50% of royalties through December 31st to Lymphoma Research Foundation.

Available for purchase or streaming on major streaming sites

A sci-fi story about the relationship between human intelligence, and intelligence created by humans.  Two scientists work to better the existing world around them while the computer they designed begins its own calculations. Let the story immerse you through 13 tracks in this indie-electronic cinematic fable. 

Welcome. To. ODYSSEY.

Calibrate

HelloWorld

Boot

This paper investigates the significant impact that the increasing use of large language models (LLMs) has on power grids. The authors highlight that AI workloads, particularly LLM training and inference, exhibit unique and demanding power consumption patterns. The paper examines the characteristics of AI loads, focusing on their high computational intensity, variability, and scalability. It explores various metrics for analyzing AI-centric data centers, such as TDP, GPU utilization, PUE, Peak/Average ratio, Peak/Idle ratio, and dP/dt, and presents mathematical models to represent these patterns. The paper then conducts case studies analyzing power consumption in various scenarios, including training and inference using different LLMs and hardware setups. Finally, the authors discuss future research directions for addressing the challenges of AI power consumption, covering perspectives from the AI-user, data center, and power grid sides.

The Unseen AI Disruptions for Power Grids: LLM-Induced Transients

In this episode we kick off a special series of episodes we recorded at the Public Health Association of Australia’s (PHAA) Australian Public Health Conference in Perth in September 2024 #AustPH2024. We had many guests come through our pop-up studio over the 3 day conference to chat about their career and recent work. 

This episode features:

Dr Jacquie McGraw from the University of Queensland - https://issr.uq.edu.au/profile/4708/jacquie-mcgraw who chats with us about Men’s health

Ms Ramya Krishnan from the University of Sydney - https://www.linkedin.com/in/ramyark30/?originalSubdomain=au who discusses her PhD work looking at antipsychotic medication prescribing

Dr Leon Booth from the George Institute at the University of New South Wales- https://www.georgeinstitute.org.au/people/leon-booth who talks through public health campaigns to reduce alcohol related harms

A big thank you to the wonderful PHAA team, and Anise Clarke who helped arrange the logistics for us to record during the conference 

As always, if you want to get in touch with the podcast, you can contact us at: meaningofhealth@outlook.com
Instagram or Twitter/X @healthmeanswhat
FaceBook @MeaningofHealth

Episode 106 - PHAA Australian Public Health Conference 2024 Part 1

Oncotarget #published this #editorial on September 30, 2024, in Volume 15, entitled “Lessons from the ACDC-RP trial: Clinical trial design for radical prostatectomy neoadjuvant therapy trials” by Rashid K. Sayyid and Neil E. Fleshner from the Division of Urologic Oncology, Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada.

DOI - https://doi.org/10.18632/oncotarget.28648

Correspondence to - Rashid K. Sayyid - rksayyid@gmail.com

Video short - https://www.youtube.com/watch?v=APkPoTlXBWY

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Keywords - cancer, clinical trial, prostatic neoplasms, neoadjuvant therapy, chemotherapy; androgen receptor agonist

About Oncotarget 

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Oncotarget is indexed and archived by PubMed/Medline, PubMed Central, Scopus, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science).

To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us:

Facebook - https://www.facebook.com/Oncotarget/
X - https://twitter.com/oncotarget
Instagram - https://www.instagram.com/oncotargetjrnl/
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LinkedIn - https://www.linkedin.com/company/oncotarget
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Reddit - https://www.reddit.com/user/Oncotarget/
Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh

MEDIA@IMPACTJOURNALS.COM

Oncotarget

Lessons from ACDC-RP Trial: Designing Neoadjuvant Therapy Trials for Prostatectomy

Here's the link to this article:

https://www.assaygenie.com/b7-h3-a-promising-new-target-in-tumor-immunotherapy/

B7-H3: A Promising New Target in Tumor Immunotherapy

https://www.assaygenie.com/nk-cells-unlocking-the-potential-of-natural-killer-cells-in-cancer-therapy/

https://www.assaygenie.com/human-ifn-gamma-elisa-kit/
https://www.assaygenie.com/human-tnf-alpha-elisa-kit/
https://www.assaygenie.com/mhc-class-i-h-2k-antibody-cpab0471/
https://www.assaygenie.com/mhc-class-i-h-2k-antibody-cpab0471/

NK Cells in Cancer Immunotherapy
Source: "NK Cells: Unlocking the Potential of Natural Killer Cells in Cancer Therapy" - Assay Genie (October 3, 2024)

Author: Sana Riaz

Main Themes:

The role of NK cells in innate immunity and cancer immunosurveillance.
Mechanisms of NK cell-mediated tumor cell killing.
Current and emerging NK cell-based cancer therapies.
Challenges and strategies to overcome limitations in NK cell therapy.
Key Ideas and Facts:

1. NK Cell Function:

NK cells are lymphocytes that can recognize and kill tumor cells without prior sensitization, unlike T cells.
They use a balance of activating and inhibitory receptors to distinguish between healthy and cancerous cells.
Key functions include:
Direct cytotoxicity: Releasing perforin and granzymes to induce apoptosis in cancer cells.
Cytokine production: Secreting IFN-γ and TNF-α to stimulate a broader immune response.
Antibody-dependent cellular cytotoxicity (ADCC): Leveraging antibodies to target and destroy cancer cells.
2. Role in Cancer Immunosurveillance:

NK cells are critical for detecting and eliminating early-stage tumors.
They are particularly effective against cancer cells that downregulate MHC class I molecules to evade T cell recognition.
"NK cells are essential in cancer immunosurveillance, identifying and destroying early-stage tumors. NK cells are particularly adept at detecting cancer cells that downregulate MHC class I molecules..."
3. NK Cell-Based Therapies:

Adoptive NK Cell Therapy: Expanding NK cells ex vivo and reinfusing them into the patient to boost their numbers and activity.
CAR-NK Cells: Genetically engineering NK cells to express CARs that target specific tumor antigens, enhancing their precision.
Monoclonal Antibodies and NK Cell Activation: Utilizing antibodies to trigger ADCC and enhance NK cell-mediated tumor cell killing.

