Was this video recorded? The visuals are important here, but there’s no clip on youtube so far as i can tell

ArtScience @ Le Lab Lecture Series: Art, Design, Engineering & Biology

What sorts of breakthroughs are possible by modifying an organism’s genome – something researchers are now able to do ever more cheaply and efficiently? Researchers around the world are already able to program microbes to treat wastewater, generate electricity, manufacture jet fuel, create hemoglobin, and fabricate new drugs. What sounds like science fiction to most of us might be a reality in our lifetimes: the ability to build diagnostic tools that live within our bodies, or find ways to eradicate malaria from mosquito lines, or possibly even to make genetic improvements in humans that are passed down to future generations. Wyss Institute Founding Core Faculty Members Pam Silver and George Church discuss the high-impact benefits of their synthetic biology work, as well as how they manage the potential of unintended consequences.

Transcript: https://s3-us-west-2.amazonaws.com/wyss-prod/app/uploads/2015/05/26123354/Ep001_Disruptive_SyntheticBiology.pdf

Disruptive: Synthetic Biology | Wyss Institute

Sepsis is a bloodstream infection caused by an uncontrolled spread of pathogens and release of toxins that can lead to systemic inflammation and multi-organ failure. Sepsis is the leading cause of hospital deaths and kills at least eight million people worldwide each year. Current treatment is to administer patients broad-spectrum antibiotics because there is often not enough time to identify the specific cause of infection. Diagnosis takes two to five days and every hour one waits can increase the risk of death by 5-9%.

In this episode of Disruptive, Wyss Institute Founding Director Don Ingber and Senior Staff Scientist Mike Super discuss how their team developed a new therapeutic device inspired by the human spleen. This blood-cleansing approach can remove sepsis-causing pathogens from circulating blood without ever needing to know their identity. In animal studies, treatment with this device reduced the number of targeted pathogens and toxins circulating in the bloodstream by more than 99%. This device may radically transform the way sepsis is treated.

Transcript: https://s3-us-west-2.amazonaws.com/wyss-prod/app/uploads/2017/08/09180758/Ep3_Disruptive_Confronting_Sepsis.pdf

Disruptive: Confronting Sepsis | Wyss Institute

How can a materials science approach lead to medical breakthroughs?
In this episode of Disruptive, Wyss Core Faculty Member Dave Mooney discusses programmable nanomaterials approaches to fighting disease. Mooney explains how a cancer vaccine, developed by his team and currently in a clinical trial at the Dana-Farber Cancer Institute, can train one’s own immune system to target specific cancer cells. He also describes the development of novel hydrogels that find application in drug delivery systems and tissue regeneration. Chris Gemmiti, a member of the Wyss Institute’s Business Development team, joins the conversation to discuss the Wyss process of translation and what is involved in bringing the hydrogel drug delivery technology from bench-to-bedside.

Transcript: https://s3-us-west-2.amazonaws.com/wyss-prod/app/uploads/2017/08/10130728/Ep4_Disruptive_Cancer_Vaccine__Hydrogel_Drug_Delivery.pdf

Disruptive: Cancer Vaccine & Hydrogel Drug Delivery | Wyss Institute

How can DNA be programmed to build novel structures, devices, and robots?

We have taken our understanding of DNA to another level, beginning to take advantage of some of DNA’s properties that have served nature so well, but in ways nature itself may have never pursued. Humans can now use DNA as a medium for nano-scale engineering. The resulting newly programmed and built DNA structures can enhance our ability to see and study molecular interactions and the inner-life of cells. As these structures become increasingly complex and versatile, they have the potential to spawn entirely new and revolutionary technologies for biological monitoring, therapeutic delivery, and applications scientists have not even thought of yet.

In this episode of Disruptive, Wyss faculty members William Shih, Wesley Wong, and Peng Yin discuss what it is like being on the frontier of science, and the potential applications of their DNA-programming work.

Transcript: https://s3-us-west-2.amazonaws.com/wyss-prod/app/uploads/2017/08/09175352/Ep5_Disruptive_Molecular-Robotics.pdf

Disruptive: Molecular Robotics | Wyss Institute

George Church
Responsibility, art & science of intentional extinction, de-extinction & aging
Wednesday, Feb 17, 2016

ArtScience @ Le Lab Lecture Series: Art, Design, Engineering & Biology – Core Faculty from the Wyss Institute for Biologically Inspired Engineering at Harvard University discuss how the arts and design are informing the frontiers of science.

