Are you ready to be part of something bigger? Join a research study TODAY and help transform lives. 

At Kessler Foundation, our award-winning scientists are developing and testing breakthrough interventions to improve mobility, cognition, and quality of life for people with neurological and developmental disabilities. 

More than 10,000 volunteers have already joined us - And over half have come back to participate in more than one study! 

Since 2020, we've completed over 7,000 research sessions - Thanks to participants who showed up, stayed committed, and helped drive real progress. 

Here are 3 reasons to join a research study: 

#1 - You Can Help Drive Discovery 

Support the development of rehabilitation strategies 
Provide valuable data that improves care and independence 
Test new therapies and help scientists better understand medical conditions 
 
#2 - Flexible Options for Taking Part 
Join us in person at our research centers in East Hanover and West Orange, NJ 
Or participate from home - some studies require no in-person visits 
Time commitments vary, and we'll make sure you know what to expect 
We make participation easy - and even enjoyable! 
 
#3 - Experience Hands-On Research 
Depending on the study, you might: 
Engage in exercise-based programs or imaging studies using MRI 
Complete questionnaires or cognitive tests that feel like fun brain games 
Try cutting-edge tech like robotic exoskeletons or virtual reality equipment 

Ready to make an impact? 

Contact Jackie Leddy at 973.323.3686 
Email us at researchstudies@kesslerfoundation.org 
Or visit kesslerfoundation.org/join 
 
Be part of the discovery. Join a research study today.

Join a research study TODAY and help transform lives

In this episode of Abstract we spoke with researchers and education leaders in the MERC region about the recent expansion of the Virginia Literacy Act to include middle schools across the Commonwealth. The conversation centers around a MERC research and policy review focused on this expansion (linked below) and how those findings resonate with efforts in local school divisions. Guests include Kendall Hunt (Education Specialist for Middle School Literacy in Henrico County Public Schools), Candace Bechtold (PhD Student in Curriculum, Culture, and Change at VCU), Val Robnolt (Associate Professor of Teaching and Learning at VCU), and David Naff (MERC Director and Associate Professor of Research, Assessment, and Evaluation at VCU). 

MERC REPORT
Virginia Literacy Act Expansion: Implications for Middle Schools
https://merc.soe.vcu.edu/reports/reports/virginia-literacy-act-expansion-implications-for-middle-schools.html

Virginia Literacy Act Expansion: Implications for Middle Schools

In this episode of Consultant Conversations, Dr Luke Yates explores getting involved in research as a consultant with Professor Terry Quinn. As a seasoned academic, Professor Quinn has held various leadership and educator roles in clinical research, and shares top tips for those new to research (and those keen to get back involved), including educational and development opportunities, funding opportunities, who to speak to for support and advice, and more.


Professor Terry Quinn is David Cargill Chair of Geriatric Medicine at the University of Glasgow and is Honorary Consultant Physician in Stroke and Geriatric Medicine. Professor Quinn has a broad research portfolio, with core research interests in trial methodology, functional assessment, and neuropsychological consequences of cardiovascular disease. He has published extensively on topics relating to stroke, cognition and test accuracy, and is Principal Investigator for a number of studies. Learn more: https://www.gla.ac.uk/schools/cardiovascularmetabolic/staff/terryquinn

Dr Luke Yates is a member of RCPE's Recently Appointed Consultants' Committee (RAC) and a Consultant Physician in NHS Lanarkshire.


-- Links --

NIHR Good Clinical Practice (GCP) Course - https://www.nihr.ac.uk/career-development/clinical-research-courses-and-support/good-clinical-practice

NIHR Introductory Courses - https://www.nihr.ac.uk/career-development/health-and-care-research-introduction/introductory-courses

NIHR Research skills e-learning - https://www.nihr.ac.uk/career-development/research-skills

Cochrane Learn - https://www.cochrane.org/learn

NIHR Research Delivery Network (RDN) - https://rdn.nihr.ac.uk/

NIHR Be Part of Research - https://bepartofresearch.nihr.ac.uk/

NIHR Associate PI Scheme - https://www.nihr.ac.uk/career-development/clinical-research-courses-and-support/associate-principal-investigator-scheme

NHS Research Scotland - https://www.nhsresearchscotland.org.uk/

RCPE Systematic Review and Meta-analysis Course - https://www.rcpe.ac.uk/events

RCPE Event, Bridging NHS care with curiosity: clinical research unplugged - https://www.rcpe.ac.uk/events/bridging-nhs-care-curiosity-clinical-research-unplugged

