FULL TEXT - https://www.drjjamesfrost.com/post/intrinsic-cellular-computation-far-reaching-implications-for-solving-the-cancer-problem

In my article Cancer’s Intelligence I conjectured that cancer is able to compute survival solutions to future environmental changes that it has not yet encountered. That is, that cancer can predict the future and ready itself to adapt to new, yet unseen environmental conditions, whether a change in oxygen tension or a chemotherapeutic drug.

A recent, exceedingly relevant paper entitled Trade-offs between cost and information in cellular prediction by Tjalma et al analyzes cellular adaptation and lays out the conditions for prediction of a survival response to an adverse environmental change. The cellular response is an intrinsically computed solution to future external events using the cell’s internal computational machinery. Historically, it has been thought that only higher organisms “can predict the future environment and initiate a response ahead of time”, but this is not the case.

At bottom, energy and time are two key computational limits. Energy (free energy) for computation, storing information, and the protein synthesis needed for future actions limits computation of the optimal solution for future survival moves.  Time is a factor in computing solutions and a in sensing and sampling the current and past environments sufficiently finely for accurate predictions. Optimal time averaging for the cell is key, which also has the advantage of filtering noise.

The Tjalma article elucidates the informational bounds a cell can possibly have about the future. The costs of a bit of informational sampling and processing are computed and compared.  As information-processing humans, we extract only the most useful information from the past environment as we plan future actions – the cell does the same. How and under what conditions a cell approaches the information bound for its internal computation is examined in detail by exploring Markovian and non-Markovian models and by examining the necessary fineness of temporal sampling of the environment and the cell’s computational speed. The information bottleneck theory is key in this analysis, as it dictates information compression for storage and its costs.

The article is a challenging, yet rewarding read and one that is intimately related to the vast computation ability of the cancer cell and more importantly, cancer cell networks. In a way, this article is the missing link between cancer’s computation from instantaneous, present environmental conditions – the constrained regime held by most cancer biologists – to the tracking and selective sampling of the past and the present to the response to yet-unseen future events – just as human and higher animal computation occurs.

For more information on the molecular imaging aspects of cancer characterization, treatment, and monitoring, please visit BioMolecular Imaging, LLC http://biomolecularimaging.com

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Intrinsic Cellular Computation: Far Reaching Implications for Solving the Cancer Problem

In this special BDAS episode we explored leadership, identity, and lived experience within the health and care sectors through the lens of the panel’s extensive expertise. It brought together voices from creative practice, policy, community leadership, and lived experience. Looking into how they intersect to shape more inclusive and equitable systems of care.
Host Corine Walker, a Bristol-based writer, director, creative producer, and performer, spoke with Sophie Chester-Glyn, Managing Director of a local care organisation and Director of Coproduce Care, and Councillor Lorraine Francis, a Green Party Councillor, social worker, and therapist.
This discussion explored how co-production, representation, and storytelling can challenge inequality and inspire structural change. It highlighted the evolving role of leadership – from community-led action to policy influence – and how authenticity and resilience can drive meaningful transformation.
 
About UWE Equity https://www.uwe.ac.uk/study/career-development/equity 
 
UWE Equity a positive action coaching programme for Global Majority students providing personal and professional development opportunities with targeted initiatives for Global majority students in the form of insight sessions, webinars, mentoring and coaching/skills sessions .As part of the programme there are speaker events linked to our Bristol Distinguished Address Series – last year’s event was Crossing Generations with Dr. Edson Burton & Guests.
Listen more from the Bristol Distinguished Address Series: soundcloud.com/uwebristol/sets/bristol-distinguished-address
Watch the Bristol Distinguished Address Series: www.youtube.com/playlist?list=PLr…2D-Bo_EtA47W6vG-T
Learn more about the Bristol Distinguished Address Series: www.uwe.ac.uk/events/bristol-dis…hed-address-series 

Thriving While Leading| Bristol Distinguished Address Series

An introduction to the Microsoft Power Suite – Your gateway to automation, building simple applications and analysing your data.

This podcast is designed for business users who are looking to understand how to access and utilise automation.

Session structure
•	What is the Power Suite of Applications
•	Power Automate
•	Power Apps
•	Power BI
•	Power Pages
•	Co-Pilot Studio


Getting to know your Power Suite - Episode 1: Part 1 Power Platform Intro

Getting to know your Power Suite
An introduction to the Microsoft Power Suite – Your gateway to automation, building simple applications and analysing your data.

This podcast is designed for business users who are looking to understand how to access and utilise automation.
 
Session structure
•	What is the Power Suite of Applications
•	Power Automate
•	Power Apps
•	Power BI
•	Power Pages
•	Co-Pilot Studio

Getting to Know your Power Suite - Episode 1: Part 2 Terminology

Getting to know your Power Suite - Episode 1:  Part 3 Power BI

An introduction to the Microsoft Power Suite – Your gateway to automation, building simple applications and analysing your data.
This podcast is designed for business users who are looking to understand how to access and utilise automation.
 
Session structure
•	What is the Power Suite of Applications
•	Power Automate
•	Power Apps
•	Power BI
•	Power Pages
•	Co-Pilot Studio


Getting to know your Power Suite - Episode 1: Part 4 Power Apps

Getting to know your Power Suite - Episode 1: Part 5 Power Automate

Getting to know your Power Suite - Episode 1: Part 6 Power Pages

Getting to know your Power Suite - Episode 1: Part 7 Co Pilot Studio

Getting to know your Power Suite - Episode 1: Part 8 Dataverse

Getting to know your Power Suite - Episode 1: Part 9 Wrap up

Molecular imaging Specialist
Clinical trials reader
Clinical radiology and nuclear medicine
Consulting for pharma, CROs, diagnostics, and biotech
Strategic partnering across industry, academia and government
Early stage companies and investment

Intrinsic Cellular Computation: Far Reaching Implications for Solving the Cancer Problem

Dr. J. James Frost

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