Darwin College Lecture Series 2014 – Plagues

Mankind is subject to plagues which affect population health including major demographic changes on a time scale which is unique.

Human reactions to plagues have been many and varied and are dependent upon the prevalent biomedical concept of disease, and a community centred response. Historically this results in measures which can significantly constrain the rights of individuals for the wider community benefit. Increasingly, control measures rely on individual action which in turn raises significant opposition, some of which is often held to be irrational by much of expert opinion.

As we look to future threats this dependence on individual participation will be even more important yet opposition, rational and irrational, can be given disproportionate weighting through modern means of communication. However, the balance of benefit, risk and individual freedom is one that transcends the biomedical and must ultimately have society’s approval if future means of control are to remain effective.

Biography

Professor Sir Leszek Borysiewicz was installed as the 345th Vice-Chancellor of the University of Cambridge on 1 October 2010. The Vice-Chancellor is the principal academic and administrative officer of the University.

Sir Leszek was previously Chief Executive of the UK’s Medical Research Council (2007-10). From 2001 to 2007 he was at Imperial College London, as Principal of the Faculty of Medicine and later as Deputy Rector, responsible for the overall academic and scientific direction of the institution. He led the development of inter-disciplinary research between engineering, physical sciences and biomedicine.

In 1988 he was a Lecturer in Medicine at Cambridge. He went on to be Professor of Medicine at the University of Wales in Cardiff, where he led a research team that carried out pioneering work on vaccines. In particular, his unit in Cardiff conducted clinical trials for a therapeutic vaccine for human papillomavirus (a cause of cervical cancer) – the first in Europe. He was knighted in 2001 for services to medical research and education.

He was a founding Fellow of the Academy of Medical Sciences in 1996 and a member of its Council from 1997 until 2002; and he became a Fellow of the Royal Society in 2008. 

Plagues & Medicine

Plagues have changed history, stopped armies in their tracks and altered the fate of nations. Mary and Christopher Dobson will outline the impact of plagues on human history and reflect on related challenges that will be faced by future generations. Taking a broad chronological perspective, their talk will range from the plagues of antiquity and the medieval period, including the Black Death of the mid-14th century, to the major infectious diseases of the 20th and 21st centuries, such as the 1918-19 Spanish flu and the recent pandemic of HIV /AIDS. They will also highlight the continuing importance of addressing the ‘silent’ killers, such as the many diseases that afflict children and the poor in low-income countries, as well as discussing the increasingly prevalent afflictions of ageing and affluent societies, including dementia and diabetes. Tremendous advances have been made over the centuries in our understanding, prevention, and treatment of disease, with triumphs such as the eradication of smallpox and a substantial rise in life expectancy in many parts of the world. Major challenges now are to find ways of preventing modern ‘plagues’, such as those facing our ageing populations, and this talk will conclude by looking at scientific research that offers hope for current and future generations.

Biographies

Mary Dobson is an historian of medicine with wide ranging interests in the plagues of the past. She has held a number of Research Fellowships, including a Harkness Fellowship at Harvard University, and was formerly Director of the Wellcome Unit for the History of Medicine at the University of Oxford, and a Fellow of Green Templeton College. She is author of a variety of publications including a groundbreaking monograph, Contours of Death and Disease in Early Modern England (Cambridge University Press, 1997), and, most recently, two books for general audiences: Disease: the Extraordinary Stories Behind History’s Deadliest Killers (Quercus, 2007) and The Story of Medicine: From Bloodletting to Biotechnology (Quercus, 2013). Her next book, Murderous Contagion, will be published in October 2014.

Christopher Dobson is the John Humphrey Plummer Professor of Chemical and Structural Biology at the University of Cambridge and Master of St. John’s College. He is a Fellow of the Royal Society and of the Academy of Medical Sciences and a Foreign Associate of the US National Academy of Sciences. He has received numerous awards, including both the Davy and Royal Medals of the Royal Society, and achieved international recognition for his research on the nature of protein misfolding and its links to disease. His work provides a fundamentally new view of the origins and means of progression of many of the most debilitating and increasingly prevalent ‘plagues’ of the modern era, ranging from Alzheimer’s disease to Type II diabetes.