NIHR Impact Prizes - https://www.nihr.ac.uk/about-us/our-impact/impact-prizes

RCP NIHR position statement: Making research everybody’s business - https://www.rcp.ac.uk/policy-and-campaigns/policy-documents/rcp-nihr-position-statement-making-research-everybody-s-business/

Commercial clinical trials in the UK: the Lord O’Shaughnessy review - final report - https://www.gov.uk/government/publications/commercial-clinical-trials-in-the-uk-the-lord-oshaughnessy-review/commercial-clinical-trials-in-the-uk-the-lord-oshaughnessy-review-final-report

The James Lind Alliance: https://www.jla.nihr.ac.uk/


Recording date: 5 November 2025


-- Upcoming RCPE events --
https://www.rcpe.ac.uk/events

-- Become an RCPE Member --
https://www.rcpe.ac.uk/membership/join-college

Feedback: cme@rcpe.ac.uk

The edited music used in this podcast, 'Corporate' by ProLuxeStudio (available on SoundCloud: https://soundcloud.com/proluxestudio/corporate-free-download), is licensed as CC BY-NC-SA 3.0 (https://creativecommons.org/licenses/by-nc-sa/3.0).

This podcast is from the Recently Appointed Consultants’ Committee (RAC) of the Royal College of Physicians of Edinburgh (RCPE).

Consultant Conversations

Getting involved in Research (04 Dec 2025)

BUFFALO, NY — December 3, 2025 — A new #essay was #published in Volume 17, Issue 11 of Aging-US on November 19, 2025, titled “On the intergenerational transfer of ideas in aging and cancer research: from the hypothalamus according to V.M. Dilman to the mTOR protein complex according to M.V. Blagosklonny.”

In this work, Aleksei G. Golubev from the N.N. Petrov National Medical Research Center of Oncology reflects on the legacy of two influential Russian scientists, Vladimir M. Dilman and his son Mikhail V. Blagosklonny, who each introduced groundbreaking ideas about aging and cancer. Drawing from his own experience working in Dilman’s lab, Golubev explores how their ideas remain deeply relevant to today’s scientific understanding.

The essay connects Dilman’s “elevation theory” with Blagosklonny’s “hyperfunction theory,” two frameworks that challenge the conventional view of aging as a process of decline. Instead, both propose that aging results from continued biological processes that once supported growth but eventually become harmful when left unchecked.

Dilman believed that aging begins with reduced sensitivity in the hypothalamus, a brain region that regulates the body’s balance. This desensitization disrupts metabolism and hormone levels, setting the stage for many chronic illnesses. Decades later, Blagosklonny expanded on this idea at the molecular level. Central to his theory is the mTOR protein complex, which regulates growth and metabolism and is now a major focus in aging research.

Golubev also explores the historical and personal connections between the two scientists. Dilman, an endocrinologist trained in the Soviet Union, and Blagosklonny, a molecular biologist educated during the post-Soviet period, represent two generations shaped by a shared scientific tradition. 

“Dilman’s scientific legacy is not as well recognized as it should be, partly due to bias in citation practices.”

The essay also draws attention to a troubling trend in science: the tendency to overlook early contributions, especially from non-Western scholars. Many of Dilman’s insights, such as the connection between high blood sugar, insulin resistance, and cancer, have since been validated by modern tools, yet his work is rarely cited. Golubev points out how citation practices, language barriers, and historical isolation have contributed to this lack of recognition.

Finally, Golubev encourages the scientific community to look back and acknowledge the foundational work that shaped modern aging science. It also highlights the importance of cross-generational knowledge in moving science forward. By tracing the intellectual journey from hormonal regulation in the brain to molecular pathways in cells, this essay demonstrated the relevance of old ideas in a new biological era.

DOI - https://doi.org/10.18632/aging.206338

Corresponding author - Aleksei G. Golubev - lxglbv@rambler.ru

Abstract video - https://www.youtube.com/watch?v=LvrdghTKGws

Sign up for free Altmetric alerts about this article - 
https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206338

Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alerts

Keywords - aging, gerontology, history of science, hyperfunction, mTOR, hypothalamus, cancer, metabolism, immunity

To learn more about the journal, please visit https://www.Aging-US.com​​ and connect with us on social media:

Facebook - https://www.facebook.com/AgingUS/
X - https://twitter.com/AgingJrnl
Instagram - https://www.instagram.com/agingjrnl/
YouTube - https://www.youtube.com/@Aging-US
LinkedIn - https://www.linkedin.com/company/aging/
Bluesky - https://bsky.app/profile/aging-us.bsky.social
Pinterest - https://www.pinterest.com/AgingUS/
Spotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6Mc

MEDIA@IMPACTJOURNALS.COM

Aging-US

How Two Russian Scientists Changed the Way We Understand Aging and Cancer

SAHMRI's Precision Cancer Medicine Theme Leader Professor Deborah White and blood cancer survivor, Janet Anderson, join FIVEaa Breakfast to talk about the link between microbiome and cancer and the exciting progress being made in tailoring cancer therapy. Raising funds to further this crucial research is the focus of this year's SAHMRI Christmas Appeal. 