ArtScience @ Le Lab is a free, biweekly evening seminar series organized for the general public in the magical "Honeycomb" of Le Lab Cambridge and Café ArtScience. Artists, designers, scientists, chefs, engineers, perfumers -- and more -- talk about creativity and culture at the edges of art, science and design. For more information, please visit http://www.lelaboratoirecambridge.com or http://wyss.harvard.edu.

George Church: Responsibility, art & science of intentional extinction, de-extinction & aging

A bionic leaf combines advanced catalysts with engineered bacteria to produce hydrocarbon fuels from light, water, and carbon dioxide.

Melding Biology and Chemistry in a Bionic Leaf

Robots - The Podcast for News and Views on Robotics

Soft Robotics Toolkit

February 15, 2017

Listen to Wyss Core Faculty member William Shih’s lecture on how custom molecular shapes can be designed using DNA building blocks and how these minuscule devices could have a profound impact on fields ranging from molecular biophysics to therapeutics to nano-optics for decades to come. Shih’s lecture is part of the ArtScience lecture series at Le Laboratoire in Cambridge, MA.

ArtScience @ Le Lab is a free, biweekly evening seminar series organized for the general public in the magical “Honeycomb” of Le Laboratoire Cambridge and Café ArtScience. Artists, designers, scientists, chefs, engineers, perfumers — and more — talk about creativity and culture at the edges of art, science and design. For more information, please visit http://www.lelaboratoirecambridge.com or http://wyss.harvard.edu/events.

William Shih: Lego-Style Construction of Future Therapeutics From DNA

Wyss Core Faculty member David Mooney presents a talk with Mary Mooney, titled Seeing Is Believing: Therapeutic Cancer Vaccines. Marshalling a patient’s immune system to recognize and destroy cancerous cells is an exciting strategy to attack cancer, and this talk will explore materials that engage the immune system through science and artistic representation.
 
Mary K. Mooney is a Massachusetts artist who spent many years working as a designer in the apparel industry. Now the Massachusetts landscape provides Mary with the inspiration for her Plein Air paintings. With the Boston area so rich in natural beauty and history, Mary finds peace being one with nature as she paints. Learning the history behind each scene has always been an important aspect in choosing a location. Classically trained in the traditional style of the French Atelier realist painters, the science of light and how it affects color plays an important role in her paintings. These techniques inform her more realistic Still life paintings that contrast the looser style of her landscape paintings. In recent years Mary has also been creating mixed media sculptures using found objects and repurposing these object to give them new life. In an age of recycling, Mary finds it satisfying to utilize an interesting object found on the street. Mary has a BFA in Fine Arts and Design from the University of Massachusetts Dartmouth.
​
David Mooney is the Pinkas Family Professor of Bioengineering in the Harvard School of Engineering and Applied Sciences, and a Core Faculty Member of the Wyss Institute. His laboratory designs biomaterials to make cell and protein therapies effective and practical approaches to treat disease. He is a member of the National Academy of Engineering, the National Academy of Medicine, and the National Academy of Inventors. He has won numerous awards, including the Clemson Award from the SFB, MERIT award from the NIH, Distinguished Scientist Award from the IADR, Phi Beta Kappa Prize for Excellence in Undergraduate Teaching, and the Everett Mendelsohn Excellence in Mentoring Award from Harvard College. His inventions have been licensed by numerous companies, leading to commercialized products, and he is active on industrial scientific advisory boards.

David and Mary Mooney: Seeing Is Believing- Therapeutic Cancer Vaccines - AUDIO ONLY

Michael Super, PhD, of the Wyss Institute, shares his story of how the spread of infectious disease throughout South Africa and London inspired him to pursue human health and combat disease.

Protein Engineering: Editing Functionality

The Wyss Institute uses Nature's design principles to develop bioinspired technologies that will revolutionize medicine and create a more sustainable world.

William Shih: Lego-Style Construction of Future Therapeutics From DNA

Wyss Institute

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