Plagues & History

The real world isn’t like the online world.

In the real world, you only have to worry about the criminals who live in your city. But in the online world, you have to worry about criminals who could be on the other side of the planet. Online crime is always international because the Internet has no borders.

Today computer viruses and other malicious software are no longer written by hobbyist hackers seeking fame and glory among their peers. Most of them are written by professional criminals who are making millions with their attacks. These criminals want access to your computer, your passwords, and your credit card numbers.

National police forces and legal systems are finding it extremely difficult to keep up with the rapid growth of online crime. They have limited resources and expertise to investigate online criminal activity. The victims, police, prosecutors, and judges rarely uncover the full scope of the crimes that often take place across international boundaries. Action against the criminals is too slow, the arrests are few and far between, and too often the penalties are very light, especially compared with those attached to real-world crimes.

Because of the low prioritization for prosecuting cybercriminals and the delays in launching effective cybercrime penalties, we are thereby sending the wrong message to the criminals and that’s why online crime is growing so fast. Right now would-be online criminals can see that the likelihood of their getting caught and punished is vanishingly small, yet the profits are great.

Computer security has gone several distinct eras. Attacks morph and change every few years. However, the biggest changes we’ve seen have not been technical. They’ve been social. It’s all about the attackers and their motives.

If we want to be able to stop the attacks, we have to understand who the attackers are.

Biography

Mikko Hypponen is the Chief Research Officer of F-Secure in Finland. He has been working with computer security for over 20 years and has fought the biggest virus outbreaks in the net, including Loveletter, Conficker and Stuxnet. His TED Talk on computer security has been seen by almost a million people and has been translated to over 35 languages. He has addressed the EU Parliament and his columns have been published in the New York Times, Wired, CNN and BBC . Mr. Hypponen was selected among the 50 most important people on the web in by the PC World magazine. The Foreign Policy magazine included him on the list of “Top 100 Global Thinkers”. Mr. Hypponen sits in the advisory boards of the ISF and the Lifeboat foundation.

Silicon Plagues

The spread of an infection is an ecological event, with the infected hosts acting like prey and the infectious agents like predators – albeit rather tiny ones. This metaphor can help us understand the spread of emerging infections, the control of existing infections and the spread of infections inside individual people. Using examples from infectious diseases that pose problems right now this lecture will illustrate how taking an ecological view of plagues helps us to understand them and, sometimes, control them.

Biography

Professor Angela McLean FRS studied mathematics at Oxford but soon after decided to become a biologist. After a brief spell in the City she joined the Mathematical Biology Group at the National Institute for Medical Research at Mill Hill then returned to Oxford as a Royal Society University Research Fellow. In 1994 she went on secondment to the Institut Pasteur in Paris to work on the population dynamics of murine lymphocytes in the immunology department there. In 1998 she became Head of Mathematical Biology at the BBSRC ’s Institute for Animal Health. Since 2008 she has been a Senior Research Fellow at All Souls College in Oxford. She was elected to the Royal Society in 2009, and was awarded the Royal Society’s Gabor Medal in 2011.

The Nature of Plagues

The gold rush of whole genome sequences spurred by the human genome project, is heralding a new way to study the previously unanswerable from pre-history; allowing us to now mine the genomic footprints of ancient defining events of humankind and other mammals. As early paleontologists conjured up extinct forms based on fossil remains, genetic archaeologists reconstruct the origins of genomic patterns derived from ancient demographic episodes. Modern scourges that clog the world’s hospitals represent a major challenge to human health and a historic selective regulator. Past interactions between constantly adapting pathogens and finely-tuned, ever-evolving immune defenses represent a biological puzzlement that is only beginning to be deciphered. In my presentation I will illustrate how we learn hidden lessons of survival, adaptation and genome evolution referred from current views of natural history with new insights from genomes of wildlife species and ourselves. I will provide an early glimpse of the coming discipline of genomic archaeology giving illustrative examples (from the plague, SARS , HIV -AIDS), and will describe how scientists track the emergence and progression of deadly outbreaks revealing unfathomed threats to their very existence. How these non-traditional approaches can ablate extinctions and unlock medical secrets will be the lessons learned from this presentation.

