On this episode of Butts and Guts, Dr. Daniel Joyce joins the podcast to discuss gastrointestinal stromal tumors (GISTs) and other sarcomas of the digestive system. Listen to learn about where sarcomas can appear in the digestive system, what causes them to form, the treatment options available, and more.

Understanding Sarcomas of the Digestive System

A new case report was published in Oncotarget's Volume 14 on July 7, 2023, entitled, “Intrathoracic synovial sarcoma with BRAF V600E mutation.”

Synovial sarcoma (SS) is a highly malignant mesenchymal tumor that occurs mainly in adolescents and young adults. The treatment of SS is multimodal, involving surgery, radiotherapy and chemotherapy. The overall prognosis is generally quite satisfactory in children and adolescents with localized SS at diagnosis. However, the outcome remains poor for patients who relapse, with a reported 5-year post-relapse survival of around 30%.

In this new paper, researchers Ida Russo, Sabina Barresi, Pier Luigi Di Paolo, Valentina Di Ruscio, Giada Del Baldo, Annalisa Serra, Silvia Vallese, Evelina Miele, Angela Mastronuzzi, Rita Alaggio, Andrea Ferrari, and Giuseppe Maria Milano from Italy’s Istituto di Ricovero e Cura a Carattere Scientifico (IRCCS) report the case of a 15-year-old boy with intrathoracic synovial sarcoma who relapsed after standard chemotherapy, surgery and radiotherapy. The molecular analysis of the tumor identified a BRAF V600E mutation at time of progression of relapsed disease under third line systemic treatment. 

This mutation is commonly seen in melanomas and papillary thyroid cancers, but less prevalent (typically <5%) across a variety of other cancer types. The patient underwent selective BRAF inhibitor Vemurafenib treatment achieving partial response (PR) with a progression free survival (PFS) ratio of 1.6 months and an overall survival of 19 months, alive in continuous PR. This case highlights the role of routine next generation sequencing (NGS) used to drive treatment choice and to investigate SS tumors for BRAF mutations.

“Our data highlight the importance of implementing molecular tests in SS patients to evaluate BRAF mutational actual incidence in these neoplasms.”

DOI - https://doi.org/10.18632/oncotarget.28475

Correspondence to - Giuseppe Maria Milano - giuseppemaria.milano@opbg.net

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Keywords - synovial sarcoma, next-generation sequencing, BRAF V600E mutation, targeted therapy

About Oncotarget

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

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Oncotarget

Case Report: Intrathoracic Synovial Sarcoma With BRAF V600E Mutation

Case Report: Intrathoracic Synovial Sarcoma with BRAF V600E Mutation

(Track 07) BRENDXN - "sarcoma" ft. Deixa Pra Lá
#IMMUREMENT2 #WOULDDIE2BEALIVE #RIH

WOULD DIE 2 BE ALIVE

BRENDXN - "sarcoma" ft. Deixa Pra Lá

BUFFALO, NY- August 14, 2024 – A new #casereport was #published in Oncotarget's Volume 15 on July 17, 2024, entitled, “Rapid but nondurable response of a BRAF exon 15 double-mutated spindle cell sarcoma to a combination of BRAF and MEK inhibitors.”

As noted in the introduction of the Abstract, the BRAF V600E substitution predicts a cancer's sensitivity to BRAF inhibitor therapy, though the mutation is rarely found in soft-tissue sarcomas.

Researchers Kseniya Sinichenkova, Iliya Sidorov, Nataliya Kriventsova, Dmitriy Konovalov, Ruslan Abasov, Nataliya Usman, Alexander Karachunskiy, Galina Novichkova, Dmitriy Litvinov, and Alexander Druy from the Dmitriy Rogachev National Medical Research Center of Pediatric Hematology, Oncology, Immunology (Ministry of Healthcare of Russian Federation) and the Research Institute of Medical Cell Technologies in Yekaterinburg, Russia, describe a case of undifferentiated spindle cell sarcoma that exhibited primary insensitivity to standard chemotherapy and a pronounced but non-sustained response to BRAF/MEK inhibitors at recurrence.

