The Supersized Science podcast features research and discoveries nationwide enabled by advanced computing technology and expertise at the Texas Advanced Computing Center of the University of Texas at Austin. Science writer Jorge Salazar of TACC hosts the podcast.

A dataset on seismic and tsunami hazards of a coastal Oregon town has received a 2023 DesignSafe Dataset award, given in recognition of the dataset's diverse contributions to natural hazards research.

DesignSafe is a comprehensive cyberinfrastructure that is part of the NSF-funded Natural Hazards Engineering Research Infrastructure (NHERI). It provides cloud-based tools to manage, analyze, understand, and publish critical data for research to understand the impacts of natural hazards. TACC works with DesignSafe to provide cyberinfrastructure and software development.

On the podcast to talk about their award-winning research are Dan Cox, a professor in Civil Engineering; and Andre Barbosa, a professor in Structural Engineering, both at Oregon State University.

Music Credit: Raro Bueno, Chuzausen freemusicarchive.org/music/Chuzausen/

Story link: https://www.designsafe-ci.org/community/news/2023/june/community-resilience-earthquakes-and-tsunamis/

Community Resilience from Earthquakes and Tsunamis

The Supersized Science podcast features research and discoveries nationwide enabled by advanced computing technology and expertise at the Texas Advanced Computing Center of the University of Texas at Austin. 

The key to understanding proteins — such as those that govern cancer, COVID-19, and other diseases — is quite simple - for scientists, anyway.  Identify their chemical structure and find which other proteins can bind to them. But there’s a catch in that the search space for proteins is enormous. 

For instance, a typical protein studied is made of 65 amino acids, and with 20 different amino acid choices at each  binding position, there are 65 to the 20th power binding combinations, a number bigger than the estimated number of atoms there are in the universe.

Joining host and TACC science writer Jorge Salazar on the podcast are Brian Coventry, a research scientist with the Institute for Protein Design, University of Washington and The Howard Hughes Medical Institute; and Nathaniel Bennett, a post-doctoral scholar at the Institute for Protein Design.

Coventry and Bennett co-authored a study published May 2023 in the journal Nature Communications. 

In it their team used deep learning methods on TACC’s Frontera supercomputer to augment existing energy-based physical models in ‘do novo’ or from-scratch computational protein design, resulting in a 10-fold increase in success rates verified in the lab for binding a designed protein with its target protein.

Music Credit: Raro Bueno, Chuzausen freemusicarchive.org/music/Chuzausen/

Story link: https://www.tacc.utexas.edu/news/latest-news/2023/08/03/deep-learning-for-new-protein-design/

Deep Learning for New Protein Design

The Supersized Science podcast features research and discoveries nationwide enabled by advanced computing technology and expertise at the Texas Advanced Computing Center of the University of Texas at Austin. TACC science writer Jorge Salazar hosts the podcast.

Optical tweezers manipulate tiny things like cells and nanoparticles using lasers. While they might sound like tractor beams from science fiction, the fact is their development garnered scientists a Nobel Prize in 2018. 

Scientists have now used TACC’s Stampede2 and Lonestar5 supercomputers to make optical tweezers safer to use on living cells with applications to cancer therapy, environmental monitoring, and more.

On the podcast is Pavana Kollipara, a recent UT Austin graduate who co-authored a study on optical tweezers published August 2023 in Nature Communications, written just before he completed his PhD in mechanical engineering under fellow study co-author Yuebing Zheng of UT Austin, the corresponding author of the paper.

Music Credit: Raro Bueno, Chuzausen freemusicarchive.org/music/Chuzausen/

Story link: https://tacc.utexas.edu/news/latest-news/2023/10/31/new-twist-on-optical-tweezers/

New Twist on Optical Tweezers

The Supersized Science podcast features research and discoveries nationwide enabled by advanced computing technology and expertise at the Texas Advanced Computing Center of the University of Texas at Austin. TACC science writer Jorge Salazar hosts the podcast.

Like a celestial beacon, distant quasars make the brightest light in the universe. They emit more light than our entire Milky Way galaxy. The light comes from matter ripped apart as it is swallowed by a supermassive black hole. Quasar light reveals clues about the large-scale structure of the universe as it shines through enormous clouds of neutral hydrogen gas formed shortly after the Big Bang on the scale of 20 million light years across or more. 

Using quasar light data, the National Science Foundation (NSF)-funded Frontera supercomputer at the Texas Advanced Computing Center (TACC) helped astronomers develop PRIYA, the largest suite of hydrodynamic simulations yet made for simulating large-scale structure in the universe.