Biography

Dr. Stephen J. O’Brien is a world leading molecular biologist and dedicated conservationist whom uses the tools of molecular biology to help protect endangered species and understand devastating diseases such as cancer and AIDS . He received his PhD in Genetics from Cornell University, USA in 1971. He then joined the prestigious National Cancer Institute, National Institutes of Health as a post-doc in 1971 and there, served as Founder and Chief of the Laboratory of Genomic Diversity from 1986-2011. In December 2011, he joined the Theodosius Dobzhansky Center for Genome Bioinformatics, St. Petersburg State University as Chief Scientific Officer. Convinced of the utility of exploring diverse species to advance our understanding of the human genome, Dr. O’Brien and his team have assembled over 62,000 animal and 424,000 human tissue/DNA specimens, facilitating wide-ranging studies of disease gene associations, species adaptation and natural history. His research interests and expertise span human and comparative genomics, genetic epidemiology, HIV /AIDS, retro-virology, bioinformatics biodiversity and species conservation. Dr. O’Brien is best known for documenting the remarkable genetic uniformity of African cheetahs, resolving the mammalian tree of life, describing heretofore unrecognized species of orangutans, African forest elephants and Bornean clouded leopards. He is credited with the discovery of CCR5 delta 32, the first of 20 human AIDS restriction genes, which imparts natural immunity to HIV . He is the one of the founders of the Genome 10K initiative, has published over 750 leading research papers, written multiple books and is adjunct professor in over 12 international leading universities. He is considered a ‘National Treasure’ by man

Plagues, Populations & Survival

What is the future of religion?

Rory Cellan-Jones talks to Iza Hussin and Paul Seabright about recent trends in world religions, the interplay between politics and religion, and the economics of religion.

This episode unpacks the widespread belief that religion is in decline and explores why this view is mistaken. Leading experts discuss the intersection between religion and politics, the rivalry within and between religions, and how wider socioeconomic trends are both impacted by and impacting religious movements. 

This episode is hosted by Rory Cellan-Jones (former technology correspondent for the BBC), and features guest experts Iza Hussin (University of Cambridge) and Paul Seabright (IAST). 

Season 2 Episode 10 transcript

For more information about the podcast and the work of the institutes, visit our websites at https://www.bennettinstitute.cam.ac.uk/ and https://www.iast.fr/.

Tweet us with your thoughts at @BennettInst and @IASToulouse



Audio production by Steve Hankey

Associate production by Stella Erker

Visuals by Tiffany Naylor

What is the future of religion?

Rory Cellan-Jones talks to Ingela Alger (IAST) and Flavio Toxvaerd (University of Cambridge) about the drivers of research silos, the merits of conducting interdisciplinary research and how to overcome disciplinary divides.

This episode takes a look at why academic research is trapped in research silos. Ingela Alger (IAST) and Flavio Toxvaerd (University of Cambridge) talk to Rory Cellan-Jones, about the challenges faced in conducting interdisciplinary research. They emphasize the significant benefits that interdisciplinarity can bring and share insight into how to foster an interdisciplinary research culture for better results. 

Listen to this episode on your preferred podcast platform

Season 3 Episode 2 transcript

For more information about this podcast series and the work of the institutes, visit our websites at https://www.bennettinstitute.cam.ac.uk/ and https://www.iast.fr/

Tweet us with your thoughts at @BennettInst and @IASToulouse.