The case presentation involved a 13-year-old girl that was diagnosed with low-grade spindle cell sarcoma of pelvic localization, BRAF exon 15 double-mutated: c.1799T>A p.V600E and c.1819T>A p.S607T in cis-position. 

“This is the first report of spindle cell sarcoma BRAF V600E/S607T double-mutated, responding to a combination of B-Raf and MEK inhibitors.”

DOI - https://doi.org/10.18632/oncotarget.28606

Correspondence to - Kseniya Sinichenkova - ksinichenkova@gmail.com

Video short - https://www.youtube.com/watch?v=QWEAaaixPxE

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Keywords - cancer, undifferentiated sarcoma, BRAF V600E mutation, low grade spindle cell sarcoma, abdominal cocoon

About Oncotarget 

Oncotarget (a primarily oncology-focused, peer-reviewed, open access journal) aims to maximize research impact through insightful peer-review; eliminate borders between specialties by linking different fields of oncology, cancer research and biomedical sciences; and foster application of basic and clinical science.

Oncotarget is indexed and archived by PubMed/Medline, PubMed Central, Scopus, EMBASE, META (Chan Zuckerberg Initiative) (2018-2022), and Dimensions (Digital Science).

To learn more about Oncotarget, please visit https://www.oncotarget.com and connect with us:

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MEDIA@IMPACTJOURNALS.COM

Response of BRAF-Mutated Spindle Cell Sarcoma to BRAF/MEK Inhibitors

Artificial intelligence continues to gain popularity as society identifies its uses and benefits. AI has shown promise despite being in the early phases of implementation in sarcoma care. For this episode we discuss Artificial intelligence, its present and the future in sarcoma care. 

Bozzo A, Tsui JMG, Bhatnagar S, Forsberg J. Deep Learning and Multimodal Artificial Intelligence in Orthopaedic Surgery. J Am Acad Orthop Surg. 2024 Jun 1;32(11):e523-e532. 
Bozzo, A., Hollingsworth, A., Chatterjee, S. et al. A multimodal neural network with gradient blending improves predictions of survival and metastasis in sarcoma. npj Precis. Onc. 8, 188 (2024).
sarcomaAIhub.com

Find out More about our Doctors:

Dr. Izuchukwu Ibe: www.linkedin.com/in/izuchukwu-ibe-a073537a/

Dr. Elyse Brinkmann: www.linkedin.com/in/elyse-brinkmann/

Episode 34: A.I and Sarcoma care - with Dr Anthony Bozzo

слышуеёмысли feat. waunty812 (prod. by @yammy)

prod. by greyrock & tewiq
mix by me

(Вступление)

Эй Эй ЭЙ

Закрывай за собой дверь

Эй эй эй

Это саркома на бите

(Припев)

Закрывай за собой дверь
Уходи из моего дома
Закрывай за собой дверь
Я не хочу видеть тебя снова

(Куплет)

Я весь в таблетках, это радужные сны
Она хавает моё сердце от осени до весны
Я забываю кем я был и мне поебать кем я стану
Она словно охотник и я попал в её капканы


Закрывай за собой дверь
И я не помогу собрать твои монатки
Закрывай за собой дверь
И тебя не должно ебать всё ли у меня в порядке

А у меня всё заебись, у меня всё заебато
Я оставил свои чувства, они где-то щас далековато
От меня
От меня

(Припев)

Закрывай за собой дверь
Уходи из моего дома
Закрывай за собой дверь
Я не хочу видеть тебя снова

до весны (prod. by greyrock & tewiq)

Killstation- Sarcoma (Pharenight Remix)

𝐃𝐫𝐞𝐚𝐦 𝐃𝐚𝐲𝐬 @dreamdays69  is a DJ, party thrower, and producer that lives in Austin, Texas USA. They enjoy playing sets that focus on "attitude and emotion." They prefer their music and parties to be more rugged and unrefined, and they view dance music through a DIY subversive lens. They play often in Texas and are known for long marathon sets that go across genres and boundaries. In Austin they throw a monthly warehouse rave called Body Mechanics. They have been going for over four years and are going strong! 