Exploring the link between gut health and cancer

This interview with Dr. Tom Devitt explores broader impacts programs geared towards undergraduate students, discussing mentorship strategies and fostering engagement with non-STEM major students. We also discuss the impact of online outreach vs. in-person events and the importance of experiential learning.

Small Talk: Broad Impacts- Tom Devitt Interview

Dr Alison McIntosh, the Director of GCU's Research and Knowledge Exchange Services, joins the Common Good Podcast to outline the role of her new department, how it was formed, and its objectives. Dr McIntosh also discusses her journey in academia.

Understanding GCU's Research and Knowledge Exchange Services with Dr Alison McIntosh

Colorectal cancer (CRC) remains the second leading cause of cancer-related deaths globally. While early detection significantly improves outcomes, many patients are diagnosed at advanced stages when treatment options are limited and relapse is common. To address this challenge, researchers are exploring whether existing drugs can be repurposed for cancer therapy, a strategy that could accelerate drug development while reducing associated costs and risks.

One class of drugs under investigation is statins, commonly prescribed to reduce cholesterol and prevent cardiovascular disease. Several studies have observed a potential link between elevated cholesterol and increased CRC risk. Cholesterol may support tumor growth by promoting membrane synthesis and energy metabolism in rapidly dividing cells.

Building on this connection, researchers from leading Indian institutions, including the Indian Institute of Science Education and Research and the Center of Excellence in Epigenetics at Shiv Nadar Institution of Eminence, investigated how statins influence CRC cells at the molecular level. Their goal was to determine whether these widely used drugs could have a therapeutic role in oncology.

The Study: Investigating the Molecular Impact of Statins in CRC Cells

The study, titled “Statins exhibit anti-tumor potential by modulating Wnt/β-catenin signaling in colorectal cancer,” was published in Oncotarget (Volume 16). Using a combination of lipidomics, transcriptomics, proteomics, and 3D tumor models, the researchers explored how two widely prescribed statins, atorvastatin and simvastatin, affect molecular pathways associated with CRC progression. This integrative, multi-omics strategy enabled tracing statin-induced effects across different layers of cellular function, linking lipid, transcript, and protein changes to pathway-level shifts.

Full blog - https://www.oncotarget.org/2025/12/03/repurposing-statins-exploring-anti-tumor-effects-in-colorectal-cancer/

Paper DOI - https://doi.org/10.18632/oncotarget.28755

Correspondence to - Sanjeev Galande - sanjeev.galande@snu.edu.in

Abstract video - https://www.youtube.com/watch?v=A95ICULaH3Y

Sign up for free Altmetric alerts about this article - https://oncotarget.altmetric.com/details/email_updates?id=10.18632%2Foncotarget.28755

Subscribe for free publication alerts from Oncotarget - https://www.oncotarget.com/subscribe/

Keywords - cancer, colorectal cancer, statins, SATB1, Wnt/β-catenin signaling, tumor-suppressive phenotype

To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us:

Facebook - https://www.facebook.com/Oncotarget/
X - https://twitter.com/oncotarget
Instagram - https://www.instagram.com/oncotargetjrnl/
YouTube - https://www.youtube.com/@OncotargetJournal
LinkedIn - https://www.linkedin.com/company/oncotarget
Pinterest - https://www.pinterest.com/oncotarget/
Reddit - https://www.reddit.com/user/Oncotarget/
Spotify - https://open.spotify.com/show/0gRwT6BqYWJzxzmjPJwtVh

MEDIA@IMPACTJOURNALS.COM

Oncotarget

Repurposing Statins: Exploring Anti-Tumor Effects in Colorectal Cancer

It seems like forever since we’ve had Jeff AND Brad on the same episode, hunkered down in a dimly lit bar, discussing entrepreneurship research over cocktails. As such, we’re delighted to have them reunited at long last at Nora’s, an honest-to-goodness speakeasy located a couple flights of stairs beneath downtown Louisville, CO. 	