On the podcast to talk about PRIYA is one of the developers, Simeon Bird, an assistant professor in astronomy at the University of California, Riverside. 

Music Credit: Raro Bueno, Chuzausen freemusicarchive.org/music/Chuzausen/

Story link:https://tacc.utexas.edu/news/latest-news/2023/12/20/cosmic-lights-in-the-forest/

Cosmic Lights in the Forest

The Supersized Science podcast features research and discoveries nationwide enabled by advanced computing technology and expertise at the Texas Advanced Computing Center of the University of Texas at Austin. TACC science writer Jorge Salazar hosts the podcast.

Scientists have created the world’s first working nanoscale electromotor, according to research published in the journal Nature Nanotechnology. The science team designed a turbine engineered from DNA that is powered by hydrodynamic flow inside a nanopore, a nanometer-sized hole in a membrane of solid-state silicon nitride.

The tiny motor could help spark research into future applications such as building molecular factories for useful chemicals or medical probes of molecules inside the bloodstream to detect diseases such as cancer.

On the podcast today is study co-author Aleksei Aksimentiev, a professor of physics at the University of Illinois at Urbana-Champaign. Aksimentiev used TACC’s Frontera supercomputer to perform all-atom molecular dynamics simulations of the rotation of the DNA turbine.

Music Credit: Raro Bueno, Chuzausen freemusicarchive.org/music/Chuzausen/ 

Story link: https://tacc.utexas.edu/news/latest-news/2024/01/19/dna-origami-folded-into-tiny-motor/

DNA Origami Folded Into Tiny Motor

The Supersized Science podcast features research and discoveries nationwide enabled by advanced computing technology and expertise at the Texas Advanced Computing Center of the University of Texas at Austin. TACC science writer Jorge Salazar hosts the podcast.

Chemists have determined for the first time the crystal structure and unlocked the mechanism of activity of a family of enzymes that produce monensin, widely used as a cattle antibiotic.

The University of Texas Research Cyberinfrastructure (UTRC) initiative awarded the monensin researchers supercomputer allocations on the Lonestar6 system at the Texas Advanced Computing Center (TACC) to meet the challenges of modeling the binding sites of monensin. UTRC provides advanced computing capabilities to researchers across all 14 UT System institutions.

On the podcast is Lela Vukovic, an associate professor at The University of Texas, at El Paso. She performed the computational studies on the monensin research, published October 2023 in Nature Communications.

Music Credit: Raro Bueno, Chuzausen freemusicarchive.org/music/Chuzausen/

Story link: https://tacc.utexas.edu/news/latest-news/2024/02/12/supercomputing-the-secrets-inside-cattle-antibiotics/

Supercomputing the Secrets Inside Cattle Antibiotics

Chapter 1 Audiobook Sample from 'Immortality: Epocalypse' by David Matorano, M.D. 

Are you ready to be captivated by a thrilling journey into the future? Dive into IMMORTALITY: Epocalypse, a gripping page-turner that transports you to 2063. Doctor and Psychiatrist David Martorano explores the deepest questions of the human soul and the ethical quandaries of eternal life in his debut fiction novel. He takes readers on journey that will challenge their perception of life, death, and what it means to be truly human.

“Readers will both be engulfed by the story and provoked into thought about a question that scientists, theologists, philosophers, storytellers, politicians and free-thinkers have asked for decades: Could Artificial Intelligence, as it keeps moving toward its full potential, evolve or destroy humanity?”
—Chris Cordani, Host of Book Spectrum

Now an Amazon bestselling book in the Mystery and Science Fiction category, IMMORTALITY: Epocalypse takes place in the aftermath of the Epocalypse, where the futuristic Colony of Babylon stands as an isolated utopia, shielded by two powerful super AIs. In this haven, advanced technologies grant unparalleled luxuries, and the promise of immortality seems within reach for a select few. Beyond Babylon's borders, the New Amish, a deeply spiritual community, have renounced all technology. They are devoted to eradicating what they see as the Abominations of Babylon, which they believe defy nature and the divine. At the center of this conflict is MARTIN, the world’s first super AI. Decades after MARTIN unleashed the Epocalypse, nearly bringing humanity to extinction, the New Amish face a dire choice: to form an unholy alliance with the AI and combat technology with technology.

Media Contact: For a review copy of IMMORTALITY: Epocalypse or to arrange an interview with David Martorano, contact Scott Lorenz of Westwind Book Marketing at scottlorenz@westwindcos.com or at 734-667-2090. Reach Lorenz on Twitter @abookpublicist.