Deep in the middle of conservative cowboy Texas, Body Mechanics provides a space of refuge for the freaks. This mix has a lot of ebm mixed with some wave, electro, synth pop, post punk, and some wildcards as well. There are also a few original Dream Days tracks (two of which are coming out this summer) and an acapella by Daniel Johnston at the end; who is an Austin hero. Pop it on your favorite speaker and be transported to a late night sleazy warehouse rave in Texas.

𝗙𝗢𝗟𝗟𝗢𝗪: #𝗗𝗥𝗘𝗔𝗠𝗗𝗔𝗬𝗦
SC - @dreamdays69 
IG - https://www.instagram.com/bunnylove.dreamdays69/
IG - https://www.instagram.com/bodymechanicsatx
BC - https://dreamdays69.bandcamp.com/

1. Haunted Strasse + Young Drums — Connection @hauntedstrasse
2. Ludgate Squatter — Get Out @ludgatesquatter
3. Wvalaam Klous — In Chains @wvalaamklous
4. Candido — Brand New Primitivism @jconcloud
5. Deomid — Give It Up
6. Dim Deck — Head of Dead
7. Semantix — Recoil @semantix
8. Magnum Opus — Area Zero  @magnumopussc
9. Meshes — Shared Ecstasy  @oberwave 
10. Idoru — Consciousness (Jennifer Touch Remix)
11. Kode IV — Insane
12. Naiborg — Fatality Acid (Fear‑E’s Flawless Victory Remix)
13. Interchain — Sigil
14. Ivan Pavletsov — No Future
15. Ten Lardell — Vibranium Pt1
16. Teatre — Regret  @musicateatre
17. Sarcoma — Apocalipsis Flúor (Aislamiento Remix)
18. Konerytmi — Elektrokone
19. Hong Kong Counterfeit — Television Man
20. Jenouise — Amor
21. Mihai Popoviciu — Deep Into Carpathian Woods
22. Bleak Engineers — La Poésie
23. Adrian Marth — Disorder (Fabrizio Mammarella Remix)
24. Dream Days — Escape the Rat Race @dreamdays69 
25. Black Spuma — Skettino
26. Dream Days — Pure Energy  @dreamdays69
27. Dream Days — Pure EBM  
28. Fox Electrochongo — Fiesta Negra (Mucha Trola)
29. Wayne, Pat + Keith — I’m Tired of You, Satan
30. The Dirty Monroes — Vibrator (Extended Dub Mix)
31. Cardinal & Nun —
32. Daniel Johnston — My Baby Cares For the Dead



𝐅𝐎𝐋𝐋𝐎𝐖 #𝐇𝐨𝐫𝐫𝐨𝐫𝐒𝐡𝐨𝐰𝐆𝐌𝐈𝐗
BC: https://horrorshowrecords.bandcamp.com/
IG: instagram.com/horrorshow_gmix/
FB: facebook.com/profile.php?id=100089549361664
SC: @horror-show-gmix
YT: www.youtube.com/@horrorshow-gh1mii

𝐅𝐎𝐋𝐋𝐎𝐖 #𝐇𝗔𝗩𝗡𝗯𝗲𝗮𝘁
🕸️ https://horrorsh.wixsite.com/havn-beat
FB: https://www.facebook.com/HAVNBEAT
IG: https://www.instagram.com/havn_beat/
SC: @horror-havnbeat

𝑯𝑶𝑹𝑹𝑶𝑹 𝑺𝑯𝑶𝑾 #68 DREAM DAYS

BUFFALO, NY - July 18, 2025 – A new #editorial was #published in Volume 16 of Oncotarget on July 16, 2025, titled “microRNAs in soft tissue sarcoma: State of the art and barriers to translation.”