Joined by guest academic researcher Nan Jia, Brad and Jeff speak with Jordan Leggett, Bar Lead and Mad Scientist at Nora’s. Jordan walks us through a trio of her innovative concoctions as she explains her creative approach to bartending. 

These libations, including a scotch cocktail with pumpkin puree and a tequila-based old-fashioned, are some of the most inventive and delicious creations we’ve encountered on Creative Distillation — and that’s saying something.

The conversation also features a Tiki Time check-in with Jeff, touches on testing new recipes, and asks whether ChatGPT is a good bartender (spoiler: it’s not). Thanks to Jordan at Nora’s for an illuminating — and perfectly dimly lit — discussion. 

Enjoy and cheers!

***

This episode of Creative Distillation was recorded at Nora’s in Louisville, Colorado. Follow them on Instagram @norasplacelouisville, and learn more at noras.place.

We’ll return from the holidays, still at Nora’s, for a deep dive with Nan Jia into her recent research on AI and productivity. 

Stay tuned for our next episode, the last of 2025, where we return to Dry Land Distillers to enjoy some holiday cheer with our favorite fall guest, CU’s Ethan Poskanzer.
--

Learn more about CU's Deming Center for Entrepreneurship: https://deming.colorado.edu

Comments/criticism/suggestions/feedback? We'd love to hear it. Drop us a note at CDpodcast@colorado.edu.

Thanks for listening.
- An Analog Digital Arts Production for the Deming Center for Entrepreneurship Produced, recorded and edited by Joel Davis

"Whiskey Before Breakfast" [Traditional] performed by Jeffrey York and Brad Werner. Recorded, mixed and mastered by George Figgs

___

CREATIVE DISTILLATION

University of Colorado-Boulder professors Jeff York and Brad Werner distill entrepreneurship research into actionable insights.

Jeff York | Associate Professor | Research Director jeffrey.york@colorado.edu

Brad Werner | Instructor | Teaching Director walter.werner@colorado.edu

Deming Center for Entrepreneurship | CU Leeds School of Business 303.492.9018 | deming@colorado.edu

89: Jordan Leggett, Bar Lead and Mad Scientist at Nora’s Speakeasy

Mysterious and intrigue-laden musical backdrop for a modern mystery, investigation, study or forensic fact-finding. Great music for journalism, detective work, investigating a story or going behind the headlines in a political drama. (Stem files available.)

For licensing, contact
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RCPE's Podcast Series 'Consultant Conversations' by the Recently Appointed Consultants' Committee (RAC).

The edited music used in this podcast, 'Corporate' by ProLuxeStudio (available on SoundCloud), is licensed as CC BY-NC-SA 3.0.

Kessler Foundation - Changing the lives of people with disabilities through research in stroke, brain injury, multiple sclerosis,  spinal cord injury and by funding innovative programs that promote employment for people with disabilities. Podcasts are from various consumer and professional lectures   presented by our researchers and guest lecturers.

Hello! My name is Sam and I am a PhD student at the University of Austin, Texas studying vertebrate paleontology. I am passionate about outreach and science communication and am excited to hear other people's outreach experiences!

Lynne Publishing is a music label representing a library of high-quality, carefully developed and curated production music, available to license for use in your own media.We develop our own music with contracted professional composers, both young and exciting talents and experienced film- and TV composers.

All our music is available for easy licensing for use in media creations, such as videos, films, games, TV, online, social media, corporate use, etc. To obtain a Master Synchronization license for any of music, contact us via www.LynnePublishing.com

Glasgow Caledonian University's podcasts showcase the very best of GCU's research and explains how it benefits people and communities locally, nationally and around the world.

Oncotarget is a primarily oncology-focused, peer-reviewed, open access journal. Papers are published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Oncotarget is now indexed by MEDLINE, PubMed and PMC/PubMed.

Read about the Oncotarget Scientific Integrity Process: https://www.oncotarget.com/scientific_integrity/

Aging-US is dedicated to advancing our understanding of the biological mechanisms that drive aging and the development of age-related diseases. Our mission is to serve as a platform for high-quality research that uncovers the cellular, molecular, and systemic processes underlying aging, and translates these insights into strategies to extend healthspan and delay the onset of chronic disease.

Read about the Aging (Aging-US) Scientific Integrity Process: https://aging-us.com/scientific-integrity

Abstract is the podcast of the Metropolitan Educational Research Consortium at Virginia Commonwealth University. We explore issues in public, PK12 education.

University of Colorado-Boulder professors Jeff York and Brad Werner distill  entrepreneurship research into actionable insights.

New tracks tagged #research