What if we could fight cancer like a sniper—targeting only the enemy, sparing the innocent? Researchers at Wroclaw Medical University are revolutionizing pediatric oncology with a novel approach that combines a natural marine compound—jasplakinolide—with electroporation, a technique that opens up cancer cells using precise electric pulses.

In this episode, we dive into: The science of precision therapy 
✔️ How electroporation allows ultra-targeted drug delivery 
✔️ Why jasplakinolide could be a breakthrough in fighting aggressive childhood cancers like rhabdomyosarcoma 
✔️ How healthy cells are spared while cancer cells collapse from within 
✔️ What this could mean for the future of chemotherapy-free treatments

This content was generated with the assistance of artificial intelligence (AI) tools: DeepDive (Notebook LM, Google).

Precision at the level of the cell - Electrical impulses versus striated muscle

Can Botox do more than smooth wrinkles? In this episode, we explore how botulinum toxin type A (BTX-A) is being used as an innovative therapy for bruxism — a condition affecting up to 20% of adults, causing jaw pain, tooth wear, and sleep disturbances. Based on a systematic review published in Dental and Medical Problems, we discuss the effectiveness, safety, and clinical potential of BTX-A in reducing symptoms of both sleep and awake bruxism. Tune in to find out whether Botox might become a new standard in dental treatment.

This content was generated with the assistance of artificial intelligence (AI) tools: DeepDive (Notebook LM, Google).

Botulinum Toxin for Bruxism - A Systematic Review

Ten materiał został wygenerowany przy wsparciu narzędzi sztucznej inteligencji (AI): DeepDive (Notebook LM, Google).

W tym odcinku podcastu zaglądamy do badań opublikowanych w czasopiśmie Polimery w Medycynie, wydawanym przez Uniwersytet Medyczny we Wrocławiu.

Tematem jest celeokoksyb – znany lek przeciwzapalny, który być może już niedługo znajdzie zastosowanie… w leczeniu chorób skóry. Ale zanim to się stanie, naukowcy muszą odpowiedzieć na jedno ważne pytanie: jakie podłoże dermatologiczne najlepiej uwalnia substancję czynną i zapewnia skuteczność leczenia?


Krem, żel czy oleożel? Jak wybrać najlepszy nośnik dla celekoksybu na skórę

This content was generated with the assistance of artificial intelligence (AI) tools: DeepDive (Notebook LM, Google).

How much science goes into a simple tube of cream? In this episode of Deep Dive, we unpack a study from Wroclaw Medical University, published in the journal Polymers in Medicine, that explores how different semi-solid bases—like gels, creams, and ointments—can radically affect the way a drug like celecoxib behaves on the skin.

From spreadability and texture to drug release rates, the researchers compared four pharmacy-compounding bases commonly used in Poland. The findings challenge assumptions and highlight how base formulation can make—or break—the effectiveness of a topical medication.
It's more than just mixing powder into a cream. It's pharmaceutical engineering at work.


Cream, gel, or oleogel? How to choose the best carrier for celecoxib for the skin

This content was generated with the assistance of artificial intelligence (AI) tools: DeepDive (Notebook LM, Google).

Why do chronic lymphocytic leukemia (CLL) cells refuse to die? In this episode, we explore the stubborn biology of CLL and a recent study that digs deep into how two drugs—venetoclax and cladribine—can work together to restore the self-destruct program in cancer cells.

We break down how this combination affects apoptosis-related gene expression, why the BCL2 protein is such a key player, and what happens when researchers zoom in on the genetic instructions, not just protein levels. Could this approach unlock more effective treatments for resistant CLL cases?

This content was generated with the assistance of artificial intelligence (AI) tools: DeepDive (Notebook LM, Google).

Combination therapies. Two drugs, one goal – killing cancer cells

Ten materiał został wygenerowany przy wsparciu narzędzi sztucznej inteligencji (AI): DeepDive (Notebook LM, Google).

Dlaczego komórki w przewlekłej białaczce limfocytowej (CLL) nie chcą umrzeć? W tym odcinku zagłębiamy się w uporczywą biologię CLL i omawiamy najnowsze badanie, które pokazuje, jak dwa leki — wenetoklaks i kladrybina — mogą wspólnie przywrócić mechanizm samozniszczenia w komórkach nowotworowych.

Przyglądamy się, jak to połączenie wpływa na ekspresję genów związanych z apoptozą, dlaczego białko BCL2 odgrywa tu kluczową rolę i co dzieje się, gdy badacze skupiają się na instrukcjach genetycznych, a nie tylko na poziomie białek. Czy takie podejście może przełożyć się na skuteczniejsze leczenie opornych przypadków CLL?

Terapie skojarzone. Dwa leki, jeden cel - śmierć komórek nowotworowych

Advances in Acute Myeloid Leukemia Treatment

A baby's first breath is a miracle of biology — but did you know that how a baby is born (vaginal delivery vs. C-section) can significantly affect how their lungs adapt in those first critical hours?

In this episode, we explore cutting-edge research using electrical impedance tomography (EIT) — a non-invasive imaging method that provides real-time insight into newborn lung aeration. The findings? Surprising differences in ventilation patterns, lung stretch, and fluid clearance between birth methods, especially visible around the 1-hour mark post-birth.

This content was generated with the assistance of artificial intelligence (AI) tools: DeepDive (Notebook LM, Google).

Labor and breathing. How the method of delivery affects the functioning of a newborn's lungs

In this episode, we explore a quiet yet crucial battleground in the body: the fight to maintain metabolic balance in chronic kidney disease (CKD). Our focus is on a new clinical indicator emerging from research at Wroclaw Medical University — the chloride-to-bicarbonate ratio. Co-authored by Dr. Tomasz Gubiowski and published in Scientific Reports, the study reveals how this simple, already routinely measured ratio could serve as a powerful early warning system for advanced metabolic acidosis in CKD stages G4 and G5.

We unpack how a shift in this ratio not only reflects impaired kidney function but may also predict faster progression toward dialysis — offering a low-cost, high-impact diagnostic tool for clinicians. Could this subtle change in blood chemistry provide an opportunity for earlier, gentler interventions — even through something as basic as diet? Tune in to find out how your body’s acid–base balance might hold more secrets than we ever imagined.

This content was generated with the assistance of artificial intelligence (AI) tools: DeepDive (Notebook LM, Google).

Chloride-Bicarbonate Ratio Predicts Advanced Acidosis in CKD

Ever feel overwhelmed by health info? You just want the key facts—fast and clear. That’s what this episode delivers.

We’re diving deep into a fascinating Polish study on how obstructive sleep apnea (OSA) and arterial hypertension don’t just coexist—they fuel each other. Add in disrupted sleep architecture, low magnesium, elevated uric acid, and some surprising findings about vitamin D, and you’ve got a complex picture of interconnected health challenges.

Discover how 133 patients in Wroclaw helped scientists trace these hidden links—and what it means for cardiovascular risk, inflammation, and future treatment strategies.

This content was generated with the assistance of artificial intelligence (AI) tools: DeepDive (Notebook LM, Google).

Unmasking_the_Silent_Threat__How_Sleep_Apnea,_High_Blood_Pressure,_and_Your_Body_Chemistry_Collide

Leading in medical research and education, Wrocław Medical University drives innovation in health sciences and clinical advancements. Based in Wrocław, Poland.

Labor and breathing. How the method of delivery affects the functioning of a newborn's lungs

Wroclaw Medical University

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