NK Cells: Unlocking the Potential of Natural Killer Cells in Cancer Therapy

In this week’s episode, host Kristin Hayes talks with Jon Krosnick, a professor at Stanford University and a university fellow at Resources for the Future, about the views held by Americans on climate change and climate policies. Krosnick discusses the latest results from the Climate Insights project, which has gauged American public opinion on climate change since 1997; the preferences of Americans for specific climate policies; the views held by Americans about environmental justice; and public demand for federal climate action.

References and recommendations:

“Climate Insights 2024” report by Jon Krosnick et al; 

Surveys of Consumers from the University of Michigan; http://www.sca.isr.umich.edu/

“Is Gen Z less supportive of Israel? We don’t know. Recent polls can’t be trusted” by Ellen Konar, Jon Krosnick, and Joe Wlos; https://www.sfchronicle.com/opinion/openforum/article/israel-american-support-poll-19484618.php

Surveying American Public Opinion on Climate Change, with Jon Krosnick

In this installment of the Longevity & Aging Series, Dr. Ming Yu and Namita Hattangady from the Fred Hutchinson Cancer Center in Seattle, join host Dr. Evgeniy Galimov to discuss a research paper they co-authored that was published as the cover for Volume 16, Issue 4 of Aging (Aging-US), entitled, “Mapping the core senescence phenotype of primary human colon fibroblasts.”

DOI - https://doi.org/10.18632/aging.205577

Corresponding authors - William M. Grady - wgrady@fredhutch.org, and Ming Yu - myu@fredhutch.org

Video interview - https://www.youtube.com/watch?v=eqSa7My_a7w

Abstract

Advanced age is the largest risk factor for many diseases and several types of cancer, including colorectal cancer (CRC). Senescent cells are known to accumulate with age in various tissues, where they can modulate the surrounding tissue microenvironment through their senescence associated secretory phenotype (SASP). Recently, we showed that there is an increased number of senescent cells in the colons of CRC patients and demonstrated that senescent fibroblasts and their SASP create microniches in the colon that are conducive to CRC onset and progression. However, the composition of the SASP is heterogenous and cell-specific, and the precise senescence profile of colon fibroblasts has not been well-defined. To generate a SASP atlas of human colon fibroblasts, we induced senescence in primary human colon fibroblasts using various in vitro methods and assessed the resulting transcriptome. Using RNASequencing and further validation by quantitative RT-PCR and Luminex assays, we define and validate a ‘core senescent profile’ that might play a significant role in shaping the colon microenvironment. We also performed KEGG analysis and GO analyses to identify key pathways and biological processes that are differentially regulated in colon fibroblast senescence. These studies provide insights into potential driver proteins involved in senescence-associated diseases, like CRC, which may lead to therapies to improve overall health in the elderly and to prevent CRC.

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Keywords - aging, senescence, senescence associated secretory phenotype, SASP, colorectal cancer, cancer

About Aging-US

The mission of the journal is to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population.

The journal aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.)

Please visit our website at https://www.Aging-US.com​​ and connect with us:

Facebook - https://www.facebook.com/AgingUS/
X - https://twitter.com/AgingJrnl
Instagram - https://www.instagram.com/agingjrnl/
YouTube - https://www.youtube.com/@AgingJournal
LinkedIn - https://www.linkedin.com/company/aging/
Pinterest - https://www.pinterest.com/AgingUS/
Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc

MEDIA@IMPACTJOURNALS.COM

Aging (Aging-US)

Longevity & Aging Series (S2, E2): Dr. Ming Yu and Namita Hattangady

Unleashing the power of discovery! 🚀
At Assay Genie, we provide cutting-edge research tools to fuel breakthroughs in life sciences. From high-quality ELISA kits to innovative bioresearch reagents, we empower scientists worldwide to explore, innovate, and transform research into results. Follow us for insights into the world of biotechnology, exciting updates, and the latest trends in scientific discovery! 🌍🔬

Oncotarget is a primarily oncology-focused, peer-reviewed, open access journal. Papers are published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Oncotarget is now indexed by MEDLINE, PubMed and PMC/PubMed.

Read about the Oncotarget Scientific Integrity Process: https://www.oncotarget.com/scientific_integrity/

Cancer and aging are two sides of age-related tumorigenesis.

The mission of the journal is to understand the mechanisms surrounding aging and age-related diseases, including cancer as the main cause of death in the modern aged population.

The journal aims to promote 1) treatment of age-related diseases by slowing down aging, 2) validation of anti-aging drugs by treating age-related diseases, and 3) prevention of cancer by inhibiting aging. (Cancer and COVID-19 are age-related diseases.)

Read about the Aging (Aging-US) Scientific Integrity Process: https://aging-us.com/scientific-integrity

Resources Radio is a weekly podcast by Resources for the Future. Each week we talk to leading experts about climate change, electricity, ecosystems, and more, making the latest research accessible to everyone.

A podcast that explores a range of health and health-related issues that affect people in the community. We sit down with lived experience, academic, and practitioner experts to take a deep dive into many different areas of health. We are based at the School of Population and Global Health at the University of Western Australia.

New tracks tagged #research