beat, mix&mastering: RHYNOBEATZ
cover edit: Director Riz-B



grownchild ENT PRESENTS

MUGABO MGB - Waste No Time (WNT)

Pancreatic cancer is one of the deadliest forms of cancer, with a very low survival rate and limited treatment options. Understanding the molecular mechanisms that drive the development and progression of this disease is crucial for finding new ways to prevent and treat it. One of the key players in pancreatic cancer is the WNT signaling pathway, which regulates many aspects of cell growth, differentiation and survival. WNT signaling is often dysregulated in pancreatic cancer, leading to uncontrolled cell proliferation, invasion and resistance to therapy.

“The canonical WNT pathway is reportedly an essential protagonist in organ development as well as oncogenesis in multiple cancers.”

How does WNT signaling become so powerful in pancreatic cancer cells? In a new study, researchers Jing Wang, Dominik T. Koch, Felix O. Hofmann, Daniel Härtwig, Iris Beirith, Klaus Peter Janssen, Alexandr V. Bazhin, Hanno Niess, Jens Werner, Bernhard W. Renz, and Matthias Ilmer from Ludwig-Maximilians-University, University of Science and Technology of China, Technical University of Munich, and German Cancer Consortium revealed a novel role for a receptor called LGR6 in enhancing WNT signals in this disease. Their research paper was published on September 27, 2023, in Aging’s Volume 15, Issue 20, entitled, “WNT enhancing signals in pancreatic cancer are transmitted by LGR6.”

Full blog - https://aging-us.org/2023/11/how-a-receptor-boosts-wnt-signals-in-pancreatic-cancer/

Paper DOI - https://doi.org/10.18632/aging.205101

Corresponding author - Matthias Ilmer - mailmer@med.lmu.de

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Keywords - aging, pancreatic ductal adenocarcinoma, WNT signaling, epithelial-mesenchymal transition, LGR6, cancer stem cells

About Aging-US

Launched in 2009, Aging-US publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging-US go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

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Aging (Aging-US)

How a Receptor Boosts WNT Signals in Pancreatic Cancer

β-catenin-IN-6 cas: 1039731-99-1 appears to be a compound designed as an inhibitor of β-catenin. β-catenin is a crucial protein in the Wnt signaling pathway, which plays a significant role in cell growth, development, and differentiation. Dysregulation of this pathway is implicated in various diseases, including cancer. As a professional chemist, let's delve into a description of this compound, its mechanism, and relevant research keywords.

Description of β-catenin-IN-6
Chemical Nature:

As an inhibitor, β-catenin-IN-6 is likely a small molecule designed to interact specifically with β-catenin.
Its structure would be tailored to bind to β-catenin, inhibiting its function in the Wnt signaling pathway.
Target Specificity:

The compound is presumed to have a high degree of specificity for β-catenin, which is essential to minimize off-target effects and maximize therapeutic potential.
Product Mechanism
Inhibition of Wnt Signaling Pathway: β-catenin-IN-6 functions by inhibiting the action of β-catenin, a key protein in the Wnt signaling pathway. This pathway is critical in regulating cell proliferation and differentiation. By inhibiting β-catenin, the compound can potentially control abnormal cell growth and proliferation associated with diseases like cancer.

Potential in Cancer Therapy: Given the role of the Wnt/β-catenin pathway in cancer, inhibitors like β-catenin-IN-6 are of considerable interest as potential anticancer agents. They can potentially halt the progression of tumors that rely on this pathway for growth and survival.

Conclusion
β-catenin-IN-6 represents an intriguing area of research in the field of targeted cancer therapy. Its specific inhibition of the Wnt/β-catenin pathway offers a promising approach to treating cancers that are dependent on this signaling mechanism. As research progresses, further insights into its efficacy, safety, and potential clinical applications are expected to emerge.

β-catenin-IN-6 cas: 1039731-99-1 A Breakthrough in Targeted Cancer Therapy

Lyrics:

No love for me
Know I treat you good
I know surely could
But you did me wrong
But you did me wrong 
But you did me wro-

I'm so high as fuck
So high as fuck
I'm so high as fuck
So high as fuck
So high as fuck
So high as fuck
So high as fuck
So high as fuck

Gave up what you need 
Know I surely could

Ion give a fuck
I wanna end it 
I want
I wanna end it 
I want
I wanna end it 
I want
I wanna end it 
I want
I wanna end it 
I wa-

Say you wanna say (say)
Cuz you sold your soul (soul)
But you dont give a fuck (fuck)
What you really want (want)
I really care (care)
This is what I want (want)
I really split (split)
For what I want (want)
I don't think im dumb (dumb)
For these fuckin goals (goals) 
Fuck these fuckin hoes (yuh)
I don't give no luv (luv)
I don't give what I want (want)
I don't give what I want (want)
I don't give what I want (want)
I don't give what i-

Are you saying that, what really wrong? 
(Masterpiece)
Are you saying that, what really wrong? 
(Masterpiece)

wat I wnt [Prod. tensei] (lyrics)

✝ No Virgin ✝ - I Wnt 2 Luv U <But U Luv CrAk Mor Thn Me>

songwriter, singer/rapper, executive producer

Aging-US is dedicated to advancing our understanding of the biological mechanisms that drive aging and the development of age-related diseases. Our mission is to serve as a platform for high-quality research that uncovers the cellular, molecular, and systemic processes underlying aging, and translates these insights into strategies to extend healthspan and delay the onset of chronic disease.

Read about the Aging (Aging-US) Scientific Integrity Process: https://aging-us.com/scientific-integrity

₩ΙTÇНHØVSΞ SΔИСТVΔЯ¥ 


Speak AFRIKAANS, English 

This account consist of mainly Russian WitchHouse artist & Russian Electronic artist. Though I do upload albums from other artist from around the world who either dabbled in the genre or had some sort of relevance, participation, or presence in the WitchHouse scene.

Looking for Rare, Lost, or Forgotten WitchHouse Albums. Click on the albums tab on my profile to find what you're looking for. Looking for WitchHouse artist Discography Playlist, click on the playlist tab on my profile to find what you're looking for.

Fun Fact: 

"Pictureplane"(Travis Egedy), is a popular artist known for making his come up in the electronic music scene, DIY Venues, also popular for hanging around artists like "Grimes" and "Crystal Castles" in the early come up days of these artist, he is also the one who came up with the word "Witch House" which is a playful word on "House" music, though "Witch House" is now a popular music genre that is enjoyed by many.

"Crystal Castles" are actually one of the very first, if not the first electronic music duo to actually invent "Witch House" music, as you can hear dark beats and sorrow drawn out voices off of some of their early (demo songs/ Demo Album) dating back from "2007" and before that, which is crazy to think since during that time "Witch House" did not have a name for itself yet.

Instagram:
https://www.instagram.com/synth.essence?igsh=MzRlODBiNWFlZA==

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#cokenotcrack
#cnc 
#sss

New tracks tagged #wnt