With thanks to:

Audio production – Steve Hankey
Associate production –  Stella Erker
Visuals – Tiffany Naylor


More about our host and guests:
Rory Cellan-Jones was a technology correspondent for the BBC. His 40 years in journalism have seen him take a particular interest in the impact of the internet and digital technology on society and business. He has also written multiple books, including his latest “Always On” which was published in 2021. @ruskin147

Ingela Alger is a CNRS Senior Scientist (DR) in Economics, and the current Director of the Institute for Advanced Study in Toulouse (IAST) as well as the Chair of the Department in Social and Behavioral Sciences. Her research, which has been published in international peer-reviewed journals such as the American Economic Review, Econometrica, and PNAS, focuses on the evolutionary foundations of human preferences, when these are transmitted from generation to generation and are subject to selection. She is particularly interested in the evolutionary foundations of morality and distributional preferences, as well as preferences guiding family-related behaviors. She has been awarded numerous grants, notably ANR Chaire d’Excellence 2012-2017, and ERC Advanced Grant 2019-2023. In 2022 she was awarded the CNRS Silver Medal. @ingelaalger 

Flavio Toxvaerd is a Professor of Economics and Public Policy at the Faculty of Economics, University of Cambridge, a Fellow of Clare College and an Affiliated Researcher with the Bennett Institute for Public Policy. He serves as UKRI Policy Fellow in Competition and Productivity Economics with the Competition and Markets Authority. His research and teaching interests are in microeconomics and game theory with applications, including industrial organisation, competition policy and economic epidemiology. @toxvaerd1

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Crossing Channels S2E5 featuring Sarah Dillon and Manvir Singh “Why are stories important for society?” 
Alger, I., Weibull, J. W., & Lehmann, L. (2020). Evolution of preferences in structured populations: genes, guns, and culture. Journal of Economic Theory, 185, 104951.
Alger, I. (2023). Evolutionarily stable preferences. Philosophical Transactions of the Royal Society B, 378(1876), 20210505.
Alger, I., Dridi, S., Stieglitz, J., & Wilson, M. L. (2023). The evolution of early hominin food production and sharing. Proceedings of the National Academy of Sciences, 120(25), e2218096120.
Toxvaerd, F., & Rowthorn, R. (2022). On the management of population immunity. Journal of Economic Theory, 204, 105501.
Toxvaerd, F. (2020). Herd immunity – crucial yet irrelevant. Bennett Institute for Public Policy, University of Cambridge.
Bromham, L., Dinnage, R., & Hua, X. (2016). Interdisciplinary research has consistently lower funding success. Nature, 534(7609), 684-687.

Why is academic research so siloed?

So, now what? the new podcast from Gates Cambridge, a leading scholarship programme for outstanding international postgraduates at the University of Cambridge.
 
Our guests are the scholars themselves - big thinkers from a range of different backgrounds and disciplines - who are out there finding solutions to some of our most wicked problems from the global economy and the environment, to technology, politics and universal healthcare.
 
They'll share their optimism and their experience, and give us a peek at their 'to do' lists too.  But they'll also be inviting the rest of us to join them - sharing 'So, now what?' actions that we can all apply today. 
 
Join me, Catherine Galloway, and a panel of Gates Cambridge scholars for conversations that lead to positive change. 
 
So, now what? with Gates Cambridge.  Available monthly on all your favourite podcast platforms.

Welcome to 'So, now what?'

In this episode, we explore how we can build back better after a crisis. What are the challenges and opportunities of addressing the climate crisis, including the need for climate justice, the costs of inaction, and the importance of green innovation. We consider the roles of governments, multilateral institutions, and grassroots movements play in driving change. And we conclude with a call to action, So, now what? Where we emphasise the need for coordinated international efforts and a just and equitable transition to a sustainable future.

Takeaways

Building back better after a crisis requires addressing climate justice and the disproportionate impact of climate change on vulnerable communities.
The costs of climate change, both economic and social, are substantial and require urgent action.
Investment in clean energy and good jobs can drive economic growth and reduce carbon emissions.
Leveraging people power and social media can help raise awareness and drive change.
Green innovation and regulation are key to building a sustainable and equitable society.


Chapters

00:00 Introduction

04:21 Expertise and perspectives

06:50 The challenge of building back better

10:10 Understanding the costs and risks of climate change

14:25 Building back better in the United States

17:15 Building back better in Africa

19:25 The Need for collaboration and connectivity. Who needs to be in the same room?