Audiobook Chapter 1 of 'Immortality: Epocalypse' by David Matorano, M.D.

Something big is coming for science—the largest by far academic supercomputer in the U.S., called Horizon, as part of the U.S. National Science Foundation Leadership-Class Computing Facility (NSF LCCF), a project awarded to the Texas Advanced Computing Center (TACC).

In July 2024, the NSF announced that TACC will begin construction of the NSF LCCF, which will be a distributed facility with six partners providing unique computational and data analytics capabilities, as well as critical software and services, for the nation’s science and engineering research community to enable discoveries that would not be possible otherwise.

TACC will build and operate the Horizon supercomputer as part of the NSF LCCF. When it comes online in 2026, the supercomputer will be 10 times as powerful as the current leading academic supercomputer in the U.S.—Frontera—also operated by TACC.

On the podcast to discuss the NSF LCCF and Horizon supercomputer is Dan Stanzione, executive director of TACC and principal investigator of the NSF LCCF. 

Highlights from the podcast include:

•	The NSF has elevated the LCCF, a computing facility with sustained, large-scale funding, to be on par with other large, strategic scientific initiatives such as the James Webb Space Telescope and the IceCube Neutrino Observatory.
•	The LCCF will have partners distributed throughout the country, including Atlanta University Center (AUC) Data Science Initiative at the AUC Consortium, a collaboration of four historically Black colleges and universities: Clark Atlanta University, Spelman College, Morehouse College and Morehouse School of Medicine; National Center for Supercomputing Applications at the University of Illinois Urbana-Champaign; Pittsburgh Supercomputing Center, a joint center of Carnegie Mellon University and the University of Pittsburgh; San Diego Supercomputer Center at the University of California San Diego; Cornell University; and Ohio State University.
•	The Horizon supercomputer will be a key universal instrument for a wide range of scientific domains, helping scientists investigate nature in time steps from the picoseconds of atoms to the gigayears cosmological galaxy clusters.
•	TACC is currently constructing Horizon with Sabey Data Centers in Round Rock, Texas, scheduled to come online in early 2026.
•	Horizon will support traditional 64-bit HPC computation as well as have a large supply of lower precision graphics processing units (GPU) tailored especially for artificial intelligence.
•	Horizon is expected to achieve 400 petaflops of HPC performance, about 10 times that of the NSF Frontera system, and the AI component will deliver 100x of Frontera performance.
•	The AI GPUs will offer tremendous power savings compared to the traditional HPC central processing unit (CPU) architecture.
•	The LCCF will offer workforce training opportunities with partners such as Moorehouse College, as well as other education and outreach services serving K-12, undergraduate, and graduate students through camps, internships, fellowships, and more.
•	Horizon will be used by academic researchers awarded allocations through a process similar to NSF Frontera awards.
•	Supercomputers bridging the gap at TACC between Frontera and Horizon include Stampede3 and Vista, which launched in 2024, as well as Lonestar6, launched in 2022.

New Heights: The U.S. NSF Leadership-Class Computing Facility and Horizon

Middle East AI News Minute - an artificial intelligence news - brought to you by Carrington Maylin - Marketing for an AI First World. In this podcast: Kazakhstan unveils first national supercomputer; Khazna Data Centers, Eni to build Milan AI campus; Masdar City trials self-driving electric shuttle

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Kazakhstan unveils first national supercomputer

Сергей Абрамов, ученый-суперкомпьютерщик, член-корреспондент РАН: «Это похоже на гражданскую инвалидность первой группы». Создателя российской суперкомпьютерной индустрии оставили на свободе, но это не спасет его от поражения в правах. Он останется в реестре «экстремистов и террористов» даже после уплаты штрафа. Прочитать этот материал вы можете вот по этой ссылке без VPN https://tinyurl.com/t-invariant/2025/07/grazhdanskaya-invalidnost-pervoj-gruppy-sozdatelya-rossijskoj-superkompyuternoj-industrii-ostavili-na-svobode-no-eto-ne-spasyot-ego-ot-porazheniya-v-pravah/ 

НАСТОЯЩИЙ МАТЕРИАЛ ПРОИЗВЕДЕН, РАСПРОСТРАНЕН И НАПРАВЛЕН ИНОСТРАННЫМ АГЕНТОМ T-INVARIANT, ЛИБО КАСАЕТСЯ ДЕЯТЕЛЬНОСТИ ИНОСТРАННОГО АГЕНТА T-INVARIANT. 18+

11 июля Переяславский суд приговорил члена-корреспондента РАН Сергея Абрамова к штрафу 150 тыс. рублей за семь донатов ФБК на сумму 7 тыс. рублей (о том, почему обвинение изначально было построено на несостоятельных основаниях, мы подробно рассказывали). По нынешним временам — «вегетарианский» приговор. Но главное — не штраф. А место в реестре «экстремистов и террористов». Даже после уплаты штрафа Абрамов в нем останется на долгое время. 