In this article, Elizaveta K. Titerina, Alessandro La Ferlita, and Joal D. Beane from Ohio State University discuss the role of microRNAs in soft tissue sarcomas (STS), a rare and diverse group of cancers that begin in connective tissues, like bone or fat. The authors explain how these small molecules regulate cancer-related processes and highlight their potential as non-invasive biomarkers for diagnosis and monitoring. They also outline the main challenges that need to be addressed before microRNA-based strategies can be used in clinical settings.

Soft tissue sarcomas include over 50 subtypes, making precise diagnosis and effective treatment difficult. The editorial describes how microRNAs influence cancer growth, spread, and response to therapies. Because microRNAs are stable in body fluids like blood and saliva, they could be used for early detection and to help guide treatment decisions. Such as, certain groups of microRNAs are linked to how patients respond to specific drugs, showing their potential as tools for precision medicine.

“For example, miR-17-92 and miR-106b-25 clusters have been associated with sensitivity or resistance to eribulin in STS.”

The authors also explain that microRNAs could help distinguish between tumor types that are often difficult to differentiate, such as benign lipomas and malignant liposarcomas. Recognizing these differences is crucial for guiding treatment decisions. Specific patterns of microRNA expression in blood samples may enable clinicians to make quicker and more reliable diagnoses without the need for invasive procedures. Beyond their diagnostic role, microRNAs are also being explored as therapeutic tools, but applying microRNA-based therapies to patients remains challenging. These molecules can act as either cancer promoters or suppressors, depending on the environment, which complicates the development of safe and targeted treatments. However, new delivery methods such as lipid nanoparticles show promise in improving precision and safety.

Overall, microRNAs are emerging as an important focus in STS research, offering new possibilities for advancing diagnosis, prognosis, and treatment. As researchers continue to address the current challenges, these small molecules could become valuable tools in improving cancer care.

DOI - https://doi.org/10.18632/oncotarget.28754

Correspondence to - Joal D. Beane, joal.beane@osumc.edu

Video short - https://www.youtube.com/watch?v=MlLGA8BObPQ

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Keywords - cancer, soft tissue sarcoma, liposarcoma, microRNA, small non-coding RNA, cancer biomarkers

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MEDIA@IMPACTJOURNALS.COM

microRNAs Emerge as Biomarkers and Diagnostic Tools in Soft Tissue Sarcoma

𝐿𝑎𝑏𝑒𝑙 / 𝐺𝑢𝑒𝑠𝑡 𝑀𝑖𝑥 / 𝑅𝑎𝑑𝑖𝑜 𝑆ℎ𝑜𝑤
𝑯𝑶𝑹𝑹𝑶𝑹 𝑺𝑯𝑶𝑾 💥
🥽 𝗙𝗢𝗨𝗡𝗗𝗘𝗥: @ultrapaulina2
📻 𝗣𝗥𝗘𝗠𝗜𝗘𝗥𝗘𝗦 𝗢𝗡 @radiokapital
🔝 𝗠𝗨𝗦𝗜𝗖 𝗖𝗛𝗔𝗥𝗧𝗦 @horror-havnbeat

𝗠𝗜𝗦𝗦𝗜𝗢𝗡:
Promote 𝐄𝐥𝐞𝐜𝐭𝐫𝐨 𝐁𝐨𝐝𝐲 𝐌𝐮𝐬𝐢𝐜:
and unite its international community.
𝐄𝐯𝐨𝐥𝐯𝐢𝐧𝐠 𝐬𝐢𝐧𝐜𝐞: 2021 