25:45 Leveraging people power and innovation. How can we talk about green innovation and change the narrative? What does a better society look like?

31:00. So, now what? Moving Forward: Political will and financing.



Bios

Kamiar Mohaddes @KamiarMohaddes is an Associate Professor in Economics & Policy at the Judge Business School at the University of Cambridge. His main areas of research include climate change, economics of the Middle East, energy economics and applied macroeconomics. He is currently a consultant at the Inter-American Development Bank and has previously served as a Departmental Special Advisor at the Bank of Canada, a consultant at the United Nations, a consultant at the Asian Development Bank and a regular visiting scholar at the International Monetary Fund to name a few. 



Todd N. Tucker @toddntucker is a political scientist and director of Industrial Policy and Trade at the Roosevelt Institute, where he helps lead research on global governance, democracy, and the administrative state. A recognised expert on trade and political economy, Dr Tucker has testified before legislatures and expert committees around the world.  He is author of Judge Knot: Politics and Development in International Investment Law  (Anthem Press, 2018). He has authored over 70 major reports, including Fixing the Senate: Equitable and Full Representation for the 21st Century and Industrial Policy and Planning: What It Is and How to Do It Better.



Queen Chinyere Quinn is a Co-Founder and Partner at Kupanda Capital, an investment platform established to create, capitalise and scale pan-African companies. In this capacity, Queen has worked to provide tailored advice and support to entrepreneurs, project developers, fund managers and corporations operating in Africa. She has worked on deals in various sectors across Africa, including those in media, consumer and energy; and leads the platform on issues related to impact investing. Queen has helped to found several new companies and ventures, including Fraym, a geospatial data company and Nithio, an AI powered energy finance platform for the off-grid solar sector in Africa.

How do we build back better after a crisis?

Best-selling author Tara Westover, researcher Aliya Khalid and Thabo Msibi Deputy Vice Chancellor for Teaching and Learning at the University of KwaZulu-Natal, tackle the issue of what education should be for. They stress the idea that small actions can have a significant impact on making a difference in the world and emphasise the power of individuals to create change within their own sphere of influence. 

We explore their own perspectives and discuss their own powerful personal stories, highlighting the importance of diverse stories in education, the impact of education on women and gender and the power of education to challenge norms and beliefs. They also emphasise the role of education as a journey of self-discovery and unlearning, as well as a tool for social justice and empowerment. In addition, the episode discusses the need for curriculum reform and inclusivity, the role of technology in education and personal stories of overcoming educational challenges. 

Takeaways

Education as a lifelong journey of learning and personal growth.
Education has the power to empower individuals, promote social justice, and transform communities.
Listening to and learning from communities is crucial in developing effective educational practices.
Small acts of support and encouragement can make a significant difference in education.
Chapters

00:00 Introduction

00:31 The purpose of education

01:13 Guest introductions

05:24 Education and gender

06:24 Education as empowerment

08:21 The value of questioning and doubt in education

10:10 Education as a tool for social justice

12:56 Education in disadvantaged communities

15:17 The importance of listening and learning from communities

19:19 Personal teachable moments

20:14 Motivation for education

23:05 The transformative power of education

25:59 Unlearning and overcoming challenges in education

29:30 Curriculum reform and empowerment

31:40 Moving forward: Taking action in education

37:12 So, now what? 

Bios

Tara Westover @tarawestover is a memoirist and historian. Her first book, Educated (2018), debuted at #1 on the New York Times bestseller list, and was a finalist for a number of awards, including the National Book Critics Circle Award, the LA Times Book Prize, and the PEN/Jean Stein Book Award. The American Booksellers Association named it the Nonfiction Book of the Year, and to date, the book has been translated into 47 languages. For her staggering impact, TIME magazine named Westover one of the 100 Most Influential People of 2019, and in 2023, she was awarded the National Humanities Medal by President Biden. 

Thabo Msibi is the Deputy Vice Chancellor for Teaching and Learning and a professor of Curriculum Studies in the School of Education at the University of KwaZulu-Natal. Msibi has published research in South African and international journals and books and is author of the book Hidden sexualities of South African Teachers: Black male educators and same-sex desire. He has also co-edited a book entitled Gender, Sexuality and Violence in South African Educational Spaces, with Deevia Bhana and Shakila Singh. 

