with 33 common healing plants. This essential guide to herbal and holistic self-care includes in-depth instructions, with step-by-step photographs, for making your own herbal remedies, as well as expert guidance on buying and effectively using comm

EPUB Holistic Cancer Care: An Herbal Approach to Reducing Cancer Risk, Helping P

The Whole-Food Guide for Breast Cancer Survivors: A Nutritional Approach to Preventing Recurrence (The New Harbinger Whole-Body Healing Series)

download : https://centerofsound.blogspot.com/?oak=1572249587

If you&#8217re a breast cancer survivor, chances are you have renewed your commitment to maintaining your good health and taking care of your body. As one of the best preventative measures known to doctors and nutritionists today, a robust, cancer-fighting diet is vital to your personal plan for breast cancer prevention.The Whole-Food Guide for Breast Cancer Survivors is an essential guide for every woman seeking to understand the effect of nutritional deficiencies and environmental factors on her overall health and wellness. Based on Edward Bauman&#8217s groundbreaking Eating for Health model, this highly comprehensive, practical approach can help you reduce the chance of breast cancer recurrence rebuild your immune system and enjoy a stronger, healthier body.Reduce the chance of

PDF The Whole-Food Guide for Breast Cancer Survivors: A Nutritional Approach to

Swedish producer Sond returns with a mesmerizing standalone EP, "Awake," on One Of A Kind, showcasing his unparalleled creativity and mastery of hardware sound creation. This three-track release epitomizes Sond's unique sonic signature, blending genres with an effortless fluidity that defies conventional boundaries.

The EP opens with two progressive house tracks that are nothing short of captivating. Each track pulses with a dynamic energy, driven by intricate synth layers and compelling rhythms that transport listeners into a euphoric state. Sond’s attention to detail and the analog warmth of his hardware setup infuse these tracks with a rich, organic quality that sets them apart in the crowded electronic music landscape.

"Awake" is a true testament to Sond's innovative spirit and technical prowess. It's a must-listen for fans of meticulously crafted, hardware-produced music, and it solidifies Sond's place as a standout artist in the electronic music scene.

Artists
@sond-kvb

Artwork @jellyforthebabies
Mastering engineer @nicholas-van-orton

Connect with One Of A Kind
www.facebook.com/oneofakindmuzik
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Beatport: bit.ly/3uSBVPR

Awake

sond - Recurrence (Original Mix)

Welcome to our newest podcast series dedicated to preventing breast cancer recurrence and disease progression. In this opening episode, we dive deep into understanding what a cancer recurrence means and explore practical steps to reduce our risk. We'll share insights and personal experiences to empower you on your journey toward sustained health and resilience. Join us as we discuss evidence-based strategies, lifestyle changes, and the mental and emotional aspects of managing your health after a breast cancer diagnosis.

S5E1: Reducing recurrence or disease progression

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Arkala Dre is back on the label with an exciting project including a whole range of close friends and artists. Featuring Addicted, Modulate, R3IDY and Unknown Entity.

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Arkala Dre & R3IDY - Recurrence

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In this episode of the Besties with Breasties podcast, hosts Sarah Hall and Beth Wilmes dive into the intricate topic of forgiveness. While sharing laughter over humorous anecdotes and off-topic conversations, they explore the emotional weight and complexity of forgiving others. The discussion covers the health benefits of letting go, how unresolved resentment can harm us, and the challenge of vulnerability when asking for or granting forgiveness. Real-life stories of extreme forgiveness are shared to inspire and uplift. The episode emphasizes the importance of compassion, setting boundaries, recognizing humanity in ourselves and others, and seeking support when struggling with forgiveness.

00:00 Introduction to Besties with Breasties

00:45 Casual Conversations and Personal Anecdotes

01:31 Diving into Forgiveness

05:36 The Health Impact of Forgiveness

09:40 Inspiring Stories of Extreme Forgiveness

14:39 Non-Boobs in the News

14:49 The Challenge of Forgiveness

15:37 Letting Things Go

16:16 The Importance of Communication

17:35 Recognizing Humanity and Setting Boundaries

21:15 Seeking Support and Practicing Compassion

27:28 The Power of Asking for Forgiveness

29:22 Conclusion and Sponsor Message


S5E9: Letting Go, the Power of Forgiveness

Download Our Music: https://linktr.ee/oneofakindmuzik

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We are confronting the boarders of creativity.
Being open minded, being creative and unique. Stepping out of the closed circle of modern socialism. Being honest with yourself. Being an artist.

Back in 2013. One Of A Kind was just an idea that burst out of the shell of imagination of one guy, Marijan Raskovic, who finally realized this project and started working in 2016. where he signed first releases.

Being a part of Proton family which counts more over 600 labels, we are proud to be carriers of a wave that doesn't have boundaries when it comes to music. Our main goal is to spread the sound worldwide and well promote every single artist that joins our label, equally.
-----------------------------------------------
▪ Label Manager @jellyforthebabies
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Co-founder//Label-Ops - https://soundcloud.com/overviewuk https://soundcloud.com/domainmusicuk
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To enquire to have a clip featured or a release premiered please email me.
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Oncotarget is a primarily oncology-focused, peer-reviewed, open access journal. Papers are published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Oncotarget is now indexed by MEDLINE, PubMed and PMC/PubMed.

Read about the Oncotarget Scientific Integrity Process: https://www.oncotarget.com/scientific_integrity/

This podcast is for breast cancer patients who feel isolated or sad and want a friend but don't feel up to talking with anyone. With Sarah and Beth, you'll get friendship and validation with zero expectations or judgment.

http://malisima.me

Malísima (it/she/they) understood art for the first time on a Tuesday at 8 a.m., crying in the streets of La Seu D’Urgell on the way to class at an arts-focused high school program they would drop out of three months later. Self-proclaimed "avant-garde experimentalist" and referred to as "malísima (in the head)" by those close to her, she draws on pop culture and her fragile psycho-emotional health as influential elements in her work.

With no clear sense of where she's from or how old she is, she seeks to build a sonic home (and make a living—because hey, that wouldn’t be so bad either) through bastardly contemporary productions that mix all the ingredients—internal and external—from her everyday environment.

And sometimes, no-input mixing, because who doesn’t love an impossible love story?

“Sometimes I thought about what time it was. Then I was on the verge of tears. Then I laughed a lot.”
-Amnesia Scanner, AS ANGELS RIG HOOK

New tracks tagged #recurrence