Судимость по «тяжкой» статье и включение в реестр Росфинмониторинга (с июня 2023) означают многолетнее поражение в правах:
— заморозка всех личных и корпоративных счетов;
— невозможность совершать сделки с имуществом;
— полный запрет на преподавание и работу в сфере образования;
— запрет на выезд за границу и даже на оформление загранпаспорта;
— профилактический надзор от МВД, включая мониторинг соцсетей.

Состоя в реестре «экстремистов и террористов», 68-летний Абрамов теряет доступ к пенсии, не может пользоваться онлайн-банком, терпит регулярные унижения и отказы в бытовых правах.

Записки несумасшедшего. Сергей Абрамов рассказывает про свой опыт в Ярославской психбольнице, куда его отправили по запросу ФСБ. https://tinyurl.com/t-invariant/2024/02/sergej-abramov-zapiski-nesumasshedshego/ 

T-invariant - медиа ученых и научных журналистов. Для читателей в РФ сайт доступен без VPN по ссылке: tinyurl.com/t-invariant  По всем вопросам 👉🏿@invariant2023_bot  t.invariant@gmail.com 
Наш телеграм-канал t.me/t_invariant 

“Это почти гражданская смерть. Счета будут и дальше заморожены, преподавать не смогу»

🚀 Dive into the *Weekly AI News with Shaily*—your go-to podcast for the latest machine learning developments and deep learning breakthroughs! Hosted by Shailendra Kumar (Shaily), this week’s roundup (November 10–17, 2025) covers quantum computing’s leap into protein prediction, as Yuqi Zhang’s hybrid quantum-classical AI outperforms AlphaFold3 for real-world biology problems. 🧬

Discover HPE’s new Cray GX5000, a supercomputing powerhouse revolutionizing AI training and deployment for researchers and engineers. 💻 Investors are pouring $3.5 billion into enterprise artificial intelligence startups like Metropolis, Armis, and Beacon Software—spotlighting smart, specialized AI agents that slash costs and automate workflows.

Shaily explains why autonomous AI agents are now transforming drug discovery, shrinking months into hours thanks to advanced large language models and reproducible reasoning. And with 150+ new machine learning research papers released, efficiency, scalability, and trustworthiness are taking center stage.

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🚀 News with Shaily for Week starting 2025-11-17: Has Quantum AI Just Outpaced AlphaFold3?

Middle East AI News Minute brought to you by Carrington Malin - Marketing for an AI First world. In this podcast: Core42 launches Maximus-384 supercomputer in US; South Korea joins UAE Stargate AI programme; and TII completes Qibo integration with NVIDIA CUDA-Q.

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Core42 reveals US-based Maximus-384 supercomputer

The Middle East AI News Minute gives you a daily one-minute daily briefing on the top AI-related stories coming out of the Middle East. If you are a busy technology, business or government leader who want to get a quick update, then this is the podcast for you.

Unlock the secrets of data mastery with Shailendra, a 27-year veteran in AI, ML, and Data Science, driving AU$ 6 Billion in transformative value. As the author of 'Making Money out of Data,' their strategies redefine digital success. With expertise honed at IBM and Accenture, they drive innovation and data monetization. Explore how loyalty programs like Flybuys and Everyday Rewards revolutionize business—connect with Shaily today.

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The Supersized Science podcast highlights research and discoveries nationwide enabled by advanced computing technology and expertise at the Texas Advanced Computing Center of the University of Texas at Austin. TACC science writer Jorge Salazar hosts Supersized Science.

Supersized Science is part of the Texas Podcast Network, brought to you by The University of Texas at Austin. Podcasts are produced by faculty members and staffers at UT Austin who work with University Communications to craft content that adheres to journalistic best practices. The University of Texas at Austin offers these podcasts at no charge. Podcasts appearing on the network and this webpage represent the views of the hosts, not of The University of Texas at Austin.

New tracks tagged #supercomputers