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As this is an electronic product, we cannot process refunds or returns as it cannot be returned once delivered. This pattern, once purchased, is not to be shared or reproduced in any way.



Articular cartilage is composed primarily of type II collagen, proteoglycans, chondrocytes, and water. Healthy articular cartilage constantly maintains an equilibrium between each of the components so that any degradation of cartilage is matched by synthesis. Healthy articular cartilage is thus maintained. In the process of osteoarthritis, matrix metalloproteases (MMPs), or degradative enzymes, are overexpressed, disrupting the equilibrium and resulting in an overall loss of collagen and proteoglycans. In the early stages of osteoarthritis, chondrocytes secrete tissue inhibitors of MMPs (TIMPs) and attempt to increase the synthesis of proteoglycans to match the degradative process. However, this reparative process is not enough. The loss in equilibrium results in a decreased amount of proteoglycans despite increased synthesis, increased water content, the disorganized pattern of collagen, and ultimately loss of articular cartilage elasticity. Macroscopically these changes result in cracking and fissuring of the cartilage and ultimately erosion of the articular surface.[8]





Please note: Normally, the Product Owner would provide this information during Sprint Reviews or the refinement process. Noting that the question Q12 itself is pointing at an anti-pattern, that would make a good topic for a Retrospective, is a bonus for the candidate.


Estimating user stories in person-hours is rarely a good idea. It intentionally diverts the emphasis away from the true purpose of the estimation process: to create a shared understanding of the task ahead among all members of the Scrum Team. Ergo, the estimate itself is just a byproduct.


The brand discovery process provokes purpose, personality, and how to deliver on the brand promise through more effective brand executions. It helps match customer insight and behaviors to well-defined marketing objectives.


The underlying purpose of brand discovery is to gain a better understanding of your audience, and how to better communicate with them. Examine customer data to determine your pattern of success with specific buyer personas, or your lack of attention to existing opportunities. The insight acquired here can help establish trust and like-ability with your audience.


This course provides a broad introduction to machine learning and statistical pattern recognition. 

Topics include: supervised learning (generative/discriminative learning, parametric/non-parametric learning, neural networks, support vector machines); unsupervised learning (clustering,dimensionality reduction, kernel methods); learning theory (bias/variance tradeoffs; VC theory; large margins); reinforcement learning and adaptive control. 
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As in the original 21 Jump Street, the social conscience and relevant topics aspect of the television series are left out again. Channing Tatum and Jonah Hill after really messing up a big drug bust are back at the Jump Street program which has now moved across the street to 22 Jump Street. Their captain Ice Cube has decided the best thing for them is a trip back to college where there is a major drug problem with some new designer product.

The bonds however look like they're going to fray as they gravitate to different crowds. Tatum looks like he's going to join the Animal House crowd as he gravitates to a fraternity where the stuff is known to be used. He bonds with a pair that look they could be John Belushi's brethren with Wyatt Russell and Jimmy Tatro.

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PHILADELPHIA (CBS) -- Police are investigating after an SUV hit a curb, then crashed into a tree and lamppost in Society Hill. Police say a car traveling up Spruce Street jumped the curb and ended up striking a tree just outside Society Hill Synagogue around 2 a.m.


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