Aliya Khalid @khalidaliya1 is a Lecturer in Comparative and International Education in the Department of Education at the University of Oxford, UK. She works on issues of educational equity with a focus on gender. Her areas of interest include the capability approach, negative capability, epistemic paradoxicality and justice, Southern epistemologies, politics of representation and knowledge production.

What is education for?

Ellie Wolmark introduces part four of our Integrated Cancer Medicine: Research in Focus series. She talks to members of the CRUK Cambridge Centre about a diverse range of topics, including Dr Raj Jena to hear about his ground-breaking research, specifically the InnerEye project and how this amazing collaboration with Microsoft Cambridge has been brought into the clinic to benefit patients. Other topics include combining being a surgeon and a clinical researcher, Professor George Vassiliou talking about his research on clonal haematopoiesis and a new clinic that he has recently set up, as well as much, much more. As always you will hear discussions about research and research collaborations, the techniques that are being developed and how they translate to the clinic to affect patient treatments and outcomes.

Ellie is Communications Manager for Integrated Cancer Medicine at the University of Cambridge, UK, and the CRUK Cambridge Centre, UK.

Integrated Cancer Medicine: Research in Focus

Integrated Cancer Medicine: Research in Focus – Part four introduction

Dr Raj Jena talks about his research on analysis of the images used for radiotherapy planning and for modelling the effects and outcomes of radiotherapy treatment. As a clinician, he uses radiotherapy and drug treatments on patients with tumours in the brain or spine. He also talks about the InnerEye Project, a collaboration with Microsoft Cambridge, which uses algorithms to map and segment tumours from CT/MRI scans.

Raj is a Clinical Consultant and Radiation Oncologist at Cambridge University Hospitals NHS Foundation Trust, UK, and is a member of the CRUK Cambridge Centre at the University of Cambridge, UK.

Using AI to map tumours: The InnerEye Project

In this episode, Professors Grant Stewart and Stephen Price discuss what it means to be both a cancer surgeon and a clinical researcher. They talk about how they can improve surgery for brain and kidney cancer patients, how they can identify cancer as quickly as possible through screening, and how they can improve on the outcomes of surgery by augmenting it with other treatments such as radiotherapy and drugs.

Grant is co-lead of both the Institute for Integrated Cancer Medicine and the Urological Malignancies Virtual Institute at the CRUK Cambridge Centre, UK, and is Professor of Surgical Oncology in the Department of Surgery at the University of Cambridge and Cambridge University Hospitals NHS Foundation Trust.

Stephen is co-lead of the Brain Cancer Virtual Institute at the CRUK Cambridge Centre, UK, and is Professor of Neurosurgical Oncology and Honorary Consultant Neurosurgeon at the University of Cambridge and Cambridge University Hospitals NHS Foundation Trust.

Surgery and clinical research in cancer

In today's episode, Ellie Wolmark is joined by Professor George Vassiliou to talk about his research on clonal haematopoiesis and a new clinic that he has recently set up. We'll uncover what clonal haematopoiesis is and how it can sometimes lead to the development of blood cancer.

George is a CRUK Senior Clinical Fellow and Professor of Haematological Medicine at the University of Cambridge, UK. He is also a member of Faculty at the Wellcome-MRC Cambridge Stem Cell Institute and a Consultant Haematologist at Cambridge University Hospitals NHS Foundation Trust.

Clonal haematopoiesis and using it to try to predict whether cancer will develop

Professor Jason Carroll speaks about his research in molecular oncology, with a focus on the work underpinning the PIONEER breast cancer trial and the outcomes of this clinical trial.

Jason is Professor of Molecular Oncology and Senior Group Leader at the CRUK Cambridge Institute, University of Cambridge, UK. He is also co-lead for the Precision Breast Cancer Virtual Institute at the CRUK Cambridge Centre, UK.

Plagues & Medicine

University of Cambridge

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