Imagine a dental assistant that never blinks, never tires, and sees details invisible to the human eye. This episode explores how artificial intelligence is transforming endodontics – from image analysis to predicting treatment outcomes.

We cover:
🔹 How AI supports diagnosis on X-rays and CBCT scans
🔹 The role of convolutional neural networks in detecting periapical changes
🔹 Global research trends, with the US, Germany, China and India at the forefront
🔹 The clinical impact for patients: earlier diagnosis, less invasive therapy, and safer outcomes

Dentistry is entering a new era where algorithms become trusted partners in care.

This content was generated with the assistance of artificial intelligence (AI) tools: DeepDive (Notebook LM, Google).

The dentist’s new assistant: artificial intelligence in endodontics

What if the next advance in vaccination didn’t come from a chemical lab — but from a living cell? This episode explores how scientists in Wrocław turned Escherichia coli into a microscopic factory capable of producing a vaccine candidate against Porphyromonas gingivalis, the stealthy bacterium behind gum disease and systemic inflammation.

We explore:
🔹 Why traditional vaccine strategies failed to stop P. gingivalis after decades of research
🔹 How engineered E. coli cells can fuse proteins and sugars into a single, precisely designed antigen
🔹 The promise of biological synthesis — safer, faster, and more reproducible than chemical methods
🔹 What this innovation could mean for the future of vaccines against other Gram-negative pathogens

Beyond the microscope lies a quiet revolution in immunology — where biology itself becomes the tool of protection.


This content was developed with the assistance of artificial intelligence (AI) tools: DeepDive (Notebook LM, Google).

Fighting Periodontal Diseases. An E. coli-based vaccine against a dangerous pathogen

What if the next step in caries prevention wasn’t a new dental tool — but a smarter material?

This episode explores how researchers from Wroclaw Medical University and Wroclaw University of Science and Technology uncover the hidden science behind dental sealants — invisible layers that protect teeth where toothbrushes can’t reach.

We explore:
🔹 How physicochemical properties like hardness, surface energy, and fluoride release determine a sealant’s durability
🔹 Why Arkona Fissure Sealant (AFS) showed superior strength, adhesion, and long-term fluoride delivery
🔹 How microstructure and filler composition influence protection against tooth decay
🔹 The rise of interdisciplinary dentistry — where chemistry, physics, and medicine work together to prevent disease before it starts

Behind every glossy surface lies a story of molecular precision — and a vision of dentistry that protects before it repairs.

This content was developed with the assistance of artificial intelligence (AI) tools: DeepDive (Notebook LM, Google).

Physicochemistry and the Effectiveness of Caries Prevention: dental sealants

In this episode, we dive into groundbreaking research from Wroclaw Medical University, where clinicians, immunologists and data scientists work together to uncover hidden mechanisms of kidney transplant rejection.

We explore the study published in Frontiers in Immunology, led by Prof. Mirosław Banasik and authored by Dr. Jakub Mizera, which examines the role of non-HLA antibodies — especially anti-AT1R — in microvascular inflammation (MVI). Using advanced analytics and AI methods, the team reveals how subtle immune signals detectable in blood may help predict rejection earlier and more accurately than traditional tests.

What does this mean for patients, clinicians and the future of precision transplant medicine? And how does young science shape complex, interdisciplinary research?
Join us to find out.

This content was developed with the assistance of artificial intelligence (AI) tools: DeepDive (Notebook LM, Google).

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There’s no single scale that fits the entire field — each dental specialty produces different effect sizes. That’s why new guidelines are needed to show which effects truly appear in research and how large the study samples must be to confirm them with proper statistical power.

The latest study delivers the first wide-ranging dataset for dentistry.
It reconstructs the real “landscape of effects” — the values reported in the literature, how often they occur, and within what ranges.

This episode breaks down what that means for research planning, clinical decision-making and the future of evidence-based dentistry.

This content was developed with the assistance of artificial intelligence (AI) tools: DeepDive (Notebook LM, Google).

In Search of the Right Measure. A new definition of effect sizes in dentistry

Light Against Tooth Decay

A Digital Tool in Periodontal Diagnosis

In this episode, we unpack the hidden public health crisis of perinatal mental health. Drawing on recent research, we reveal the true prevalence of prenatal and postpartum depression, the impact of mother–infant bonding difficulties, and why suicide remains a leading cause of late maternal death in high-income countries.

We explore the intertwined nature of depression and bonding issues, key risk factors—including adverse childhood experiences—and the distinct predictors of suicidal ideation. Finally, we highlight the future of care: integrated, family-centered models that combine psychotherapy, bonding interventions, lifestyle strategies, and digital tools to support long-term maternal and infant wellbeing.

This content was developed with the assistance of artificial intelligence (AI) tools: DeepDive (Notebook LM, Google).

Perinatal Mental Health Is Not Secondary

In this deep-dive episode, we explore an unexpected breakthrough in dental material science: reinforcing traditional PMMA denture bases with propolis—yes, bee glue. Despite being the global standard, PMMA suffers from low strength, poor impact resistance, high wear, and susceptibility to microbial buildup. Researchers tested whether a simple natural bio-resin could solve problems that decades of metal fillers and synthetic additives failed to fix.

The results? Remarkable. A 1% concentration of propolis micropowder improved transverse strength, impact resistance, hardness, and—most dramatically—reduced surface roughness by over 50%, making the material far more resistant to biofilm formation. Higher concentrations, however, weakened the polymer due to wax-related interference during curing.

We unpack the chemistry, the “Goldilocks zone” of reinforcement, and the potential for a new generation of denture materials that are not only stronger, but actively therapeutic—offering antifungal and anti-inflammatory benefits directly within the prosthesis.

This content was developed with the assistance of artificial intelligence (AI) tools: DeepDive (Notebook LM, Google).

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In this episode, we explore photodynamic therapy (PDT)—a highly selective, light-activated treatment reshaping modern precision medicine. We break down how PDT targets diseased cells while sparing healthy tissue, why its unique Type I, II and III mechanisms matter, and how advances in nanotechnology and immunotherapy are pushing the technique far beyond oncology. From dermatology and ophthalmology to pediatric infections, cardiovascular disease and neurodegeneration, PDT is emerging as a versatile, low-toxicity tool with game-changing clinical potential.

This content was developed with the assistance of artificial intelligence (AI) tools: DeepDive (Notebook LM, Google).

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Leading in medical research and education, Wrocław Medical University drives innovation in health sciences and clinical advancements. Based in Wrocław, Poland.