𝗚𝗨𝗘𝗦𝗧𝗦:🦇
2023
#1 @Illnurse ILLNURSE
#2 @ekatamusic EKATA
#3 @4fgang1  DJ ZAMOCNO
#4 @odilonsgrip ODILONS GRIP
#5 @saintclairr b2b @theppie MIDNIGHT CHAOS
#6 @connor_noctambuss 
CONNOR NOCTAMBUSS
#7 @manasyt MANASYt
#8 @laurapalmer11 LAURAPALM3R
#9 @thenorthernscum LORENZO MORI
#10 @rynzler1 RYNZLER (LIVE ACT)
#11 @ona_vera ONA:V
#12 @evildust  EVIL DUST
#13 @panternoise PANTERNOISE
#14 @dj-delectro DELECTRO
#15 @georgi-penstkart PENSTKART
#16 @giallovirgo GIALLO VIRGO
#17 @post_traumaticcc POST TRAUMATIC
#18 @ricardocastro RICARDO CASTRO
#19 @aufnahme-wiedergabe PHILIPP STROBEL
#20 @go-nuclear GO NUCLEAR!
#21 @romancedisaster ROMANCE DISASTER
#22 @zeitreise_brutal_forms ZEITREISE
#23 @notausgangmusic NOTAUSGANG
#24 @shialabiff SHIA LABIFF
#25 @w1ldatheart WILD AT ♡
#26 @djgraftak GRAFTAK
#27 @dvsnme DVS NME

2024
#28 @electrosexual ELECTROSEXUAL
#29 @ezuri EZURI/LESS
#30 @adam_ra ADAM RÅ
#31 @disco_for_the_damned BYRNE
#32 @flora_xc FLORA
#33 @heatherhelix HEATHER HELIX
#34 @miseriarecords 89s† CARLOS GRABSTEIN
#35 @mildaffect MILD AFFECT
#36 @zosia-ho-ubowska MALA HEBRA
#37 @jorgenthorvald JØRGEN THORVALD
#38 @madmoizel MADMOIZEL
#39 @cat-gadget CATGET
#40 @luct_melod LUCT MELOD
#41 @existentialdoubt EXISTENTIAL DOUBT
#42 @carmillasioux CARMILLA SIOUX
#43 @alone-in-the-dark-dj ALONE IN THE DARK
#44 @kunihiko-yoshida  FECROMASS
#45 @djtygre TYGRE
#46 @norbert-thunder NORBERT THUNDER
#47 @klangwergkh KLANGWERGKH
#48 @thildaart THILDAA
#49 @mysterykidbaker  MYSTERY KID
#50 @lzndj  LZN
#51  @dj-mademoisellecherie 
MADEMOISELLE CHÉRIE
#52 @sv3n SV3N
#53 @ultrapaulina2  ULTRA👩🏼‍✈️🦇
#54 @kowaofficial KOWA
#55 @misslucifer MISS LUCIFER
#56 @rlaeuchli ROLANDO PORRO

2025 
#57 @rq_6470 Q-6470 
#58 @user-909973132-441989573 
ELECTRIC VISIONARY
#59 @la_sanguijuela666 LA SANGUIJUELA 
#60 @solowinski SOLOWINSKI 
#61 @andrea-arias-zige ANDREA ARIAS | ZIGE
#62 @holoe HOLOE
#63 @joelewandowski Joe Lewandowski

дм - @komatoznikkk
тгк - t.me/k0m4_toznik

Oncotarget is a primarily oncology-focused, peer-reviewed, open access journal. Papers are published continuously within yearly volumes in their final and complete form and then quickly released to Pubmed.

Oncotarget is now indexed by MEDLINE, PubMed and PMC/PubMed.

Read about the Oncotarget Scientific Integrity Process: https://www.oncotarget.com/scientific_integrity/

Musican from Georgia
brendondwynn@gmail.com
https://brendxnofficalstore.com/

A Cleveland Clinic podcast exploring your digestive and surgical health from end to end. You’ll learn how to have the best digestive health possible from your gall bladder to your liver and more from our host, Colorectal Surgery Chairman Scott Steele, MD.

Sarcomas are rare cancers that affect bone and soft tissue.  Due to their rarity, a diagnosis of sarcoma can be difficult to navigate and the impact on individuals and families are far reaching. The goal of this podcast is to improve sarcoma education for patients, friends, families and trainees. Our goal is to shed light on the diagnostic workup, treatment and follow up process for patients diagnosed with sarcoma or other tumors of bone and soft tissue treated by orthopedic oncologists.

New tracks tagged #sarcoma